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The present research focuses on the synthesis of 2,3,2\u02b9,3\u02b9-tetra(pyridin-2-yl)-6,6\u02b9-biquinoxaline) and (2,3,2\u02b9,3\u02b9-tetra(thiophen-2-yl)-6,6\u02b9-biquinoxaline) containing copper(II) and platinum(II) compounds as prodrug candidates. The binding interaction of these compounds with calf thymus DNA (CT-DNA) and human serum albumin were assessed with UV titration, thermal decomposition, viscometric, and fluorometric methods. The thermodynamical parameters and the temperature-dependent binding constant (K\u02b9b) values point out to spontaneous interactions between the complexes and CT-DNA via the van der Waals interactions and\/or hydrogen bonding, except Cu(ttbq)Cl2 for which electrostatic interaction was proposed. The antitumor activity of the complexes against several human glioblastomata, lung, breast, cervix, and prostate cell lines were investigated by examining cell viability, oxidative stress, apoptosis-terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling, in vitro migration and invasion, in vitro-comet DNA damage, and plasmid DNA interaction assays. The U87 and HeLa cells were investigated as the cancer cells most sensitive to our complexes. The exerted cytotoxic effect of complexes was attributed to the formation of the reactive oxygen species in vitro. It is clearly demonstrated that Cu(ttbq)Cl2, Pt(ttbq)Cl2, and Pt(tpbq)Cl2 have the highest DNA degradation potential and anticancer effect among the tested complexes by leading apoptosis. The wound healing and invasion analysis results also supported the higher anticancer activity of these two compounds.<\/jats:p>","DOI":"10.1093\/mtomcs\/mfae001","type":"journal-article","created":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T08:16:46Z","timestamp":1704356206000},"source":"Crossref","is-referenced-by-count":4,"title":["Antiproliferative activity of platinum(II) and copper(II) complexes containing novel biquinoxaline ligands"],"prefix":"10.1093","volume":"16","author":[{"given":"Hager Sadek","family":"El-Beshti","sequence":"first","affiliation":[{"name":"Atilim University, Department of Chemical Engineering , Incek, Ankara , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuhal","family":"Gercek","sequence":"additional","affiliation":[{"name":"Zonguldak B\u00fclent Ecevit University, Department of Chemistry , Incevez, Zonguldak , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakan","family":"Kayi","sequence":"additional","affiliation":[{"name":"Ankara University, Department of Chemical Engineering , 06100, Tando\u011fan, Ankara , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasemin","family":"Yildizhan","sequence":"additional","affiliation":[{"name":"TUBITAK, Marmara Research Center, Life Sciences, Medical Biotechnology Unit , Gebze\/Kocaeli , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuksel","family":"Cetin","sequence":"additional","affiliation":[{"name":"TUBITAK, Marmara Research Center, Life Sciences, Medical Biotechnology Unit , Gebze\/Kocaeli , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zelal","family":"Adig\u00fczel","sequence":"additional","affiliation":[{"name":"Ko\u00e7 University, School of Medicine , KUTTAM, Istanbul , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamze","family":"G\u00fcng\u00f6r","sequence":"additional","affiliation":[{"name":"TUBITAK, Marmara Research Center, Life Sciences, Medical Biotechnology Unit , Gebze\/Kocaeli , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4166-0529","authenticated-orcid":false,"given":"\u015eeniz","family":"\u00d6zalp-Yaman","sequence":"additional","affiliation":[{"name":"Atilim University, Department of Chemical Engineering , Incek, Ankara , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,1,5]]},"reference":[{"issue":"2","key":"2024020720460414200_bib1","first-page":"83","article-title":"Cancer Chemotherapy-Induced Nausea and Vomiting: Role of Mediators, Development of Drugs and Treatment Methods","volume":"60","author":"Mahesh","year":"2005","journal-title":"Pharmazie"},{"key":"2024020720460414200_bib2","first-page":"1","article-title":"Platinum Complexes as Anticancer","volume-title":"PRA","author":"Kostova","year":"2006"},{"issue":"9","key":"2024020720460414200_bib3","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1021\/cr980419w","article-title":"Medicinal Inorganic Chemistry: Introduction","volume":"99","author":"Orvig","year":"1999","journal-title":"Chem. 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