{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:31:25Z","timestamp":1787841085592,"version":"build-2784847793"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Pro-Rectory of Research at the Federal University of Rio Grande do Norte"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Maternal nutrition can influence genetic health during pregnancy, increasing the risk of DNA damage in both the mother and fetus. This study investigated the effect of maternal nutritional factors on DNA damage biomarkers in the mother\u2013infant dyad. A cross-sectional study was conducted with pregnant women residing in Northeast Brazil. Participants included women aged \u226518\u00a0years in the third trimester, excluding those with non-communicable chronic diseases and smokers. Data collection included sociodemographic, lifestyle, anthropometric information, and a 76-item Food Frequency Questionnaire. The micronucleus cytome assay was performed on oral mucosa cells, with DNA damage biomarkers expressed per thousand cells (\u2030). Statistical analysis involved hierarchical clustering and Generalized Linear Models using Jamovi 2.5.6. The median age of the pregnant women (n\u2009=\u2009209) was 26\u00a0years. Only 44.5% had adequate pre-pregnancy nutritional status, with a 9.5% increase in low birth weight. Total energy intake was 1842 (588\u20135709) kcal, with 72% consuming less than 90% of their caloric needs. The diet was predominantly hyperproteic and hyperlipidic, with over 60% showing inadequate intake of magnesium and folic acid. Among 209 participants, 80 consented to oral mucosa cell collection, and 59 mother\u2013infant pairs were analyzed. Three maternal nutritional profiles were identified: Cluster 1 (\"Multiple Burdens of Malnutrition\"), Cluster 2 (\"Low Burdens of Malnutrition\"), and Cluster 3 (\"High Nutritional Intake\"). While maternal nutritional profiles did not affect nuclear abnormalities in mothers, they influenced newborns. Infants of mothers in Clusters 1 and 2 exhibited more nuclear abnormalities than those in Cluster 3. Maternal nutritional inadequacy was associated with increased nuclear abnormalities in newborns, suggesting an impact on fetal genomic stability.<\/jats:p>","DOI":"10.1093\/mutage\/geag023","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T12:20:07Z","timestamp":1781612407000},"page":"298-309","source":"Crossref","is-referenced-by-count":1,"title":["Nutritional maternal factors affect the frequency of DNA damage in newborns"],"prefix":"10.1093","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6562-9876","authenticated-orcid":false,"given":"Anny Cristine","family":"de Ara\u00fajo","sequence":"first","affiliation":[{"name":"Health Sciences Postgraduate Program, Center for Health Sciences, Federal University of Rio Grande do Norte , Natal, RN, 59012-570 ,","place":["Brasil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabr\u00edcia de Medeiros","family":"Morais","sequence":"additional","affiliation":[{"name":"Faculty of Health Science of Trairi, Federal University of Rio Grande do Norte , Santa Cruz, RN, 59012-570 ,","place":["Brasil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daline Fernandes de Souza","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Faculty of Health Science of Trairi, Federal University of Rio Grande do Norte , Santa Cruz, RN, 59012-570 ,","place":["Brasil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle Soares","family":"Bezerra","sequence":"additional","affiliation":[{"name":"Faculty of Health Science of Trairi, Federal University of Rio Grande do Norte , Santa Cruz, RN, 59012-570 ,","place":["Brasil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio Alejandro","family":"Navoni","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte , Natal, RN, 59064-741 ,","place":["Brasil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana Cristina Medeiros Tavares","family":"Marques","sequence":"additional","affiliation":[{"name":"Faculty of Health Science of Trairi, Federal University of Rio Grande do Norte , Santa Cruz, RN, 59012-570 ,","place":["Brasil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"2026082709421115500_ref1","doi-asserted-by":"publisher","first-page":"692","DOI":"10.3390\/nu13020692","article-title":"Nutrient requirements during pregnancy and lactation","volume":"13","author":"Jouanne","year":"2021","journal-title":"Nutrients"},{"key":"2026082709421115500_ref2","doi-asserted-by":"publisher","first-page":"443","DOI":"10.3390\/nu11020443","article-title":"Macronutrient and micronutrient intake during pregnancy: an overview of recent 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