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Fungicidal properties against Candida albicans were found for the Cu complexes with benzyl and phenyl substituents. An in vitro evaluation of the cytotoxic properties of Cu chelates against HEK293, Jurkat, MCF-7, and THP-1 cells identified the Cu complex with the cyclohexylsulfanyl substituent in the pyrazole core as the lead compound, whereas the Cu complex without a sulfur atom in the pyrazole ligand had virtually no cytotoxic or fungicidal activity. The lead Cu(II) complex was more active than cisplatin. Effect of the S-containing Cu complex on apoptosis and cell cycle distribution has been investigated as well.<\/jats:p>","DOI":"10.1093\/mtomcs\/mfae024","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T00:25:50Z","timestamp":1716855950000},"source":"Crossref","is-referenced-by-count":4,"title":["Novel binuclear copper(II) complexes with sulfanylpyrazole ligands: synthesis, crystal structure, fungicidal, cytostatic, and cytotoxic activity"],"prefix":"10.1093","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5638-7046","authenticated-orcid":false,"given":"Vnira R","family":"Akhmetova","sequence":"first","affiliation":[{"name":"Institute of Petrochemistry and Catalysis, Ufa Federal Research Center of the Russian Academy of Sciences , Prospekt Oktyabrya 141, Ufa 450075 , Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8625-4674","authenticated-orcid":false,"given":"Nail S","family":"Akhmadiev","sequence":"additional","affiliation":[{"name":"Institute of Petrochemistry and Catalysis, Ufa Federal Research Center of the Russian Academy of Sciences , Prospekt Oktyabrya 141, Ufa 450075 , Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aidar T","family":"Gubaidullin","sequence":"additional","affiliation":[{"name":"Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of the Russian Academy of Sciences , Arbuzov str. 8, Kazan 420088 , Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aida I","family":"Samigullina","sequence":"additional","affiliation":[{"name":"Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of the Russian Academy of Sciences , Arbuzov str. 8, Kazan 420088 , Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrey B","family":"Glazyrin","sequence":"additional","affiliation":[{"name":"Ufa University of Science and Technology , Mingazheva str. 100, Ufa 450078 , Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rais A","family":"Sadykov","sequence":"additional","affiliation":[{"name":"Ufa Institute of Chemistry, Ufa Federal Research Center of the Russian Academy of Sciences , Prospekt Oktyabrya 71, Ufa 450054 , Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana V","family":"Ishmetova","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Genetics, Ufa Federal Research Center of the Russian Academy of Sciences , Prospekt Oktyabrya 71, Ufa 450054 , Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulia V","family":"Vakhitova","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Genetics, Ufa Federal Research Center of the Russian Academy of Sciences , Prospekt Oktyabrya 71, Ufa 450054 , Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,5,27]]},"reference":[{"key":"2024060410113915200_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphar.2015.00205","article-title":"Multi-target pharmacology: possibilities and limitations of the \u201cskeleton key approach\u201d from a medicinal chemist perspective","volume":"6","author":"Talevi","year":"2015","journal-title":"Front. 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