{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:24:56Z","timestamp":1791239096621,"version":"4.1.0"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T00:00:00Z","timestamp":1644624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Methylmercury (MeHg) is one of the most potent neurotoxins to which humans are exposed via the consumption of fish, from which it is effectively absorbed via the gastrointestinal tract into the bloodstream. Its interactions with plasma proteins, small-molecular-weight (SMW) molecules, and red blood cells, however, are incompletely understood, but critical as they determine whether and how much MeHg reaches target organs. To better define the role that SMW thiols play in the delivery of MeHg to known transporters located at the placental and blood\u2013brain barrier, we have employed size exclusion chromatography\u2013inductively coupled plasma-atomic emission spectroscopy to analyze MeHg-spiked rabbit plasma in the absence and presence of SMW thiols dissolved in the phosphate-buffered saline buffer mobile phase. While 300\u00a0\u03bcM methionine did not affect the binding of MeHg to rabbit serum albumin (RSA), cysteine (Cys), homocysteine (hCys), and glutathione resulted in the elution of the main Hg peak in the SMW elution range. In addition, 50\u00a0\u03bcM of hCys or Cys in the mobile phase resulted in the mobilization of MeHg from RSA in rabbit plasma and from pure RSA in solution. The Hg peak that eluted in the SMW elution range (50\u00a0\u03bcM of hCys) was identified by electrospray ionization\u2013mass spectrometry as an MeHg\u2013hCys complex. Since l-type amino acid transporters are present at the blood\u2013brain barrier (BBB), which facilitate the uptake of MeHg\u2013Cys species into the brain, our results contribute to establish the bioinorganic mechanisms that deliver MeHg to the BBB, which is critical to predict organ-based adverse health effects.<\/jats:p>","DOI":"10.1093\/mtomcs\/mfac010","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T20:10:25Z","timestamp":1644523825000},"source":"Crossref","is-referenced-by-count":16,"title":["Physiologically relevant hCys concentrations mobilize MeHg from rabbit serum albumin to form MeHg\u2013hCys complexes"],"prefix":"10.1093","volume":"14","author":[{"given":"Tristen G","family":"Bridle","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of Calgary , 2500 University Drive NW, Calgary, AB T2N 1N4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Doroudian","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Calgary , 2500 University Drive NW, Calgary, AB T2N 1N4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wade","family":"White","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Calgary , 2500 University Drive NW, Calgary, AB T2N 1N4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8264-8243","authenticated-orcid":false,"given":"J\u00fcrgen","family":"Gailer","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Calgary , 2500 University Drive NW, Calgary, AB T2N 1N4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,2,12]]},"reference":[{"key":"2024020308275220000_bib1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3109\/10408369708998098","article-title":"The toxicology of mercury","volume":"34","author":"Clarkson","year":"1997","journal-title":"Crit. 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