{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T21:50:10Z","timestamp":1785361810443,"version":"3.55.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100005363","name":"University of Buenos Aires","doi-asserted-by":"publisher","award":["20020170100197BA"],"award-info":[{"award-number":["20020170100197BA"]}],"id":[{"id":"10.13039\/501100005363","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Research Council of Argentina"},{"name":"National Agency of Science and Technology of Argentina","award":["PICT-2016-002077"],"award-info":[{"award-number":["PICT-2016-002077"]}]},{"name":"National Agency of Science and Technology of Argentina","award":["PICT-2020-001264"],"award-info":[{"award-number":["PICT-2020-001264"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Copper is a highly reactive element involved in a myriad of biological reactions. Thus, while essential for mammalian cells, its concentrations must be kept in check in order to avoid toxicity. This metal participates in redox reactions and may exacerbate oxidative stress in aerobic organisms. Nonetheless, the actual driving force of copper-induced cell death is yet unknown. Likely, free copper ions may target different biomolecules that are crucial for the proper functioning of an organism. In this work, we show that free copper induces protein aggregation in serum. The wide set of proteins present in these biological samples are not equally prone to copper-induced aggregation and some, such as albumin, are highly resistant, whereas \u03b3-globulins are highly sensitive. The identity of the proteins in the aggregates becomes fairly homogeneous as metal concentrations go as low as 20 \u03bcM. The identification of the proteins by mass spectrometry indicates a preponderance of IgG and a minor presence of other different proteins. Therefore, free copper in blood may contribute to the formation of circulating protein aggregates with a core of IgG. This may impact health not only due to the activity of aggregated IgG but also due to the many proteins co-aggregated. Understanding whether the \u03b3-globulin core and the heterogeneous subgroup of proteins elicit differential responses in the organisms requires further research.<\/jats:p>","DOI":"10.1093\/mtomcs\/mfad005","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T18:34:35Z","timestamp":1675276475000},"source":"Crossref","is-referenced-by-count":10,"title":["Copper-induced aggregation of IgG: a potential driving force for the formation of circulating protein aggregates"],"prefix":"10.1093","volume":"15","author":[{"given":"Christian","family":"Saporito-Magri\u00f1a","sequence":"first","affiliation":[{"name":"Universidad de Buenos Aires, Facultad de Farmacia y Bioqu\u00edmica, Departamento de Ciencias Qu\u00edmicas , C\u00e1tedra de Qu\u00edmica General e Inorg\u00e1nica, Buenos Aires 1113AAD , Argentina"},{"name":"Instituto de Bioqu\u00edmica y Medicina Molecular Prof. Alberto Boveris (IBIMOL Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, , UBA-CONICET), Buenos Aires 1113AAD , Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Laura","family":"Facio","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires, Facultad de Farmacia y Bioqu\u00edmica, Instituto de Fisiopatolog\u00eda y Bioqu\u00edmica Cl\u00ednica (INFIBIOC), Departamento de Bioqu\u00edmica Cl\u00ednica, Laboratorio de Prote\u00ednas , Buenos Aires 1113AAD , Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lila","family":"Lopez-Monta\u00f1ana","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires, Facultad de Farmacia y Bioqu\u00edmica, Departamento de Ciencias Qu\u00edmicas , C\u00e1tedra de Qu\u00edmica General e Inorg\u00e1nica, Buenos Aires 1113AAD , Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guadalupe","family":"Pagano","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires, Facultad de Farmacia y Bioqu\u00edmica, Departamento de Ciencias Qu\u00edmicas , C\u00e1tedra de Qu\u00edmica General e Inorg\u00e1nica, Buenos Aires 1113AAD , Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7599-8333","authenticated-orcid":false,"given":"Marisa Gabriela","family":"Repetto","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires, Facultad de Farmacia y Bioqu\u00edmica, Departamento de Ciencias Qu\u00edmicas , C\u00e1tedra de Qu\u00edmica General e Inorg\u00e1nica, Buenos Aires 1113AAD , Argentina"},{"name":"Instituto de Bioqu\u00edmica y Medicina Molecular Prof. Alberto Boveris (IBIMOL Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, , UBA-CONICET), Buenos Aires 1113AAD , Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,1,31]]},"reference":[{"issue":"12","key":"2024012010381650400_bib1","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1039\/C8MT00182K","article-title":"Copper-induced cell death and the protective role of glutathione: the implication of impaired protein folding rather than oxidative stress","volume":"10","author":"Saporito-Magri\u00f1\u00e1","year":"2018","journal-title":"Metallomics"},{"issue":"1","key":"2024012010381650400_bib2","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1021\/acschembio.0c00900","article-title":"Protein folding stability changes across the proteome reveal targets of Cu toxicity in E. coli","volume":"16","author":"Wiebelhaus","year":"2021","journal-title":"ACS Chem. 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