{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T15:29:00Z","timestamp":1784820540184,"version":"3.55.0"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004219","name":"Paul Scherrer Institut","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Contrasting reports exist in the literature regarding the effect of chloroquine treatment on cellular zinc uptake or secretion. Here, we tested the effect of chloroquine administration in the Drosophila model organism. We show that larvae grown on a diet supplemented with 2.5\u00a0mg\/ml chloroquine lose up to 50% of their stored zinc and around 10% of their total potassium content. This defect in chloroquine-treated animals correlates with the appearance of abnormal autophagolysosomes in the principal cells of the Malpighian tubules, where zinc storage granules reside. We further show that the reported increase of Fluozin-3 fluorescence following treatment of cells with 300 \u03bcM chloroquine for 1 h may not reflect increased zinc accumulation, since a similar treatment in Madin\u2013Darby canine kidney cells results in a 36% decrease in their total zinc content. Thus, chloroquine should not be considered a zinc ionophore. Zinc supplementation plus chloroquine treatment restored zinc content both in vivo and in vitro, without correcting autophagic or other ionic alterations, notably in potassium, associated with the chloroquine treatment. We suggest that chloroquine or hydroxychloroquine administration to patients could reduce intracellular zinc storage pools and be part of the drug's mechanism of action.<\/jats:p>","DOI":"10.1093\/mtomcs\/mfac075","type":"journal-article","created":{"date-parts":[[2022,9,24]],"date-time":"2022-09-24T13:09:44Z","timestamp":1664024984000},"source":"Crossref","is-referenced-by-count":7,"title":["Chloroquine disrupts zinc storage granules in primary Malpighian tubule cells of <i>Drosophila melanogaster<\/i>"],"prefix":"10.1093","volume":"14","author":[{"given":"Jessica P","family":"Campos-Bl\u00e1zquez","sequence":"first","affiliation":[{"name":"Department of Physiology, Biophysics and Neuroscience, Cinvestav , 07360 Mexico City , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Schuth","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Cinvestav , 07360 Mexico City , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Garay","sequence":"additional","affiliation":[{"name":"Department of Physiology, Biophysics and Neuroscience, Cinvestav , 07360 Mexico City , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam H","family":"Clark","sequence":"additional","affiliation":[{"name":"Paul Scherrer Institut , CH-5232 Villigen , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urs","family":"Vogelsang","sequence":"additional","affiliation":[{"name":"Paul Scherrer Institut , CH-5232 Villigen , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"Nachtegaal","sequence":"additional","affiliation":[{"name":"Paul Scherrer Institut , CH-5232 Villigen , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rub\u00e9n G","family":"Contreras","sequence":"additional","affiliation":[{"name":"Department of Physiology, Biophysics and Neuroscience, Cinvestav , 07360 Mexico City , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Quintanar","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Cinvestav , 07360 Mexico City , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0467-8444","authenticated-orcid":false,"given":"Fanis","family":"Missirlis","sequence":"additional","affiliation":[{"name":"Department of Physiology, Biophysics and Neuroscience, Cinvestav , 07360 Mexico City , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,9,24]]},"reference":[{"issue":"16","key":"2024013108254006300_bib1","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1001\/jama.1946.02870160015006","article-title":"Activity of a new antimalarial agent, chloroquine (SN 7618)","volume":"130","author":"Loeb","year":"1946","journal-title":"J. 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