{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T12:56:54Z","timestamp":1776776214892,"version":"3.51.2"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100007772","name":"Agir Pour les Maladies Chroniques","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007772","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Zinc is an essential trace element with antioxidant and signaling functions critical to cardiac physiology. This study investigated the role of zinc in myocardial ischemia-reperfusion (IR)-induced cardiac damage using a rat model, and whether zinc deficiency induced by intermittent hypoxia (IH) exacerbates cardiac injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Regional IR was performed in isolated rat hearts, and zinc concentrations were measured in coronary effluents. Plasma zinc status was assessed following 14- or 35-day IH exposure (1-min cycles alternating 21% and 5% FiO\u2082, 8\u00a0h\/day). The cardioprotective effects of intracoronary zinc administration with the ionophore pyrithione were evaluated based on arrhythmias, infarct size, and contractile recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Myocardial IR induced significant zinc release upon reperfusion (615.7\u00a0\u00b1\u00a078.2\u00a0nM vs. 374.5\u00a0\u00b1\u00a040.3\u00a0nM pre-reperfusion, P\u00a0&amp;lt;\u00a00.01). Zinc administration during reperfusion reduced arrhythmia duration (358.0\u00a0\u00b1\u00a061.7\u00a0sec vs. 559.9\u00a0\u00b1\u00a031.6\u00a0sec, P\u00a0&amp;lt;\u00a00.01) and improved myocardial recovery. IH exposure led to reduced plasma zinc levels (10.3\u00a0\u00b1\u00a00.5 \u00b5M vs. 13.0\u00a0\u00b1\u00a01.2 \u00b5M, P\u00a0=\u00a00.057) and significantly increased infarct size following IR (43.9\u00a0\u00b1\u00a04.2%\u00a0vs. 29.2\u00a0\u00b1\u00a04.3%, P\u00a0&amp;lt;\u00a00.05). Zinc-pyrithione treatment during reperfusion abolished the deleterious effects of IH on infarct size.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>IH-induced zinc deficiency exacerbates cardiac vulnerability to IR injury, while zinc restoration through targeted administration mitigates this damage. Zinc\u2019s protective effects may involve antioxidant action, calcium homeostasis, and signaling modulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Zinc plays a critical role in limiting IR-induced cardiac damage. Zinc supplementation during reperfusion may offer therapeutic benefit, particularly in conditions associated with chronic IH, such as obstructive sleep apnea.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/mtomcs\/mfag009","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T12:44:12Z","timestamp":1772109852000},"source":"Crossref","is-referenced-by-count":0,"title":["Cardioprotective effect of intracoronary zinc administration in isolated rat hearts during ischemia-reperfusion following intermittent hypoxia exposure\n                    <i>in vivo<\/i>"],"prefix":"10.1093","volume":"18","author":[{"given":"Jessica","family":"Morand","sequence":"first","affiliation":[{"name":"University Grenoble Alpes , Inserm, CHU Grenoble Alpes, HP2, 38000 Grenoble ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane","family":"Godin-Ribuot","sequence":"additional","affiliation":[{"name":"University Grenoble Alpes , Inserm, CHU Grenoble Alpes, HP2, 38000 Grenoble ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josiane","family":"Arnaud","sequence":"additional","affiliation":[{"name":"CHUGA, Biochimie Hormonale et Nutritionnelle , Grenoble F-38043 ,","place":["France"]},{"name":"INSERM , U1055, Grenoble F-38000 ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John H","family":"Beattie","sequence":"additional","affiliation":[{"name":"The Rowett Institute, University of Aberdeen , Foresterhill, Aberdeen AB25 2ZD ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Korichneva","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Picardie Jules Verne, Department of Pharmacology, 7517 MP3CV, CURS, , Amiens 80054 , ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"2026042108041938100_bib1","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1089\/ars.2006.8.1707","article-title":"Zinc dynamics in the myocardial redox signaling network","volume":"8","author":"Korichneva","year":"2006","journal-title":"Antioxid Redox Signal"},{"key":"2026042108041938100_bib2","doi-asserted-by":"publisher","first-page":"5647","DOI":"10.1021\/bi00476a001","article-title":"Zinc coordination, function, and structure of zinc enzymes and other proteins","volume":"29","author":"Vallee","year":"1990","journal-title":"Biochemistry"},{"key":"2026042108041938100_bib3","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/s0065-2776(08)00003-5","article-title":"Roles of zinc and zinc signaling in immunity: zinc as an intracellular signaling molecule","volume":"97","author":"Hirano","year":"2008","journal-title":"Adv Immunol"},{"key":"2026042108041938100_bib4","doi-asserted-by":"publisher","first-page":"419","DOI":"10.3390\/biom4020419","article-title":"Zinc-binding cysteines: diverse functions and structural motifs","volume":"4","author":"Pace","year":"2014","journal-title":"Biomolecules"},{"key":"2026042108041938100_bib5","doi-asserted-by":"publisher","first-page":"44327","DOI":"10.1074\/jbc.m205634200","article-title":"Zinc release from protein kinase C as the common event during activation by lipid second messenger or reactive oxygen","volume":"277","author":"Korichneva","year":"2002","journal-title":"J Biol Chem"},{"key":"2026042108041938100_bib6","doi-asserted-by":"publisher","first-page":"1447S","DOI":"10.1093\/jn\/130.5.1447s","article-title":"The antioxidant properties of zinc","volume":"130","author":"Powell","year":"2000","journal-title":"J Nutr"},{"key":"2026042108041938100_bib7","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1039\/an9952000859","article-title":"Study of antioxidant properties of metal aspartates","volume":"120","author":"Afanas\u2019ev","year":"1995","journal-title":"Analyst"},{"key":"2026042108041938100_bib8","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/bf02990343","article-title":"Effects of low copper and high zinc intakes and related changes in Cu,Zn-superoxide dismutase activity on DMBA-induced mammary tumorigenesis","volume":"30","author":"Fischer","year":"1991","journal-title":"Biol Trace Elem Res"},{"key":"2026042108041938100_bib9","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1007\/s00204-011-0775-1","article-title":"Zinc and human health: an update","volume":"86","author":"Chasapis","year":"2012","journal-title":"Arch Toxicol"},{"key":"2026042108041938100_bib10","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1136\/hrt.38.12.1339","article-title":"Plasma zinc in acute myocardial infarction. 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