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Conveniently, three trematode parasites viz. Schistosoma haematobium, Opisthorchis viverrini, and Clonorchis sinensis have been reported to be intrinsically linked with human cancer. Similar studies for other parasitic infections are still imprecise and need further validation. Plasmodium falciparum is known to cause holoendemic Burkitt lymphoma despite the non-carcinogenic role of malaria. This review is endowed with a coupled correlation and underlying mechanisms by which parasitic infections lead to carcinogenicity. An empirical documentation covering the prevalence and incidence of viral, bacterial, and parasitic carcinogenicity is illustrated in this article. Moreover, some probable diagnostic and treatment procedures for parasitic carcinogenicity are also summarized. A detailed account of various mutational and genetic changes that lead to carcinogenesis via different pathways is appended in this article.<\/jats:p>","DOI":"10.1093\/mutage\/geaf007","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T11:33:39Z","timestamp":1741692819000},"page":"465-479","source":"Crossref","is-referenced-by-count":6,"title":["Carcinogenic parasites: insights into the epidemiology and possible mechanisms of cancer"],"prefix":"10.1093","volume":"40","author":[{"given":"Shabir Ahmad","family":"Rather","sequence":"first","affiliation":[{"name":"Department of Zoology, School of Biosciences and Biotechnology, Baba Ghulam Shah Badshah University , Rajouri 185234, Jammu and Kashmir,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahoor Ahmad","family":"Wani","sequence":"additional","affiliation":[{"name":"Division of Veterinary Parasitology, SKUAST-K , Shuhama 190006, Jammu and Kashmir,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashaid Ali","family":"Mustafa","sequence":"additional","affiliation":[{"name":"Department of Zoology, School of Biosciences and Biotechnology, Baba Ghulam Shah Badshah University , Rajouri 185234, Jammu and Kashmir,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Bharti","sequence":"additional","affiliation":[{"name":"Department of Zoology, University of Kashmir Srinagar 190006, Jammu and Kashmir,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rukhsana","family":"Kousar","sequence":"additional","affiliation":[{"name":"Department of Zoology, School of Biosciences and Biotechnology, Baba Ghulam Shah Badshah University , Rajouri 185234, Jammu and Kashmir,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad 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