{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T09:55:18Z","timestamp":1780048518183,"version":"3.53.1"},"reference-count":94,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,5,22]],"date-time":"2021-05-22T00:00:00Z","timestamp":1621641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Pt-ttpy (tolyl terpyridin-Pt complex) covalently binds to G-quadruplex (G4) structures in vitro and to telomeres in cellulo via its Pt moiety. Here, we identified its targets in the human genome, in comparison to Pt-tpy, its derivative without G4 affinity, and cisplatin. Pt-ttpy, but not Pt-tpy, induces the release of the shelterin protein TRF2 from telomeres concomitantly to the formation of DNA damage foci at telomeres but also at other chromosomal locations. \u03b3-H2AX chromatin immunoprecipitation (ChIP-seq) after treatment with Pt-ttpy or cisplatin revealed accumulation in G- and A-rich tandemly repeated sequences, but not particularly in potential G4 forming sequences. Collectively, Pt-ttpy presents dual targeting efficiency on DNA, by inducing telomere dysfunction and genomic DNA damage at specific loci.<\/jats:p>","DOI":"10.1093\/mtomcs\/mfab029","type":"journal-article","created":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T19:16:02Z","timestamp":1621451762000},"source":"Crossref","is-referenced-by-count":7,"title":["Pt-ttpy, a G-quadruplex binding platinum complex, induces telomere dysfunction and G-rich regions DNA damage"],"prefix":"10.1093","volume":"13","author":[{"given":"Samar","family":"Ali","sequence":"first","affiliation":[{"name":"INSERM UMRS 1007, Universit\u00e9 de Paris, 75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6387-8740","authenticated-orcid":false,"given":"Emilia Puig","family":"Lombardi","sequence":"additional","affiliation":[{"name":"Institut Curie, PSL Research University, CNRS UMR3244, Sorbonne Universit\u00e9, Telomeres and Cancer lab, 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepanjan","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Institut Curie, CNRS UMR9187-INSERMU1196, CMBC, 91405 Orsay, France"},{"name":"Institut Curie, CNRS UMR9187-INSERMU1196, Universit\u00e9 Paris-Saclay, 91405 Orsay, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8358-6005","authenticated-orcid":false,"given":"Tao","family":"Jia","sequence":"additional","affiliation":[{"name":"Institut Curie, CNRS UMR9187-INSERMU1196, CMBC, 91405 Orsay, France"},{"name":"Institut Curie, CNRS UMR9187-INSERMU1196, Universit\u00e9 Paris-Saclay, 91405 Orsay, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9raldine","family":"Vitry","sequence":"additional","affiliation":[{"name":"INSERM UMRS 1007, Universit\u00e9 de Paris, 75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Saker","sequence":"additional","affiliation":[{"name":"INSERM UMRS 1007, Universit\u00e9 de Paris, 75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00ebl","family":"Poupon","sequence":"additional","affiliation":[{"name":"H\u00f4pital Lariboisi\u00e8re, Laboratoire de Toxicologie Biologique, 2 rue Ambroise Par\u00e9, 75475 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2053-7513","authenticated-orcid":false,"given":"Marie-Paule","family":"Teulade-Fichou","sequence":"additional","affiliation":[{"name":"Institut Curie, CNRS UMR9187-INSERMU1196, CMBC, 91405 Orsay, France"},{"name":"Institut Curie, CNRS UMR9187-INSERMU1196, Universit\u00e9 Paris-Saclay, 91405 Orsay, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5606-7808","authenticated-orcid":false,"given":"Alain","family":"Nicolas","sequence":"additional","affiliation":[{"name":"Institut Curie, PSL Research University, CNRS UMR3244, Sorbonne Universit\u00e9, Telomeres and Cancer lab, 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3535-7563","authenticated-orcid":false,"given":"Arturo","family":"Londono-Vallejo","sequence":"additional","affiliation":[{"name":"Institut Curie, PSL Research University, CNRS UMR3244, Sorbonne Universit\u00e9, Telomeres and Cancer lab, 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6543-4497","authenticated-orcid":false,"given":"Sophie","family":"Bombard","sequence":"additional","affiliation":[{"name":"Institut Curie, CNRS UMR9187-INSERMU1196, CMBC, 91405 Orsay, France"},{"name":"Institut Curie, CNRS UMR9187-INSERMU1196, Universit\u00e9 Paris-Saclay, 91405 Orsay, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,5,22]]},"reference":[{"issue":"19","key":"2021120813093085400_bib1","doi-asserted-by":"crossref","first-page":"5402","DOI":"10.1093\/nar\/gkl655","article-title":"Quadruplex DNA: sequence, topology and structure","volume":"34","author":"Burge","year":"2006","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"2021120813093085400_bib2","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1093\/nar\/gkl1057","article-title":"G-quadruplexes in promoters throughout the human genome","volume":"35","author":"Huppert","year":"2007","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"2021120813093085400_bib3","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1093\/nar\/gkw006","article-title":"Re-evaluation of G-quadruplex propensity with G4Hunter","volume":"44","author":"Bedrat","year":"2016","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"2021120813093085400_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkz1097","article-title":"A guide to computational methods for G-quadruplex prediction","volume":"48","author":"Puig Lombardi","year":"2019","journal-title":"Nucleic. Acids. Res."},{"issue":"8","key":"2021120813093085400_bib5","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/nbt.3295","article-title":"High-throughput sequencing of DNA G-quadruplex structures in the human genome","volume":"33","author":"Chambers","year":"2015","journal-title":"Nat. Biotechnol."},{"issue":"10","key":"2021120813093085400_bib6","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1038\/ng.3662","article-title":"G-quadruplex structures mark human regulatory chromatin","volume":"48","author":"Hansel-Hertsch","year":"2016","journal-title":"Nat. Genet."},{"issue":"2","key":"2021120813093085400_bib7","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.trechm.2019.07.002","article-title":"The structure and function of DNA G-Quadruplexes","volume":"2","author":"Spiegel","year":"2020","journal-title":"Trends Chem."},{"issue":"8","key":"2021120813093085400_bib8","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/s41580-020-0236-x","article-title":"The regulation and functions of DNA and RNA G-quadruplexes","volume":"21","author":"Varshney","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"3","key":"2021120813093085400_bib9","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nchem.1548","article-title":"Quantitative visualization of DNA G-quadruplex structures in human cells","volume":"5","author":"Biffi","year":"2013","journal-title":"Nat. Chem."},{"issue":"13","key":"2021120813093085400_bib10","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.1093\/nar\/gki722","article-title":"Preferential binding of a G-quadruplex ligand to human chromosome ends","volume":"33","author":"Granotier","year":"2005","journal-title":"Nucleic Acids Res."},{"issue":"8","key":"2021120813093085400_bib11","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nrg1656","article-title":"Telomeres and human disease: ageing, cancer and beyond","volume":"6","author":"Blasco","year":"2005","journal-title":"Nat. Rev. Genet."},{"issue":"1","key":"2021120813093085400_bib12","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev.genet.41.110306.130350","article-title":"How shelterin protects mammalian telomeres","volume":"42","author":"Palm","year":"2008","journal-title":"Annu. Rev. Genet."},{"issue":"1","key":"2021120813093085400_bib13","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1146\/annurev-genet-032918-021921","article-title":"Shelterin-Mediated Telomere Protection","volume":"52","author":"de Lange","year":"2018","journal-title":"Annu. Rev. Genet."},{"issue":"1","key":"2021120813093085400_bib14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3390\/antiox6010015","article-title":"Treating Cancer by Targeting Telomeres and Telomerase","volume":"6","author":"Ivancich","year":"2017","journal-title":"Antioxidants"},{"issue":"18","key":"2021120813093085400_bib15","doi-asserted-by":"crossref","first-page":"8627","DOI":"10.1093\/nar\/gkv862","article-title":"G-quadruplexes and their regulatory roles in biology","volume":"43","author":"Rhodes","year":"2015","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"2021120813093085400_bib16","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1749-6632.2012.06586.x","article-title":"G4 motifs in human genes","volume":"1267","author":"Maizels","year":"2012","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"2021120813093085400_bib17","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.gde.2013.10.012","article-title":"Existence and consequences of G-quadruplex structures in DNA","volume":"25","author":"Murat","year":"2014","journal-title":"Curr. Opin. Genet. Dev."},{"issue":"4","key":"2021120813093085400_bib18","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nchembio.1475","article-title":"G quadruplexes are genomewide targets of transcriptional helicases XPB and XPD","volume":"10","author":"Gray","year":"2014","journal-title":"Nat. Chem. Biol."},{"issue":"11","key":"2021120813093085400_bib19","doi-asserted-by":"crossref","first-page":"4727","DOI":"10.1093\/nar\/gks068","article-title":"5'-UTR RNA G-quadruplexes: translation regulation and targeting","volume":"40","author":"Bugaut","year":"2012","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"2021120813093085400_bib20","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1039\/B714772B","article-title":"A hitchhiker's guide to G-quadruplex ligands","volume":"6","author":"Monchaud","year":"2008","journal-title":"Org. Biomol. Chem."},{"issue":"3","key":"2021120813093085400_bib21","doi-asserted-by":"crossref","first-page":"429","DOI":"10.3390\/molecules24030429","article-title":"Recent progress of targeted G-Quadruplex-preferred ligands toward cancer therapy","volume":"24","author":"Asamitsu","year":"2019","journal-title":"Molecules"},{"issue":"24","key":"2021120813093085400_bib22","doi-asserted-by":"crossref","first-page":"4020","DOI":"10.1002\/anie.200906363","article-title":"Interaction of metal complexes with G-Quadruplex DNA","volume":"49","author":"Georgiades","year":"2010","journal-title":"Angew. Chem. Int. Ed."},{"key":"2021120813093085400_bib23","first-page":"325","article-title":"Nucleic acid quadruplexes and metallo-drugs","volume":"18","author":"Vilar","year":"2018","journal-title":"Metal ions in life sciences"},{"issue":"5","key":"2021120813093085400_bib24","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1586\/17512433.2014.945909","article-title":"G-quadruplex interacting small molecules and drugs: from bench toward bedside","volume":"7","author":"M\u00fcller","year":"2014","journal-title":"Expert Rev. Clin. Pharmacol."},{"issue":"1","key":"2021120813093085400_bib25","doi-asserted-by":"crossref","first-page":"12192","DOI":"10.1038\/s41598-020-68944-w","article-title":"A G-quadruplex-binding compound shows potent activity in human gemcitabine-resistant pancreatic cancer cells","volume":"10","author":"Ahmed","year":"2020","journal-title":"Sci. Rep."},{"issue":"9","key":"2021120813093085400_bib26","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.molmed.2020.05.002","article-title":"Friend or Foe: The Role of the G-quartet in Anticancer Strategies","volume":"26","author":"Carvalho","year":"2020","journal-title":"Trends Mol. Med."},{"issue":"51","key":"2021120813093085400_bib27","doi-asserted-by":"crossref","first-page":"15764","DOI":"10.1021\/ja077390a","article-title":"Kinetically favored platination of adenine in the g-rich human telomeric repeat","volume":"129","author":"Rao","year":"2007","journal-title":"J. Am. Chem. Soc."},{"issue":"46","key":"2021120813093085400_bib28","doi-asserted-by":"crossref","first-page":"13701","DOI":"10.1021\/jp207265s","article-title":"Interactions of a Platinum-Modified Perylene Derivative with the Human Telomeric G-Quadruplex","volume":"115","author":"Rao","year":"2011","journal-title":"J. Phys. Chem. B"},{"issue":"7","key":"2021120813093085400_bib29","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1007\/s00775-007-0273-3","article-title":"A Platinum-Quinacridine Hybrid as G-Quadruplex Ligand","volume":"12","author":"Bertrand","year":"2007","journal-title":"JBIC Journal of Biological Inorganic Chemistry"},{"issue":"14","key":"2021120813093085400_bib30","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1039\/b904599f","article-title":"Exclusive platination of loop adenines in the human telomeric G-quadruplex","volume":"7","author":"Bertrand","year":"2009","journal-title":"Org. Biomol. Chem."},{"issue":"6","key":"2021120813093085400_bib31","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1021\/acs.bioconjchem.6b00079","article-title":"Linking of antitumour trans NHC-Pt(II) complexes to G-quadruplex DNA ligand for telomeric targeting","volume":"27","author":"Betzer","year":"2016","journal-title":"Bioconjug. Chem."},{"issue":"1","key":"2021120813093085400_bib32","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/s41598-017-19095-y","article-title":"Dual functional dinuclear platinum complex with selective reactivity towards c-myc G-quadruplex","volume":"8","author":"He","year":"2018","journal-title":"Sci. Rep."},{"issue":"16","key":"2021120813093085400_bib33","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1039\/b708635k","article-title":"The importance of metal geometry in the recognition of G-quadruplex-DNA by metal-terpyridine complexes","volume":"5","author":"Bertrand","year":"2007","journal-title":"Org. Biomol. Chem."},{"issue":"3","key":"2021120813093085400_bib34","doi-asserted-by":"crossref","first-page":"404","DOI":"10.3390\/molecules24030404","article-title":"Selectivity of Terpyridine Platinum Anticancer Drugs for G-quadruplex DNA","volume":"24","author":"Morel","year":"2019","journal-title":"Molecules"},{"issue":"21","key":"2021120813093085400_bib35","doi-asserted-by":"crossref","first-page":"7798","DOI":"10.1002\/chem.201500347","article-title":"Interactions of Pt-ttpy with G-Quadruplexes Originating from Promoter Region of the c-myc Gene Deciphered by NMR and Gel Electrophoresis Analysis","volume":"21","author":"Trajkovski","year":"2015","journal-title":"Chem. Eur. J."},{"issue":"1","key":"2021120813093085400_bib36","doi-asserted-by":"crossref","first-page":"16255","DOI":"10.1038\/srep16255","article-title":"Highly efficient radiosensitization of human glioblastoma and lung cancer cells by a G-quadruplex DNA binding compound","volume":"5","author":"Merle","year":"2015","journal-title":"Sci. Rep."},{"issue":"7","key":"2021120813093085400_bib37","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.3390\/ijms19071951","article-title":"Platinum Complexes Can Bind to Telomeres by Coordination","volume":"19","author":"Saker","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"21","key":"2021120813093085400_bib38","doi-asserted-by":"crossref","first-page":"6282","DOI":"10.1158\/0008-5472.CAN-18-0894","article-title":"Systematic analysis of compounds specifically targeting telomeres and telomerase for clinical implications in cancer therapy","volume":"78","author":"Lee","year":"2018","journal-title":"Cancer Res."},{"issue":"5","key":"2021120813093085400_bib39","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1021\/cr068207j","article-title":"Direct cellular responses to platinum-induced DNA damage","volume":"107","author":"Jung","year":"2007","journal-title":"Chem. Rev."},{"issue":"5","key":"2021120813093085400_bib40","doi-asserted-by":"crossref","first-page":"e63583","DOI":"10.1371\/journal.pone.0063583","article-title":"A simple high-content cell cycle assay reveals frequent discrepancies between cell number and ATP and MTS proliferation assays","volume":"8","author":"Chan","year":"2013","journal-title":"PLoS One"},{"issue":"6","key":"2021120813093085400_bib41","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1021\/acs.bioconjchem.6b00079","article-title":"Linking of Antitumor trans NHC-Pt(II) Complexes to G-Quadruplex DNA Ligand for Telomeric Targeting","volume":"27","author":"Betzer","year":"2016","journal-title":"Bioconjug. Chem."},{"issue":"2","key":"2021120813093085400_bib42","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/nsmb1192","article-title":"A topological mechanism for TRF2-enhanced strand invasion","volume":"14","author":"Amiard","year":"2007","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"10","key":"2021120813093085400_bib43","doi-asserted-by":"crossref","first-page":"47e","DOI":"10.1093\/nar\/30.10.e47","article-title":"Telomere measurement by quantitative PCR","volume":"30","author":"Cawthon","year":"2002","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"2021120813093085400_bib44","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1385\/MB:27:2:169","article-title":"Real-time quantitative PCR of telomere length","volume":"27","author":"Gil","year":"2004","journal-title":"Mol. Biotechnol."},{"issue":"43","key":"2021120813093085400_bib45","doi-asserted-by":"crossref","first-page":"15539","DOI":"10.1073\/pnas.0507915102","article-title":"DNA damage-induced phosphorylation of the human telomere-associated protein TRF2","volume":"102","author":"Tanaka","year":"2005","journal-title":"Proc. Natl. Acad. Sci."},{"key":"2021120813093085400_bib46","article-title":"Aligning sequence reads, clone sequences and assembly contigs with BWA-MEM","author":"Li","year":"2013","journal-title":"arXivorg"},{"issue":"9","key":"2021120813093085400_bib47","doi-asserted-by":"crossref","first-page":"R137","DOI":"10.1186\/gb-2008-9-9-r137","article-title":"Model-based analysis of ChIP-Seq (MACS)","volume":"9","author":"Zhang","year":"2008","journal-title":"Genome Biol."},{"key":"2021120813093085400_bib48","volume-title":"R: A language and environment for statistical computing. R Foundation for Statistical Computing","author":"R. R Core Team","year":"2017"},{"issue":"4","key":"2021120813093085400_bib49","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","article-title":"Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities","volume":"38","author":"Heinz","year":"2010","journal-title":"Mol. Cell"},{"issue":"1","key":"2021120813093085400_bib50","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.critrevonc.2004.08.008","article-title":"Recognition and processing of cisplatin- and oxaliplatin-DNA adducts","volume":"53","author":"Chaney","year":"2005","journal-title":"Crit. Rev. Oncol. Hematol."},{"issue":"2","key":"2021120813093085400_bib51","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1021\/acs.bioconjchem.6b00598","article-title":"Coordination to imidazole ring switches on phosphorescence of platinum cyclometalated complexes: The route to selective labeling of peptides and proteins via histidine residues","volume":"28","author":"Solomatina","year":"2017","journal-title":"Bioconjug. Chem."},{"issue":"21","key":"2021120813093085400_bib52","doi-asserted-by":"crossref","first-page":"11491","DOI":"10.1021\/acs.analchem.7b02746","article-title":"Quantitative evaluation of cisplatin uptake in sensitive and resistant individual cells by single-cell ICP-MS (SC-ICP-MS)","volume":"89","author":"Corte Rodriguez","year":"2017","journal-title":"Anal. Chem."},{"key":"2021120813093085400_bib53","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.phrs.2016.01.001","article-title":"Cisplatin resistance and opportunities for precision medicine","volume":"106","author":"Amable","year":"2016","journal-title":"Pharmacol. Res."},{"issue":"10","key":"2021120813093085400_bib54","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1158\/1535-7163.MCT-05-0102","article-title":"Abnormal lysosomal trafficking and enhanced exosomal export of cisplatin in drug-resistant human ovarian carcinoma cells","volume":"4","author":"Safaei","year":"2005","journal-title":"Mol. Cancer Ther."},{"issue":"6","key":"2021120813093085400_bib55","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1039\/c0mt00101e","article-title":"Cellular uptake and subcellular distribution of ruthenium-based metallodrugs under clinical investigation versus cisplatin","volume":"3","author":"Groessl","year":"2011","journal-title":"Metallomics"},{"issue":"10","key":"2021120813093085400_bib56","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1039\/C7MT00153C","article-title":"Differences in cisplatin distribution in sensitive and resistant ovarian cancer cells: a TEM\/NanoSIMS study","volume":"9","author":"Lee","year":"2017","journal-title":"Metallomics"},{"issue":"17","key":"2021120813093085400_bib57","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/S0960-9822(03)00542-6","article-title":"DNA damage foci at dysfunctional telomeres","volume":"13","author":"Takai","year":"2003","journal-title":"Curr. Biol."},{"issue":"13","key":"2021120813093085400_bib58","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1038\/sj.onc.1209217","article-title":"G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3' telomeric overhang in cancer cells","volume":"25","author":"Tahara","year":"2006","journal-title":"Oncogene"},{"issue":"14","key":"2021120813093085400_bib59","doi-asserted-by":"crossref","first-page":"6908","DOI":"10.1158\/0008-5472.CAN-06-1581","article-title":"The G-quadruplex ligand telomestatin inhibits POT1 binding to telomeric sequences in vitro and induces GFP-POT1 dissociation from telomeres in human cells","volume":"66","author":"Gomez","year":"2006","journal-title":"Cancer Res."},{"issue":"12","key":"2021120813093085400_bib60","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.1158\/1535-7163.MCT-09-0244","article-title":"G-quadruplex ligand SYUIQ-5 induces autophagy by telomere damage and TRF2 delocalization in cancer cells","volume":"8","author":"Zhou","year":"2009","journal-title":"Mol. Cancer Ther."},{"issue":"4","key":"2021120813093085400_bib61","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/cmdc.201402552","article-title":"Looking for efficient G-quadruplex ligands: evidence for selective stabilizing properties and telomere damage by drug-like molecules","volume":"10","author":"Pagano","year":"2015","journal-title":"ChemMedChem"},{"key":"2021120813093085400_bib62","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s13046-014-0081-x","article-title":"Identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities","volume":"33","author":"Rizzo","year":"2014","journal-title":"J. Exp. Clin. Cancer Res. : CR"},{"issue":"45","key":"2021120813093085400_bib63","doi-asserted-by":"crossref","first-page":"16201","DOI":"10.1021\/jacs.7b07490","article-title":"Metallo-supramolecular Complexes Enantioselectively Eradicate Cancer Stem Cells in Vivo","volume":"139","author":"Qin","year":"2017","journal-title":"J. Am. Chem. Soc."},{"issue":"8","key":"2021120813093085400_bib64","first-page":"1629","article-title":"Association of a platinum complex to a G-quadruplex ligand enhances the telomere disruption","volume":"38","author":"Charif","year":"2017","journal-title":"Chem ResTox"},{"issue":"18","key":"2021120813093085400_bib65","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1038\/sj.onc.1208468","article-title":"Apoptosis related to telomere instability and cell cycle alterations in human glioma cells treated by new highly selective G-quadruplex ligands","volume":"24","author":"Pennarun","year":"2005","journal-title":"Oncogene"},{"issue":"3","key":"2021120813093085400_bib66","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1124\/mol.107.036574","article-title":"A new steroid derivative stabilizes g-quadruplexes and induces telomere uncapping in human tumor cells","volume":"72","author":"Brassart","year":"2007","journal-title":"Mol Pharmacol"},{"issue":"7","key":"2021120813093085400_bib67","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/cr.2011.40","article-title":"The human TTAGGG repeat factors 1 and 2 bind to a subset of interstitial telomeric sequences and satellite repeats","volume":"21","author":"Simonet","year":"2011","journal-title":"Cell Res."},{"issue":"20","key":"2021120813093085400_bib68","doi-asserted-by":"crossref","first-page":"7187","DOI":"10.1093\/nar\/gkq563","article-title":"A G-quadruplex structure within the 5'-UTR of TRF2 mRNA represses translation in human cells","volume":"38","author":"Gomez","year":"2010","journal-title":"Nucleic Acids Res."},{"issue":"18","key":"2021120813093085400_bib69","doi-asserted-by":"crossref","first-page":"9073","DOI":"10.1093\/nar\/gks424","article-title":"Mammalian NUMT insertion is non-random","volume":"40","author":"Tsuji","year":"2012","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"2021120813093085400_bib70","doi-asserted-by":"crossref","first-page":"e313","DOI":"10.1038\/emm.2016.174","article-title":"miR-24-mediated knockdown of H2AX damages mitochondria and the insulin signaling pathway","volume":"49","author":"Jeong","year":"2017","journal-title":"Exp. Mol. Med."},{"issue":"5","key":"2021120813093085400_bib71","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1039\/c0mb00277a","article-title":"Shot-gun proteomic analysis of mitochondrial D-loop DNA binding proteins: identification of mitochondrial histones","volume":"7","author":"Choi","year":"2011","journal-title":"Mol. Biosyst."},{"issue":"46","key":"2021120813093085400_bib72","doi-asserted-by":"crossref","first-page":"14246","DOI":"10.1002\/anie.201607380","article-title":"Base-resolution analysis of cisplatin-DNA adducts at the genome scale","volume":"55","author":"Shu","year":"2016","journal-title":"Angew. Chem. Int. Ed."},{"issue":"41","key":"2021120813093085400_bib73","doi-asserted-by":"crossref","first-page":"11507","DOI":"10.1073\/pnas.1614430113","article-title":"Cisplatin DNA damage and repair maps of the human genome at single-nucleotide resolution","volume":"113","author":"Hu","year":"2016","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"15","key":"2021120813093085400_bib74","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1038\/onc.2011.384","article-title":"Molecular mechanisms of cisplatin resistance","volume":"31","author":"Galluzzi","year":"2012","journal-title":"Oncogene"},{"issue":"5","key":"2021120813093085400_bib75","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1021\/jm301780s","article-title":"Antitumor trans-N-heterocyclic carbene-amine-Pt(II) complexes: synthesis of dinuclear species and exploratory investigations of DNA binding and cytotoxicity mechanisms","volume":"56","author":"Chtchigrovsky","year":"2013","journal-title":"J. Med. Chem."},{"issue":"14","key":"2021120813093085400_bib76","doi-asserted-by":"crossref","first-page":"3384","DOI":"10.3390\/ijms20143384","article-title":"Mitochondrial Involvement in Cisplatin Resistance","volume":"20","author":"Cocetta","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"2021120813093085400_bib77","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ica.2012.07.013","article-title":"Cellular interactions of platinum drugs","volume":"393","author":"Wexeslblatt","year":"2012","journal-title":"Inorg. Chim. Acta"},{"issue":"20","key":"2021120813093085400_bib78","doi-asserted-by":"crossref","first-page":"3769","DOI":"10.1111\/febs.14628","article-title":"Naphthalene diimide-derivatives G-quadruplex ligands induce cell proliferation inhibition, mild telomeric dysfunction and cell cycle perturbation in U251MG glioma cells","volume":"285","author":"Muoio","year":"2018","journal-title":"FEBS J."},{"issue":"98","key":"2021120813093085400_bib79","doi-asserted-by":"crossref","first-page":"14101","DOI":"10.1039\/C6CC08254H","article-title":"Trigeminal star-like platinum complexes induce cancer cell senescence through quadruplex-mediated telomere dysfunction","volume":"52","author":"Zheng","year":"2016","journal-title":"Chem. Commun."},{"key":"2021120813093085400_bib80","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3389\/fchem.2014.00054","article-title":"Bis-indole derivatives with antitumor activity turn out to be specific ligands of human telomeric G-quadruplex","volume":"2","author":"Amato","year":"2014","journal-title":"Front Chem"},{"issue":"5","key":"2021120813093085400_bib81","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s00775-010-0631-4","article-title":"Platination of telomeric DNA by cisplatin disrupts recognition by TRF2 and TRF1","volume":"15","author":"Ourliac-Garnier","year":"2010","journal-title":"JBIC J. Biol. Inorganic Chem."},{"issue":"40","key":"2021120813093085400_bib82","doi-asserted-by":"crossref","first-page":"41487","DOI":"10.1074\/jbc.M406123200","article-title":"Interaction of telomestatin with the telomeric single-strand overhang","volume":"279","author":"Gomez","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"50","key":"2021120813093085400_bib83","doi-asserted-by":"crossref","first-page":"38721","DOI":"10.1074\/jbc.M605828200","article-title":"Telomestatin induced telomere uncapping is modulated by POT1 through G-overhang extension in HT1080 human tumor cells","volume":"281","author":"Gomez","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"13","key":"2021120813093085400_bib84","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1128\/MCB.00944-08","article-title":"DNA damage-induced phosphorylation of TRF2 is required for the fast pathway of DNA double-strand break repair","volume":"29","author":"Huda","year":"2009","journal-title":"Mol. Cell. Biol."},{"issue":"4","key":"2021120813093085400_bib85","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1093\/nar\/gkw1202","article-title":"SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage","volume":"45","author":"Rizzo","year":"2017","journal-title":"Nucleic Acids Res."},{"issue":"11","key":"2021120813093085400_bib86","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/nsmb.3092","article-title":"Complex interactions between the DNA-damage response and mammalian telomeres","volume":"22","author":"Arnoult","year":"2015","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"6081","key":"2021120813093085400_bib87","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1126\/science.1218498","article-title":"Removal of shelterin reveals the telomere end-protection problem","volume":"336","author":"Sfeir","year":"2012","journal-title":"Science"},{"issue":"12","key":"2021120813093085400_bib88","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1016\/j.celrep.2019.08.041","article-title":"Dual processing of R-loops and topoisomerase i induces transcription-dependent DNA double-strand breaks","volume":"28","author":"Cristini","year":"2019","journal-title":"Cell Rep."},{"issue":"9","key":"2021120813093085400_bib89","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1093\/nar\/gki609","article-title":"Prevalence of quadruplexes in the human genome","volume":"33","author":"Huppert","year":"2005","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"2021120813093085400_bib90","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/nchembio.780","article-title":"Small-molecule-induced DNA damage identifies alternative DNA structures in human genes","volume":"8","author":"Rodriguez","year":"2012","journal-title":"Nat. Chem. Biol."},{"issue":"2","key":"2021120813093085400_bib91","doi-asserted-by":"crossref","first-page":"481\u2013496 e21","DOI":"10.1016\/j.cell.2020.05.040","article-title":"A genetic map of the response to DNA damage in human cells","volume":"182","author":"Olivieri","year":"2020","journal-title":"Cell"},{"issue":"1","key":"2021120813093085400_bib92","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/s41467-019-08290-2","article-title":"Differential damage and repair of DNA-adducts induced by anti-cancer drug cisplatin across mouse organs","volume":"10","author":"Yimit","year":"2019","journal-title":"Nat. Commun."},{"issue":"22","key":"2021120813093085400_bib93","doi-asserted-by":"crossref","first-page":"6747","DOI":"10.1021\/bi034264k","article-title":"Nucleotide excision repair from site-specifically platinum-modified nucleosomes","volume":"42","author":"Wang","year":"2003","journal-title":"Biochemistry"},{"issue":"7598","key":"2021120813093085400_bib94","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nature17437","article-title":"Differential DNA repair underlies mutation hotspots at active promoters in cancer genomes","volume":"532","author":"Perera","year":"2016","journal-title":"Nature"}],"container-title":["Metallomics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/metallomics\/advance-article-pdf\/doi\/10.1093\/mtomcs\/mfab029\/38103894\/mfab029.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/metallomics\/article-pdf\/13\/6\/mfab029\/41654494\/mfab029.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/metallomics\/article-pdf\/13\/6\/mfab029\/41654494\/mfab029.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T13:29:40Z","timestamp":1638970180000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/metallomics\/article\/doi\/10.1093\/mtomcs\/mfab029\/6280987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,22]]},"references-count":94,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6,12]]}},"URL":"https:\/\/doi.org\/10.1093\/mtomcs\/mfab029","relation":{},"ISSN":["1756-591X"],"issn-type":[{"value":"1756-591X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,6]]},"published":{"date-parts":[[2021,5,22]]},"article-number":"mfab029"}}