{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T09:59:43Z","timestamp":1760522383733},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,9,1]]},"DOI":"10.1093\/mutage\/gei049","type":"journal-article","created":{"date-parts":[[2005,7,21]],"date-time":"2005-07-21T20:24:28Z","timestamp":1121977468000},"page":"359-364","source":"Crossref","is-referenced-by-count":29,"title":["Genetic polymorphisms and the effect of cigarette smoking in the comet assay"],"prefix":"10.1093","volume":"20","author":[{"given":"Heike","family":"Hoffmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Isner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"H\u00f6gel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcnter","family":"Speit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,7,21]]},"reference":[{"key":"key\n\t\t\t\t20171013133230_B1","unstructured":"Moller,P., Knudsen,L.E., Loft,S. and Wallin,H. (2000) The comet assay as a rapid test in biomonitoring occupational exposure to DNA-damaging agents and effect of confounding factors. Cancer Epidemiol. Biomarkers Prev., 9, 1005\u20131015."},{"key":"key\n\t\t\t\t20171013133230_B2","doi-asserted-by":"crossref","unstructured":"Faust,F., Kassie,F., Knasmuller,S., Boedecker,R.H., Mann,M. and Mersch-Sundermann,V. (2004) The use of the alkaline comet assay with lymphocytes in human biomonitoring studies. Mutat. Res., 566, 209\u2013229.","DOI":"10.1016\/j.mrrev.2003.09.007"},{"key":"key\n\t\t\t\t20171013133230_B3","doi-asserted-by":"crossref","unstructured":"Pavanello,S. and Clonfero,E. (2000) Biological indicators of genotoxic risk and metabolic polymorphisms. Mutat. Res., 463, 285\u2013308.","DOI":"10.1016\/S1383-5742(00)00051-X"},{"key":"key\n\t\t\t\t20171013133230_B4","doi-asserted-by":"crossref","unstructured":"Wiencke,J.K. (2002) DNA adduct burden and tobacco carcinogenesis. Oncogene, 21, 7376\u20137391.","DOI":"10.1038\/sj.onc.1205799"},{"key":"key\n\t\t\t\t20171013133230_B5","doi-asserted-by":"crossref","unstructured":"DeMarini,D.M. (2004) Genotoxicity of tobacco smoke and tobacco smoke condensate: a review. Mutat. Res., 567, 447\u2013474.","DOI":"10.1016\/j.mrrev.2004.02.001"},{"key":"key\n\t\t\t\t20171013133230_B6","doi-asserted-by":"crossref","unstructured":"Wu,X., Zhao,H., Suk,R. and Christiani,D.C. (2004) Genetic susceptibility to tobacco-related cancer. Oncogene, 23, 6500\u20136523.","DOI":"10.1038\/sj.onc.1207811"},{"key":"key\n\t\t\t\t20171013133230_B7","doi-asserted-by":"crossref","unstructured":"Hecht,S.S. (1999) Tobacco smoke carcinogens and lung cancer. J. Natl. Cancer Inst., 91, 1194\u20131210.","DOI":"10.1093\/jnci\/91.14.1194"},{"key":"key\n\t\t\t\t20171013133230_B8","doi-asserted-by":"crossref","unstructured":"Stabbert,R., Voncken,P., Rustemeier,K., Haussmann,H.J., Roemer,E., Schaffernicht,H. and Patskan,G. (2003) Toxicological evaluation of an electrically heated cigarette. Part 2: Chemical composition of mainstream smoke. J. Appl. Toxicol., 23, 329\u2013339.","DOI":"10.1002\/jat.924"},{"key":"key\n\t\t\t\t20171013133230_B9","unstructured":"Goode,E.L., Ulrich,C.M. and Potter,J.D. (2002) Polymorphisms in DNA repair genes and associations with cancer risk. Cancer Epidemiol. Biomarkers Prev., 11, 1513\u20131530."},{"key":"key\n\t\t\t\t20171013133230_B10","doi-asserted-by":"crossref","unstructured":"Crofts,F., Taioli,E., Trachman,J., Cosma,G.N., Currie,D., Toniolo,P. and Garte,S.J. (1994) Functional significance of different human CYP1A1 genotypes. Carcinogenesis, 15, 2961\u20132963.","DOI":"10.1093\/carcin\/15.12.2961"},{"key":"key\n\t\t\t\t20171013133230_B11","doi-asserted-by":"crossref","unstructured":"Vodicka,P., Kumar,R., Stetina,R. et al. (2004) Genetic polymorphisms in DNA repair genes and possible links with DNA repair rates, chromosomal aberrations and single-strand breaks in DNA. Carcinogenesis, 25, 757\u2013763.","DOI":"10.1093\/carcin\/bgh064"},{"key":"key\n\t\t\t\t20171013133230_B12","doi-asserted-by":"crossref","unstructured":"Vodicka,P., Kumar,R., Stetina,R. et al. (2004) Markers of individual susceptibility and DNA repair rate in workers exposed to xenobiotics in a tire plant. Environ. Mol. Mutagen., 44, 283\u2013292.","DOI":"10.1002\/em.20055"},{"key":"key\n\t\t\t\t20171013133230_B13","doi-asserted-by":"crossref","unstructured":"Pavanello,S., Pulliero,A., Siwinska,E., Mielzynska,D. and Clonfero,E. (2005) Reduced nucleotide excision repair and GSTM1-null genotypes influence anti-B[a]PDE-DNA adduct levels in mononuclear white blood cells of highly PAH-exposed coke oven workers. Carcinogenesis, 26, 169\u2013175.","DOI":"10.1093\/carcin\/bgh303"},{"key":"key\n\t\t\t\t20171013133230_B14","doi-asserted-by":"crossref","unstructured":"Au,W.W., Salama,S.A. and Sierra-Torres,C.H. (2003) Functional characterization of polymorphisms in DNA repair genes using cytogenetic challenge assays. Environ. Health Perspect., 111, 1843\u20131850.","DOI":"10.1289\/ehp.6632"},{"key":"key\n\t\t\t\t20171013133230_B15","doi-asserted-by":"crossref","unstructured":"Nia,A.B., Van Schooten,F.J., Schilderman,P.A., De Kok,T.M., Haenen,G.R., Van Herwijnen,M.H., Van Agen,E., Pachen,D. and Kleinjans,J.C. (2001) A multi-biomarker approach to study the effects of smoking on oxidative DNA damage and repair and antioxidative defense mechanisms. Carcinogenesis, 22, 395\u2013401.","DOI":"10.1093\/carcin\/22.3.395"},{"key":"key\n\t\t\t\t20171013133230_B16","doi-asserted-by":"crossref","unstructured":"Speit,G., Witton-Davies,T., Heepchantree,W., Trenz,K. and Hoffmann,H. (2003) Investigations on the effect of cigarette smoking in the comet assay. Mutat. Res., 542, 33\u201342.","DOI":"10.1016\/j.mrgentox.2003.08.002"},{"key":"key\n\t\t\t\t20171013133230_B17","doi-asserted-by":"crossref","unstructured":"Hoffmann,H. and Speit,G. (2005) Assessment of DNA damage in peripheral blood of heavy smokers with the comet assay and the micronucleus test. Mutat. Res., 581, 105\u2013114.","DOI":"10.1016\/j.mrgentox.2004.11.015"},{"key":"key\n\t\t\t\t20171013133230_B18","unstructured":"Speit,G. and Hartmann,A. (2005) The comet assay: a sensitive genotoxicity test for the detection of DNA damage. Meth. Mol. Biol., 291, 85\u201395."},{"key":"key\n\t\t\t\t20171013133230_B19","doi-asserted-by":"crossref","unstructured":"Sturgis,E.M., Zheng,R., Li,L., Castillo,E.J., Eicher,S.A., Chen,M., Strom,S.S., Spitz,M.R. and Wei,Q. (2000) XPD\/ERCC2 polymorphisms and risk of head and neck cancer: a case-control analysis. Carcinogenesis, 21, 2219\u20132223.","DOI":"10.1093\/carcin\/21.12.2219"},{"key":"key\n\t\t\t\t20171013133230_B20","doi-asserted-by":"crossref","unstructured":"Husgafvel-Pursiainen,K. (2004) Genotoxicity of environmental tobacco smoke: a review. Mutat. Res., 567, 427\u2013445.","DOI":"10.1016\/j.mrrev.2004.06.004"},{"key":"key\n\t\t\t\t20171013133230_B21","doi-asserted-by":"crossref","unstructured":"Crebelli,R., Carta,P., Andreoli,C., Aru,G., Dobrowolny,G., Rossi,S. and Zijno,A. (2002) Biomonitoring of primary aluminium industry workers: detection of micronuclei and repairable DNA lesions by alkaline SCGE. Mutat. Res., 516, 63\u201370.","DOI":"10.1016\/S1383-5718(02)00028-1"},{"key":"key\n\t\t\t\t20171013133230_B22","doi-asserted-by":"crossref","unstructured":"Speit,G., Schutz,P. and Hoffmann,H. (2004) Enhancement of genotoxic effects in the comet assay with human blood samples by aphidicolin. Toxicol. Lett., 153, 303\u2013310.","DOI":"10.1016\/j.toxlet.2004.04.047"},{"key":"key\n\t\t\t\t20171013133230_B23","doi-asserted-by":"crossref","unstructured":"Dusinska,M., Ficek,A., Horska,A. et al. (2001) Glutathione S-transferase polymorphisms influence the level of oxidative DNA damage and antioxidant protection in humans. Mutat. Res., 482, 47\u201355.","DOI":"10.1016\/S0027-5107(01)00209-3"},{"key":"key\n\t\t\t\t20171013133230_B24","doi-asserted-by":"crossref","unstructured":"Peluso,M., Neri,M., Margarino,G. et al. (2004) Comparison of DNA adduct levels in nasal mucosa, lymphocytes and bronchial mucosa of cigarette smokers and interaction with metabolic gene polymorphisms. Carcinogenesis, 25, 2459\u20132465.","DOI":"10.1093\/carcin\/bgh259"},{"key":"key\n\t\t\t\t20171013133230_B25","doi-asserted-by":"crossref","unstructured":"Pitarque,M., Vaglenov,A., Nosko,M., Hirvonen,A., Norppa,H., Creus,A. and Marcos,R. (1999) Evaluation of DNA damage by the Comet assay in shoe workers exposed to toluene and other organic solvents. Mutat. Res., 441, 115\u2013127.","DOI":"10.1016\/S1383-5718(99)00042-X"},{"key":"key\n\t\t\t\t20171013133230_B26","doi-asserted-by":"crossref","unstructured":"Pavanello,S., Siwinska,E., Mielzynska,D. and Clonfero,E. (2004) GSTM1 null genotype as a risk factor for anti-BPDE-DNA adduct formation in mononuclear white blood cells of coke-oven workers. Mutat. Res., 558, 53\u201362.","DOI":"10.1016\/j.mrgentox.2003.10.019"},{"key":"key\n\t\t\t\t20171013133230_B27","doi-asserted-by":"crossref","unstructured":"van Delft,J.H., Steenwinkel,M.S., van Asten,J.G. et al. (2001) Biological monitoring of the exposure to polycyclic aromatic hydrocarbons of coke oven workers in relation to smoking and genetic polymorphisms for GSTM1 and GSTT1. Ann. Occup. Hyg., 45, 395\u2013408.","DOI":"10.1016\/S0003-4878(00)00065-X"},{"key":"key\n\t\t\t\t20171013133230_B28","doi-asserted-by":"crossref","unstructured":"Carere,A., Andreoli,C., Galati,R. et al. (2002) Biomonitoring of exposure to urban air pollutants: analysis of sister chromatid exchanges and DNA lesions in peripheral lymphocytes of traffic policemen. Mutat. Res., 518, 215\u2013224.","DOI":"10.1016\/S1383-5718(02)00108-0"},{"key":"key\n\t\t\t\t20171013133230_B29","doi-asserted-by":"crossref","unstructured":"Marczynski,B., Rihs,H.P., Rossbach,B., Holzer,J., Angerer,J., Scherenberg,M., Hoffmann,G., Bruning,T. and Wilhelm,M. (2002) Analysis of 8-oxo-7,8-dihydro-2\u2032-deoxyguanosine and DNA strand breaks in white blood cells of occupationally exposed workers: comparison with ambient monitoring, urinary metabolites and enzyme polymorphisms. Carcinogenesis, 23, 273\u2013281.","DOI":"10.1093\/carcin\/23.2.273"},{"key":"key\n\t\t\t\t20171013133230_B30","doi-asserted-by":"crossref","unstructured":"Mino,C., Arevalo,M., Sanchez,M.E. and Leone,P.E. (2004) Chromosome and DNA damage analysis in individuals occupationally exposed to pesticides with relation to genetic polymorphism for CYP 1A1 gene in Ecuador. Mutat. Res., 562, 77\u201389.","DOI":"10.1016\/j.mrgentox.2004.05.005"},{"key":"key\n\t\t\t\t20171013133230_B31","doi-asserted-by":"crossref","unstructured":"Georgiadis,P., Topinka,J., Vlachodimitropoulos,D. et al. (2005) Interactions between CYP1A1 polymorphisms and exposure to environmental tobacco smoke in the modulation of lymphocyte bulky DNA adducts and chromosomal aberrations. Carcinogenesis, 26, 93\u2013101.","DOI":"10.1093\/carcin\/bgh294"},{"key":"key\n\t\t\t\t20171013133230_B32","doi-asserted-by":"crossref","unstructured":"Collins,A.R. (2004) The comet assay for DNA damage and repair: principles, applications, and limitations. Mol. Biotechnol., 26, 249\u2013261.","DOI":"10.1385\/MB:26:3:249"},{"key":"key\n\t\t\t\t20171013133230_B33","doi-asserted-by":"crossref","unstructured":"Affatato,A.A., Wolfe,K.J., Lopez,M.S., Hallberg,C., Ammenheuser,M.M. and Abdel-Rahman,S.Z. (2004) Effect of XPD\/ERCC2 polymorphisms on chromosome aberration frequencies in smokers and on sensitivity to the mutagenic tobacco-specific nitrosamine NNK. Environ. Mol. Mutagen., 44, 65\u201373.","DOI":"10.1002\/em.20032"},{"key":"key\n\t\t\t\t20171013133230_B34","doi-asserted-by":"crossref","unstructured":"Schmezer,P., Rajaee-Behbahani,N., Risch,A., Thiel,S., Rittgen,W., Drings,P., Dienemann,H., Kayser,K.W., Schulz,V. and Bartsch,H. (2001) Rapid screening assay for mutagen sensitivity and DNA repair capacity in human peripheral blood lymphocytes. Mutagenesis, 16, 25\u201330.","DOI":"10.1093\/mutage\/16.1.25"},{"key":"key\n\t\t\t\t20171013133230_B35","doi-asserted-by":"crossref","unstructured":"Popanda,O., Schattenberg,T., Phong,C.T. et al. (2004) Specific combinations of DNA repair gene variants and increased risk for non-small cell lung cancer. Carcinogenesis, 25, 2433\u20132441.","DOI":"10.1093\/carcin\/bgh264"},{"key":"key\n\t\t\t\t20171013133230_B36","doi-asserted-by":"crossref","unstructured":"Vineis,P. (2004) Individual susceptibility to carcinogens. Oncogene, 23, 6477\u20136483.","DOI":"10.1038\/sj.onc.1207897"}],"container-title":["Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/mutage\/article-pdf\/20\/5\/359\/3572805\/gei049.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T13:33:33Z","timestamp":1507901613000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/mutage\/article\/20\/5\/359\/1049162\/Genetic-polymorphisms-and-the-effect-of-cigarette"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7,21]]},"references-count":36,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2005,7,21]]},"published-print":{"date-parts":[[2005,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/mutage\/gei049","relation":{},"ISSN":["1464-3804","0267-8357"],"issn-type":[{"value":"1464-3804","type":"electronic"},{"value":"0267-8357","type":"print"}],"subject":[],"published-other":{"date-parts":[[2005,9]]},"published":{"date-parts":[[2005,7,21]]}}}