{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T07:42:57Z","timestamp":1770968577094,"version":"3.50.1"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:00:00Z","timestamp":1714003200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01ES027078"],"award-info":[{"award-number":["R01ES027078"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30AG10161"],"award-info":[{"award-number":["P30AG10161"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30AG72975"],"award-info":[{"award-number":["P30AG72975"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG15819"],"award-info":[{"award-number":["R01AG15819"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Mercury is a well-recognized environmental contaminant and neurotoxin, having been associated with a number of deleterious neurological conditions including neurodegenerative diseases, such as Alzheimer's disease. To investigate how mercury and other metals behave in the brain, we used synchrotron micro-X-ray fluorescence to map the distribution pattern and quantify concentrations of metals in human brain. Brain tissue was provided by the Rush Alzheimer's Disease Center and samples originated from individuals diagnosed with Alzheimer's disease and without cognitive impairment. Data were collected at the 2-ID-E beamline at the Advanced Photon Source at Argonne National Laboratory with an incident beam energy of 13\u00a0keV. Course scans were performed at low resolution to determine gross tissue features, after which smaller regions were selected to image at higher resolution. The findings revealed (1) the existence of mercury particles in the brain samples of two subjects; (2) co-localization and linear correlation of mercury and selenium in all particles; (3) co-localization of these particles with zinc structures; and (4) association with sulfur in some of these particles. These results suggest that selenium and sulfur may play protective roles against mercury in the brain, potentially binding with the metal to reduce the induced toxicity, although at different affinities. Our findings call for further studies to investigate the relationship between mercury, selenium, and sulfur, as well as the potential implications in Alzheimer's disease and related dementias.<\/jats:p>","DOI":"10.1093\/mtomcs\/mfae018","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T01:32:48Z","timestamp":1714095168000},"source":"Crossref","is-referenced-by-count":5,"title":["Mercury and selenium distribution in human brain tissue using synchrotron micro-X-ray fluorescence"],"prefix":"10.1093","volume":"16","author":[{"given":"Alexis N","family":"Webb","sequence":"first","affiliation":[{"name":"School of Health Sciences, Purdue University , West Lafayette, IN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Antipova","sequence":"additional","affiliation":[{"name":"Advanced Photon Source, Argonne National Laboratory , Lemont, IL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"Shughoury","sequence":"additional","affiliation":[{"name":"School of Health Sciences, Purdue University , West Lafayette, IN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose M","family":"Farfel","sequence":"additional","affiliation":[{"name":"Rush Alzheimer's Disease Center, Rush University Medical Center , Chicago, IL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3689-554X","authenticated-orcid":false,"given":"David A","family":"Bennett","sequence":"additional","affiliation":[{"name":"Rush Alzheimer's Disease Center, Rush University Medical Center , Chicago, IL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yansheng","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Neurology, Indiana University School of Medicine , Indianapolis, IN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Health Sciences, Purdue University , West Lafayette, IN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda H","family":"Nie","sequence":"additional","affiliation":[{"name":"School of Health Sciences, Purdue University , West Lafayette, IN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,4,25]]},"reference":[{"key":"2024050213032316000_bib1","first-page":"55","article-title":"Biological and health implications of toxic heavy metal and essential trace element interactions","volume":"11","author":"Chowdhury","year":"1987","journal-title":"Prog. 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