{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:07:37Z","timestamp":1789574857429,"version":"build-2803163510"},"reference-count":56,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Inflammatory bowel disease (IBD) is associated with alterations in the intestinal luminal environment that may modify the composition of fecal water (FW) and its capacity to induce DNA damage. The aim of this study was to identify FW metabolites associated with DNA damage and aryl hydrocarbon receptor (AhR) activity and to investigate whether shared metabolic pathways may link these responses in patients with IBD. FW samples from 80 IBD patients and 20 healthy controls were analyzed. DNA damage in Caco-2 cells following FW exposure was assessed using the comet assay, AhR activity using the ethoxyresorufin-O-deethylase assay, and FW metabolites by using liquid chromatography\u2013mass spectrometry. Metabolite signatures associated with DNA damage and AhR activity were identified separately, and subsequent pathway analysis revealed overlapping metabolic pathways, prompting further investigation of AhR-associated tryptophan metabolites. Kynurenine was inversely associated with AhR activity but positively associated with DNA damage in IBD, whereas serotonin was positively related to AhR activity and was protective against FW-induced DNA damage. Indoles did not significantly contribute to FW-induced DNA damage. These findings suggest that inflammation-associated alterations in tryptophan metabolism are associated with altered AhR signaling and epithelial DNA damage in IBD.<\/jats:p>","DOI":"10.1093\/mutage\/geag032","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T18:57:24Z","timestamp":1788289044000},"source":"Crossref","is-referenced-by-count":0,"title":["Tryptophan metabolism and aryl hydrocarbon receptor activation are associated with fecal water\u2013induced DNA damage in patients with inflammatory bowel disease"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2114-8672","authenticated-orcid":false,"given":"Luping","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Institute for Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University , PO box 616, 6200 MD, Maastricht ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Institute for Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University , PO box 616, 6200 MD, Maastricht ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2575-8400","authenticated-orcid":false,"given":"Corinne","family":"Spooren","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology\u2013Hepatology, Institute for Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University , PO box 616, 6200M MD, Maastricht ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine A S","family":"Langie","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Institute for Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University , PO box 616, 6200 MD, Maastricht ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Mommers","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Institute for Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University , PO box 616, 6200 MD, Maastricht ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik-Jan van","family":"Schooten","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Institute for Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University , PO box 616, 6200 MD, Maastricht ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisy","family":"Jonkers","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology\u2013Hepatology, Institute for Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University , PO box 616, 6200M MD, Maastricht ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Godschalk","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Institute for Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University , PO box 616, 6200 MD, Maastricht ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"2026091611263706900_ref1","doi-asserted-by":"publisher","first-page":"2437","DOI":"10.1016\/j.cgh.2020.02.048","article-title":"Progression of elderly onset inflammatory bowel diseases: a systematic review and meta-analysis of population-based cohort studies","volume":"18","author":"Rozich","year":"2020","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2026091611263706900_ref2","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1097\/CM9.0000000000003542","article-title":"Epidemiology, pathogenesis, diagnosis, and treatment of inflammatory bowel disease: insights from the past two years","volume":"138","author":"Wan","year":"2025","journal-title":"Chin Med J"},{"key":"2026091611263706900_ref3","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/s12951-021-00832-5","article-title":"Graphene oxide exacerbates dextran sodium sulfate-induced colitis via ROS\/AMPK\/p53 signaling to mediate apoptosis","volume":"19","author":"Liu","year":"2021","journal-title":"J Nanobiotechnology"},{"key":"2026091611263706900_ref4","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/s41575-018-0022-9","article-title":"The role of diet in the aetiopathogenesis of inflammatory bowel disease","volume":"15","author":"Khalili","year":"2018","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"2026091611263706900_ref5","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1053\/j.gastro.2020.09.056","article-title":"Inflammatory bowel diseases (IBD) and the microbiome-searching the crime scene for clues","volume":"160","author":"Lee","year":"2021","journal-title":"Gastroenterology"},{"key":"2026091611263706900_ref6","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1002\/ibd.20880","article-title":"Innate immune signaling by toll-like receptor-4 (TLR4) shapes the inflammatory microenvironment in colitis-associated tumors","volume":"15","author":"Fukata","year":"2009","journal-title":"Inflamm Bowel Dis"},{"key":"2026091611263706900_ref7","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/nri3661","article-title":"Cytokines in inflammatory bowel disease","volume":"14","author":"Neurath","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"2026091611263706900_ref8","doi-asserted-by":"publisher","first-page":"1390351","DOI":"10.3389\/fendo.2024.1390351","article-title":"The emerging role of oxidative stress in inflammatory bowel disease","volume":"15","author":"Muro","year":"2024","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2026091611263706900_ref9","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1038\/s41467-020-15549-6","article-title":"Limiting oxidative DNA damage reduces microbe-induced colitis-associated colorectal cancer","volume":"11","author":"Irrazabal","year":"2020","journal-title":"Nat Commun"},{"key":"2026091611263706900_ref10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/19490976.2020.1788899","article-title":"Intestinal microbiota-derived tryptophan metabolites are predictive of ah receptor activity","volume":"12","author":"Dong","year":"2020","journal-title":"Gut Microbes"},{"key":"2026091611263706900_ref11","doi-asserted-by":"publisher","first-page":"100246","DOI":"10.1016\/j.xcrm.2021.100246","article-title":"Potential role of indolelactate and butyrate in multiple sclerosis revealed by integrated microbiome-metabolome analysis","volume":"2","author":"Levi","year":"2021","journal-title":"Cell Rep Med"},{"key":"2026091611263706900_ref12","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1186\/s40168-023-01551-9","article-title":"Gut microbiota-derived 3-phenylpropionic acid promotes intestinal epithelial barrier function via AhR signaling","volume":"11","author":"Hu","year":"2023","journal-title":"Microbiome"},{"key":"2026091611263706900_ref13","doi-asserted-by":"publisher","first-page":"113153","DOI":"10.1016\/j.celrep.2023.113153","article-title":"Commensal bacteria signal through TLR5 and AhR to improve barrier integrity and prevent allergic responses to food","volume":"42","author":"Kemter","year":"2023","journal-title":"Cell Rep"},{"key":"2026091611263706900_ref14","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izaf155","article-title":"Hypoxia-inducible factor signaling compensates for aryl hydrocarbon receptor in maintaining gut barrier integrity","volume":"31","author":"Gwak","year":"2025","journal-title":"Inflamm Bowel Dis"},{"key":"2026091611263706900_ref15","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232415578","article-title":"Intestinal stem cells damaged by deoxycholic acid via AHR pathway contributes to mucosal barrier dysfunction in high-fat feeding mice","volume":"23","author":"Liu","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2026091611263706900_ref16","doi-asserted-by":"publisher","first-page":"116769","DOI":"10.1016\/j.taap.2023.116769","article-title":"Heavy metals, oxidative stress, and the role of AhR signaling","volume":"482","author":"Kou","year":"2024","journal-title":"Toxicol Appl Pharmacol"},{"key":"2026091611263706900_ref17","doi-asserted-by":"publisher","first-page":"116314","DOI":"10.1016\/j.taap.2022.116314","article-title":"Oxidative stress modulates expression of immune checkpoint genes via activation of AhR signaling","volume":"457","author":"Kou","year":"2022","journal-title":"Toxicol Appl Pharmacol"},{"key":"2026091611263706900_ref18","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/s41564-018-0306-4","article-title":"Gut microbiome structure and metabolic activity in inflammatory bowel disease","volume":"4","author":"Franzosa","year":"2019","journal-title":"Nat Microbiol"},{"key":"2026091611263706900_ref19","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1136\/gutjnl-2023-329969","article-title":"Untargeted faecal metabolomics for the discovery of biomarkers and treatment targets for inflammatory bowel diseases","volume":"73","author":"Vich Vila","year":"2024","journal-title":"Gut"},{"key":"2026091611263706900_ref20","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/s41575-019-0258-z","article-title":"Gut microbiota-derived metabolites as key actors in inflammatory bowel disease","volume":"17","author":"Lavelle","year":"2020","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"2026091611263706900_ref21","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12090834","article-title":"Microbial tryptophan metabolism tunes host immunity, metabolism, and extraintestinal disorders","volume":"12","author":"Liu","year":"2022","journal-title":"Metabolites"},{"key":"2026091611263706900_ref22","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1136\/gutjnl-2018-317232","article-title":"Bacteria engineered to produce IL-22 in intestine induce expression of REG3G to reduce ethanol-induced liver disease in mice","volume":"68","author":"Hendrikx","year":"2019","journal-title":"Gut"},{"key":"2026091611263706900_ref23","doi-asserted-by":"publisher","first-page":"903526","DOI":"10.3389\/fimmu.2022.903526","article-title":"Dual role of indoles derived from intestinal microbiota on human health","volume":"13","author":"Ye","year":"2022","journal-title":"Front Immunol"},{"key":"2026091611263706900_ref24","doi-asserted-by":"publisher","first-page":"1178646919852996","DOI":"10.1177\/1178646919852996","article-title":"Microorganisms, tryptophan metabolism, and kynurenine pathway: a complex interconnected loop influencing human health status","volume":"12","author":"Dehhaghi","year":"2019","journal-title":"Int J Tryptophan Res"},{"key":"2026091611263706900_ref25","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1136\/gutjnl-2022-327337","article-title":"Rewiring the altered tryptophan metabolism as a novel therapeutic strategy in inflammatory bowel diseases","volume":"72","author":"Michaudel","year":"2023","journal-title":"Gut"},{"key":"2026091611263706900_ref26","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1002\/JLB.3A0617-261R","article-title":"Effects of anti-inflammatory drugs on the expression of tryptophan-metabolism genes by human macrophages","volume":"103","author":"Regan","year":"2018","journal-title":"J Leukoc Biol"},{"key":"2026091611263706900_ref27","doi-asserted-by":"publisher","first-page":"11786469241232871","DOI":"10.1177\/11786469241232871","article-title":"Kynurenine pathway in respiratory diseases","volume":"17","author":"Pamart","year":"2024","journal-title":"Int J Tryptophan Res"},{"key":"2026091611263706900_ref28","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1515\/revneuro-2019-0095","article-title":"Gut dysbiosis and serotonin: intestinal 5-HT as a ubiquitous membrane permeability regulator in host tissues, organs, and the brain","volume":"31","author":"Szoke","year":"2020","journal-title":"Rev Neurosci"},{"key":"2026091611263706900_ref29","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3389\/fcimb.2018.00013","article-title":"Impact of the gut microbiota on intestinal immunity mediated by tryptophan metabolism","volume":"8","author":"Gao","year":"2018","journal-title":"Front Cell Infect Microbiol"},{"key":"2026091611263706900_ref30","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1517\/14712598.2011.577060","article-title":"miRNA-based therapies for the irritable bowel syndrome","volume":"11","author":"Zhou","year":"2011","journal-title":"Expert Opin Biol Ther"},{"key":"2026091611263706900_ref31","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s40168-023-01486-1","article-title":"IL-22 alters gut microbiota composition and function to increase aryl hydrocarbon receptor activity in mice and humans","volume":"11","author":"Mar","year":"2023","journal-title":"Microbiome"},{"key":"2026091611263706900_ref32","doi-asserted-by":"publisher","first-page":"113393","DOI":"10.1016\/j.fct.2022.113393","article-title":"The role of diet in genotoxicity of fecal water derived from IBD patients and healthy controls","volume":"168","author":"Wang","year":"2022","journal-title":"Food Chem Toxicol"},{"key":"2026091611263706900_ref33","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1093\/ecco-jcc\/jjab008","article-title":"Dietary intake pattern is associated with occurrence of flares in IBD patients","volume":"15","author":"Peters","year":"2021","journal-title":"J Crohns Colitis"},{"key":"2026091611263706900_ref34","doi-asserted-by":"publisher","first-page":"e2200574","DOI":"10.1002\/mnfr.202200574","article-title":"Effect of protein fermentation products on gut health assessed in an in vitro model of human colon (TIM-2)","volume":"67","author":"Wang","year":"2023","journal-title":"Mol Nutr Food Res"},{"key":"2026091611263706900_ref35","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1093\/toxsci\/kfl011","article-title":"The role of the aryl hydrocarbon receptor pathway in mediating synergistic developmental toxicity of polycyclic aromatic hydrocarbons to zebrafish","volume":"92","author":"Billiard","year":"2006","journal-title":"Toxicol Sci"},{"key":"2026091611263706900_ref36","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1038\/s41596-022-00754-y","article-title":"Measuring DNA modifications with the comet assay: a compendium of protocols","volume":"18","author":"Collins","year":"2023","journal-title":"Nat Protoc"},{"key":"2026091611263706900_ref37","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1538\/expanim.16-0092","article-title":"The aryl hydrocarbon receptor: a multifunctional chemical sensor for host defense and homeostatic maintenance","volume":"66","author":"Kawajiri","year":"2017","journal-title":"Exp Anim"},{"key":"2026091611263706900_ref38","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1038\/nrc2015","article-title":"The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis","volume":"6","author":"Nebert","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"2026091611263706900_ref39","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1146\/annurev.pharmtox.43.100901.135828","article-title":"Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals","volume":"43","author":"Denison","year":"2003","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"2026091611263706900_ref40","doi-asserted-by":"publisher","first-page":"860867","DOI":"10.3389\/fimmu.2022.860867","article-title":"Editorial: multiple implications of the kynurenine pathway in inflammatory diseases: diagnostic and therapeutic applications","volume":"13","author":"Mandi","year":"2022","journal-title":"Front Immunol"},{"key":"2026091611263706900_ref41","doi-asserted-by":"publisher","DOI":"10.3390\/cells10071603","article-title":"Role of kynurenine pathway in oxidative stress during neurodegenerative disorders","volume":"10","author":"Mor","year":"2021","journal-title":"Cells"},{"key":"2026091611263706900_ref42","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22031268","article-title":"Serotonin pathway in cancer","volume":"22","author":"Balakrishna","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2026091611263706900_ref43","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/s41398-022-01969-z","article-title":"Systemic DNA and RNA damage from oxidation after serotonergic treatment of unipolar depression","volume":"12","author":"Jorgensen","year":"2022","journal-title":"Transl Psychiatry"},{"key":"2026091611263706900_ref44","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22157931","article-title":"The mechanism of secretion and metabolism of gut-derived 5-hydroxytryptamine","volume":"22","author":"Liu","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2026091611263706900_ref45","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12020470","article-title":"Oxidative stress in depression: the link with the stress response, neuroinflammation, serotonin, neurogenesis and synaptic plasticity","volume":"12","author":"Correia","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"2026091611263706900_ref46","first-page":"157","article-title":"Expression of 5-HT1A and 5-HT7 receptors in Caco-2 cells and their role in the regulation of serotonin transporter activity","volume":"60","author":"Iceta","year":"2009","journal-title":"J Physiol Pharmacol"},{"key":"2026091611263706900_ref47","doi-asserted-by":"publisher","first-page":"5487","DOI":"10.1158\/0008-5472.CAN-07-6171","article-title":"Serotonin receptors, novel targets of sulforaphane identified by proteomic analysis in Caco-2 cells","volume":"68","author":"Mastrangelo","year":"2008","journal-title":"Cancer Res"},{"key":"2026091611263706900_ref48","doi-asserted-by":"publisher","first-page":"e14673","DOI":"10.1111\/nmo.14673","article-title":"Protective actions of a luminally acting 5-HT(4) receptor agonist in mouse models of colitis","volume":"35","author":"Hurd","year":"2023","journal-title":"Neurogastroenterol Motil"},{"key":"2026091611263706900_ref49","doi-asserted-by":"publisher","first-page":"748254","DOI":"10.3389\/fendo.2021.748254","article-title":"Crosstalk between intestinal serotonergic system and pattern recognition receptors on the microbiota-gut-brain axis","volume":"12","author":"Layunta","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2026091611263706900_ref50","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1007\/s10753-024-02135-x","article-title":"The kynurenine pathway in gut permeability and inflammation","volume":"48","author":"Kearns","year":"2025","journal-title":"Inflammation"},{"key":"2026091611263706900_ref51","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1089\/ars.2021.0215","article-title":"Kynurenine\/aryl hydrocarbon receptor modulates mitochondria-mediated oxidative stress and neuronal apoptosis in experimental intracerebral hemorrhage","volume":"37","author":"Ren","year":"2022","journal-title":"Antioxid Redox Signal"},{"key":"2026091611263706900_ref52","doi-asserted-by":"publisher","first-page":"11786469231185102","DOI":"10.1177\/11786469231185102","article-title":"The role of the kynurenine\/AhR pathway in diseases related to metabolism and cancer","volume":"16","author":"Shadboorestan","year":"2023","journal-title":"Int J Tryptophan Res"},{"key":"2026091611263706900_ref53","doi-asserted-by":"publisher","DOI":"10.3390\/biom12070998","article-title":"The role of tryptophan dysmetabolism and quinolinic acid in depressive and neurodegenerative diseases","volume":"12","author":"Hestad","year":"2022","journal-title":"Biomolecules"},{"key":"2026091611263706900_ref54","doi-asserted-by":"publisher","first-page":"eade8653","DOI":"10.1126\/sciadv.ade8653","article-title":"A microbiota and dietary metabolite integrates DNA repair and cell death to regulate embryo viability and aneuploidy during aging","volume":"9","author":"Sonowal","year":"2023","journal-title":"Sci Adv"},{"key":"2026091611263706900_ref55","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8020191","article-title":"Indoxyl sulfate induces apoptosis through oxidative stress and mitogen-activated protein kinase signaling pathway inhibition in human astrocytes","volume":"8","author":"Lin","year":"2019","journal-title":"J Clin Med"},{"key":"2026091611263706900_ref56","doi-asserted-by":"publisher","first-page":"2583","DOI":"10.1038\/s41598-024-53164-3","article-title":"Dose-dependent exposure to indoxyl sulfate alters AHR signaling, sirtuins gene expression, oxidative DNA damage, and bone mineral status in rats","volume":"14","author":"Karbowska","year":"2024","journal-title":"Sci Rep"}],"container-title":["Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/mutage\/advance-article-pdf\/doi\/10.1093\/mutage\/geag032\/70895816\/geag032.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mutage\/advance-article-pdf\/doi\/10.1093\/mutage\/geag032\/70895816\/geag032.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:26:46Z","timestamp":1789572406000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mutage\/advance-article\/doi\/10.1093\/mutage\/geag032\/8778735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":56,"URL":"https:\/\/doi.org\/10.1093\/mutage\/geag032","relation":{},"ISSN":["0267-8357","1464-3804"],"issn-type":[{"value":"0267-8357","type":"print"},{"value":"1464-3804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,1]]},"article-number":"geag032"}}