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Given the requirement for copper and its potential toxicity, intracellular copper levels are tightly controlled. Disturbances of human copper homeostasis are characterized by disorders of copper overload (Wilson\u2019s disease) or copper deficiency (Menkes disease). The maintenance of cellular copper levels involves numerous copper transporters and copper chaperones. Recently, accumulating evidence has revealed that components of the ubiquitin proteasome system (UPS) participate in the posttranslational regulation of these proteins, suggesting that they might play a role in maintaining copper homeostasis. Cellular copper levels could also affect the activity of the UPS, indicating that copper homeostasis and the UPS are interdependent. Copper homeostasis and the UPS are essential to the integrity of normal brain function and while separate links between neurodegenerative diseases and UPS inhibition\/copper dyshomeostasis have been extensively reported, there is growing evidence that these two networks might contribute synergistically to the occurrence of neurodegenerative diseases. Here, we review the role of copper and the UPS in the development of Alzheimer\u2019s disease, Parkinson\u2019s disease, and amyotrophic lateral sclerosis, and discuss the genetic interactions between copper transporters\/chaperones and components of the UPS.<\/jats:p>","DOI":"10.1093\/mtomcs\/mfad010","type":"journal-article","created":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T01:31:26Z","timestamp":1677202286000},"source":"Crossref","is-referenced-by-count":37,"title":["Copper homeostasis and the ubiquitin proteasome system"],"prefix":"10.1093","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3954-4764","authenticated-orcid":false,"given":"Bichao","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Life Science and Technology, Xinxiang Medical University , Xinxiang 453003 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0086-0767","authenticated-orcid":false,"given":"Richard","family":"Burke","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, Monash University , Clayton 3800, Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,2,23]]},"reference":[{"issue":"1","key":"2024012010410666000_bib1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1146\/annurev.nutr.22.012502.114457","article-title":"Ceruloplasmin Metabolism and Function","volume":"22","author":"Hellman","year":"2002","journal-title":"Annu. 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