{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T09:25:52Z","timestamp":1787304352048,"version":"build-2736575974"},"reference-count":250,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Metals and metalloids play essential roles in cancer biology, influencing redox balance, epigenetic regulation, immune responses, and cell death throughout tumour development, progression, and resistance to therapy. Despite this broad biological relevance, the systematic clinical integration of metallomics into oncology remains in its early stages. This review introduces the Cancer Metallome Continuum, a framework illustrating how metallomic reprogramming evolves from cancer initiation through progression to therapy-resistant states, and evaluates the analytical, systems-level, and translational approaches needed to test it. In early stages of cancer, toxic metals such as As, Cd, hexavalent chromium [Cr(VI)], and Ni induce oxidative stress, epigenetic modifications, and DNA repair defects. During progression, dyshomeostasis of essential metals creates tumour-specific dependencies. For example, Fe accumulation can support tumour growth, while tumour cells concurrently engage antiferroptotic programs; Cu contributes to angiogenesis and kinase signalling, and Zn transporter networks regulate apoptosis and immune responses. Under treatment pressure, tumours adapt by rewiring metal transporters, upregulating metallothionein buffering, and suppressing metal-dependent cell death pathways, including ferroptosis and cuproptosis. Translational advances include selenium-based prognostic panels with replicated evidence in breast cancer (SCAN-B) and colorectal cancer (CORSA), Cu-chelation trials, and spatially resolved metallodrug imaging. The strongest human evidence currently supports Se-based prognostic panels (replicated across breast and colorectal cancer cohorts) and the feasibility of biomarker-guided Cu depletion (a Phase II single-arm trial), while spatial integration and artificial intelligence\/machine learning applications remain at the proof-of-concept or emerging stages. Clinical translation will require tighter control of preanalytical variability, prospective multicentre validation, and standardized reporting.<\/jats:p>","DOI":"10.1093\/mtomcs\/mfag024","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T11:46:23Z","timestamp":1782387983000},"source":"Crossref","is-referenced-by-count":0,"title":["The cancer metallome continuum: a framework for understanding metal dysregulation from carcinogenesis to therapeutic resistance"],"prefix":"10.1093","volume":"18","author":[{"given":"Mohamed Ali","family":"Hussein","sequence":"first","affiliation":[{"name":"Department of Biological, Chemical, and Global Health Sciences, School of Sciences & Engineering, The American University in Cairo , Cairo, 11835 ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8002-6693","authenticated-orcid":false,"given":"Mahmoud M","family":"Mokhtar","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Misr University for Science and Technology , 6th of October City, Giza 16878 ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jassy","family":"Salim","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Modern University for Technology and Information (MTI University) , Mokattam, Cairo 11571 ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lobna","family":"Abdelsalam","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy and Biotechnology, German University in Cairo (GUC), New Cairo , 11835 ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9722-4274","authenticated-orcid":false,"given":"Rahma Wael","family":"Soliman","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Helwan University, Helwan , Cairo 11795 ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7405-5108","authenticated-orcid":false,"given":"Shrouk Khaled","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Kasr Al-Ainy Faculty of Medicine, Cairo University , Cairo 12111 ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramez","family":"Tharwat","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, MTI University , Cairo 11571 ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0088-6799","authenticated-orcid":false,"given":"Anwar","family":"Abdelnaser","sequence":"additional","affiliation":[{"name":"Department of Biological, Chemical, and Global Health Sciences, School of Sciences & Engineering, The American University in Cairo , Cairo, 11835 ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"key":"2026082104412061900_bib1","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1039\/c2mt90041f","article-title":"Metallomics: whence and whither","volume":"4","author":"Maret","year":"2012","journal-title":"Metallomics"},{"key":"2026082104412061900_bib2","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1039\/b713633c","article-title":"Metallomics: the concept and methodology","volume-title":"Chem Soc Rev","author":"Mounicou","year":"2009"},{"key":"2026082104412061900_bib3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-3-319-90143-5_1","article-title":"Metallomics: the science of biometals and biometalloids","volume":"1055","author":"Maret","year":"2018","journal-title":"Adv Exp Med Biol"},{"key":"2026082104412061900_bib4","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/978-3-319-90143-5_7","article-title":"Bioimaging metallomics","volume":"1055","author":"Dressler","year":"2018","journal-title":"Adv Exp Med Biol"},{"key":"2026082104412061900_bib5","doi-asserted-by":"publisher","first-page":"3293","DOI":"10.1007\/s00018-020-03484-0","article-title":"Isotope metallomics approaches for medical research","volume-title":"Cell Mol Life Sci","author":"Mahan","year":"2020"},{"key":"2026082104412061900_bib6","doi-asserted-by":"publisher","first-page":"1625874","DOI":"10.3389\/ftox.2025.1625874","article-title":"Uncovering exposome-related diseases through the pathologic metallome: a novel approach for clinical populations","volume":"7","author":"Leinardi","year":"2025","journal-title":"Front Toxicol"},{"key":"2026082104412061900_bib7","doi-asserted-by":"publisher","first-page":"695873","DOI":"10.3389\/fnmol.2021.695873","article-title":"The metallome as a link between the \u201comes\u201d in autism spectrum disorders","volume":"14","author":"Stanton","year":"2021","journal-title":"Front Mol Neurosci"},{"key":"2026082104412061900_bib8","doi-asserted-by":"publisher","first-page":"106810","DOI":"10.1016\/j.envint.2021.106810","article-title":"An atlas of metallome and metabolome interactions and associations with incident diabetes in the Strong Heart Family Study","volume-title":"Environ Int","author":"Sanchez","year":"2021"},{"key":"2026082104412061900_bib9","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1097\/FTD.0000000000001416","article-title":"Toxicology of heavy metals in biological matrices: a paradigm shift from single-analyte measurement to comprehensive screening","volume-title":"Ther Drug Monit","author":"El\u00a0Balkhi","year":"2026"},{"key":"2026082104412061900_bib10","doi-asserted-by":"publisher","first-page":"mfac037","DOI":"10.1093\/mtomcs\/mfac037","article-title":"Recent advances in the application of metallomics in diagnosis and prognosis of human cancer","volume":"14","author":"Zhang","year":"2022","journal-title":"Metallomics"},{"key":"2026082104412061900_bib11","doi-asserted-by":"publisher","first-page":"mfaf005","DOI":"10.1093\/mtomcs\/mfaf005","article-title":"A critical review on the relevance, essentiality, and analytical techniques of trace elements in human cancer","volume":"17","author":"Liu","year":"2025","journal-title":"Metallomics"},{"key":"2026082104412061900_bib12","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1146\/annurev-nutr-082117-051732","article-title":"Iron and cancer","volume-title":"Annu Rev Nutr","author":"Torti","year":"2018"},{"key":"2026082104412061900_bib13","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/s41419-023-06045-y","article-title":"The diversified role of mitochondria in ferroptosis in cancer","volume":"14","author":"Liu","year":"2023","journal-title":"Cell Death Dis"},{"key":"2026082104412061900_bib14","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1126\/science.abf0529","article-title":"Copper induces cell death by targeting lipoylated TCA cycle proteins","volume":"375","author":"Tsvetkov","year":"2022","journal-title":"Science"},{"key":"2026082104412061900_bib15","doi-asserted-by":"publisher","first-page":"612","DOI":"10.20892\/j.issn.2095-3941.2020.0106","article-title":"Zinc dysregulation in cancers and its potential as a therapeutic target","volume":"17","author":"Wang","year":"2020","journal-title":"Cancer Biol Med"},{"key":"2026082104412061900_bib16","doi-asserted-by":"publisher","first-page":"8870","DOI":"10.1039\/c3cs60272a","article-title":"Which form is that? The importance of selenium speciation and metabolism in the prevention and treatment of disease","volume-title":"Chem Soc Rev","author":"Weekley","year":"2013"},{"key":"2026082104412061900_bib17","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1111\/cas.16124","article-title":"Serum and tissue metallome of pancreatic ductal adenocarcinoma","volume":"115","author":"Byeon","year":"2024","journal-title":"Cancer Sci"},{"key":"2026082104412061900_bib18","doi-asserted-by":"publisher","first-page":"126629","DOI":"10.1016\/j.jtemb.2020.126629","article-title":"Serum copper and zinc levels in breast cancer: a meta-analysis","volume-title":"J Trace Elem Med Biol","author":"Feng","year":"2020"},{"key":"2026082104412061900_bib19","doi-asserted-by":"publisher","first-page":"5323","DOI":"10.21873\/anticanres.16039","article-title":"Changes in serum trace element concentrations before and after surgery in resectable breast cancer","volume-title":"Anticancer Res","author":"Takahashi","year":"2022"},{"key":"2026082104412061900_bib20","doi-asserted-by":"publisher","first-page":"7337","DOI":"10.1007\/s00216-022-04259-1","article-title":"Facets of ICP-MS and their potential in the medical sciences-Part 1: fundamentals, stand-alone and hyphenated techniques","volume":"414","author":"Clases","year":"2022","journal-title":"Anal Bioanal Chem"},{"key":"2026082104412061900_bib21","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.aca.2011.08.027","article-title":"Matrix effects in inductively coupled plasma mass spectrometry: a review","volume":"706","author":"Agatemor","year":"2011","journal-title":"Anal Chim Acta"},{"key":"2026082104412061900_bib22","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1007\/s00216-003-2325-z","article-title":"Isotope-dilution ICP-MS for trace element determination and speciation: from a reference method to a routine method?","volume":"378","author":"Heumann","year":"2004","journal-title":"Anal Bioanal Chem"},{"key":"2026082104412061900_bib23","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.talanta.2013.03.029","article-title":"Microwave plasma-atomic emission spectroscopy as a tool for the determination of copper, iron, manganese and zinc in animal feed and fertilizer","volume-title":"Talanta","author":"Li","year":"2013"},{"key":"2026082104412061900_bib24","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.foodchem.2018.08.114","article-title":"Analytical features of microwave plasma-atomic emission spectrometry (MP-AES) for the quantitation of manganese (Mn) in wild grape (Vitis coignetiae) red wines: comparison with inductively coupled plasma-optical emission spectrometry (ICP-OES)","volume-title":"Food Chem","author":"Jung","year":"2019"},{"key":"2026082104412061900_bib25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.aca.2014.04.048","article-title":"Bioimaging mass spectrometry of trace elements\u2014recent advance and applications of LA-ICP-MS: a review","volume":"835","author":"Becker","year":"2014","journal-title":"Anal Chim Acta"},{"key":"2026082104412061900_bib26","doi-asserted-by":"publisher","first-page":"6593","DOI":"10.1007\/s00216-015-8858-0","article-title":"Recent advances in quantitative LA-ICP-MS analysis: challenges and solutions in the life sciences and environmental chemistry","volume-title":"Anal Bioanal Chem","author":"Limbeck","year":"2015"},{"key":"2026082104412061900_bib27","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1039\/c2an15792f","article-title":"Quantification strategies for elemental imaging of biological samples using laser ablation-inductively coupled plasma-mass spectrometry","volume":"137","author":"Hare","year":"2012","journal-title":"Analyst"},{"key":"2026082104412061900_bib28","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1007\/s00216-016-0124-6","article-title":"A comparison of sample preparation strategies for biological tissues and subsequent trace element analysis using LA-ICP-MS","volume-title":"Anal Bioanal Chem","author":"Bonta","year":"2017"},{"key":"2026082104412061900_bib29","doi-asserted-by":"publisher","first-page":"mfae034","DOI":"10.1093\/mtomcs\/mfae034","article-title":"P-based referencing for correcting tissue artifacts in laser ablation-inductively coupled plasma-mass spectrometry imaging of cancer samples","volume":"16","author":"Kronenberg","year":"2024","journal-title":"Metallomics"},{"key":"2026082104412061900_bib30","doi-asserted-by":"publisher","first-page":"2597","DOI":"10.1021\/acs.analchem.1c04857","article-title":"Elemental mapping of human malignant mesothelioma tissue samples using high-speed LA-ICP-TOFMS imaging","volume-title":"Anal Chem","author":"Voloaca","year":"2022"},{"key":"2026082104412061900_bib31","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.cbpa.2007.02.039","article-title":"Biological applications of X-ray fluorescence microscopy: exploring the subcellular topography and speciation of transition metals","volume-title":"Curr Opin Chem Biol","author":"Fahrni","year":"2007"},{"key":"2026082104412061900_bib32","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1111\/jmi.12466","article-title":"Preserving elemental content in adherent mammalian cells for analysis by synchrotron-based x-ray fluorescence microscopy","volume":"265","author":"Jin","year":"2017","journal-title":"J Microsc"},{"key":"2026082104412061900_bib33","doi-asserted-by":"publisher","first-page":"1992","DOI":"10.3390\/molecules28041992","article-title":"Impact of sample preparation methods on single-cell X-ray microscopy and light elemental analysis evaluated by combined low energy X-ray fluorescence, STXM and AFM","volume":"28","author":"Merolle","year":"2023","journal-title":"Molecules"},{"key":"2026082104412061900_bib34","doi-asserted-by":"publisher","first-page":"127086","DOI":"10.1016\/j.jtemb.2022.127086","article-title":"Single-cell ICP-MS to address the role of trace elements at a cellular level","volume":"75","author":"da\u00a0Silva","year":"2023","journal-title":"J Trace Elem Med Biol"},{"key":"2026082104412061900_bib35","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1039\/c7mt00285h","article-title":"Single-cell analysis by ICP-MS\/MS as a fast tool for cellular bioavailability studies of arsenite","volume":"10","author":"Meyer","year":"2018","journal-title":"Metallomics"},{"key":"2026082104412061900_bib36","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.aca.2019.04.064","article-title":"High-resolution imaging and single-cell analysis via laser ablation-inductively coupled plasma-mass spectrometry for the determination of membranous receptor expression levels in breast cancer cell lines using receptor-specific hybrid tracers","volume":"1074","author":"Van\u00a0Acker","year":"2019","journal-title":"Anal Chim Acta"},{"key":"2026082104412061900_bib37","doi-asserted-by":"publisher","first-page":"1055356","DOI":"10.3389\/fmolb.2022.1055356","article-title":"The copper transporter CTR1 and cisplatin accumulation at the single-cell level by LA-ICP-TOFMS","volume":"9","author":"Schoeberl","year":"2022","journal-title":"Front Mol Biosci"},{"key":"2026082104412061900_bib38","doi-asserted-by":"publisher","first-page":"11874","DOI":"10.1021\/acs.analchem.3c02506","article-title":"Single-Cell ICP-MS in combination with fluorescence-activated cell sorting for investigating the effects of nanotransported cisplatin(IV) prodrugs","volume":"95","author":"Gutierrez-Romero","year":"2023","journal-title":"Anal Chem"},{"key":"2026082104412061900_bib39","doi-asserted-by":"publisher","first-page":"274","DOI":"10.14336\/AD.2024.1577","article-title":"Exploiting the fractionation of stable isotopes in biochemical processes for medical diagnosis: a narrative review","volume":"17","author":"Hobert","year":"2025","journal-title":"Aging Dis"},{"key":"2026082104412061900_bib40","doi-asserted-by":"publisher","first-page":"mfad060","DOI":"10.1093\/mtomcs\/mfad060","article-title":"Copper isotope ratios in serum do not track cancerous tumour evolution, but organ failure","volume":"15","author":"Miaou","year":"2023","journal-title":"Metallomics"},{"key":"2026082104412061900_bib41","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1007\/s00216-018-1498-4","article-title":"A new anion exchange purification method for Cu stable isotopes in blood samples","volume":"411","author":"Yang","year":"2019","journal-title":"Anal Bioanal Chem"},{"key":"2026082104412061900_bib42","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.3945\/jn.116.247171","article-title":"Identification of a haemolysis threshold that increases plasma and serum zinc concentration","volume":"147","author":"Killilea","year":"2017","journal-title":"J Nutr"},{"key":"2026082104412061900_bib43","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.clnu.2007.10.003","article-title":"Acute inflammatory response does not affect erythrocyte concentrations of copper, zinc and selenium","volume-title":"Clin Nutr","author":"Oakes","year":"2008"},{"key":"2026082104412061900_bib44","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.clnu.2015.02.010","article-title":"The effect of the systemic inflammatory response on plasma zinc and selenium adjusted for albumin","volume":"35","author":"Ghashut","year":"2016","journal-title":"Clin Nutr"},{"key":"2026082104412061900_bib45","doi-asserted-by":"publisher","first-page":"1748","DOI":"10.1038\/s41430-022-01181-8","article-title":"Relationship of serum copper and zinc with kidney function and urinary albumin to creatinine ratio: cross-sectional data from the NHANES 2011-2016","volume":"76","author":"Jiang","year":"2022","journal-title":"Eur J Clin Nutr"},{"key":"2026082104412061900_bib46","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1080\/15298669391355134","article-title":"Interpretation of urine results used to assess chemical exposure with emphasis on creatinine adjustments: a review","volume-title":"Am Ind Hyg Assoc J","author":"Boeniger","year":"1993"},{"key":"2026082104412061900_bib47","doi-asserted-by":"publisher","first-page":"e0233357","DOI":"10.1371\/journal.pone.0233357","article-title":"ICP-MS trace element analysis in serum and whole blood","volume":"15","author":"Laur","year":"2020","journal-title":"PLoS One"},{"key":"2026082104412061900_bib48","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1093\/carcin\/bgaa076","article-title":"Metals and molecular carcinogenesis","volume":"41","author":"Zhu","year":"2020","journal-title":"Carcinogenesis"},{"key":"2026082104412061900_bib49","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/S1470-2045(22)00219-4","article-title":"Carcinogenicity of cobalt, antimony compounds, and weapons-grade tungsten alloy","volume":"23","author":"Karagas","year":"2022","journal-title":"Lancet Oncol"},{"key":"2026082104412061900_bib50","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1289\/ehp.94102s345","article-title":"Role of DNA repair inhibition in lead- and cadmium-induced genotoxicity: a review","volume":"102","author":"Hartwig","year":"1994","journal-title":"Environ Health Perspect"},{"key":"2026082104412061900_bib51","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/s0378-4274(98)00312-9","article-title":"Carcinogenicity of metal compounds: possible role of DNA repair inhibition","volume-title":"Toxicol Lett","author":"Hartwig","year":"1998"},{"key":"2026082104412061900_bib52","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.freeradbiomed.2012.11.009","article-title":"Metal interaction with redox regulation: an integrating concept in metal carcinogenesis?","volume-title":"Free Radic Biol Med","author":"Hartwig","year":"2013"},{"key":"2026082104412061900_bib53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1385\/BTER:89:1:1","article-title":"Serum and tissue trace elements in patients with breast cancer in Taiwan","volume-title":"Biol Trace Elem Res","author":"Kuo","year":"2002"},{"key":"2026082104412061900_bib54","doi-asserted-by":"publisher","first-page":"95","DOI":"10.3390\/ijms20010095","article-title":"Iron Metabolism in Cancer","volume":"20","author":"Wang","year":"2018","journal-title":"Int J Mol Sci"},{"key":"2026082104412061900_bib55","first-page":"916","article-title":"Transferrin receptor 1 in cancer: a new sight for cancer therapy","volume":"8","author":"Shen","year":"2018","journal-title":"Am J Cancer Res"},{"key":"2026082104412061900_bib56","doi-asserted-by":"publisher","first-page":"2257","DOI":"10.3390\/ijms21062257","article-title":"Iron metabolism in cancer progression","volume-title":"Int J Mol Sci","author":"Forciniti","year":"2020"},{"key":"2026082104412061900_bib57","doi-asserted-by":"publisher","first-page":"118893","DOI":"10.1016\/j.bbamcr.2020.118893","article-title":"Copper metabolism as a unique vulnerability in cancer","volume-title":"Biochim Biophys Acta Mol Cell Res","author":"Shanbhag","year":"2021"},{"key":"2026082104412061900_bib58","doi-asserted-by":"publisher","first-page":"34158","DOI":"10.18632\/oncotarget.5779","article-title":"Copper activates HIF-1alpha\/GPER\/VEGF signalling in cancer cells","volume":"6","author":"Rigiracciolo","year":"2015","journal-title":"Oncotarget"},{"key":"2026082104412061900_bib59","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1111\/j.1440-1681.2008.04969.x","article-title":"Copper and angiogenesis: unravelling a relationship key to cancer progression","volume":"36","author":"Finney","year":"2009","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"2026082104412061900_bib60","doi-asserted-by":"publisher","first-page":"623","DOI":"10.2741\/4507","article-title":"Zinc transporters and dysregulated channels in cancers","volume":"22","author":"Pan","year":"2017","journal-title":"Front Biosci (Landmark Ed)"},{"key":"2026082104412061900_bib61","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/1479-5876-8-118","article-title":"Zinc in innate and adaptive tumour immunity","volume-title":"J Transl Med","author":"John","year":"2010"},{"key":"2026082104412061900_bib62","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1038\/s41422-020-00395-4","article-title":"Manganese is critical for antitumour immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy","volume-title":"Cell Res","author":"Lv","year":"2020"},{"key":"2026082104412061900_bib63","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1007\/s10787-020-00690-x","article-title":"Selenium and selenoproteins: it\u2019s role in regulation of inflammation","volume":"28","author":"Hariharan","year":"2020","journal-title":"Inflammopharmacology"},{"key":"2026082104412061900_bib64","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1016\/j.freeradbiomed.2010.07.028","article-title":"Roles of dioxins and heavy metals in cancer and neurological diseases using ROS-mediated mechanisms","volume-title":"Free Radic Biol Med","author":"Mat\u00e9s","year":"2010"},{"key":"2026082104412061900_bib65","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1743-8977-7-9","article-title":"Vanadium pentoxide induces pulmonary inflammation and tumour promotion in a strain-dependent manner","volume-title":"Part Fibre Toxicol","author":"Rondini","year":"2010"},{"key":"2026082104412061900_bib66","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1080\/10937400903094166","article-title":"A review of current toxicological concerns on vanadium pentoxide and other vanadium compounds: gaps in knowledge and directions for future research","volume-title":"J Toxicol Environ Health B Crit Rev","author":"Assem","year":"2009"},{"key":"2026082104412061900_bib67","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.yrtph.2016.05.009","article-title":"Inhalation cancer risk assessment of cobalt metal","volume":"79","author":"Suh","year":"2016","journal-title":"Regul Toxicol Pharmacol"},{"key":"2026082104412061900_bib68","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1093\/mutage\/get032","article-title":"Beryllium chloride-induced oxidative DNA damage and alteration in the expression patterns of DNA repair-related genes","volume-title":"Mutagenesis","author":"Attia","year":"2013"},{"key":"2026082104412061900_bib69","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.mrfmmm.2005.06.008","article-title":"Nickel carcinogenesis: epigenetics and hypoxia signalling","volume":"592","author":"Costa","year":"2005","journal-title":"Mutat Res"},{"key":"2026082104412061900_bib70","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1039\/b903049b","article-title":"Epigenetics in metal carcinogenesis: nickel, arsenic, chromium and cadmium","volume":"1","author":"Arita","year":"2009","journal-title":"Metallomics"},{"key":"2026082104412061900_bib71","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1016\/j.toxrep.2022.03.037","article-title":"Epigenetic mechanisms in metal carcinogenesis","volume":"9","author":"Mani\u0107","year":"2022","journal-title":"Toxicol Rep"},{"key":"2026082104412061900_bib72","doi-asserted-by":"publisher","first-page":"5768","DOI":"10.3390\/cancers14235768","article-title":"Epigenetic regulation in chromium-, nickel- and cadmium-induced carcinogenesis","volume":"14","author":"Zhao","year":"2022","journal-title":"Cancers (Basel)"},{"key":"2026082104412061900_bib73","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1289\/ehp.1002114","article-title":"An emerging role for epigenetic dysregulation in arsenic toxicity and carcinogenesis","volume":"119","author":"Ren","year":"2011","journal-title":"Environ Health Perspect"},{"key":"2026082104412061900_bib74","doi-asserted-by":"publisher","first-page":"87","DOI":"10.2217\/epi.09.45","article-title":"Effects of arsenic exposure on DNA methylation and epigenetic gene regulation","volume":"2","author":"Reichard","year":"2010","journal-title":"Epigenomics"},{"key":"2026082104412061900_bib75","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1615\/jenvironpatholtoxicoloncol.2014012066","article-title":"Epigenetic targets of arsenic: emphasis on epigenetic modifications during carcinogenesis","volume":"34","author":"Roy","year":"2015","journal-title":"J Environ Pathol Toxicol Oncol"},{"key":"2026082104412061900_bib76","first-page":"307","article-title":"Epigenetic mechanisms of nickel carcinogenesis","volume":"19","author":"Salnikow","year":"2000","journal-title":"J Environ Pathol Toxicol Oncol"},{"key":"2026082104412061900_bib77","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1515\/BC.2002.102","article-title":"Molecular mechanisms of nickel carcinogenesis","volume-title":"Biol Chem","author":"Costa","year":"2002"},{"key":"2026082104412061900_bib78","doi-asserted-by":"publisher","first-page":"3728","DOI":"10.1128\/MCB.26.10.3728-3737.2006","article-title":"Nickel ions increase histone H3 lysine 9 dimethylation and induce transgene silencing","volume-title":"Mol Cell Biol","author":"Chen","year":"2006"},{"key":"2026082104412061900_bib79","doi-asserted-by":"publisher","first-page":"114636","DOI":"10.1016\/j.taap.2019.114636","article-title":"Molecular and epigenetic mechanisms of Cr(VI)-induced carcinogenesis","volume":"377","author":"Chen","year":"2019","journal-title":"Toxicol Appl Pharmacol"},{"key":"2026082104412061900_bib80","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/s0014-4827(03)00062-4","article-title":"Effects of cadmium on DNA-(Cytosine-5) methyltransferase activity and DNA methylation status during cadmium-induced cellular transformation","volume":"286","author":"Takiguchi","year":"2003","journal-title":"Exp Cell Res"},{"key":"2026082104412061900_bib81","doi-asserted-by":"publisher","first-page":"2611","DOI":"10.2174\/092986712800492913","article-title":"Cadmium and its epigenetic effects","volume":"19","author":"Wang","year":"2012","journal-title":"Curr Med Chem"},{"key":"2026082104412061900_bib82","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1289\/ehp.0901429","article-title":"Biomarkers of lead exposure and DNA methylation within retrotransposons","volume":"118","author":"Wright","year":"2010","journal-title":"Environ Health Perspect"},{"key":"2026082104412061900_bib83","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/s41370-019-0183-9","article-title":"Blood DNA methylation biomarkers of cumulative lead exposure in adults","volume":"31","author":"Colicino","year":"2021","journal-title":"J Expo Sci Environ Epidemiol"},{"key":"2026082104412061900_bib84","doi-asserted-by":"publisher","first-page":"116351","DOI":"10.1016\/j.ecoenv.2024.116351","article-title":"Tracing toxic path of antimony: from bioaccumulation to DNA hypomethylation in zebrafish (Danio rerio)","volume":"277","author":"Zhang","year":"2024","journal-title":"Ecotoxicol Environ Saf"},{"key":"2026082104412061900_bib85","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1002\/mc.22634","article-title":"Tungsten exposure causes a selective loss of histone demethylase protein","volume":"56","author":"Laulicht-Glick","year":"2017","journal-title":"Mol Carcinog"},{"key":"2026082104412061900_bib86","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1289\/ehp.02110s5797","article-title":"Interference by toxic metal ions with DNA repair processes and cell cycle control: molecular mechanisms","volume":"110","author":"Hartwig","year":"2002","journal-title":"Environ Health Perspect"},{"key":"2026082104412061900_bib87","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/s0378-4274(01)00482-9","article-title":"Interactions by carcinogenic metal compounds with DNA repair processes: toxicological implications","volume-title":"Toxicol Lett","author":"Hartwig","year":"2002"},{"key":"2026082104412061900_bib88","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.tox.2003.08.004","article-title":"Modulation of DNA repair processes by arsenic and selenium compounds","volume":"193","author":"Hartwig","year":"2003","journal-title":"Toxicology"},{"key":"2026082104412061900_bib89","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.semcancer.2021.05.009","article-title":"Arsenic co-carcinogenesis: inhibition of DNA repair and interaction with zinc finger proteins","volume":"76","author":"Zhou","year":"2021","journal-title":"Semin Cancer Biol"},{"key":"2026082104412061900_bib90","doi-asserted-by":"publisher","first-page":"22855","DOI":"10.1074\/jbc.M111.232926","article-title":"Arsenite interacts selectively with zinc finger proteins containing C3H1 or C4 motifs","volume-title":"J Biol Chem","author":"Zhou","year":"2011"},{"key":"2026082104412061900_bib91","doi-asserted-by":"publisher","first-page":"4307","DOI":"10.3390\/ijerph19074307","article-title":"Genotoxic effects of lead and their impact on the expression of DNA repair genes","volume":"19","author":"Hemmaphan","year":"2022","journal-title":"Int J Environ Res Public Health"},{"key":"2026082104412061900_bib92","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1093\/carcin\/bgg012","article-title":"Chromium(VI) exposure enhances polycyclic aromatic hydrocarbon-DNA binding at the p53 gene in human lung cells","volume-title":"Carcinogenesis","author":"Feng","year":"2003"},{"key":"2026082104412061900_bib93","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1093\/carcin\/bgs237","article-title":"Chromium (VI) induces both bulky DNA adducts and oxidative DNA damage at adenines and guanines in the p53 gene of human lung cells","volume":"33","author":"Arakawa","year":"2012","journal-title":"Carcinogenesis"},{"key":"2026082104412061900_bib94","doi-asserted-by":"publisher","first-page":"101900","DOI":"10.1016\/j.redox.2021.101900","article-title":"Are trace element concentrations suitable biomarkers for the diagnosis of cancer?","volume":"42","author":"Lossow","year":"2021","journal-title":"Redox Biol"},{"key":"2026082104412061900_bib95","doi-asserted-by":"publisher","first-page":"127060","DOI":"10.1016\/j.jtemb.2022.127060","article-title":"Role of iron biomarkers and iron intakes in lung cancer risk: a systematic review and meta-analysis","volume-title":"J Trace Elem Med Biol","author":"Wang","year":"2022"},{"key":"2026082104412061900_bib96","doi-asserted-by":"publisher","first-page":"14195","DOI":"10.1038\/s41598-021-93369-4","article-title":"Metallomic profile in non-cirrhotic hepatocellular carcinoma supports a phenomenon of metal metabolism adaptation in tumour cells","volume":"11","author":"Cano","year":"2021","journal-title":"Sci Rep"},{"key":"2026082104412061900_bib97","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.toxlet.2022.03.003","article-title":"Cadmium and breast cancer\u2014Current state and research gaps in the underlying mechanisms","volume-title":"Toxicol Lett","author":"Tarhonska","year":"2022"},{"key":"2026082104412061900_bib98","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1038\/s41420-025-02676-6","article-title":"Lead bioaccumulation in human breast cancer tissue is associated with DNA instability and cell death resistance","volume":"11","author":"Scimeca","year":"2025","journal-title":"Cell Death Discov"},{"key":"2026082104412061900_bib99","doi-asserted-by":"publisher","first-page":"4427","DOI":"10.3390\/ijms26094427","article-title":"Mercury Bioaccumulation in Female Breast Cancer Is Associated to CXCR4 Expression","volume":"26","author":"Servadei","year":"2025","journal-title":"Int J Mol Sci"},{"key":"2026082104412061900_bib100","doi-asserted-by":"publisher","first-page":"mfac071","DOI":"10.1093\/mtomcs\/mfac051","article-title":"The quintessence of metallomics: a harbinger of a different life science based on the periodic table of the bioelements","volume":"14","author":"Maret","year":"2022","journal-title":"Metallomics"},{"key":"2026082104412061900_bib101","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1039\/c5mt00149h","article-title":"Targeting copper in cancer therapy: \u2018Copper That Cancer","volume-title":"Metallomics","author":"Denoyer","year":"2015"},{"key":"2026082104412061900_bib102","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1038\/nrc3495","article-title":"Iron and cancer: more ore to be mined","volume":"13","author":"Torti","year":"2013","journal-title":"Nat Rev Cancer"},{"key":"2026082104412061900_bib103","doi-asserted-by":"publisher","first-page":"110546","DOI":"10.1016\/j.cbi.2023.110546","article-title":"Copper deprivation enhances the chemosensitivity of pancreatic cancer to rapamycin by mTORC1\/2 inhibition","volume-title":"Chem Biol Interact","author":"Geng","year":"2023"},{"key":"2026082104412061900_bib104","doi-asserted-by":"publisher","first-page":"17029","DOI":"10.1038\/sigtrans.2017.29","article-title":"The emerging role of zinc transporters in cellular homeostasis and cancer","volume":"2","author":"Bafaro","year":"2017","journal-title":"Sig Transduct Target Ther"},{"key":"2026082104412061900_bib105","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1097\/CEJ.0b013e3283627f14","article-title":"Roles of the hepcidin-ferroportin axis and iron in cancer","volume-title":"Eur J Cancer Prev","author":"Wu","year":"2014"},{"key":"2026082104412061900_bib106","doi-asserted-by":"publisher","first-page":"913","DOI":"10.3892\/ol.2015.3363","article-title":"Decreased expression of ferroportin in prostate cancer","volume-title":"Oncol Lett","author":"Xue","year":"2015"},{"key":"2026082104412061900_bib107","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1089\/ars.2017.7023","article-title":"Effects of ferroportin-mediated iron depletion in cells representative of different histological subtypes of prostate cancer","volume":"30","author":"Deng","year":"2019","journal-title":"Antioxid Redox Signal"},{"key":"2026082104412061900_bib108","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/s41568-021-00417-2","article-title":"Connecting copper and cancer: from transition metal signalling to metalloplasia","volume-title":"Nat Rev Cancer","author":"Ge","year":"2022"},{"key":"2026082104412061900_bib109","doi-asserted-by":"publisher","first-page":"H1821","DOI":"10.1152\/ajpheart.01015.2001","article-title":"Copper-induced vascular endothelial growth factor expression and wound healing","volume":"282","author":"Sen","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2026082104412061900_bib110","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.2174\/092986709787846622","article-title":"Role of copper in angiogenesis and its medicinal implications","volume":"16","author":"Xie","year":"2009","journal-title":"Curr Med Chem"},{"key":"2026082104412061900_bib111","doi-asserted-by":"publisher","first-page":"51151","DOI":"10.18632\/oncotarget.17712","article-title":"CD147 functions as the signalling receptor for extracellular divalent copper in hepatocellular carcinoma cells","volume":"8","author":"Ding","year":"2017","journal-title":"Oncotarget"},{"key":"2026082104412061900_bib112","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/s41587-020-0707-9","article-title":"Mitochondrial copper depletion suppresses triple-negative breast cancer in mice","volume":"39","author":"Cui","year":"2021","journal-title":"Nat Biotechnol"},{"key":"2026082104412061900_bib113","doi-asserted-by":"publisher","first-page":"7311","DOI":"10.1038\/s41467-021-27559-z","article-title":"Copper depletion modulates mitochondrial oxidative phosphorylation to impair triple negative breast cancer metastasis","volume":"12","author":"Ramchandani","year":"2021","journal-title":"Nat Commun"},{"key":"2026082104412061900_bib114","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1161\/01.RES.0000070112.80711.3D","article-title":"Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry","volume":"92","author":"Visse","year":"2003","journal-title":"Circ Res"},{"key":"2026082104412061900_bib115","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.1038\/onc.2012.202","article-title":"Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK","volume":"32","author":"Baker","year":"2013","journal-title":"Oncogene"},{"key":"2026082104412061900_bib116","doi-asserted-by":"publisher","first-page":"6836","DOI":"10.1073\/pnas.1817473116","article-title":"ATP7A delivers copper to the lysyl oxidase family of enzymes and promotes tumourigenesis and metastasis","volume":"116","author":"Shanbhag","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026082104412061900_bib117","doi-asserted-by":"publisher","first-page":"895887","DOI":"10.3389\/fmolb.2022.895887","article-title":"p53 and Zinc: a malleable relationship","volume-title":"Front Mol Biosci","author":"Ha","year":"2022"},{"key":"2026082104412061900_bib118","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s13046-015-0206-x","article-title":"The beneficial effect of Zinc(II) on low-dose chemotherapeutic sensitivity involves p53 activation in wild-type p53-carrying colorectal cancer cells","volume-title":"J Exp Clin Cancer Res","author":"Garufi","year":"2015"},{"key":"2026082104412061900_bib119","doi-asserted-by":"publisher","first-page":"18530","DOI":"10.1074\/jbc.272.30.18530","article-title":"Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis","volume-title":"J Biol Chem","author":"Perry","year":"1997"},{"key":"2026082104412061900_bib120","doi-asserted-by":"publisher","first-page":"18346","DOI":"10.3748\/wjg.v20.i48.18346","article-title":"Zinc finger protein 139 expression in gastric cancer and its clinical significance","volume":"20","author":"Li","year":"2014","journal-title":"World J Gastroenterol"},{"key":"2026082104412061900_bib121","doi-asserted-by":"publisher","first-page":"626812","DOI":"10.3389\/fimmu.2020.626812","article-title":"Iron metabolism in the tumour microenvironment: contributions of innate immune cells","volume":"11","author":"Liang","year":"2020","journal-title":"Front Immunol"},{"key":"2026082104412061900_bib122","doi-asserted-by":"publisher","first-page":"39","DOI":"10.3892\/ijmm.2024.5480","article-title":"Iron metabolism and the tumour microenvironment: a new perspective on cancer intervention and therapy (Review)","volume":"55","author":"Bu","year":"2025","journal-title":"Int J Mol Med"},{"key":"2026082104412061900_bib123","doi-asserted-by":"publisher","first-page":"1626888","DOI":"10.3389\/fimmu.2025.1626888","article-title":"Iron overload promotes myeloid differentiation of normal hematopoietic stem cells and educates macrophage mediated immunosuppression in acute myeloid leukaemia","volume":"16","author":"Yang","year":"2025","journal-title":"Front Immunol"},{"key":"2026082104412061900_bib124","doi-asserted-by":"publisher","first-page":"5685","DOI":"10.1038\/s41467-022-33301-0","article-title":"A protein-based cGAS-STING nanoagonist enhances T cell-mediated anti-tumour immune responses","volume":"13","author":"Wang","year":"2022","journal-title":"Nat Commun"},{"key":"2026082104412061900_bib125","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.7150\/ijbs.69808","article-title":"Ferroptosis-associated molecular classification characterized by distinct tumour microenvironment profiles in colorectal cancer","volume":"18","author":"Luo","year":"2022","journal-title":"Int J Biol Sci"},{"key":"2026082104412061900_bib126","doi-asserted-by":"publisher","first-page":"e12568","DOI":"10.1111\/cpr.12568","article-title":"Blockage of SLC31A1-dependent copper absorption increases pancreatic cancer cell autophagy to resist cell death","volume-title":"Cell Prolif","author":"Yu","year":"2019"},{"key":"2026082104412061900_bib127","doi-asserted-by":"publisher","first-page":"1952","DOI":"10.7150\/jca.19029","article-title":"A role for the ATP7A copper transporter in tumourigenesis and cisplatin resistance","volume":"8","author":"Zhu","year":"2017","journal-title":"J Cancer"},{"key":"2026082104412061900_bib128","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1038\/nature24297","article-title":"Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition","volume":"551","author":"Hangauer","year":"2017","journal-title":"Nature"},{"key":"2026082104412061900_bib129","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1039\/c9mt00136k","article-title":"Activated zinc transporter ZIP7 as an indicator of anti-hormone resistance in breast cancer","volume":"11","author":"Ziliotto","year":"2019","journal-title":"Metallomics"},{"key":"2026082104412061900_bib130","doi-asserted-by":"publisher","first-page":"1047194","DOI":"10.3389\/fonc.2022.1047194","article-title":"p53 inhibits CTR1-mediated cisplatin absorption by suppressing SP1 nuclear translocation in osteosarcoma","volume":"12","author":"Yong","year":"2022","journal-title":"Front Oncol"},{"key":"2026082104412061900_bib131","doi-asserted-by":"publisher","first-page":"608","DOI":"10.3390\/cancers12030608","article-title":"Synthetic lethality screening identifies FDA-approved drugs that overcome ATP7B-mediated tolerance of tumour cells to cisplatin","volume":"12","author":"Mariniello","year":"2020","journal-title":"Cancers"},{"key":"2026082104412061900_bib132","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1007\/s00280-018-3548-1","article-title":"MircroRNA-139 sensitizes ovarian cancer cell to cisplatin-based chemotherapy through regulation of ATP7A\/B","volume":"81","author":"Xiao","year":"2018","journal-title":"Cancer Chemother Pharmacol"},{"key":"2026082104412061900_bib133","doi-asserted-by":"publisher","first-page":"15330338211039127","DOI":"10.1177\/15330338211039127","article-title":"MiR-495 inhibits cisplatin resistance and angiogenesis in oesophageal cancer by targeting ATP7A","volume":"20","author":"Li","year":"2021","journal-title":"Technol Cancer Res Treat"},{"key":"2026082104412061900_bib134","doi-asserted-by":"publisher","first-page":"18677","DOI":"10.1038\/s41598-020-75807-x","article-title":"Impact of metallothionein-knockdown on cisplatin resistance in malignant pleural mesothelioma","volume":"10","author":"Borchert","year":"2020","journal-title":"Sci Rep"},{"key":"2026082104412061900_bib135","doi-asserted-by":"publisher","first-page":"5496","DOI":"10.1038\/s41598-021-84185-x","article-title":"Metallothionein-3 promotes cisplatin chemoresistance remodelling in neuroblastoma","volume":"11","author":"Rodrigo","year":"2021","journal-title":"Sci Rep"},{"key":"2026082104412061900_bib136","doi-asserted-by":"publisher","first-page":"eadk0330","DOI":"10.1126\/scitranslmed.adk0330","article-title":"TRPML1 triggers ferroptosis defence and is a potential therapeutic target in AKT-hyperactivated cancer","volume":"16","author":"Zhang","year":"2024","journal-title":"Sci Transl Med"},{"key":"2026082104412061900_bib137","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1038\/s41586-021-03539-7","article-title":"DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer","volume":"593","author":"Mao","year":"2021","journal-title":"Nature"},{"key":"2026082104412061900_bib138","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1038\/s41556-023-01091-2","article-title":"Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis","volume":"25","author":"Liu","year":"2023","journal-title":"Nat Cell Biol"},{"key":"2026082104412061900_bib139","doi-asserted-by":"publisher","first-page":"41","DOI":"10.20517\/cdr.2024.123","article-title":"NFE2L2 and ferroptosis resistance in cancer therapy","volume":"7","author":"Tang","year":"2024","journal-title":"Cancer Drug Resist"},{"key":"2026082104412061900_bib140","doi-asserted-by":"publisher","first-page":"105046","DOI":"10.1016\/j.jbc.2023.105046","article-title":"FDX1 regulates cellular protein lipoylation through direct binding to LIAS","volume-title":"J Biol Chem","author":"Dreishpoon","year":"2023"},{"key":"2026082104412061900_bib141","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1038\/s41419-021-03482-5","article-title":"Zinc transporter ZIP7 is a novel determinant of ferroptosis","volume":"12","author":"Chen","year":"2021","journal-title":"Cell Death Dis"},{"key":"2026082104412061900_bib142","doi-asserted-by":"publisher","first-page":"6947","DOI":"10.1038\/s41467-024-50524-5","article-title":"PTPN2 copper-sensing relays copper level fluctuations into EGFR\/CREB activation and associated CTR1 transcriptional repression","volume-title":"Nat Commun","author":"Ross","year":"2024"},{"key":"2026082104412061900_bib143","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.immuni.2018.03.017","article-title":"Manganese increases the sensitivity of the cGAS-STING pathway for double-stranded DNA and is required for the host defence against DNA viruses","volume":"48","author":"Wang","year":"2018","journal-title":"Immunity"},{"key":"2026082104412061900_bib144","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1016\/j.ccr.2010.04.011","article-title":"Enhancing tumour-specific uptake of the anticancer drug cisplatin with a copper chelator","volume":"17","author":"Ishida","year":"2010","journal-title":"Cancer Cell"},{"key":"2026082104412061900_bib145","doi-asserted-by":"publisher","first-page":"84439","DOI":"10.18632\/oncotarget.12992","article-title":"Ammonium tetrathiomolybdate treatment targets the copper transporter ATP7A and enhances sensitivity of breast cancer to cisplatin","volume":"7","author":"Chisholm","year":"2016","journal-title":"Oncotarget"},{"key":"2026082104412061900_bib146","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.3390\/biomedicines9121887","article-title":"Evaluation of ATOX1 as a potential predictive biomarker for tetrathiomolybdate treatment of breast cancer patients with high risk of recurrence","volume-title":"Biomedicines","author":"Blockhuys","year":"2021"},{"key":"2026082104412061900_bib147","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1038\/s41416-022-02127-4","article-title":"AMPK phosphorylates and stabilises copper transporter 1 to synergise metformin and copper chelator for breast cancer therapy","volume":"128","author":"Zhang","year":"2023","journal-title":"Br J Cancer"},{"key":"2026082104412061900_bib148","doi-asserted-by":"publisher","first-page":"e234149","DOI":"10.1001\/jamanetworkopen.2023.4149","article-title":"Effect of disulfiram and copper plus chemotherapy vs chemotherapy alone on survival in patients with recurrent glioblastoma: a randomized clinical trial","volume":"6","author":"Werlenius","year":"2023","journal-title":"JAMA Netw Open"},{"key":"2026082104412061900_bib149","doi-asserted-by":"publisher","first-page":"mfaf034","DOI":"10.1093\/mtomcs\/mfaf034","article-title":"Integration of elemental imaging and spatial transcriptomic profiling for proof-of-concept metals-based pathway analysis of colon tumour microenvironment","volume":"17","author":"Srivastava","year":"2025","journal-title":"Metallomics"},{"key":"2026082104412061900_bib150","doi-asserted-by":"publisher","first-page":"e70372","DOI":"10.1002\/cnr2.70372","article-title":"Cuproptosis-related ferroptosis gene signature: a prognostic tool for colon cancer patients","volume":"8","author":"Tan","year":"2025","journal-title":"Cancer Rep (Hoboken)"},{"key":"2026082104412061900_bib151","doi-asserted-by":"publisher","first-page":"1742855","DOI":"10.3389\/fimmu.2025.1742855","article-title":"Metabolic reprogramming in the post-metastatic tumour microenvironment: multi-omics insights into determinants of immunotherapy response","volume":"16","author":"Li","year":"2025","journal-title":"Front Immunol"},{"key":"2026082104412061900_bib152","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/s00216-024-05652-8","article-title":"Quantitative distribution of essential elements and non-essential metals in breast cancer tissues by LA-ICP-TOF-MS","volume":"417","author":"Escudero-Cernuda","year":"2025","journal-title":"Anal Bioanal Chem"},{"key":"2026082104412061900_bib153","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1186\/s12885-023-10782-w","article-title":"Elemental profiles in distant tissues during tumour progression","volume":"23","author":"Salles","year":"2023","journal-title":"BMC Cancer"},{"key":"2026082104412061900_bib154","doi-asserted-by":"publisher","first-page":"vbaf001","DOI":"10.1093\/bioadv\/vbaf001","article-title":"Integrative co-registration of elemental imaging and histopathology for enhanced spatial multimodal analysis of tissue sections through TRACE","volume":"5","author":"Lu","year":"2025","journal-title":"Bioinform Adv"},{"key":"2026082104412061900_bib155","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.1021\/jacsau.5c00217","article-title":"LA-ICP-TOFMS imaging reveals significant influence of cancer cell resistance on oxaliplatin compartmentalization in the tumour microenvironment","volume":"5","author":"Schaier","year":"2025","journal-title":"JACS Au"},{"key":"2026082104412061900_bib156","doi-asserted-by":"publisher","first-page":"mfab026","DOI":"10.1093\/mtomcs\/mfab026","article-title":"Transcriptomic insights into the zinc homeostasis of MCF-7 breast cancer cells via next-generation RNA sequencing","volume":"13","author":"Zaman","year":"2021","journal-title":"Metallomics"},{"key":"2026082104412061900_bib157","doi-asserted-by":"publisher","first-page":"967205","DOI":"10.3389\/fmolb.2022.967205","article-title":"Computational approaches for network-based integrative multi-omics analysis","volume":"9","author":"Agamah","year":"2022","journal-title":"Front Mol Biosci"},{"key":"2026082104412061900_bib158","doi-asserted-by":"publisher","first-page":"444","DOI":"10.3389\/fpls.2016.00444","article-title":"Learning from co-expression networks: possibilities and challenges","volume":"7","author":"Serin","year":"2016","journal-title":"Front Plant Sci"},{"key":"2026082104412061900_bib159","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume-title":"BMC Bioinf","author":"Langfelder","year":"2008"},{"key":"2026082104412061900_bib160","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1038\/nmeth.4463","article-title":"SCENIC: single-cell regulatory network inference and clustering","volume-title":"Nat Methods","author":"Aibar","year":"2017"},{"key":"2026082104412061900_bib161","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.3390\/molecules28041623","article-title":"The role of ferroptosis and cuproptosis in curcumin against hepatocellular carcinoma","volume":"28","author":"Liu","year":"2023","journal-title":"Molecules"},{"key":"2026082104412061900_bib162","doi-asserted-by":"publisher","first-page":"16554","DOI":"10.1038\/s41598-023-43795-3","article-title":"Comprehensive analysis of cuproptosis and copper homeostasis genotyping and related immune land scape in lung adenocarcinoma","volume":"13","author":"Luo","year":"2023","journal-title":"Sci Rep"},{"key":"2026082104412061900_bib163","doi-asserted-by":"publisher","first-page":"4997","DOI":"10.1007\/s10238-023-01108-y","article-title":"Pan-cancer analysis of cuproptosis-promoting gene signature from multiple perspectives","volume-title":"Clin Exp Med","author":"Ma","year":"2023"},{"key":"2026082104412061900_bib164","doi-asserted-by":"publisher","first-page":"e3548","DOI":"10.1002\/jgm.3548","article-title":"Identifying potential anti-metastasis drugs for prostate cancer through integrative bioinformatics analysis and compound library screening","volume-title":"J Gene Med","author":"Li","year":"2023"},{"key":"2026082104412061900_bib165","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.cels.2020.02.003","article-title":"Inferring causal gene regulatory networks from coupled single-cell expression dynamics using scribe","volume-title":"Cell Syst","author":"Qiu","year":"2020"},{"key":"2026082104412061900_bib166","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.1038\/s41592-024-02316-4","article-title":"Deciphering spatial domains from spatial multi-omics with SpatialGlue","volume-title":"Nat Methods","author":"Long","year":"2024"},{"key":"2026082104412061900_bib167","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/s13059-022-02663-5","article-title":"Explainable multiview framework for dissecting spatial relationships from highly multiplexed data","volume":"23","author":"Tanevski","year":"2022","journal-title":"Genome Biol"},{"key":"2026082104412061900_bib168","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/s41592-021-01343-9","article-title":"Identifying temporal and spatial patterns of variation from multimodal data using MEFISTO","volume-title":"Nat Methods","author":"Velten","year":"2022"},{"key":"2026082104412061900_bib169","doi-asserted-by":"publisher","first-page":"103798","DOI":"10.1016\/j.isci.2022.103798","article-title":"Machine learning for multi-omics data integration in cancer","volume":"25","author":"Cai","year":"2022","journal-title":"iScience"},{"key":"2026082104412061900_bib170","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.semcancer.2022.12.009","article-title":"Artificial intelligence-based multi-omics analysis fuels cancer precision medicine","volume":"88","author":"He","year":"2023","journal-title":"Semin Cancer Biol"},{"key":"2026082104412061900_bib171","doi-asserted-by":"publisher","first-page":"e081554","DOI":"10.1136\/bmj-2024-081554","article-title":"FUTURE-AI: international consensus guideline for trustworthy and deployable artificial intelligence in healthcare","volume":"388","author":"Lekadir","year":"2025","journal-title":"BMJ"},{"key":"2026082104412061900_bib172","doi-asserted-by":"publisher","first-page":"e082505","DOI":"10.1136\/bmj-2024-082505","article-title":"PROBAST+AI: an updated quality, risk of bias, and applicability assessment tool for prediction models using regression or artificial intelligence methods","volume":"388","author":"Moons","year":"2025","journal-title":"BMJ"},{"key":"2026082104412061900_bib173","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1093\/jamia\/ocad178","article-title":"A framework for understanding label leakage in machine learning for health care","volume":"31","author":"Davis","year":"2023","journal-title":"J Am Med Inform Assoc"},{"key":"2026082104412061900_bib174","doi-asserted-by":"publisher","first-page":"e1011224","DOI":"10.1371\/journal.pcbi.1011224","article-title":"Ten quick tips for avoiding pitfalls in multi-omics data integration analyses","volume":"19","author":"Chicco","year":"2023","journal-title":"PLoS Comput Biol"},{"key":"2026082104412061900_bib175","doi-asserted-by":"publisher","first-page":"e078378","DOI":"10.1136\/bmj-2023-078378","article-title":"TRIPOD+AI statement: updated guidance for reporting clinical prediction models that use regression or machine learning methods","volume":"385","author":"Collins","year":"2024","journal-title":"BMJ"},{"key":"2026082104412061900_bib176","doi-asserted-by":"publisher","first-page":"W1","DOI":"10.7326\/M18-1377","article-title":"PROBAST: a tool to assess risk of bias and applicability of prediction model studies: explanation and elaboration","volume":"170","author":"Moons","year":"2019","journal-title":"Ann Intern Med"},{"key":"2026082104412061900_bib177","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1007\/s10534-009-9231-6","article-title":"Elemental fingerprinting of tumourous and adjacent non-tumourous tissues from patients with colorectal cancer using ICP-MS, ICP-OES and chemometric analysis","volume-title":"Biometals","author":"Lavilla","year":"2009"},{"key":"2026082104412061900_bib178","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.talanta.2018.12.061","article-title":"Differential diagnosis of multielements in cancerous and non-cancerous oesophageal tissues","volume":"196","author":"Xie","year":"2019","journal-title":"Talanta"},{"key":"2026082104412061900_bib179","doi-asserted-by":"publisher","first-page":"127678","DOI":"10.1016\/j.jtemb.2025.127678","article-title":"An integrated analytical approach for biomarker discovery in oesophageal cancer: combining trace element and oxidative stress profiling with machine learning","volume":"89","author":"Kocak","year":"2025","journal-title":"J Trace Elem Med Biol"},{"key":"2026082104412061900_bib180","doi-asserted-by":"publisher","first-page":"123486","DOI":"10.1016\/j.talanta.2022.123486","article-title":"Non-targeted metallomics through synchrotron radiation X-ray fluorescence with machine learning for cancer screening using blood samples","volume":"245","author":"He","year":"2022","journal-title":"Talanta"},{"key":"2026082104412061900_bib181","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1021\/envhealth.4c00124","article-title":"Metallomic classification of pulmonary nodules using blood by deep-learning-boosted synchrotron radiation X-ray fluorescence","volume":"3","author":"Wei","year":"2025","journal-title":"Environ Health (Wash)"},{"key":"2026082104412061900_bib182","doi-asserted-by":"publisher","first-page":"47004","DOI":"10.1289\/EHP5838","article-title":"A quantile-based g-computation approach to addressing the effects of exposure Mixtures","volume":"128","author":"Keil","year":"2020","journal-title":"Environ Health Perspect"},{"key":"2026082104412061900_bib183","doi-asserted-by":"publisher","first-page":"104004","DOI":"10.1289\/EHP7342","article-title":"Quantile g-computation: a new method for analyzing mixtures of environmental exposures","volume":"128","author":"Schmidt","year":"2020","journal-title":"Environ Health Perspect"},{"key":"2026082104412061900_bib184","doi-asserted-by":"publisher","first-page":"140200","DOI":"10.1016\/j.chemosphere.2023.140200","article-title":"Association between blood heavy metals and lung cancer risk: a case-control study in China","volume":"343","author":"Zhang","year":"2023","journal-title":"Chemosphere"},{"key":"2026082104412061900_bib185","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1002\/ijc.33902","article-title":"Selenium and cancer risk: wide-angled Mendelian randomization analysis","volume":"150","author":"Yuan","year":"2022","journal-title":"Int J Cancer"},{"key":"2026082104412061900_bib186","doi-asserted-by":"publisher","first-page":"6584","DOI":"10.1038\/s41467-025-61034-3","article-title":"Integrative spatial omics reveals distinct tumour-promoting multicellular niches and immunosuppressive mechanisms in Black American and White American patients with TNBC","volume":"16","author":"Zhu","year":"2025","journal-title":"Nat Commun"},{"key":"2026082104412061900_bib187","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1002\/cyto.a.23053","article-title":"Imaging mass cytometry","volume-title":"Cytometry A","author":"Chang","year":"2017"},{"key":"2026082104412061900_bib188","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s13073-019-0703-1","article-title":"Molecular profiling for precision cancer therapies","volume":"12","author":"Malone","year":"2020","journal-title":"Genome Med"},{"key":"2026082104412061900_bib189","doi-asserted-by":"publisher","first-page":"264","DOI":"10.3322\/caac.21825","article-title":"Interpreting and integrating genomic tests results in clinical cancer care: overview and practical guidance","volume":"74","author":"Casolino","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"2026082104412061900_bib190","doi-asserted-by":"publisher","first-page":"102145","DOI":"10.1016\/j.redox.2021.102145","article-title":"Serum selenium, selenoprotein P and glutathione peroxidase 3 as predictors of mortality and recurrence following breast cancer diagnosis: a multicentre cohort study","volume-title":"Redox Biol","author":"Demircan","year":"2021"},{"key":"2026082104412061900_bib191","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.3390\/biomedicines9111521","article-title":"Prediagnostic blood selenium status and mortality among patients with colorectal cancer in western European populations","volume":"9","author":"Baker","year":"2021","journal-title":"Biomedicines"},{"key":"2026082104412061900_bib192","doi-asserted-by":"publisher","first-page":"103701","DOI":"10.1016\/j.redox.2025.103701","article-title":"Colorectal cancer mortality is associated with low selenoprotein P status at diagnosis","volume":"84","author":"Brezina","year":"2025","journal-title":"Redox Biol"},{"key":"2026082104412061900_bib193","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.1016\/j.bbagen.2014.10.008","article-title":"Selenium compounds as therapeutic agents in cancer","volume-title":"Biochim Biophys Acta","author":"Fernandes","year":"2015"},{"key":"2026082104412061900_bib194","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1007\/s00280-008-0745-3","article-title":"Sodium selenite induces apoptosis by generation of superoxide via the mitochondrial-dependent pathway in human prostate cancer cells","volume":"63","author":"Xiang","year":"2009","journal-title":"Cancer Chemother Pharmacol"},{"key":"2026082104412061900_bib195","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.taap.2006.09.006","article-title":"Metabolism of 76Se-methylselenocysteine compared with that of 77Se-selenomethionine and 82Se-selenite","volume":"217","author":"Suzuki","year":"2006","journal-title":"Toxicol Appl Pharmacol"},{"key":"2026082104412061900_bib196","first-page":"630","article-title":"Baseline characteristics and the effect of selenium supplementation on cancer incidence in a randomized clinical trial: a summary report of the Nutritional Prevention of Cancer Trial","volume-title":"Cancer Epidemiol Biomarkers Prev","author":"Duffield-Lillico","year":"2002"},{"key":"2026082104412061900_bib197","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1001\/jama.2008.864","article-title":"Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)","volume":"301","author":"Lippman","year":"2009","journal-title":"JAMA"},{"key":"2026082104412061900_bib198","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1001\/jama.2011.1437","article-title":"Tangen CM Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)","volume":"306","author":"Klein","year":"2011","journal-title":"JAMA"},{"key":"2026082104412061900_bib199","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1093\/jaoac\/87.1.225","article-title":"Speciation and bioavailability of selenium in yeast-based intervention agents used in cancer chemoprevention studies","volume":"87","author":"Larsen","year":"2004","journal-title":"J AOAC Int"},{"key":"2026082104412061900_bib200","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1007\/s002160000475","article-title":"Stability studies of arsenic, selenium, antimony and tellurium species in water, urine, fish and soil extracts using HPLC\/ICP-MS","volume-title":"Fresenius J Anal Chem","author":"Lindemann","year":"2000"},{"key":"2026082104412061900_bib201","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1039\/c8mt00139a","article-title":"Metal dyshomeostasis based biomarkers of lung cancer using human biofluids","volume":"10","author":"Callej\u00f3n-Leblic","year":"2018","journal-title":"Metallomics"},{"key":"2026082104412061900_bib202","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1039\/c4mt00285g","article-title":"Classification models based on the level of metals in hair and nails of laryngeal cancer patients: diagnosis support or rather speculation?","volume-title":"Metallomics","author":"Golasik","year":"2015"},{"key":"2026082104412061900_bib203","doi-asserted-by":"publisher","first-page":"818069","DOI":"10.3389\/fpubh.2022.818069","article-title":"Arsenic speciation and metallomics profiling of human toenails as a biomarker to assess prostate cancer cases: atlantic PATH cohort study","volume":"10","author":"Keltie","year":"2022","journal-title":"Front Public Health"},{"key":"2026082104412061900_bib204","doi-asserted-by":"publisher","first-page":"1148283","DOI":"10.3389\/fpubh.2023.1148283","article-title":"Toenail arsenic species and metallome profiles associated with breast, cervical, prostate, and skin cancer prevalence in the Atlantic Partnership for Tomorrow\u2019s Health cohort","volume":"11","author":"Hood","year":"2023","journal-title":"Front Public Health"},{"key":"2026082104412061900_bib205","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1039\/c7mt00153c","article-title":"Differences in cisplatin distribution in sensitive and resistant ovarian cancer cells: a TEM\/NanoSIMS study","volume":"9","author":"Lee","year":"2017","journal-title":"Metallomics"},{"key":"2026082104412061900_bib206","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s40824-023-00374-x","article-title":"Responsive manganese-based nanoplatform amplifying cGAS-STING activation for immunotherapy","volume":"27","author":"He","year":"2023","journal-title":"Biomater Res"},{"key":"2026082104412061900_bib207","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1186\/s12951-024-02809-6","article-title":"Tumour microenvironment-responsive manganese-based nano-modulator activate the cGAS-STING pathway to enhance innate immune system response","volume":"22","author":"Liang","year":"2024","journal-title":"J Nanobiotechnology"},{"key":"2026082104412061900_bib208","doi-asserted-by":"publisher","first-page":"120658","DOI":"10.1016\/j.cca.2025.120658","article-title":"Nanoparticle-based liquid biopsy","volume":"579","author":"Falih","year":"2026","journal-title":"Clin Chim Acta"},{"key":"2026082104412061900_bib209","doi-asserted-by":"publisher","first-page":"5122","DOI":"10.3390\/cancers14205122","article-title":"High-Affinity Cu(I)-chelator with potential anti-tumourigenic action-a proof-of-principle experimental study of human H460 Tumours in the CAM Assay","volume":"14","author":"Heuberger","year":"2022","journal-title":"Cancers"},{"key":"2026082104412061900_bib210","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1158\/1078-0432.CCR-16-1326","article-title":"Influencing the tumour microenvironment: a phase II study of copper depletion using tetrathiomolybdate in patients with breast cancer at high risk for recurrence and in preclinical models of lung metastases","volume-title":"Clin Cancer Res","author":"Chan","year":"2017"},{"key":"2026082104412061900_bib211","doi-asserted-by":"publisher","first-page":"3048","DOI":"10.1039\/d4md00171k","article-title":"Copper selective 8-aminoquinoline based tetradentate chelators as anticancer agents","volume":"15","author":"Guan","year":"2024","journal-title":"RSC Med Chem"},{"key":"2026082104412061900_bib212","doi-asserted-by":"publisher","first-page":"3927","DOI":"10.1021\/acsnano.9b06111","article-title":"Manganese-based nanoactivator optimizes cancer immunotherapy via enhancing innate immunity","volume-title":"ACS Nano","author":"Hou","year":"2020"},{"key":"2026082104412061900_bib213","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s10555-025-10266-2","article-title":"Metal-modulated T cell antitumour immunity and emerging metalloimmunotherapy","volume-title":"Cancer Metastasis Rev","author":"Liao","year":"2025"},{"key":"2026082104412061900_bib214","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1038\/s41551-024-01221-7","article-title":"Strategies for the development of metalloimmunotherapies","volume-title":"Nat Biomed Eng","author":"Sun","year":"2024"},{"key":"2026082104412061900_bib215","doi-asserted-by":"publisher","first-page":"119848","DOI":"10.1016\/j.biomaterials.2020.119848","article-title":"Iridium\/ruthenium nanozyme reactors with cascade catalytic ability for synergistic oxidation therapy and starvation therapy in the treatment of breast cancer","volume-title":"Biomaterials","author":"Wei","year":"2020"},{"key":"2026082104412061900_bib216","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.clnesp.2025.02.011","article-title":"Zinc supplementation for mitigating oral mucositis in head and neck cancer patients undergoing radiotherapy and chemoradiotherapy\u2014a systematic review","volume":"67","author":"Agare","year":"2025","journal-title":"Clin Nutr ESPEN"},{"key":"2026082104412061900_bib217","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1590\/S1679-45082017AO3830","article-title":"Effects of zinc supplementation on fatigue and quality of life in patients with colorectal cancer","volume":"15","author":"Ribeiro","year":"2017","journal-title":"Einstein (Sao Paulo)"},{"key":"2026082104412061900_bib218","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.3390\/biom12111581","article-title":"Metabolism of selenium, selenocysteine, and selenoproteins in ferroptosis in solid tumour cancers","volume":"12","author":"Shimada","year":"2022","journal-title":"Biomolecules"},{"key":"2026082104412061900_bib219","doi-asserted-by":"publisher","first-page":"e165988","DOI":"10.1172\/JCI165988","article-title":"SELENOP modifies sporadic colorectal carcinogenesis and WNT signalling activity through LRP5\/6 interactions","volume":"133","author":"Pilat","year":"2023","journal-title":"J Clin Invest"},{"key":"2026082104412061900_bib220","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1016\/j.molonc.2014.10.004","article-title":"Biomarker validation and testing","volume":"9","author":"Hayes","year":"2015","journal-title":"Mol Oncol"},{"key":"2026082104412061900_bib221","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.cca.2015.11.014","article-title":"Urinary metallomics as a novel biomarker discovery platform: breast cancer as a case study","volume":"452","author":"Burton","year":"2016","journal-title":"Clin Chim Acta"},{"key":"2026082104412061900_bib222","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1039\/d0mt00061b","article-title":"Urine metallomics signature as an indicator of pancreatic cancer","volume":"12","author":"Schilling","year":"2020","journal-title":"Metallomics"},{"key":"2026082104412061900_bib223","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1039\/c8mt00012c","article-title":"Bioimaging of isosteric osmium and ruthenium anticancer agents by LA-ICP-MS","volume-title":"Metallomics","author":"Klose","year":"2018"},{"key":"2026082104412061900_bib224","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1002\/jms.3168","article-title":"Imaging of metals in biological tissue by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS): state of the art and future developments","volume-title":"J Mass Spectrom","author":"Sabine\u00a0Becker","year":"2013"},{"key":"2026082104412061900_bib225","doi-asserted-by":"publisher","first-page":"1442788","DOI":"10.3389\/fimmu.2024.1442788","article-title":"Exploring micronutrients and microbiome synergy: pioneering new paths in cancer therapy","volume":"15","author":"Bhatnagar","year":"2024","journal-title":"Front Immunol"},{"key":"2026082104412061900_bib226","doi-asserted-by":"publisher","first-page":"3763","DOI":"10.1007\/s12602-025-10500-x","article-title":"Efficacy evaluation of selenium-enriched akkermansia muciniphila in the treatment of colon tumour mice","volume":"17","author":"Li","year":"2025","journal-title":"Probiotics Antimicrob Proteins"},{"key":"2026082104412061900_bib227","doi-asserted-by":"publisher","first-page":"104","DOI":"10.3390\/biom14010104","article-title":"Recent Advances in Metalloproteomics","volume":"14","author":"Coverdale","year":"2024","journal-title":"Biomolecules"},{"key":"2026082104412061900_bib228","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1007\/s13346-020-00744-1","article-title":"Critical quality attributes in the development of therapeutic nanomedicines toward clinical translation","volume":"10","author":"Taha","year":"2020","journal-title":"Drug Deliv Transl Res"},{"key":"2026082104412061900_bib229","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1007\/s13346-021-01024-2","article-title":"Current hurdles to the translation of nanomedicines from bench to the clinic","volume":"12","author":"\u0110or\u0111evi\u0107","year":"2022","journal-title":"Drug Deliv Transl Res"},{"key":"2026082104412061900_bib230","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.medj.2022.12.001","article-title":"Cancer nanomedicine toward clinical translation: obstacles, opportunities, and future prospects","volume":"4","author":"Zhang","year":"2023","journal-title":"Med"},{"key":"2026082104412061900_bib231","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1016\/j.gim.2022.04.009","article-title":"Health equity in the implementation of genomics and precision medicine: a public health imperative","volume":"24","author":"Khoury","year":"2022","journal-title":"Genet Med"},{"key":"2026082104412061900_bib232","doi-asserted-by":"publisher","first-page":"5","DOI":"10.2217\/pme-2023-0097","article-title":"The roots of (in)equity in precision medicine: gaps in the discourse","volume":"21","author":"Green","year":"2024","journal-title":"Per Med"},{"key":"2026082104412061900_bib233","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1093\/eurpub\/ckae055","article-title":"Contextual factors influencing the equitable implementation of precision medicine in routine cancer care in Belgium","volume":"34","author":"Schmitt","year":"2024","journal-title":"Eur J Public Health"},{"key":"2026082104412061900_bib234","doi-asserted-by":"publisher","first-page":"165100","DOI":"10.1016\/j.scitotenv.2023.165100","article-title":"Machine learning-aided metallomic profiling in serum and urine of thyroid cancer patients and its environmental implications","volume":"895","author":"Chen","year":"2023","journal-title":"Sci Total Environ"},{"key":"2026082104412061900_bib235","doi-asserted-by":"publisher","first-page":"14274","DOI":"10.1038\/s41598-025-97682-0","article-title":"Associations between plasma and urinary heavy metal concentrations and the risk of prostate cancer","volume":"15","author":"Coradduzza","year":"2025","journal-title":"Sci Rep"},{"key":"2026082104412061900_bib236","doi-asserted-by":"publisher","first-page":"2818","DOI":"10.3390\/diagnostics15212818","article-title":"Diagnostic Stratification of Pancreatic Ductal Adenocarcinoma via Metallomics and Blood-Based Biomarkers","volume":"15","author":"Coradduzza","year":"2025","journal-title":"Diagnostics (Basel)"},{"key":"2026082104412061900_bib237","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1039\/c8mt00235e","article-title":"Across the spectrum: integrating multidimensional metal analytics for in situ metallomic imaging","volume":"11","author":"Stewart","year":"2019","journal-title":"Metallomics"},{"key":"2026082104412061900_bib238","doi-asserted-by":"publisher","first-page":"130329","DOI":"10.1016\/j.bbagen.2023.130329","article-title":"Mass spectrometry imaging of metals in tissues and cells: methods and biological applications","volume":"1868","author":"Gorman","year":"2024","journal-title":"Biochim Biophys Acta"},{"key":"2026082104412061900_bib239","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/bs.acc.2025.04.001","article-title":"The cancer microbiome","volume":"127","author":"Li","year":"2025","journal-title":"Adv Clin Chem"},{"key":"2026082104412061900_bib240","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1038\/s42255-025-01287-w","article-title":"The gut microbiome and cancer: from tumourigenesis to therapy","volume":"7","author":"Nobels","year":"2025","journal-title":"Nat Metab"},{"key":"2026082104412061900_bib241","doi-asserted-by":"publisher","first-page":"1448388","DOI":"10.3389\/fnut.2024.1448388","article-title":"Toxic and essential metals: metabolic interactions with the gut microbiota and health implications","volume":"11","author":"Zhu","year":"2024","journal-title":"Front Nutr"},{"key":"2026082104412061900_bib242","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1007\/s12011-014-0033-5","article-title":"Analysis of human serum and whole blood for mineral content by ICP-MS and ICP-OES: development of a mineralomics method","volume":"160","author":"Harrington","year":"2014","journal-title":"Biol Trace Elem Res"},{"key":"2026082104412061900_bib243","doi-asserted-by":"publisher","first-page":"5756","DOI":"10.1021\/acs.analchem.9b05056","article-title":"Sub-micrometer nanosecond LA-ICP-MS imaging at pixel acquisition rates above 250 Hz via a low-dispersion setup","volume":"92","author":"Van\u00a0Malderen","year":"2020","journal-title":"Anal Chem"},{"key":"2026082104412061900_bib244","doi-asserted-by":"publisher","first-page":"mfac032","DOI":"10.1093\/mtomcs\/mfac032","article-title":"X-ray fluorescence microscopy methods for biological tissues","volume":"14","author":"Pushie","year":"2022","journal-title":"Metallomics"},{"key":"2026082104412061900_bib245","doi-asserted-by":"publisher","first-page":"2841","DOI":"10.4081\/ejh.2018.2841","article-title":"Energy Dispersive X-ray (EDX) microanalysis: a powerful tool in biomedical research and diagnosis","volume":"62","author":"Scimeca","year":"2018","journal-title":"Eur J Histochem"},{"key":"2026082104412061900_bib246","doi-asserted-by":"publisher","first-page":"3052","DOI":"10.1039\/c5sc04383b","article-title":"Multi-scale imaging of anticancer platinum(iv) compounds in murine tumour and kidney","volume-title":"Chem Sci","author":"Legin","year":"2016"},{"key":"2026082104412061900_bib247","doi-asserted-by":"publisher","first-page":"03B301","DOI":"10.1116\/1.4993628","article-title":"NanoSIMS for biological applications: current practices and analyses","volume":"13","author":"Nu\u00f1ez","year":"2017","journal-title":"Biointerphases"},{"key":"2026082104412061900_bib248","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1039\/c3mt20261e","article-title":"The use of X-ray absorption and synchrotron based micro-X-ray fluorescence spectroscopy to investigate anti-cancer metal compounds in vivo and in vitro","volume":"5","author":"Hummer","year":"2013","journal-title":"Metallomics"},{"key":"2026082104412061900_bib249","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1080\/10590501.2012.705159","article-title":"The role of cadmium and nickel in estrogen receptor signalling and breast cancer: metalloestrogens or not?","volume":"30","author":"AQUINO","year":"2012","journal-title":"J Environ Sci Health C Environ Carcinog Ecotoxicol Rev"},{"key":"2026082104412061900_bib250","doi-asserted-by":"publisher","first-page":"115109","DOI":"10.1016\/j.envres.2022.115109","article-title":"Cadmium exposure and risk of breast cancer: a meta-analysis","volume-title":"Environ Res","author":"Florez-Garcia","year":"2023"}],"container-title":["Metallomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/metallomics\/advance-article-pdf\/doi\/10.1093\/mtomcs\/mfag024\/68627846\/mfag024.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/metallomics\/article-pdf\/18\/1\/mfag024\/68627846\/mfag024.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/metallomics\/article-pdf\/18\/1\/mfag024\/68627846\/mfag024.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T08:41:30Z","timestamp":1787301690000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/metallomics\/article\/doi\/10.1093\/mtomcs\/mfag024\/8719009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":250,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,31]]}},"URL":"https:\/\/doi.org\/10.1093\/mtomcs\/mfag024","relation":{},"ISSN":["1756-591X"],"issn-type":[{"value":"1756-591X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026]]},"published":{"date-parts":[[2026]]},"article-number":"mfag024"}}