{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:15:31Z","timestamp":1791501331572,"version":"4.3.4"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T00:00:00Z","timestamp":1696550400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100006961","name":"Caltech","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006961","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Relative to healthy controls, lighter copper isotopic compositions have been observed in the serum of breast cancer and end-stage liver disease patients, raising the possibility that Cu isotope ratios could be used as a tracer for disease progression. Here, we assess the potential of natural Cu isotopic variations (expressed as \u03b465Cu) as diagnostic tools for cancer progression and\/or liver failure by performing a first-order analysis of Cu isotopic cycling in the human body. Using a box model, we simulate the kinetics of Cu mass transfer throughout significant reservoirs in the body, allowing isotopic fractionation to occur during Cu uptake\/release from these reservoirs. With this model, we determine under which conditions the serum \u03b465Cu values would reflect perturbation related to cancer growth and\/or liver failure at a level resolvable with modern mass spectrometry. We find that tumor growth alone is unable to explain the light isotopic signature observed in serum. Instead, we find that metabolic changes to the liver function resulting in a \u223c1\u2030 isotope fractionation during Cu uptake from the blood into the liver can readily explain the long-term serum isotopic shift of \u223c0.2\u2030 observed in cancer patients. A similar fractionation (\u223c1.3\u2030) during Cu uptake into the liver also readily explains the \u22121.2\u2030 shift observed in the serum of cirrhosis patients with ascites, suggesting a potentially common driver of isotopic fractionation in both cases. Using this model, we then test hypotheses put forward by previous studies and begin to probe the mechanisms behind the measured isotopic compositions.<\/jats:p>","DOI":"10.1093\/mtomcs\/mfad060","type":"journal-article","created":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T00:27:15Z","timestamp":1696552035000},"source":"Crossref","is-referenced-by-count":10,"title":["Copper isotope ratios in serum do not track cancerous tumor evolution, but organ failure"],"prefix":"10.1093","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4688-3024","authenticated-orcid":false,"given":"Emily","family":"Miaou","sequence":"first","affiliation":[{"name":"The Isotoparium, Division of Geological and Planetary Sciences, California Institute of Technology , Pasadena, CA 91125 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6622-2907","authenticated-orcid":false,"given":"Fran\u00e7ois L H","family":"Tissot","sequence":"additional","affiliation":[{"name":"The Isotoparium, Division of Geological and Planetary Sciences, California Institute of Technology , Pasadena, CA 91125 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,10,6]]},"reference":[{"key":"2024012010382032300_bib1","volume-title":"Treatise on Geochemistry","author":"Holland","year":"2014","edition":"2nd ed."},{"issue":"1\u20134","key":"2024012010382032300_bib2","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0009-2541(98)00191-0","article-title":"Precise analysis of copper and zinc isotopic compositions by plasma-source mass spectrometry","volume":"156","author":"Mar\u00e9chal","year":"1999","journal-title":"Chem. Geol."},{"key":"2024012010382032300_bib3","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1515\/9783110545630-021","article-title":"Medical applications of isotope metallomics","volume":"82","author":"Albar\u00e8de","year":"2017","journal-title":"Non-Traditional Stable Isot."},{"issue":"17","key":"2024012010382032300_bib4","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1007\/s00018-020-03484-0","article-title":"Isotope metallomics approaches for medical research","volume":"77","author":"Mahan","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"issue":"2","key":"2024012010382032300_bib5","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1039\/C4MT00269E","article-title":"Copper isotope effect in serum of cancer patients. A pilot study","volume":"7","author":"T\u00e9louk","year":"2015","journal-title":"Metallomics"},{"key":"2024012010382032300_bib6","first-page":"1","article-title":"Natural variations of copper and sulfur stable isotopes in blood of hepatocellular carcinoma patients","author":"Balter","year":"2015"},{"issue":"3","key":"2024012010382032300_bib7","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1039\/C4MT00319E","article-title":"Isotopic analysis of Cu in blood serum by multi-collector ICP-mass spectrometry: a new approach for the diagnosis and prognosis of liver cirrhosis?","volume":"7","author":"Costas-Rodr\u00edguez","year":"2015","journal-title":"Metallomics"},{"issue":"11","key":"2024012010382032300_bib8","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1039\/C6MT00102E","article-title":"Hypoxia induces copper stable isotope fractionation in hepatocellular carcinoma, in a HIF-independent manner","volume":"8","author":"Bondanese","year":"2016","journal-title":"Metallomics"},{"key":"2024012010382032300_bib9","first-page":"1","article-title":"Cu isotopic signature in blood serum of liver transplant patients: a follow-up study","volume":"6","author":"Lauwens","year":"2016","journal-title":"Sci Reports 2016 61"},{"issue":"9","key":"2024012010382032300_bib10","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1007\/s00216-018-0909-x","article-title":"Cu isotope fractionation response to oxidative stress in a hepatic cell line studied using multi-collector ICP-mass spectrometry","volume":"410","author":"Fl\u00f3rez","year":"2018","journal-title":"Anal. Bioanal. Chem."},{"issue":"6","key":"2024012010382032300_bib11","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1039\/c8mt00362a","article-title":"Body distribution of stable copper isotopes during the progression of cholestatic liver disease induced by common bile duct ligation in mice","volume":"11","author":"Costas-Rodr\u00edguez","year":"2019","journal-title":"Metallomics"},{"issue":"1","key":"2024012010382032300_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13104-020-05069-3","article-title":"Lighter serum copper isotopic composition in patients with early non-alcoholic fatty liver disease","volume":"13","author":"Van Campenhout","year":"2020","journal-title":"BMC Res. Notes"},{"issue":"1","key":"2024012010382032300_bib13","first-page":"e12112","article-title":"Copper and zinc isotopic excursions in the human brain affected by Alzheimer's disease","volume":"12","author":"Moynier","year":"2020","journal-title":"Alzheimer's Dement.: Diagn. Assess. Dis. Monit"},{"issue":"3","key":"2024012010382032300_bib14","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.gastha.2022.02.024","article-title":"Copper isotope evidence of oxidative stress\u2014induced hepatic breakdown and the transition to hepatocellular carcinoma","volume":"1","author":"Telouk","year":"2022","journal-title":"Gastro Hep. Adv."},{"key":"2024012010382032300_bib15","first-page":"3812","article-title":"Hereditary hemochromatosis is reflected in the iron isotope composition of blood","author":"Krayenbuehl","year":"2005"},{"issue":"11","key":"2024012010382032300_bib16","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1039\/c3mt00054k","article-title":"The relationship between the iron isotopic composition of human whole blood and iron status parameters","volume":"5","author":"Van Heghe","year":"2013","journal-title":"Metallomics"},{"issue":"1","key":"2024012010382032300_bib17","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1039\/C4MT00260A","article-title":"Zinc isotopic compositions of breast cancer tissue","volume":"7","author":"Larner","year":"2015","journal-title":"Metallomics"},{"issue":"6","key":"2024012010382032300_bib18","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/mtomcs\/mfab027","article-title":"Zinc stable isotope analysis reveals Zn dyshomeostasis in benign tumours, breast cancer, and adjacent histologically normal tissue","volume":"13","author":"Sullivan","year":"2021","journal-title":"Metallomics"},{"issue":"24","key":"2024012010382032300_bib19","doi-asserted-by":"crossref","first-page":"13709","DOI":"10.1073\/pnas.96.24.13709","article-title":"Calcium isotope fractionation between soft and mineralized tissues as a monitor of calcium use in vertebrates","volume":"96","author":"Skulan","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"6","key":"2024012010382032300_bib20","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1373\/clinchem.2006.080143","article-title":"Natural calcium isotopic composition of urine as a marker of bone mineral balance","volume":"53","author":"Skulan","year":"2007","journal-title":"Clin. Chem."},{"issue":"4","key":"2024012010382032300_bib21","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.bone.2009.11.037","article-title":"A pilot study on the use of natural calcium isotope (44Ca\/40Ca) fractionation in urine as a proxy for the human body calcium balance","volume":"46","author":"Heuser","year":"2010","journal-title":"Bone"},{"issue":"25","key":"2024012010382032300_bib22","doi-asserted-by":"crossref","first-page":"9989","DOI":"10.1073\/pnas.1119587109","article-title":"Rapidly assessing changes in bone mineral balance using natural stable calcium isotopes","volume":"109","author":"Morgan","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2024012010382032300_bib23","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.bone.2015.04.023","article-title":"Using natural, stable calcium isotopes of human blood to detect and monitor changes in bone mineral balance","volume":"77","author":"Channon","year":"2015","journal-title":"Bone"},{"issue":"1","key":"2024012010382032300_bib24","doi-asserted-by":"crossref","first-page":"16751","DOI":"10.1038\/s41598-018-34568-4","article-title":"Assessing bone mineral changes in response to vitamin D supplementation using natural variability in stable isotopes of calcium in urine","volume":"8","author":"Rangarajan","year":"2018","journal-title":"Sci. Rep."},{"key":"2024012010382032300_bib25","doi-asserted-by":"crossref","first-page":"100200","DOI":"10.1016\/j.bonr.2019.100200","article-title":"Calcium isotope ratios in blood and urine: a new biomarker for the diagnosis of osteoporosis","volume":"10","author":"Eisenhauer","year":"2019","journal-title":"Bone Rep."},{"issue":"1","key":"2024012010382032300_bib26","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/jbmr.4158","article-title":"Naturally occurring stable calcium isotope ratios in body compartments provide a novel biomarker of bone mineral balance in children and young adults","volume":"36","author":"Shroff","year":"2021","journal-title":"J Bone Miner Res"},{"issue":"9","key":"2024012010382032300_bib27","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/S0016-7037(01)00815-8","article-title":"Ion-exchange fractionation of copper and zinc isotopes","volume":"66","author":"Mar\u00e9chal","year":"2002","journal-title":"Geochim. Cosmochim. Acta."},{"issue":"2","key":"2024012010382032300_bib28","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1039\/b306958c","article-title":"High-precision Cu and Zn isotope analysis by plasma source mass spectrometry. Part 2. Correcting for mass discrimination effects","volume":"19","author":"Mason","year":"2004","journal-title":"J. Anal. At. Spectrom."},{"issue":"2","key":"2024012010382032300_bib29","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1039\/b306958c","article-title":"High-precision Cu and Zn isotope analysis by plasma source mass spectrometry, Part 1. Spectral interferences and their correction","volume":"19","author":"Mason","year":"2004","journal-title":"J. Anal. At. Spectrom."},{"issue":"5","key":"2024012010382032300_bib30","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1039\/b315853e","article-title":"Mass discrimination correction in multiple-collector plasma source mass spectrometry: an example using Cu and Zn isotopes","volume":"19","author":"Archer","year":"2004","journal-title":"J. Anal. At. Spectrom."},{"issue":"3\u20134","key":"2024012010382032300_bib31","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.chemgeo.2005.09.025","article-title":"The determination of the isotopic composition of Cu and Zn in seawater","volume":"226","author":"Bermin","year":"2006","journal-title":"Chem. Geol."},{"issue":"1","key":"2024012010382032300_bib32","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1039\/B710977F","article-title":"A simple combined sample\u2014standard bracketing and inter-element correction procedure for accurate mass bias correction and precise Zn and Cu isotope ratio measurements","volume":"23","author":"Peel","year":"2007","journal-title":"J. Anal. At. Spectrom."},{"issue":"3\u20134","key":"2024012010382032300_bib33","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.chemgeo.2007.04.004","article-title":"Separation of copper, iron, and zinc from complex aqueous solutions for isotopic measurement","volume":"242","author":"Borrok","year":"2007","journal-title":"Chem. Geol."},{"issue":"2","key":"2024012010382032300_bib34","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1751-908X.2014.00298.x","article-title":"Combined separation of Cu, Fe and Zn from rock matrices and improved analytical protocols for stable isotope determination","volume":"39","author":"Sossi","year":"2015","journal-title":"Geostand. Geoanalytical Res."},{"issue":"3","key":"2024012010382032300_bib35","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/s00216-018-1498-4","article-title":"A new anion exchange purification method for Cu stable isotopes in blood samples","volume":"411","author":"Yang","year":"2019","journal-title":"Anal. Bioanal. Chem."},{"issue":"2","key":"2024012010382032300_bib36","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/ggr.12315","article-title":"Copper isotopic analysis in geological and biological reference materials by MC-ICP-MS","volume":"44","author":"Sullivan","year":"2020","journal-title":"Geostand. Geoanal. Res."},{"issue":"3","key":"2024012010382032300_bib37","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/ggr.12379","article-title":"Copper, Zinc and lead isotopic delta values and isotope ratios of various geological and biological reference materials","volume":"45","author":"Jeong","year":"2021","journal-title":"Geostand. Geoanal. Res."},{"issue":"6","key":"2024012010382032300_bib38","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1039\/c8mt00286j","article-title":"Dynamic homeostasis modeling of Zn isotope ratios in the human body","volume":"11","author":"Jaouen","year":"2019","journal-title":"Metallomics"},{"key":"2024012010382032300_bib39","doi-asserted-by":"crossref","first-page":"110173","DOI":"10.1016\/j.cbi.2022.110173","article-title":"Essential metals in health and disease","volume":"367","author":"Jomova","year":"2022","journal-title":"Chem. Biol. Interact."},{"issue":"3","key":"2024012010382032300_bib40","doi-asserted-by":"crossref","first-page":"e0149516","DOI":"10.1371\/journal.pone.0149516","article-title":"Mechanism of copper uptake from blood plasma ceruloplasmin by mammalian cells","volume":"11","author":"Ramos","year":"2016","journal-title":"PLoS One"},{"key":"2024012010382032300_bib41","volume-title":"Modern Nutrition in Health and Disease","author":"Ross","year":"2012","edition":"11th edn."},{"key":"2024012010382032300_bib42","volume-title":"Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc","author":"Russell","year":"2001"},{"issue":"1","key":"2024012010382032300_bib43","doi-asserted-by":"crossref","first-page":"44533","DOI":"10.1038\/srep44533","article-title":"Copper transporters are responsible for copper isotopic fractionation in eukaryotic cells","volume":"7","author":"Cadiou","year":"2017","journal-title":"Sci. Rep."},{"issue":"12","key":"2024012010382032300_bib44","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1039\/C7MT00248C","article-title":"Computational modelling of the redistribution of copper isotopes by proteins in the liver \u2020","volume":"9","author":"Tennant","year":"2017","journal-title":"Metallomics"},{"key":"2024012010382032300_bib45","doi-asserted-by":"crossref","DOI":"10.46427\/gold2022.11355","article-title":"Experimental investigation of amino acid binding as a mechanism for fractionating metal stable isotopes","volume-title":"Annual V.M. Goldschmidt Conference.","author":"Selden","year":"2022"},{"issue":"2","key":"2024012010382032300_bib46","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1039\/C6MT00202A","article-title":"Defining the human copper proteome and analysis of its expression variation in cancers","volume":"9","author":"Blockhuys","year":"2017","journal-title":"Metallomics"},{"issue":"5","key":"2024012010382032300_bib47","doi-asserted-by":"crossref","first-page":"960S","DOI":"10.1093\/ajcn\/67.5.960S","article-title":"Human whole-body copper metabolism","volume":"67","author":"Turnlund","year":"1998","journal-title":"Am. J. Clin. Nutr."},{"issue":"1","key":"2024012010382032300_bib48","doi-asserted-by":"crossref","first-page":"E115","DOI":"10.1152\/ajpendo.1991.261.1.E115","article-title":"Kinetics of copper metabolism in rats: a compartmental model","volume":"261","author":"Dunn","year":"1991","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"2024012010382032300_bib49","volume-title":"Introduction to Geochemical Modeling","author":"Albar\u00e9de","year":"1996"},{"key":"2024012010382032300_bib50","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4757-9432-8","volume-title":"The Biochemistry of Copper","author":"Linder","year":"1991"},{"issue":"2","key":"2024012010382032300_bib51","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1006\/abio.1994.1408","article-title":"Long-term measurement of organ copper turnover in rats by continuous feeding of a stable isotope","volume":"221","author":"Levenson","year":"1994","journal-title":"Anal. Biochem."},{"issue":"7","key":"2024012010382032300_bib52","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/0955-2863(94)90064-7","article-title":"Compartmental model of copper metabolism in adult men","volume":"5","author":"Scott","year":"1994","journal-title":"J. Nutr. Biochem."},{"key":"2024012010382032300_bib53","first-page":"1888","article-title":"Growth Rates of Primary Breast Cancers","volume-title":"Cancer","author":"Heuser","year":"1979"},{"issue":"1\u20134","key":"2024012010382032300_bib54","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1093\/rpd\/ncv417","article-title":"Estimates of breast cancer growth rate from mammograms and its relation to tumor characteristics","volume":"169","author":"F\u00f6rnvik","year":"2016","journal-title":"Radiat. Prot. Dosimetry"},{"issue":"1","key":"2024012010382032300_bib55","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/s12885-016-2164-x","article-title":"Differences in predictions of ODE models of tumor growth: a cautionary example","volume":"16","author":"Murphy","year":"2016","journal-title":"BMC Cancer"},{"issue":"5","key":"2024012010382032300_bib56","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1016\/S0006-3495(03)74715-8","article-title":"The universal dynamics of tumor growth","volume":"85","author":"Br\u00fa","year":"2003","journal-title":"Biophys. J."},{"issue":"2","key":"2024012010382032300_bib57","first-page":"970","article-title":"Growth rates, and duration of cancer and carcinoma in situ of the breast before detection by screening","volume":"46","author":"Spratt","year":"1986","journal-title":"Cancer Res."},{"issue":"15","key":"2024012010382032300_bib58","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1056\/NEJMoa1600249","article-title":"Breast-cancer tumor size, overdiagnosis, and mammography screening effectiveness","volume":"375","author":"Welch","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"2024012010382032300_bib59","first-page":"1","article-title":"Serum and tissue trace elements in Patients with Breast Cancer in Taiwan","volume-title":"Biol. Trace Elem. Res.","author":"Kuo","year":"2002"},{"key":"2024012010382032300_bib60","first-page":"868","article-title":"Copper and zinc levels in normal and malignant tissues","volume-title":"Cancer","author":"Margalioth"},{"key":"2024012010382032300_bib61","first-page":"1","article-title":"Cu and Zn isotope ratio variations in plasma for survival prediction in hematological malignancy cases","volume":"10","author":"Hastuti","year":"2020","journal-title":"Sci. Reports 2020 101"},{"issue":"11","key":"2024012010382032300_bib62","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1039\/d0mt00167h","article-title":"The blood copper isotopic composition is a prognostic indicator of the hepatic injury in Wilson disease \u2020","volume":"12","author":"Lamboux","year":"2020","journal-title":"Metallomics"},{"key":"2024012010382032300_bib63","first-page":"1","article-title":"Oxidative stress: harms and benefits for human health","volume":"2017","author":"Pizzino","year":"2017","journal-title":"Oxid. Med. Cell. Long."},{"issue":"2","key":"2024012010382032300_bib64","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S1665-2681(19)31651-5","article-title":"Effects of systemic chemotherapy on the liver","volume":"9","author":"Ramadori","year":"2010","journal-title":"Ann. Hepatol."},{"key":"2024012010382032300_bib65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/815105","article-title":"Liver injury induced by anticancer chemotherapy and radiation therapy","volume":"2013","author":"Maor","year":"2013","journal-title":"Int. J. Hepatol."},{"key":"2024012010382032300_bib66","first-page":"95","article-title":"Hepatotoxicity Secondary to chemotherapy","volume":"2","author":"Grigorian","year":"2014","journal-title":"J. Clin. Transl. Hepatol."},{"key":"2024012010382032300_bib67","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.gca.2014.05.051","article-title":"Density functional theory estimation of isotope fractionation of Fe, Ni, Cu, and Zn among species relevant to geochemical and biological environments","volume":"140","author":"Fujii","year":"2014","journal-title":"Geochim. Cosmochim. Acta."}],"container-title":["Metallomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/metallomics\/advance-article-pdf\/doi\/10.1093\/mtomcs\/mfad060\/51928450\/mfad060.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/metallomics\/article-pdf\/15\/11\/mfad060\/56255263\/mfad060.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/metallomics\/article-pdf\/15\/11\/mfad060\/56255263\/mfad060.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T05:39:12Z","timestamp":1705729152000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/metallomics\/article\/doi\/10.1093\/mtomcs\/mfad060\/7296145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,6]]},"references-count":67,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11,2]]}},"URL":"https:\/\/doi.org\/10.1093\/mtomcs\/mfad060","relation":{},"ISSN":["1756-591X"],"issn-type":[{"value":"1756-591X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,11]]},"published":{"date-parts":[[2023,10,6]]},"article-number":"mfad060"}}