{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:58:22Z","timestamp":1753876702049,"version":"3.41.2"},"reference-count":83,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,2,25]],"date-time":"2023-02-25T00:00:00Z","timestamp":1677283200000},"content-version":"vor","delay-in-days":55,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DMR1559880"],"award-info":[{"award-number":["DMR1559880"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009455","name":"West Virginia University","doi-asserted-by":"publisher","award":["1144676"],"award-info":[{"award-number":["1144676"]}],"id":[{"id":"10.13039\/100009455","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["#U54 GM104942"],"award-info":[{"award-number":["#U54 GM104942"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016596","name":"The Clinical and Translational Science Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016596","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The increased use of antimicrobial compounds such as copper into nanoparticles changes how living cells interact with these novel materials. The increased use of antimicrobial nanomaterials combats infectious disease and food spoilage. Fungal infections are particularly difficult to treat because of the few druggable targets, and Saccharomyces cerevisiae provides an insightful model organism to test these new materials. However, because of the novel characteristics of these materials, it is unclear how these materials interact with living cells and if resistance to copper-based nanomaterials could occur. Copper nanoparticles built on carboxymethylcellulose microfibril strands with copper (CMC-Cu) are a promising nanomaterial when imported into yeast cells and induce cell death. The \u03b1-arrestins are cargo adaptors that select which molecules are imported into eukaryotic cells. We screened \u03b1-arrestins mutants and identified Aly2, Rim8, and Rog3 \u03b1-arrestins, which are necessary for the internalization of CMC-Cu nanoparticles. Internal reactive oxygen species in these mutants were lower and corresponded to the increased viability in the presence of CMC-Cu. Using lattice light-sheet microscopy on live cells, we determined that CMC-Cu were imported into yeast within 30 min of exposure. Initially, the cytoplasmic pH decreased but returned to basal level 90 min later. However, there was heterogeneity in response to CMC-Cu exposure, which could be due to the heterogeneity of the particles or differences in the metabolic states within the population. When yeast were exposed to sublethal concentrations of CMC-Cu no resistance occurred. Internalization of CMC-Cu increases the potency of these antimicrobial nanomaterials and is likely key to preventing fungi from evolving resistance.<\/jats:p>","DOI":"10.1093\/mtomcs\/mfad011","type":"journal-article","created":{"date-parts":[[2023,2,25]],"date-time":"2023-02-25T23:31:55Z","timestamp":1677367915000},"source":"Crossref","is-referenced-by-count":0,"title":["Toxicity and assimilation of cellulosic copper nanoparticles require \u03b1-arrestins in <i>S. cerevisiae<\/i>"],"prefix":"10.1093","volume":"15","author":[{"given":"Ni Putu Dewi","family":"Nurmalasari","sequence":"first","affiliation":[{"name":"Department of Nanoscience & Biomedical Engineering, South Dakota School of Mines and Technology , Rapid City, SD , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3346-0594","authenticated-orcid":false,"given":"Matthew J","family":"Winans","sequence":"additional","affiliation":[{"name":"Department of Biology, West Virginia University , Morgantown, WV , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katelyn","family":"Perroz","sequence":"additional","affiliation":[{"name":"Department of Biology, West Virginia University , Morgantown, WV , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria R","family":"Bovard","sequence":"additional","affiliation":[{"name":"Department of Biology, West Virginia University , Morgantown, WV , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Nanoscience & Biomedical Engineering, South Dakota School of Mines and Technology , Rapid City, SD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Nanoscience & Biomedical Engineering, South Dakota School of Mines and Technology , Rapid City, SD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6163-3181","authenticated-orcid":false,"given":"Jennifer E G","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Department of Biology, West Virginia University , Morgantown, WV , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,2,25]]},"reference":[{"issue":"6","key":"2024022507113631100_bib1","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1021\/cr900339w","article-title":"Cellulose nanocrystals: chemistry, self-assembly, and applications","volume":"110","author":"Habibi","year":"2010","journal-title":"Chem. 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Chem."},{"issue":"12","key":"2024022507113631100_bib43","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1111\/j.1600-0854.2009.00990.x","article-title":"Arrestin-mediated endocytosis of yeast plasma membrane transporters","volume":"10","author":"Nikko","year":"2009","journal-title":"Traffic"},{"issue":"1","key":"2024022507113631100_bib44","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev.physiol.69.022405.154712","article-title":"Regulation of receptor trafficking by grks and arrestins","volume":"69","author":"Moore","year":"2007","journal-title":"Annu. Rev. 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