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While the AD brain accumulates some metals, it purges others, namely K (accompanied by increased serum K, suggesting brain\u2013blood transferal). Here, K isotope compositions of G\u00f6ttingen minipig brain regions for two AD models at midlife are reported. Results indicate heavy K isotope enrichment where amyloid beta (A\u03b2) accumulation is observed, and this enrichment correlates with relative K depletion. These results suggest preferential efflux of isotopically light K+ from the brain, a linkage between brain K concentrations and isotope compositions, and linkage to A\u03b2 (previously shown to purge cellular brain K+). Brain K isotope compositions differ from that for serum and brain K is much more abundant than in serum, suggesting that changes in brain K may transfer a measurable K isotope excursion to serum, thereby generating an early AD biomarker.<\/jats:p>","DOI":"10.1093\/mtomcs\/mfac090","type":"journal-article","created":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T16:41:56Z","timestamp":1669221716000},"source":"Crossref","is-referenced-by-count":11,"title":["Exploring the K isotope composition of G\u00f6ttingen minipig brain regions, and implications for Alzheimer's disease"],"prefix":"10.1093","volume":"14","author":[{"given":"Brandon","family":"Mahan","sequence":"first","affiliation":[{"name":"IsoTropics Geochemistry Lab, Earth and Environmental Science, James Cook University , Townsville, Queensland 4814, Australia"},{"name":"Thermo Fisher Isotope Development Hub, Department of Earth and Planetary Sciences, Macquarie University , Sydney, New South Wales 2109, Australia"},{"name":"Department of Biomedical Research, Macquarie University , Sydney, New South Wales 2109, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theo","family":"Tacail","sequence":"additional","affiliation":[{"name":"Bristol Isotope Group, School of Earth Sciences, University of Bristol , Bristol BS8 1RJ, UK"},{"name":"Institute of Geosciences, Johannes Gutenberg University , Mainz 55099, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie","family":"Lewis","sequence":"additional","affiliation":[{"name":"Bristol Isotope Group, School of Earth Sciences, University of Bristol , Bristol BS8 1RJ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Elliott","sequence":"additional","affiliation":[{"name":"Bristol Isotope Group, School of Earth Sciences, University of Bristol , Bristol BS8 1RJ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mette","family":"Habekost","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Aarhus University , 8000 Aarhus C , Denmark"},{"name":"Center for Neuroscience, University of Copenhagen Faculty of Health and Medical Sciences , 2200 Copenhagen N , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6426-6495","authenticated-orcid":false,"given":"Simon","family":"Turner","sequence":"additional","affiliation":[{"name":"Thermo Fisher Isotope Development Hub, Department of Earth and Planetary Sciences, Macquarie University , Sydney, New South Wales 2109, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Chung","sequence":"additional","affiliation":[{"name":"Thermo Fisher Isotope Development Hub, Department of Earth and Planetary Sciences, Macquarie University , Sydney, New South Wales 2109, Australia"},{"name":"Department of Biomedical Research, Macquarie University , Sydney, New South Wales 2109, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4321-5581","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric","family":"Moynier","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Paris, Institut de Physique du Globe de Paris, CNRS , 75238 Paris , France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,11,23]]},"reference":[{"issue":"2-3","key":"2024020308350280300_bib1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3233\/JAD-2006-102-303","article-title":"Metals and Alzheimer's disease","volume":"10","author":"Adlard","year":"2006","journal-title":"J. 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