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While the significance of metals continues to be uncovered in many neurological disorders, their implication in repetitive mild traumatic brain injury remains uncharted. To address this gap, we characterized the spatial distribution of metal levels (iron, zinc, and copper) using laser ablation\u2013inductively coupled plasma\u2013mass spectrometry, the profile of metal-binding proteins via size exclusion chromatography\u2013inductively coupled plasma\u2013mass spectrometry and the expression of the major iron storing protein ferritin via western blotting. Using a mouse model of repetitive mild traumatic brain injury, 3-month-old male and female C57Bl6 mice received one or five impacts (48\u00a0h apart). At 1 month following 5\u00d7 TBI (traumatic brain injury), iron and ferritin levels were significantly elevated in the contralateral cortex. There was a trend toward increased iron levels in the entire contralateral hemisphere and a reduction in contralateral cortical iron-binding proteins following 1\u00d7 TBI. No major changes in zinc levels were seen in both hemispheres following 5\u00d7 or 1\u00d7 TBI, although there was a reduction in ipsilateral zinc-binding proteins following 5\u00d7 TBI and a contralateral increase in zinc-binding proteins following 1\u00d7 TBI. Copper levels were significantly increased in both hemispheres following 5\u00d7 TBI, without changes in copper-binding proteins. This study shows for the first time that repetitive mild TBI (r-mTBI) leads to metal dyshomeostasis, highlighting its potential involvement in promoting neurodegeneration, which provides a rationale for examining the benefit of metal-targeting drugs, which have shown promising results in neurodegenerative conditions and single TBI, but have yet to be tested following r-mTBI.<\/jats:p>","DOI":"10.1093\/mtomcs\/mfac092","type":"journal-article","created":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T00:05:37Z","timestamp":1670025937000},"source":"Crossref","is-referenced-by-count":10,"title":["Characterization of the spatial distribution of metals and profile of metalloprotein complexes in a mouse model of repetitive mild traumatic brain injury"],"prefix":"10.1093","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1563-1302","authenticated-orcid":false,"given":"Sydney M A","family":"Juan","sequence":"first","affiliation":[{"name":"Synaptic Neurobiology Laboratory, The Florey Institute of Neuroscience and Mental Health, The Melbourne Dementia Research Centre and The University of Melbourne , Melbourne , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Daglas","sequence":"additional","affiliation":[{"name":"Synaptic Neurobiology Laboratory, The Florey Institute of Neuroscience and Mental Health, The Melbourne Dementia Research Centre and The University of Melbourne , Melbourne , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam P","family":"Gunn","sequence":"additional","affiliation":[{"name":"Neuropathology Laboratory, The Florey Institute of Neuroscience and Mental Health , Parkville , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"Lago","sequence":"additional","affiliation":[{"name":"Synaptic Neurobiology Laboratory, The Florey Institute of Neuroscience and Mental Health, The Melbourne Dementia Research Centre and The University of Melbourne , Melbourne , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A","family":"Adlard","sequence":"additional","affiliation":[{"name":"Synaptic Neurobiology Laboratory, The Florey Institute of Neuroscience and Mental Health, The Melbourne Dementia Research Centre and The University of Melbourne , Melbourne , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,12,2]]},"reference":[{"issue":"3","key":"2024020308351010700_bib1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/ana.410270315","article-title":"Traumatic brain injury: a silent epidemic","volume":"27","author":"Goldstein","year":"1990","journal-title":"Ann. 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Chem."},{"issue":"7124","key":"2024020308351010700_bib41","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nature05453","article-title":"Genome-wide atlas of gene expression in the adult mouse brain","volume":"445","author":"Lein","year":"2007","journal-title":"Nature"},{"key":"2024020308351010700_bib42","first-page":"e53737","article-title":"Standards for quantitative metalloproteomic analysis using size exclusion ICP-MS","volume-title":"J. Vis. Exp.","author":"Lothian","year":"2016"},{"issue":"2","key":"2024020308351010700_bib43","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1039\/B916722F","article-title":"Bioimaging of metals in brain tissue by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) and metallomics","volume":"2","author":"Sabine Becker","year":"2010","journal-title":"Metallomics"},{"issue":"4","key":"2024020308351010700_bib44","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1039\/C6MT00260A","article-title":"Age modulates the injury-induced metallomic profile in the brain","volume":"9","author":"Portbury","year":"2017","journal-title":"Metallomics"},{"issue":"2","key":"2024020308351010700_bib45","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3233\/JAD-143048","article-title":"Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease: common pathologies potentiated by altered zinc homeostasis","volume":"46","author":"Portbury","year":"2015","journal-title":"J. Alzheimers Dis."},{"issue":"6","key":"2024020308351010700_bib46","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1007\/s10534-010-9359-4","article-title":"The effect of formalin fixation on the levels of brain transition metals in archived samples","volume":"23","author":"Schrag","year":"2010","journal-title":"Biometals"},{"issue":"14","key":"2024020308351010700_bib47","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1039\/c0an00269k","article-title":"Chemical alterations to murine brain tissue induced by formalin fixation: implications for biospectroscopic imaging and mapping studies of disease pathogenesis","volume":"136","author":"Hackett","year":"2011","journal-title":"Analyst"},{"issue":"11","key":"2024020308351010700_bib48","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1039\/D0JA00323A","article-title":"Sample preparation with sucrose cryoprotection dramatically alters Zn distribution in the rodent hippocampus, as revealed by elemental mapping","volume":"35","author":"Pushie","year":"2020","journal-title":"J. Anal. At. Spectrom."},{"key":"2024020308351010700_bib49","first-page":"1","article-title":"Effects of sub-chronic lead exposure on essential element levels in mice","author":"Li","year":"2022","journal-title":"Biol. Trace Elem. Res."},{"issue":"2","key":"2024020308351010700_bib50","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/s00216-004-2697-8","article-title":"Regional distribution of manganese, iron, copper, and zinc in the rat brain during development","volume":"380","author":"Tarohda","year":"2004","journal-title":"Anal. Bioanal. Chem."},{"key":"2024020308351010700_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jtemb.2018.04.030","article-title":"Elemental changes of hippocampal formation occurring during postnatal brain development","volume":"49","author":"Chwiej","year":"2018","journal-title":"J. Trace Elem. Med. Biol."},{"issue":"1","key":"2024020308351010700_bib52","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/BF00304607","article-title":"Variations in trace metal levels in rat hippocampus during ontogenetic development","volume":"167","author":"Szerdahelyi","year":"1983","journal-title":"Anat. Embryol. (Berl.)"},{"issue":"11","key":"2024020308351010700_bib53","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1039\/c3mt00133d","article-title":"X-ray fluorescence imaging of the hippocampal formation after manganese exposure","volume":"5","author":"Robison","year":"2013","journal-title":"Metallomics"},{"issue":"1","key":"2024020308351010700_bib54","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1039\/C8MT00230D","article-title":"Elemental characterisation of the pyramidal neuron layer within the rat and mouse hippocampus","volume":"11","author":"Hackett","year":"2019","journal-title":"Metallomics"},{"issue":"3","key":"2024020308351010700_bib55","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1039\/C3JA50281C","article-title":"The effect of paraformaldehyde fixation and sucrose cryoprotection on metal concentration in murine neurological tissue","volume":"29","author":"Hare","year":"2014","journal-title":"J. Anal. At. Spectrom."},{"issue":"12","key":"2024020308351010700_bib56","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1016\/j.sab.2005.10.002","article-title":"Preparation of tissue samples for X-ray fluorescence microscopy","volume":"60","author":"Chwiej","year":"2005","journal-title":"Spectrochim. Acta Part B"},{"issue":"3","key":"2024020308351010700_bib57","doi-asserted-by":"crossref","first-page":"839","DOI":"10.3390\/ijms21030839","article-title":"Zinc Transporter-3 Knockout Mice Demonstrate Age-Dependent Alterations in the Metalloproteome","volume":"21","author":"Hancock","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"2024020308351010700_bib58","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.expneurol.2017.11.003","article-title":"Single severe traumatic brain injury produces progressive pathology with ongoing contralateral white matter damage one year after injury","volume":"300","author":"Pischiutta","year":"2018","journal-title":"Exp. 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