{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T22:00:57Z","timestamp":1785276057524,"version":"3.55.0"},"reference-count":69,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100020613","name":"Graduate School of Life Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020613","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008769","name":"University of W\u00fcrzburg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Anthocyanins are flavonoid pigments responsible for red, blue, and purple coloration in plants and play a protective role against abiotic stress through reactive oxygen species (ROS) scavenging. They are abundant in the human diet, with berries serving as a primary source. These flavonoids are known for their antioxidant and potential genoprotective properties. However, the effect of glycosylation on their biological activity remains incompletely understood. This study investigated the influence of glycosylation on the antioxidant and DNA-protective effects of delphinidin (aglycone), comparing the aglycone with pure glycosylated derivatives and a standardized maqui berry extract \u201cPREVAID\u00ae\u201d rich in delphinidin glycosides. Using human colon adenocarcinoma cells, oxidative stress was induced with hydrogen peroxide (H2O2) and assessed via 2\u2032,7\u2032-dichlorodihydrofluorescein diacetate. Oxidative DNA damage protection was evaluated with the formamidopyrimidine DNA glycosylase-modified comet assay, and geno-protection against cytochrome P450 (CYP450)-mediated activation of riddelliine was assessed by the micronucleus assay in human hepatoma cells. Both delphinidin and its glycosylated derivatives significantly reduced intracellular ROS and protected against oxidative DNA damage. Protective effects persisted following medium replacement, indicating intracellular uptake and activity. In the micronucleus assay, delphinidin and its glycosides attenuated riddelliine-induced genotoxicity, suggesting interference with CYP450-mediated metabolic activation. These findings demonstrate that glycosylation does not abolish the antioxidant and genoprotective properties of delphinidin. The results have important implications for understanding dietary anthocyanin bioactivity and guiding the development of anthocyanin-based nutraceuticals.<\/jats:p>\n                  <jats:p>Highlights Delphinidin and its glycosides reduce intracellular reactive oxygen species in human colon adenocarcinoma cells.Glycosylation does not abolish delphinidin\u2019s antioxidant effectiveness.Delphinidin and its glycosides protect against H2O2-induced oxidative DNA damage.Delphinidin derivatives attenuate riddelliine-induced micronuclei in human hepatoma cells.Findings support the genoprotective potential of dietary anthocyanins.<\/jats:p>","DOI":"10.1093\/mutage\/geag027","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:50:24Z","timestamp":1783511424000},"source":"Crossref","is-referenced-by-count":0,"title":["Antioxidant and genoprotective effects of naturally occurring delphinidin glycosides"],"prefix":"10.1093","author":[{"given":"Giorgia","family":"Martelli","sequence":"first","affiliation":[{"name":"Institute of Pharmacology and Toxicology, Julius-Maximillians-University of Wuerzburg , Versbacher Strasse 9, 97078 Wuerzburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carima","family":"L\u00f6rch","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology, Julius-Maximillians-University of Wuerzburg , Versbacher Strasse 9, 97078 Wuerzburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5492-3375","authenticated-orcid":false,"given":"Naji Said Aboud","family":"Hadi","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology, Julius-Maximillians-University of Wuerzburg , Versbacher Strasse 9, 97078 Wuerzburg ,","place":["Germany"]},{"name":"School of Health and Human Sciences, Pwani University , P.O Box 195-80108, Kilifi ,","place":["Kenya"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezgi Eyluel","family":"Bankoglu","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology, Julius-Maximillians-University of Wuerzburg , Versbacher Strasse 9, 97078 Wuerzburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Roewer","sequence":"additional","affiliation":[{"name":"Cutaneum Hamburg, Eppendorfer Landstra\u00dfe 77, 20249 Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Roewer","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, University Hospital of Wuerzburg , 97080, Wuerzburg 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