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New mononuclear and binuclear Cu(II) complexes with 1-(N,N-dimethylamino)methyl-6-quinolinol were synthesized for the first time. The same way Cu(II) complexes with 1-(dimethylamino)methyl-2-naphtol ligand were synthesized. The structures of mono- and binuclear Cu(II) complexes with 1-aminomethyl-2-naphtol were confirmed by X-ray diffraction. The obtained compounds were examined for in vitro cytotoxic activity against Jurkat, K562, U937, MDA-MB-231, MCF7, T47D, and HEK293 cells. The induction of apoptosis and the effect of novel Cu complexes on the cell cycle were investigated. The cells showed a higher sensitivity to mononuclear Cu(II) complex with 1-(N,N-dimethylamino)methyl-6-quinolinolligand. All synthesized Cu(II) complexes had higher antitumor activity than the drugs topotecan, camptothecin, and platinum containing cisplatin.<\/jats:p>","DOI":"10.1093\/mtomcs\/mfad037","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T16:17:13Z","timestamp":1686932233000},"source":"Crossref","is-referenced-by-count":5,"title":["Mono- and binuclear complexes of copper(II) with dimethylaminomethyl derivatives of 2-naphthol and 6-quinolinol: synthesis and <i>in vitro<\/i> study of antitumor properties"],"prefix":"10.1093","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5638-7046","authenticated-orcid":false,"given":"Vnira R","family":"Akhmetova","sequence":"first","affiliation":[{"name":"Institute of Petrochemistry and Catalysis, Russian Academy of Sciences , 450075, Prospekt Oktyabrya 141, Ufa , Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0054-8466","authenticated-orcid":false,"given":"El'miraM","family":"Galimova","sequence":"additional","affiliation":[{"name":"Institute of Petrochemistry and Catalysis, Russian Academy of Sciences , 450075, Prospekt Oktyabrya 141, Ufa , Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9401-8153","authenticated-orcid":false,"given":"Ekaterina S","family":"Mescheryakova","sequence":"additional","affiliation":[{"name":"Institute of Petrochemistry and Catalysis, Russian Academy of Sciences , 450075, Prospekt Oktyabrya 141, Ufa , Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3315-4746","authenticated-orcid":false,"given":"Lilya U","family":"Dzhemileva","sequence":"additional","affiliation":[{"name":"N. 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