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Induction of oxidative stress, apoptosis resistance, genotoxic effects, and epigenetic modulations have been indicated to regulate cadmium-induced carcinogenesis. Circular RNAs are epigenetic regulators that have been recognized to play essential roles in carcinogenesis. Yet, the involvement of circular RNAs in cadmium carcinogenesis remains unclear. In this study, a novel circular RNA, circPUS7, was identified and described for the first time. CircPUS7 was significantly upregulated at week 12, 16, and 20 during the cadmium-induced transformation of human bronchial epithelial BEAS-2B cells. Knockdown of circPUS7 in cadmium-transformed BEAS-2B (T-BEAS-2B) cells significantly attenuated transformation markers including cell proliferation, migration, invasion, and anchorage-independent growth. Moreover, circPUS7 promoted malignant phenotypes by competitively binding with miR-770. Overexpression of miR-770 significantly inhibited the transformation properties of T-BEAS-2B cells while inhibition of miR-770 potently reversed the inhibitory effects of circPUS7 knockdown in proliferation, migration, invasion, and anchorage-independent growth of the T-BEAS-2B cells. Kirsten rat sarcoma viral oncogene homolog (KRAS), which was increased synchronically with circPUS7 during cadmium-induced cell transformation, was regulated by circPUS7 through sponging miR-770. In summary, our findings demonstrate that circPUS7 promotes cadmium-induced cell transformation through sponging miR-770 to regulate KRAS expression, providing a new perspective with the involvement of circular RNAs to further understand the mechanisms of cadmium carcinogenesis.<\/jats:p>","DOI":"10.1093\/mtomcs\/mfab043","type":"journal-article","created":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T11:08:57Z","timestamp":1625310537000},"source":"Crossref","is-referenced-by-count":12,"title":["A novel circular RNA, circPUS7 promotes cadmium-induced transformation of human bronchial epithelial cells by regulating Kirsten rat sarcoma viral oncogene homolog expression via sponging miR-770"],"prefix":"10.1093","volume":"13","author":[{"given":"Shuya","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luyao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8254-9341","authenticated-orcid":false,"given":"Xue","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,7,24]]},"reference":[{"key":"2021120812593391800_bib1","volume-title":"Exposure to cadmium: a major public health concern","author":"WHO","year":"2019"},{"key":"2021120812593391800_bib2","volume-title":"Global refinery production of cadmium by country","author":"Garside","year":"2019"},{"key":"2021120812593391800_bib3","volume-title":"Toxicological profile for cadmium","author":"Faroon","year":"2012"},{"key":"2021120812593391800_bib4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jhazmat.2016.11.069","article-title":"Metals transfer from tobacco to cigarette smoke: evidences in smokers\u2019 lung tissue","volume":"325","author":"Pinto","year":"2017","journal-title":"J. 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