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However, the regulatory mechanism of miRNA in chicken lungs and the mechanism of lipopolysaccharide (LPS)-induced pneumonia remained unclear. To further study these mechanisms, we established a supplement of selenomethionine (SeMet) and\/or LPS-treated chicken model and a cell model of LPS and\/or high and low expression of miR-15a in chicken hepatocellular carcinoma (LMH) cells. We detected the expression of some selenoproteins, p-c-Jun N-terminal kinase (JNK), nod-like receptor protein 3 (NLRP3), caspase1, receptor-interacting serine-threonine kinase 1 (RIPK1), receptor-interacting serine-threonine kinase 3 (RIPK3), mixed lineage kinase domain-like pseudokinase (MLKL), miR-15a, and oxidative stress kits. Additionally, we observed the morphology of lungs by H.E. staining in vitro. The results indicated that necroptosis occurred in LPS-treated chicken and LMH cells. Moreover, LPS stimulation inhibited miR-15a, and increased the expression of JNK, NLRP3, caspase1, RIPK1, RIPK3, and MLKL. We also found that LPS treatment not only increased the content of H2O2 and MDA in the lungs but also increased the activities of iNOS and CAT and the content of GSH decreased. Conclusion: SeMet could reduce the oxidative damage and activate NLRP3 inflammasome reaction by stimulating miR-15a\/JNK, thus reduced the pulmonary necroptosis induced by LPS.<\/jats:p>","DOI":"10.1093\/mtomcs\/mfab048","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T11:08:04Z","timestamp":1627297684000},"source":"Crossref","is-referenced-by-count":22,"title":["Selenomethionine alleviates LPS-induced JNK\/NLRP3 inflammasome-dependent necroptosis by modulating miR-15a and oxidative stress in chicken lungs"],"prefix":"10.1093","volume":"13","author":[{"given":"Bing","family":"Wang","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Road, Harbin, 150030, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Cui","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Road, Harbin, 150030, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaojian","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Road, Harbin, 150030, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengchen","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Road, Harbin, 150030, P. R. 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