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However, its non-specific cytotoxicity towards non-cancerous cells prompts concerns regarding potential adverse effects. Azithromycin is an antibiotic for treating bacterial infections and an anti-inflammatory agent, particularly beneficial in managing respiratory conditions like bronchitis and sinusitis. Despite azithromycin\u2019s well-documented antibacterial properties, its potential cellular\/genomic protective effects remain unexplored. As an in vitro model, BEAS-2B cells (normal human bronchial epithelium cells) were employed in this study to assess whether azithromycin possesses any protective properties against doxorubicin-induced cellular toxicity. Cells in pretreatment culture were treated to various amounts of azithromycin (3.125, 6.25, 12.5, 25, and 50 \u03bcg\/ml) in combination with doxorubicin at IC50 (0.08 \u03bcg\/ml). Doxorubicin at 0.08 \u03bcg\/ml highlighted cytotoxicity, oxidative stress, and genotoxicity. Azithromycin at 25 and 50 \u03bcg\/ml markedly modulated oxidative stress and genomic damage by decreasing the ROS and LPO amounts and suppressing DNA fragmentation in the comet assay parameters. Consequently, azithromycin may be regarded as a cytomodulating, antigenotoxic, and antioxidant agent.<\/jats:p>","DOI":"10.1093\/mutage\/geae024","type":"journal-article","created":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T07:16:40Z","timestamp":1728112600000},"page":"126-136","source":"Crossref","is-referenced-by-count":2,"title":["An added value of azithromycin: mitigation of doxorubicin-associated oxidative damage and genotoxicity in normal human bronchial epithelium cells"],"prefix":"10.1093","volume":"40","author":[{"given":"Shaghayegh","family":"Shokrzadeh","sequence":"first","affiliation":[{"name":"Ramsar Campus, Mazandaran University of Medical Sciences , Ramsar ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahrzad","family":"Moghim","sequence":"additional","affiliation":[{"name":"Student Research Committee, Faculty of Pharmacy, Mazandaran University of Medical Sciences , Sari 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