{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T19:55:55Z","timestamp":1762113355171},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1093\/mutage\/ges038","type":"journal-article","created":{"date-parts":[[2012,8,31]],"date-time":"2012-08-31T05:30:33Z","timestamp":1346391033000},"page":"721-729","source":"Crossref","is-referenced-by-count":15,"title":["The in vivo rat skin photomicronucleus assay: phototoxicity and photogenotoxicity evaluation of six fluoroquinolones"],"prefix":"10.1093","volume":"27","author":[{"given":"Astrid A.","family":"Reus","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Usta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia D.","family":"Kenny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Clements","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Pruimboom-Brees","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mike","family":"Aylott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony M.","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cyrille A.M","family":"Krul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2012,8,30]]},"reference":[{"key":"key\n\t\t\t\t20170515175604_CIT0001","doi-asserted-by":"crossref","first-page":"345","DOI":"10.2165\/00002018-200225050-00004","article-title":"Drug-induced cutaneous photosensitivity: incidence, mechanism, prevention and management.","volume":"25","author":"Moore","year":"2002","journal-title":"Drug Safety"},{"key":"key\n\t\t\t\t20170515175604_CIT0002","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1007\/s10227-005-0017-3","article-title":"Photosensitivity to exogenous agents.","volume":"8","author":"Lankerani","year":"2004","journal-title":"J. Cutan. Med. Surg."},{"key":"key\n\t\t\t\t20170515175604_CIT0003","doi-asserted-by":"crossref","first-page":"S139","DOI":"10.1016\/j.jaad.2007.12.007","article-title":"Skin DNA photodamage and its biological consequences.","volume":"58","author":"Marrot","year":"2008","journal-title":"J. Am. Acad. Dermatol."},{"key":"key\n\t\t\t\t20170515175604_CIT0004","author":"EMEA\/CPMP","year":"2002"},{"key":"key\n\t\t\t\t20170515175604_CIT0005","author":"FDA\/CDER","year":"2003"},{"key":"key\n\t\t\t\t20170515175604_CIT0006","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/0278-6915(87)90177-3","article-title":"Phototoxicity testing\u2013in vivo and in vitro.","volume":"25","author":"Maurer","year":"1987","journal-title":"Food Chem. Toxicol."},{"key":"key\n\t\t\t\t20170515175604_CIT0007","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/mutage\/geq023","article-title":"Development and characterization of an in vivo skin photomicronucleus assay in rats","volume":"25","author":"Reus","year":"2010","journal-title":"Mutagenesis"},{"key":"key\n\t\t\t\t20170515175604_CIT0008","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/mutage\/10.4.343","article-title":"Genotoxicity of 17 gyrase and 4 mammalian topoisomerases II-poisons in prokaryotic and eukaryotic test systems","volume":"10","author":"Albertini","year":"1995","journal-title":"Mutagenesis"},{"key":"key\n\t\t\t\t20170515175604_CIT0009","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0378-4274(98)00235-5","article-title":"The photomutagenicity of fluoroquinolones and other drugs","volume":"102\u2013103","author":"Gocke","year":"1998","journal-title":"Toxicol. Lett"},{"key":"key\n\t\t\t\t20170515175604_CIT0010","first-page":"455","article-title":"Quinolones: a comprehensive review","volume":"65","author":"Oliphant","year":"2002","journal-title":"Am. Fam. Physician"},{"key":"key\n\t\t\t\t20170515175604_CIT0011","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1093\/mutage\/geg003","article-title":"Investigations into the concept of a threshold for topoisomerase inhibitor-induced clastogenicity","volume":"18","author":"Lynch","year":"2003","journal-title":"Mutagenesis"},{"key":"key\n\t\t\t\t20170515175604_CIT0012","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1111\/j.1751-1097.1995.tb02392.x","article-title":"Fluoroquinolone photosensitization: a review of clinical and laboratory studies","volume":"62","author":"Ferguson","year":"1995","journal-title":"Photochem. Photobiol"},{"key":"key\n\t\t\t\t20170515175604_CIT0013","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S1011-1344(96)07422-2","article-title":"Phototoxicity and possible enhancement of photocarcinogenesis by fluorinated quinolone antibiotics","volume":"37","author":"Urbach","year":"1997","journal-title":"J. Photochem. Photobiol. B: Biol"},{"key":"key\n\t\t\t\t20170515175604_CIT0014","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/mutage\/11.5.497","article-title":"The photomutagenicity of fluoroquinolones in tests for gene mutation, chromosomal abberation, gene conversion and DNA breakage (Comet assay)","volume":"11","author":"Ch\u00e9talat","year":"1996","journal-title":"Mutagenesis"},{"key":"key\n\t\t\t\t20170515175604_CIT0015","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1562\/0031-8655(2003)077<0077:PITTAM>2.0.CO;2","article-title":"Photocarcinogenesis in the Tg.AC mouse: Lomefloxacin and 8-methoxypsoralen","volume":"77","author":"Chignell","year":"2003","journal-title":"Photochem. Photobiol"},{"key":"key\n\t\t\t\t20170515175604_CIT0016","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S1383-5718(02)00198-5","article-title":"In vivo photochemical micronucleus induction due to certain quinolone antimicrobial agents in the skin of hairless mice","volume":"520","author":"Itoh","year":"2002","journal-title":"Mutat. Res"},{"key":"key\n\t\t\t\t20170515175604_CIT0017","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S1011-1344(96)07424-6","article-title":"Fluoroquinolone antibacterials enhance UVA-induced skin tumours","volume":"37","author":"Klecak","year":"1997","journal-title":"J. Photochem. Photobiol. B: Biol"},{"key":"key\n\t\t\t\t20170515175604_CIT0018","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S1011-1344(96)07425-8","article-title":"Quinolone antibacterials: a new class of photochemical carcinogens","volume":"37","author":"M\u00e4kinen","year":"1997","journal-title":"J. Photochem. Photobiol. B: Biol"},{"key":"key\n\t\t\t\t20170515175604_CIT0019","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1039\/b715756h","article-title":"Detection of photogenotoxicity in skin and eye in rat with the photo comet assay","volume":"7","author":"Struwe","year":"2008","journal-title":"Photochem. Photobiol. Sci"},{"key":"key\n\t\t\t\t20170515175604_CIT0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mrgentox.2006.05.009","article-title":"Photo-chemically induced DNA effects in the comet assay with epidermal cells of SKH-1 mice after a single oral administration of different fluoroquinolones and 8-methoxypsoralen in combination with exposure to UVA","volume":"609","author":"Wirnitzer","year":"2006","journal-title":"Mutat. Res"},{"key":"key\n\t\t\t\t20170515175604_CIT0021","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0887-2333(01)00089-3","article-title":"In vitro method for prediction of the phototoxic potentials of fluoroquinolones","volume":"15","author":"Yamamoto","year":"2001","journal-title":"Toxicol. In Vitro"},{"key":"key\n\t\t\t\t20170515175604_CIT0022","first-page":"171","article-title":"Compare two methods of measuring DNA damage induced by photogenotoxicity of fluoroquinolones","volume":"25","author":"Zhang","year":"2004","journal-title":"Acta Pharmacol. Sin"},{"key":"key\n\t\t\t\t20170515175604_CIT0023","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.mrgentox.2007.04.014","article-title":"The photo comet assay \u2013 A fast screening assay for the determination of photogenotoxicity in vitro","volume":"632","author":"Struwe","year":"2007","journal-title":"Mutat. Res"},{"key":"key\n\t\t\t\t20170515175604_CIT0024","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jphotobiol.2004.11.014","article-title":"Evaluation of phototoxic and photoallergic potentials of 13 compounds by different in vitro and in vivo methods","volume":"79","author":"Neumann","year":"2005","journal-title":"J. Photochem. Photobiol. B"},{"key":"key\n\t\t\t\t20170515175604_CIT0025","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1002\/cbdv.200490061","article-title":"Photophysical and phototoxic properties of the antibacterial fluoroquinolones levofloxacin and moxifloxacin","volume":"1","author":"Viola","year":"2004","journal-title":"Chem. Biodivers"},{"key":"key\n\t\t\t\t20170515175604_CIT0026","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1177\/019262339302100606","article-title":"Phototoxic lesions induced by quinolone antibacterial agents in auricular skin and retina of albino mice","volume":"21","author":"Shimoda","year":"1993","journal-title":"Toxicol. Pathol"},{"key":"key\n\t\t\t\t20170515175604_CIT0027","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.toxlet.2005.02.006","article-title":"Structure-phototoxicity relationship in Balb\/c mice treated with fluoroquinolone derivatives, followed by ultraviolet-A irradiation","volume":"157","author":"Yabe","year":"2005","journal-title":"Toxicol. Lett"},{"key":"key\n\t\t\t\t20170515175604_CIT0028","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0027-5107(76)90105-6","article-title":"The production of micronuclei from chromosome aberrations in irradiated cultures of human lymphocytes","volume":"41","author":"Countryman","year":"1976","journal-title":"Mutat. Res."},{"key":"key\n\t\t\t\t20170515175604_CIT0029","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1006\/taap.1999.8653","article-title":"In vitro photogenotoxic activity of clinafoxacin: a paradigm predicting photocarcinogenicity","volume":"156","author":"Bulera","year":"1999","journal-title":"Toxicol. Appl. Pharm"},{"key":"key\n\t\t\t\t20170515175604_CIT0030","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/jid.2008.263","article-title":"Repair of sparfloxacin-induced photochemical DNA damage in vivo","volume":"129","author":"Struwe","year":"2009","journal-title":"J. Inv. Dermatol"},{"key":"key\n\t\t\t\t20170515175604_CIT0031","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mrgentox.2007.03.007","article-title":"In vivo photochemical skin micronucleus test using a sunlight simulator: detection of 8-methoxypsoralen and benzo[a]pyrene in hairless mice","volume":"631","author":"Hara","year":"2007","journal-title":"Mutat. Res"},{"key":"key\n\t\t\t\t20170515175604_CIT0032","doi-asserted-by":"crossref","first-page":"30761","DOI":"10.1016\/S0021-9258(18)47344-9","article-title":"CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme","volume":"269","author":"Fernandes-Alnemri","year":"1994","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t20170515175604_CIT0033","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1385\/1-59259-973-7:073","article-title":"Cytometric Assessment of Histone H2AX Phosphorylation: A Reporter of DNA Damage","volume":"314","author":"Huang","year":"2006","journal-title":"Methods Mol. Biol"},{"key":"key\n\t\t\t\t20170515175604_CIT0034","doi-asserted-by":"crossref","first-page":"614","DOI":"10.4161\/cc.2.6.565","article-title":"DNA damage induced by DNA topoisomerase I- and topoisomerase II-inhibitors detected by histone H2AX phosphorylation in relation to the cell cycle phase and apoptosis","volume":"2","author":"Huang","year":"2003","journal-title":"Cell Cycle"},{"key":"key\n\t\t\t\t20170515175604_CIT0035","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/cyto.a.20018","article-title":"Assessment of histone H2AX phosphorylation induced by DNA topoisomerase I and II inhibitors topotecan and mitoxantrone and by the DNA cross-linking agent cisplatin","volume":"58","author":"Huang","year":"2004","journal-title":"Cytometry A"},{"key":"key\n\t\t\t\t20170515175604_CIT0036","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1038\/sj.onc.1204326","article-title":"Histone H3 phosphorylation and cell division","volume":"20","author":"Hans","year":"2001","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20170515175604_CIT0037","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/(SICI)1097-4652(200003)182:3<311::AID-JCP1>3.0.CO;2-9","article-title":"The Ki-67 protein: from the known and the unknown","volume":"182","author":"Scholzen","year":"2000","journal-title":"J. Cell. Physiol"},{"issue":"suppl. 32","key":"key\n\t\t\t\t20170515175604_CIT0038","first-page":"36.","article-title":"Measurement of stabilised topoisomerase cleavage complexes using the TARDIS assay","volume":"37","author":"Harvey","year":"2001","journal-title":"Environ. Mol. Mutagenesis"},{"key":"key\n\t\t\t\t20170515175604_CIT0039","first-page":"56.","article-title":"Is Muta\u2122Mouse insensitive to clastogens?","volume":"17","author":"Bradford","year":"2002","journal-title":"Mutagenesis"},{"key":"key\n\t\t\t\t20170515175604_CIT0040","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/mutage\/geq075","article-title":"Micronuclei frequency in peripheral blood lymphocytes and cancer risk: evidence from human studies","volume":"26","author":"Bonassi","year":"2011","journal-title":"Mutagenesis"}],"container-title":["Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/mutage\/article-pdf\/27\/6\/721\/17087611\/ges038.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T00:03:07Z","timestamp":1643328187000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mutage\/article-lookup\/doi\/10.1093\/mutage\/ges038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,30]]},"references-count":40,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2012,8,30]]},"published-print":{"date-parts":[[2012,11]]}},"URL":"https:\/\/doi.org\/10.1093\/mutage\/ges038","relation":{},"ISSN":["1464-3804","0267-8357"],"issn-type":[{"value":"1464-3804","type":"electronic"},{"value":"0267-8357","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8,30]]}}}