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Here, the impact of long-term modulation of dietary intake of copper, iron, selenium, and zinc was investigated in murine cerebellum. Four- and 40-wk-old mice of both sexes were supplied with different amounts of those TEs for 26 wk. In an adequate supply group, TE concentrations were in accordance with recommendations for laboratory mice while suboptimally supplied animals received only limited amounts of copper, iron, selenium, and zinc. An additional age-adjusted group was fed selenium and zinc in amounts exceeding recommendations. Cerebellar TE concentrations were measured by inductively coupled plasma\u2013tandem mass spectrometry. Furthermore, the expression of genes involved in TE transport, DNA damage response, and DNA repair as well as selected markers of genomic stability [8-oxoguanine, incision efficiency toward 8-oxoguanine, 5-hydroxyuracil, and apurinic\/apyrimidinic sites and global DNA (hydroxy)methylation] were analysed. Ageing resulted in a mild increase of iron and copper concentrations in the cerebellum, which was most pronounced in the suboptimally supplied groups. Thus, TE changes in the cerebellum were predominantly driven by age and less by nutritional intervention. Interestingly, deviation from adequate TE supply resulted in higher manganese concentrations of female mice even though the manganese supply itself was not modulated. Parameters of genomic stability were neither affected by age, sex, nor diet. Overall, this study revealed that suboptimal dietary TE supply does not substantially affect TE homeostasis in the murine cerebellum.<\/jats:p>","DOI":"10.1093\/mtomcs\/mfae003","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T13:44:39Z","timestamp":1706795079000},"source":"Crossref","is-referenced-by-count":4,"title":["Long-term suboptimal dietary trace element supply does not affect trace element homeostasis in murine cerebellum"],"prefix":"10.1093","volume":"16","author":[{"given":"Sharleen","family":"Friese","sequence":"first","affiliation":[{"name":"Department of Food Chemistry, Institute of Nutritional Science, University of Potsdam , Arthur-Scheunert-Allee 114-116, 14558 Nuthetal , Germany"},{"name":"TraceAge\u2014DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly (FOR 2558), Berlin -Potsdam-Jena-Wuppertal, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Ranzini","sequence":"additional","affiliation":[{"name":"Department of Food Chemistry, Institute of Nutritional Science, University of Potsdam , Arthur-Scheunert-Allee 114-116, 14558 Nuthetal , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max","family":"Tuchtenhagen","sequence":"additional","affiliation":[{"name":"Department of Food Chemistry, Institute of Nutritional Science, University of Potsdam , Arthur-Scheunert-Allee 114-116, 14558 Nuthetal , Germany"},{"name":"TraceAge\u2014DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly (FOR 2558), Berlin -Potsdam-Jena-Wuppertal, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Lossow","sequence":"additional","affiliation":[{"name":"TraceAge\u2014DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly (FOR 2558), Berlin -Potsdam-Jena-Wuppertal, Germany"},{"name":"Nutritional Physiology, Institute of Nutritional Sciences, Friedrich Schiller University Jena , Dornburger Str. 24, 07743 Jena , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Hertel","sequence":"additional","affiliation":[{"name":"Department of Food Chemistry, Institute of Nutritional Science, University of Potsdam , Arthur-Scheunert-Allee 114-116, 14558 Nuthetal , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Pohl","sequence":"additional","affiliation":[{"name":"Department of Food Chemistry, Institute of Nutritional Science, University of Potsdam , Arthur-Scheunert-Allee 114-116, 14558 Nuthetal , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franziska","family":"Ebert","sequence":"additional","affiliation":[{"name":"Department of Food Chemistry, Institute of Nutritional Science, University of Potsdam , Arthur-Scheunert-Allee 114-116, 14558 Nuthetal , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Bornhorst","sequence":"additional","affiliation":[{"name":"TraceAge\u2014DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly (FOR 2558), Berlin -Potsdam-Jena-Wuppertal, Germany"},{"name":"Food Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal , Gau\u00dfstra\u00dfe 20, 42119 Wuppertal , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Patricia","family":"Kipp","sequence":"additional","affiliation":[{"name":"TraceAge\u2014DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly (FOR 2558), Berlin -Potsdam-Jena-Wuppertal, Germany"},{"name":"Nutritional Physiology, Institute of Nutritional Sciences, Friedrich Schiller University Jena , Dornburger Str. 24, 07743 Jena , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4873-7488","authenticated-orcid":false,"given":"Tanja","family":"Schwerdtle","sequence":"additional","affiliation":[{"name":"Department of Food Chemistry, Institute of Nutritional Science, University of Potsdam , Arthur-Scheunert-Allee 114-116, 14558 Nuthetal , Germany"},{"name":"TraceAge\u2014DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly (FOR 2558), Berlin -Potsdam-Jena-Wuppertal, Germany"},{"name":"German Federal Institute for Risk Assessment (BfR) , Max-Dohrn-Str. 8-10, 10589 Berlin , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,1,31]]},"reference":[{"key":"2024021704281189300_bib1","first-page":"183","article-title":"The Crux of Inept Biomarkers for Risks and Benefits of Trace Elements","volume-title":"TrAC Trends Anal. 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