{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T13:56:52Z","timestamp":1778939812958,"version":"3.51.4"},"reference-count":89,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,7]]},"DOI":"10.1093\/mutage\/gel024","type":"journal-article","created":{"date-parts":[[2006,6,15]],"date-time":"2006-06-15T01:17:31Z","timestamp":1150334251000},"page":"219-224","source":"Crossref","is-referenced-by-count":55,"title":["TDP1-dependent DNA single-strand break repair and neurodegeneration"],"prefix":"10.1093","volume":"21","author":[{"given":"Sherif F.","family":"El-Khamisy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith W.","family":"Caldecott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,6,14]]},"reference":[{"key":"key\n\t\t\t\t20170614055012_b1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/362709a0","article-title":"Instability and decay of the primary structure of DNA","volume":"362","author":"Lindahl","year":"1993","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170614055012_b2","doi-asserted-by":"crossref","first-page":"19633","DOI":"10.1074\/jbc.272.32.19633","article-title":"Oxidative decay of DNA","volume":"272","author":"Beckman","year":"1997","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170614055012_b3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0921-8777(99)00058-0","article-title":"XRCC1 keeps DNA from getting stranded","volume":"459","author":"Thompson","year":"2000","journal-title":"Mutat. Res."},{"key":"key\n\t\t\t\t20170614055012_b4","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.dnarep.2004.04.011","article-title":"DNA single-strand breaks and neurodegeneration","volume":"3","author":"Caldecott","year":"2004","journal-title":"DNA Repair (Amst.)"},{"key":"key\n\t\t\t\t20170614055012_b5","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/ng1001-184","article-title":"Early-onset ataxia with ocular motor apraxia and hypoalbuminemia is caused by mutations in a new HIT superfamily gene","volume":"29","author":"Date","year":"2001","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170614055012_b6","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1086\/318191","article-title":"Homozygosity mapping of Portuguese and Japanese forms of ataxia-oculomotor apraxia to 9p13, and evidence for genetic heterogeneity","volume":"68","author":"Moreira","year":"2001","journal-title":"Am. J. Hum. Genet."},{"key":"key\n\t\t\t\t20170614055012_b7","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/ng987","article-title":"Mutation of TDP1, encoding a topoisomerase I-dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy","volume":"32","author":"Takashima","year":"2002","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170614055012_b8","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/nrn1474","article-title":"Pathways to motor incoordination: the inherited ataxias","volume":"5","author":"Taroni","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"key\n\t\t\t\t20170614055012_b9","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/ng0793-221","article-title":"Expansion of an unstable trinucleotide CAG repeat in spinocerebellar ataxia type 1","volume":"4","author":"Orr","year":"1993","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170614055012_b10","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1093\/hmg\/ddi483","article-title":"Polyglutamine expansion causes neurodegeneration by altering the neuronal differentiation program","volume":"15","author":"Abou-Sleymane","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170614055012_b11","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s100720100017","article-title":"The complex clinical and genetic classification of inherited ataxias. II. Autosomal recessive ataxias","volume":"22","author":"Di Donato","year":"2001","journal-title":"Neurol. Sci."},{"key":"key\n\t\t\t\t20170614055012_b12","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1093\/hmg\/ddi461","article-title":"Mitochondrial iron detoxification is a primary function of frataxin that limits oxidative damage and preserves cell longevity","volume":"15","author":"Gakh","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170614055012_b13","doi-asserted-by":"crossref","first-page":"3857","DOI":"10.1093\/hmg\/ddi410","article-title":"Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice","volume":"14","author":"Thierbach","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170614055012_b14","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jns.2005.03.012","article-title":"Oxidative stress, mitochondrial dysfunction and cellular stress response in Friedreich's ataxia","volume":"233","author":"Calabrese","year":"2005","journal-title":"J. Neurol. Sci."},{"key":"key\n\t\t\t\t20170614055012_b15","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1093\/carcin\/21.3.453","article-title":"Nucleotide excision repair and human syndromes","volume":"21","author":"de Boer","year":"2000","journal-title":"Carcinogenesis"},{"key":"key\n\t\t\t\t20170614055012_b16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrg1746","article-title":"The role of double-strand break repair\u2014insights from human genetics","volume":"7","author":"O'Driscoll","year":"2006","journal-title":"Nat. Rev. Genet."},{"key":"key\n\t\t\t\t20170614055012_b17","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.dnarep.2004.04.009","article-title":"Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis","volume":"3","author":"Taylor","year":"2004","journal-title":"DNA Repair (Amst.)"},{"key":"key\n\t\t\t\t20170614055012_b18","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0092-8674(00)81547-0","article-title":"The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder","volume":"99","author":"Stewart","year":"1999","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170614055012_b19","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/nrm831","article-title":"Cellular roles of DNA topoisomerases: a molecular perspective","volume":"3","author":"Wang","year":"2002","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170614055012_b20","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.mrfmmm.2003.08.016","article-title":"Repair of and checkpoint response to topoisomerase I-mediated DNA damage","volume":"532","author":"Pommier","year":"2003","journal-title":"Mutat. Res."},{"key":"key\n\t\t\t\t20170614055012_b21","doi-asserted-by":"crossref","first-page":"4657","DOI":"10.1093\/nar\/gkh796","article-title":"Design and synthesis of fluorescent substrates for human tyrosyl-DNA phosphodiesterase I","volume":"32","author":"Rideout","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170614055012_b22","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.1128\/MCB.8.8.3026","article-title":"Camptothecin, a specific inhibitor of type I DNA topoisomerase, induces DNA breakage at replication forks","volume":"8","author":"Avemann","year":"1988","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170614055012_b23","first-page":"6365","article-title":"Differential requirement of DNA replication for the cytotoxicity of DNA topoisomerase I and II inhibitors in Chinese hamster DC3F cells","volume":"49","author":"Holm","year":"1989","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t20170614055012_b24","first-page":"5077","article-title":"Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin","volume":"49","author":"Hsiang","year":"1989","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t20170614055012_b25","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1093\/nar\/19.12.3295","article-title":"Camptothecin cytotoxicity in mammalian cells is associated with the induction of persistent double strand breaks in replicating DNA","volume":"19","author":"Ryan","year":"1991","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170614055012_b26","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1128\/MCB.20.11.3977-3987.2000","article-title":"Conversion of topoisomerase I cleavage complexes on the leading strand of ribosomal DNA into 5\u2032-phosphorylated DNA double-strand breaks by replication runoff","volume":"20","author":"Strumberg","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170614055012_b27","doi-asserted-by":"crossref","first-page":"5613","DOI":"10.1021\/bi00475a028","article-title":"Camptothecin-stabilized topoisomerase I-DNA adducts cause premature termination of transcription","volume":"29","author":"Bendixen","year":"1990","journal-title":"Biochemistry"},{"key":"key\n\t\t\t\t20170614055012_b28","doi-asserted-by":"crossref","first-page":"4181","DOI":"10.1093\/nar\/25.21.4181","article-title":"Processing of topoisomerase I cleavable complexes into DNA damage by transcription","volume":"25","author":"Wu","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170614055012_b29","doi-asserted-by":"crossref","first-page":"8495","DOI":"10.1093\/nar\/17.21.8495","article-title":"Interaction of topoisomerase 1 with the transcribed region of the Drosophila HSP 70 heat shock gene","volume":"17","author":"Kroeger","year":"1989","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170614055012_b30","doi-asserted-by":"crossref","first-page":"27245","DOI":"10.1074\/jbc.273.42.27245","article-title":"Induction of topoisomerase I cleavage complexes by the vinyl chloride adduct 1,N6-ethenoadenine","volume":"273","author":"Pourquier","year":"1998","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170614055012_b31","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1073\/pnas.040397497","article-title":"Benzo[a]pyrene diol epoxide adducts in DNA are potent suppressors of a normal topoisomerase I cleavage site and powerful inducers of other topoisomerase I cleavages","volume":"97","author":"Pommier","year":"2000","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170614055012_b32","first-page":"53","article-title":"Topoisomerase I-mediated cytotoxicity of N-methyl-N\u2032-nitro-N-nitrosoguanidine: trapping of topoisomerase I by the O6-methylguanine","volume":"61","author":"Pourquier","year":"2001","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t20170614055012_b33","doi-asserted-by":"crossref","first-page":"10739","DOI":"10.1073\/pnas.190312697","article-title":"Position-specific trapping of topoisomerase I-DNA cleavage complexes by intercalated benzo[a]-pyrene diol epoxide adducts at the 6-amino group of adenine","volume":"97","author":"Pommier","year":"2000","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170614055012_b34","doi-asserted-by":"crossref","first-page":"26441","DOI":"10.1074\/jbc.272.42.26441","article-title":"Trapping of mammalian topoisomerase I and recombinations induced by damaged DNA containing nicks or gaps. Importance of DNA end phosphorylation and camptothecin effects","volume":"272","author":"Pourquier","year":"1997","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170614055012_b35","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0167-4781(99)00198-0","article-title":"Mapping of eukaryotic DNA topoisomerase I catalyzed cleavage without concomitant religation in the vicinity of DNA structural anomalies","volume":"1489","author":"Christiansen","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"key\n\t\t\t\t20170614055012_b36","doi-asserted-by":"crossref","first-page":"6978","DOI":"10.1074\/jbc.271.12.6978","article-title":"Human DNA topoisomerase I-mediated cleavages stimulated by ultraviolet light-induced DNA damage","volume":"271","author":"Lanza","year":"1996","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170614055012_b37","doi-asserted-by":"crossref","first-page":"7792","DOI":"10.1074\/jbc.272.12.7792","article-title":"Effects of uracil incorporation, DNA mismatches, and abasic sites on cleavage and religation activities of mammalian topoisomerase I","volume":"272","author":"Pourquier","year":"1997","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170614055012_b38","doi-asserted-by":"crossref","first-page":"11534","DOI":"10.1073\/pnas.93.21.11534","article-title":"A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases","volume":"93","author":"Yang","year":"1996","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170614055012_b39","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1126\/science.286.5439.552","article-title":"Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes","volume":"286","author":"Pouliot","year":"1999","journal-title":"Science"},{"key":"key\n\t\t\t\t20170614055012_b40","doi-asserted-by":"crossref","first-page":"3697","DOI":"10.1046\/j.1432-1033.2002.03059.x","article-title":"Kinetic studies of human tyrosyl-DNA phosphodiesterase, an enzyme in the topoisomerase I DNA repair pathway","volume":"269","author":"Cheng","year":"2002","journal-title":"Eur. J. Biochem."},{"key":"key\n\t\t\t\t20170614055012_b41","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S1097-2765(04)00056-5","article-title":"Repair of DNA covalently linked to protein","volume":"13","author":"Connelly","year":"2004","journal-title":"Mol. Cell"},{"key":"key\n\t\t\t\t20170614055012_b42","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1021\/jm030487x","article-title":"Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes","volume":"47","author":"Davies","year":"2004","journal-title":"J. Med. Chem."},{"key":"key\n\t\t\t\t20170614055012_b43","doi-asserted-by":"crossref","first-page":"12009","DOI":"10.1073\/pnas.211429198","article-title":"The tyrosyl-DNA phosphodiesterase Tdp1 is a member of the phospholipase D superfamily","volume":"98","author":"Interthal","year":"2001","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170614055012_b44","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0969-2126(02)00707-4","article-title":"The crystal structure of human tyrosyl-DNA phosphodiesterase, Tdp1","volume":"10","author":"Davies","year":"2002","journal-title":"Structure (Camb.)"},{"key":"key\n\t\t\t\t20170614055012_b45","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S1074-5521(03)00021-8","article-title":"Crystal structure of a transition state mimic for Tdp1 assembled from vanadate, DNA, and a topoisomerase I-derived peptide","volume":"10","author":"Davies","year":"2003","journal-title":"Chem. Biol."},{"key":"key\n\t\t\t\t20170614055012_b46","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1534\/genetics.104.028795","article-title":"Multiple endonucleases function to repair covalent topoisomerase I complexes in Saccharomyces cerevisiae","volume":"170","author":"Deng","year":"2005","journal-title":"Genetics"},{"key":"key\n\t\t\t\t20170614055012_b47","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1046\/j.1365-2443.2001.00452.x","article-title":"Pathways for repair of topoisomerase I covalent complexes in Saccharomyces cerevisiae","volume":"6","author":"Pouliot","year":"2001","journal-title":"Genes Cells"},{"key":"key\n\t\t\t\t20170614055012_b48","doi-asserted-by":"crossref","first-page":"13669","DOI":"10.1073\/pnas.202242599","article-title":"Yeast Tdp1 and Rad1-Rad10 function as redundant pathways for repairing Top1 replicative damage","volume":"99","author":"Vance","year":"2002","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170614055012_b49","first-page":"2834","article-title":"Effects of camptothecin on the breakage and repair of DNA during the cell cycle","volume":"33","author":"Horwitz","year":"1973","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t20170614055012_b50","first-page":"6919","article-title":"Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons","volume":"50","author":"D'Arpa","year":"1990","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t20170614055012_b51","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1093\/carcin\/15.5.823","article-title":"Different fates of camptothecin-induced replication fork-associated double-strand DNA breaks in mammalian cells","volume":"15","author":"Ryan","year":"1994","journal-title":"Carcinogenesis"},{"key":"key\n\t\t\t\t20170614055012_b52","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s004390050903","article-title":"Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced apoptosis in S-phase","volume":"104","author":"Poot","year":"1999","journal-title":"Hum. Genet."},{"key":"key\n\t\t\t\t20170614055012_b53","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1158\/1535-7163.393.3.4","article-title":"Homologous recombination is a highly conserved determinant of the synergistic cytotoxicity between cisplatin and DNA topoisomerase I poisons","volume":"3","author":"van Waardenburg","year":"2004","journal-title":"Mol. Cancer Ther."},{"key":"key\n\t\t\t\t20170614055012_b54","doi-asserted-by":"crossref","first-page":"20303","DOI":"10.1074\/jbc.M300198200","article-title":"Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes","volume":"278","author":"Furuta","year":"2003","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170614055012_b55","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1124\/mol.61.4.742","article-title":"Induction of biphasic DNA double strand breaks and activation of multiple repair protein complexes by DNA topoisomerase I drug 7-ethyl-10-hydroxy-camptothecin","volume":"61","author":"Wu","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"key\n\t\t\t\t20170614055012_b56","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1006\/jmbi.2001.4564","article-title":"DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells","volume":"307","author":"Arnaudeau","year":"2001","journal-title":"J. Mol. Biol."},{"key":"key\n\t\t\t\t20170614055012_b57","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1093\/emboj\/18.5.1397","article-title":"Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA\u2013PK complexes","volume":"18","author":"Shao","year":"1999","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170614055012_b58","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0169-328X(01)00008-0","article-title":"Hippocampal neurons of mice deficient in DNA-dependent protein kinase exhibit increased vulnerability to DNA damage, oxidative stress and excitotoxicity","volume":"87","author":"Culmsee","year":"2001","journal-title":"Brain Res. Mol. Brain Res."},{"key":"key\n\t\t\t\t20170614055012_b59","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1093\/nar\/30.10.2172","article-title":"Mammalian Rad51C contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability","volume":"30","author":"Godthelp","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170614055012_b60","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/carcin\/24.2.249","article-title":"Reduced apoptotic response to camptothecin in CHO cells deficient in XRCC3","volume":"24","author":"Hinz","year":"2003","journal-title":"Carcinogenesis"},{"key":"key\n\t\t\t\t20170614055012_b61","doi-asserted-by":"crossref","DOI":"10.1124\/mol.105.021865","article-title":"Inhibition of human tyrosyl-DNA phosphodiesterase (Tdp1) by aminoglycoside antibiotics and ribosome inhibitors","author":"Liao","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"key\n\t\t\t\t20170614055012_b62","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1038\/sj.emboj.7600694","article-title":"SCAN1 mutant Tdp1 accumulates the enzyme\u2014DNA intermediate and causes camptothecin hypersensitivity","volume":"24","author":"Interthal","year":"2005","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170614055012_b63","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nature03314","article-title":"Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1","volume":"434","author":"El-Khamisy","year":"2005","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170614055012_b64","doi-asserted-by":"crossref","first-page":"27162","DOI":"10.1074\/jbc.M204688200","article-title":"Conversion of phosphoglycolate to phosphate termini on 3\u2032-overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1","volume":"277","author":"Inamdar","year":"2002","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170614055012_b65","doi-asserted-by":"crossref","first-page":"36518","DOI":"10.1074\/jbc.M508898200","article-title":"Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages","volume":"280","author":"Interthal","year":"2005","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170614055012_b66","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.dnarep.2004.03.030","article-title":"The role of TDP1 from budding yeast in the repair of DNA damage","volume":"3","author":"Liu","year":"2004","journal-title":"DNA Repair (Amst.)"},{"key":"key\n\t\t\t\t20170614055012_b67","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/nar\/gki170","article-title":"Deficiency in 3\u2032-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)","volume":"33","author":"Zhou","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170614055012_b68","doi-asserted-by":"crossref","first-page":"3531","DOI":"10.1093\/nar\/gkh676","article-title":"APE1 is the major 3\u2032-phosphoglycolate activity in human cell extracts","volume":"32","author":"Parsons","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170614055012_b69","doi-asserted-by":"crossref","first-page":"8516","DOI":"10.1074\/jbc.274.13.8516","article-title":"Induction of reversible complexes between eukaryotic DNA topoisomerase I and DNA-containing oxidative base damages. 7, 8-dihydro-8-oxoguanine and 5-hydroxycytosine","volume":"274","author":"Pourquier","year":"1999","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170614055012_b70","doi-asserted-by":"crossref","first-page":"12102","DOI":"10.1073\/pnas.192282699","article-title":"8-Oxoguanine rearranges the active site of human topoisomerase I","volume":"99","author":"Lesher","year":"2002","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170614055012_b71","doi-asserted-by":"crossref","first-page":"12461","DOI":"10.1074\/jbc.M212930200","article-title":"Structural impact of the leukemia drug 1-beta-D-arabinofuranosylcytosine (Ara-C) on the covalent human topoisomerase I-DNA complex","volume":"278","author":"Chrencik","year":"2003","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170614055012_b72","doi-asserted-by":"crossref","first-page":"14587","DOI":"10.1074\/jbc.M311370200","article-title":"Hydrogen peroxide induces topoisomerase I-mediated DNA damage and cell death","volume":"279","author":"Daroui","year":"2004","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170614055012_b73","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/S1568-7864(03)00116-2","article-title":"Association of XRCC1 and tyrosyl DNA phosphodiesterase (Tdp1) for the repair of topoisomerase I-mediated DNA lesions","volume":"2","author":"Plo","year":"2003","journal-title":"DNA Repair (Amst.)"},{"key":"key\n\t\t\t\t20170614055012_b74","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1128\/MCB.20.2.735-740.2000","article-title":"A cell cycle-specific requirement for the XRCC1 BRCT II domain during mammalian DNA strand break repair","volume":"20","author":"Taylor","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170614055012_b75","doi-asserted-by":"crossref","first-page":"13649","DOI":"10.1073\/pnas.250477597","article-title":"Mutation of a BRCT domain selectively disrupts DNA single-strand break repair in noncycling Chinese hamster ovary cells","volume":"97","author":"Moore","year":"2000","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170614055012_b76","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0921-8777(00)00028-8","article-title":"Abasic site recognition by two apurinic\/apyrimidinic endonuclease families in DNA base excision repair: the 3\u2032 ends justify the means","volume":"460","author":"Mol","year":"2000","journal-title":"Mutat. Res."},{"key":"key\n\t\t\t\t20170614055012_b77","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/82818","article-title":"Passing the baton in base excision repair","volume":"7","author":"Wilson","year":"2000","journal-title":"Nat. Struct. Biol."},{"key":"key\n\t\t\t\t20170614055012_b78","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1042\/bst0310247","article-title":"Protein\u2013protein interactions during mammalian DNA single-strand break repair","volume":"31","author":"Caldecott","year":"2003","journal-title":"Biochem. Soc. Trans."},{"key":"key\n\t\t\t\t20170614055012_b79","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.dnarep.2004.06.017","article-title":"The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4","volume":"3","author":"Clements","year":"2004","journal-title":"DNA Repair (Amst.)"},{"key":"key\n\t\t\t\t20170614055012_b80","doi-asserted-by":"crossref","first-page":"6530","DOI":"10.1093\/emboj\/20.22.6530","article-title":"XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein\u2013protein interactions","volume":"20","author":"Vidal","year":"2001","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170614055012_b81","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0092-8674(01)00195-7","article-title":"XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair","volume":"104","author":"Whitehouse","year":"2001","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170614055012_b82","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S1568-7864(01)00007-6","article-title":"ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage","volume":"1","author":"Barzilai","year":"2002","journal-title":"DNA Repair (Amst.)"},{"key":"key\n\t\t\t\t20170614055012_b83","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1083\/jcb.134.3.757","article-title":"Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: evidence for cell cycle-independent toxicity","volume":"134","author":"Morris","year":"1996","journal-title":"J. Cell. Biol."},{"key":"key\n\t\t\t\t20170614055012_b84","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1111\/j.1471-4159.1970.tb03373.x","article-title":"Differential metabolism of RNA in neuronal-enriched and glial-enriched fractions of rat cerebrum","volume":"17","author":"Flangas","year":"1970","journal-title":"J. Neurochem."},{"key":"key\n\t\t\t\t20170614055012_b85","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0014-5793(76)80897-6","article-title":"Comparison of the number of RNA initiation sites in rat brain fractions enriched in neuronal or glial nuclei","volume":"72","author":"Sarkander","year":"1976","journal-title":"FEBS Lett."},{"key":"key\n\t\t\t\t20170614055012_b86","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/BF00237292","article-title":"Studies on the regulation of RNA synthesis in neuronal and glial nuclei isolated from rat brain","volume":"31","author":"Sarkander","year":"1978","journal-title":"Exp. Brain Res."},{"key":"key\n\t\t\t\t20170614055012_b87","first-page":"24","article-title":"Skeletal muscle adaptation and cell cycle regulation","volume":"28","author":"Yan","year":"2000","journal-title":"Exerc. Sport Sci. Rev."},{"key":"key\n\t\t\t\t20170614055012_b88","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1006\/cbir.2000.0499","article-title":"Satellite cell regulation following myotrauma caused by resistance exercise","volume":"24","author":"Vierck","year":"2000","journal-title":"Cell Biol. Int."},{"key":"key\n\t\t\t\t20170614055012_b89","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1568-7864(01)00005-2","article-title":"DNA repair in terminally differentiated cells","volume":"1","author":"Nouspikel","year":"2002","journal-title":"DNA Repair (Amst.)"}],"container-title":["Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/mutage\/article-pdf\/21\/4\/219\/17710755\/gel024.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,7]],"date-time":"2023-05-07T18:49:54Z","timestamp":1683485394000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mutage\/article-lookup\/doi\/10.1093\/mutage\/gel024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6,14]]},"references-count":89,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2006,6,14]]},"published-print":{"date-parts":[[2006,7]]}},"URL":"https:\/\/doi.org\/10.1093\/mutage\/gel024","relation":{},"ISSN":["1464-3804","0267-8357"],"issn-type":[{"value":"1464-3804","type":"electronic"},{"value":"0267-8357","type":"print"}],"subject":[],"published":{"date-parts":[[2006,6,14]]}}}