{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T09:41:45Z","timestamp":1780998105256,"version":"3.54.1"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T00:00:00Z","timestamp":1725062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["408831\/2022-7"],"award-info":[{"award-number":["408831\/2022-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The COVID-19 pandemic has led to the emergence of acute and chronic post-COVID syndromes, which present diverse clinical manifestations. The underlying pathophysiology of these conditions is not yet fully understood, but genetic instability has been proposed as a potential contributing factor. This study aimed to explore the differential impact of physical and psychological health factors on genetic instability in individuals with acute and chronic post-COVID syndromes. In this study, three groups of subjects were analyzed: a control group, an acute post-COVID group, and a chronic post-COVID group, with a total of 231 participants. The participants were assessed using a questionnaire for long-COVID-19COVID, and female participants reported more symptoms than male participants in areas related to fatigue, memory, mental health, and well-being during the chronic phase. Genetic instability was assessed using the comet assay, and participants\u2019 physical and psychological profiles were evaluated. The overall results showed no significant differences in DNA damage, as measured by the comet assay, among the three groups, suggesting that genetic instability, as assessed by this method, may not be a primary driver of the distinct clinical presentations observed in post-COVID syndromes. However, when gender was considered, male participants in the acute long COVID group exhibited higher levels of genetic instability compared to females. Multiple linear regression analysis revealed that gender, age, and waist circumference were significant predictors of DNA damage. Among females in the acute group, sexual health, and eye-related symptoms significantly influenced the increase in DNA damage. These findings indicate the need for further investigation on the gender-specific differences in genetic instability and their potential implications for the pathophysiology of post-COVID syndromes. Exploring alternative markers of genetic instability and the interplay between genetic, inflammatory, and cellular processes could provide valuable insights for the management of these debilitating post-viral sequelae.<\/jats:p>","DOI":"10.1093\/mutage\/geae022","type":"journal-article","created":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T11:45:53Z","timestamp":1725104753000},"page":"287-300","source":"Crossref","is-referenced-by-count":4,"title":["Exploring the relationship between genetic instability and health outcomes in acute and chronic post-COVID syndrome"],"prefix":"10.1093","volume":"39","author":[{"given":"Bruna Alves Alonso","family":"Martins","sequence":"first","affiliation":[{"name":"Graduate Program in Genetics and Molecular Biology, Federal University of Rio Grande do Sul (UFRGS) , Porto Alegre-RS 91501-970 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Let\u00edcia","family":"Silva","sequence":"additional","affiliation":[{"name":"Health Secretariat of Campo Bom , Campo Bom-RS, 93700-000 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiana","family":"Dalberto","sequence":"additional","affiliation":[{"name":"Laboratory of Genetic Toxicology, La Salle University (UniLaSalle) and Lutheran University of Brazil (ULBRA) , Canoas-RS, 92010-000 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alana Witt","family":"Hansen","sequence":"additional","affiliation":[{"name":"Institute Ciencias Saude, Molecular Microbiology Lab, University Feevale , Novo Hamburgo-RS, 93525-075 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5804-7045","authenticated-orcid":false,"given":"Fernando Rosado","family":"Spilki","sequence":"additional","affiliation":[{"name":"Institute Ciencias Saude, Molecular Microbiology Lab, University Feevale , Novo Hamburgo-RS, 93525-075 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2428-0460","authenticated-orcid":false,"given":"Lav\u00ednia","family":"Schuler-Faccini","sequence":"additional","affiliation":[{"name":"Graduate Program in Genetics and Molecular Biology, Federal University of Rio Grande do Sul (UFRGS) , Porto Alegre-RS 91501-970 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8992-9697","authenticated-orcid":false,"given":"Pabulo Henrique","family":"Rampelotto","sequence":"additional","affiliation":[{"name":"Bioinformatics and Biostatistics Core Facility, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul (UFRGS) , Porto Alegre-RS, 91501-970 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