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During brain neuroinflammation, activated microglial cells resulting from amyloid-beta (A\u03b2) overload trigger toxic proinflammatory responses. Bis(ethylmaltolato)oxidovanadium (BEOV) (IV), an important vanadium compound, has been reported to have anti-diabetic, anti-cancer, and neuroprotective effects, but its anti-inflammatory property has rarely been investigated. In the present study, the inhibitory effects of BEOV on neuroinflammation were revealed in both A\u03b2-stimulated BV2 microglial cell line and APPswe\/PS1E9 transgenic mouse brain. BEOV administration significantly decreased the levels of tumor necrosis factor-\u03b1, interleukin-6, interleukin-1\u03b2, inducible nitric oxide synthase, and cyclooxygenase-2 both in the hippocampus of APPswe\/PS1E9 mice and in the A\u03b2-stimulated BV2 microglia. Furthermore, BEOV suppressed the A\u03b2-induced activation of nuclear factor-\u03baB (NF-\u03baB) signaling and upregulated the protein expression level of peroxisome proliferator-activated receptor gamma (PPAR\u03b3) in a dose-dependent manner. PPAR\u03b3 inhibitor GW9662 could eliminate the effect of BEOV on A\u03b2-induced NF-\u03baB activation and proinflammatory mediator production. Taken altogether, these findings suggested that BEOV ameliorates A\u03b2-stimulated neuroinflammation by inhibiting NF-\u03baB signaling pathway through a PPAR\u03b3-dependent mechanism.<\/jats:p>","DOI":"10.1093\/mtomcs\/mfab036","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T11:19:43Z","timestamp":1623410383000},"source":"Crossref","is-referenced-by-count":30,"title":["Bis(ethylmaltolato)oxidovanadium (IV) attenuates amyloid-beta-mediated neuroinflammation by inhibiting NF-\u03baB signaling pathway via a PPAR\u03b3-dependent mechanism"],"prefix":"10.1093","volume":"13","author":[{"given":"Zhijun","family":"He","sequence":"first","affiliation":[{"name":"Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong, 518060, China"},{"name":"Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqian","family":"Li","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong, 518060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangxue","family":"Han","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430073, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingyu","family":"Ren","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong, 518060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Hu","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430073, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Li","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong, 518060, China"},{"name":"Shenzhen Bay Laboratory, Shenzhen, 518055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiubo","family":"Du","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong, 518060, China"},{"name":"Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, 518055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiazuan","family":"Ni","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong, 518060, China"},{"name":"Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaogai","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratories of Natural and Biomimetic Drugs, Department of Chemical Biology, Peking University School of Pharmaceutical Sciences, Beijing, 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6431-3650","authenticated-orcid":false,"given":"Qiong","family":"Liu","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong, 518060, China"},{"name":"Shenzhen Bay Laboratory, Shenzhen, 518055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,6,14]]},"reference":[{"issue":"4","key":"2021120813001698300_bib1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1056\/NEJMe1714638","article-title":"Amyloid-beta solubility in the treatment of Alzheimer's disease","volume":"378","author":"Murphy","year":"2018","journal-title":"N. 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