{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:47:41Z","timestamp":1761238061010},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1093\/mutage\/get065","type":"journal-article","created":{"date-parts":[[2014,1,14]],"date-time":"2014-01-14T04:44:47Z","timestamp":1389674687000},"page":"101-106","source":"Crossref","is-referenced-by-count":14,"title":["Folate deficiency is not associated with increased mitochondrial genomic instability: results from dietary intake and lymphocytic mtDNA 4977-bp deletion in healthy young women in Italy"],"prefix":"10.1093","volume":"29","author":[{"given":"Antonella","family":"Agodi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Barchitta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annalisa","family":"Quattrocchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Elisa","family":"Marchese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Boffetta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,1,13]]},"reference":[{"key":"key\n\t\t\t\t20170517094956_CIT0001","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/carcin\/bgp269","article-title":"Biomarkers in cancer epidemiology: an integrative approach","volume":"31","author":"Boffetta","year":"(2010)","journal-title":"Carcinogenesis"},{"key":"key\n\t\t\t\t20170517094956_CIT0002","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0378-4274(01)00288-0","article-title":"The use of surrogate endpoints to assess potential toxicity in humans","volume":"120","author":"Renwick","year":"(2001)","journal-title":"Toxicol. Lett."},{"key":"key\n\t\t\t\t20170517094956_CIT0003","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/S0278-6915(03)00064-4","article-title":"Risk characterisation of chemicals in food and diet","volume":"41","author":"Renwick","year":"(2003)","journal-title":"Food Chem. Toxicol."},{"key":"key\n\t\t\t\t20170517094956_CIT0004","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1073\/pnas.94.2.514","article-title":"Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress","volume":"94","author":"Yakes","year":"(1997)","journal-title":"Proc. Natl Acad. Sci. U. S. A."},{"key":"key\n\t\t\t\t20170517094956_CIT0005","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1471-2350-12-8","article-title":"The mitochondrial DNA 4,977-bp deletion and its implication in copy number alteration in colorectal cancer","volume":"12","author":"Chen","year":"(2011)","journal-title":"BMC Med. Genet."},{"key":"key\n\t\t\t\t20170517094956_CIT0006","doi-asserted-by":"crossref","first-page":"e67953","DOI":"10.1371\/journal.pone.0067953","article-title":"Mitochondrial common deletion, a potential biomarker for cancer occurrence, is selected against in cancer background: a meta-analysis of 38 studies","volume":"8","author":"Nie","year":"(2013)","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170517094956_CIT0007","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.exger.2008.03.004","article-title":"The 4977bp deletion of mitochondrial DNA in human skeletal muscle, heart and different areas of the brain: a useful biomarker or more?","volume":"43","author":"Meissner","year":"(2008)","journal-title":"Exp. Gerontol."},{"key":"key\n\t\t\t\t20170517094956_CIT0008","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0531-5565(01)00200-5","article-title":"Mitochondrial DNA damage in lymphocytes: a role in immunosenescence?","volume":"37","author":"Ross","year":"(2002)","journal-title":"Exp. Gerontol."},{"key":"key\n\t\t\t\t20170517094956_CIT0009","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.mad.2010.01.005","article-title":"Low level of the mtDNA(4977) deletion in blood of exceptionally old individuals","volume":"131","author":"von Wurmb-Schwark","year":"(2010)","journal-title":"Mech. Ageing Dev."},{"key":"key\n\t\t\t\t20170517094956_CIT0010","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s00394-009-0031-0","article-title":"Mitochondrial DNA deletions of blood lymphocytes as genetic markers of low folate-related mitochondrial genotoxicity in peripheral tissues","volume":"48","author":"Chou","year":"(2009)","journal-title":"Eur. J. Nutr."},{"key":"key\n\t\t\t\t20170517094956_CIT0011","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1017\/S0007114509243054","article-title":"Lymphocytic mitochondrial DNA deletions, biochemical folate status and hepatocellular carcinoma susceptibility in a case\u2013control study","volume":"102","author":"Wu","year":"(2009)","journal-title":"Br. J. Nutr."},{"key":"key\n\t\t\t\t20170517094956_CIT0012","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0140-6736(91)90133-A","article-title":"Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Medical Research Council Vitamin Study Research Group","volume":"338","year":"(1991)","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170517094956_CIT0013","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1093\/ajcn\/83.5.993","article-title":"Folate and human reproduction","volume":"83","author":"Tamura","year":"(2006)","journal-title":"Am. J. Clin. Nutr."},{"key":"key\n\t\t\t\t20170517094956_CIT0014","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1740-8709.2010.00261.x","article-title":"Perinatal folate supply: relevance in health outcome parameters","volume":"6","author":"Fekete","year":"(2010)","journal-title":"Matern. Child Nutr."},{"key":"key\n\t\t\t\t20170517094956_CIT0015","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1158\/1055-9965.EPI-09-0493","article-title":"Folate status and aberrant DNA methylation are associated with HPV infection and cervical pathogenesis","volume":"18","author":"Flatley","year":"(2009)","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"key\n\t\t\t\t20170517094956_CIT0016","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/mnfr.200600191","article-title":"Folate and colorectal cancer: an evidence-based critical review","volume":"51","author":"Kim","year":"(2007)","journal-title":"Mol. Nutr. Food Res."},{"key":"key\n\t\t\t\t20170517094956_CIT0017","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1158\/1940-6207.CAPR-08-0175","article-title":"Lower risk of cervical intraepithelial neoplasia in women with high plasma folate and sufficient vitamin B12 in the post-folic acid fortification era","volume":"2","author":"Piyathilake","year":"(2009)","journal-title":"Cancer Prev. Res."},{"key":"key\n\t\t\t\t20170517094956_CIT0018","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/IGC.0b013e3181c20842","article-title":"Distribution of p53, GST, and MTHFR polymorphisms and risk of cervical intraepithelial lesions in Sicily","volume":"20","author":"Agodi","year":"(2010)","journal-title":"Int. J. Gynecol. Cancer"},{"key":"key\n\t\t\t\t20170517094956_CIT0019","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1093\/mutage\/gel031","article-title":"Effects of folic acid deficiency and MTHFR C677T polymorphism on spontaneous and radiation-induced micronuclei in human lymphocytes","volume":"21","author":"Leopardi","year":"(2006)","journal-title":"Mutagenesis"},{"key":"key\n\t\t\t\t20170517094956_CIT0020","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1038\/ejcn.2011.125","article-title":"Increase in the prevalence of the MTHFR 677 TT polymorphism in women born since 1959: potential implications for folate requirements","volume":"65","author":"Agodi","year":"(2011)","journal-title":"Eur. J. Clin. Nutr."},{"key":"key\n\t\t\t\t20170517094956_CIT0021","first-page":"1","article-title":"Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee","volume":"854","author":"World Health Organization","year":"(1995)","journal-title":"World Health Organ. Tech. Rep. Ser."},{"key":"key\n\t\t\t\t20170517094956_CIT0022","volume-title":"Institute of Medicine Dietary Reference Intakes","author":"Food and Nutrition Board","year":"(2001)"},{"key":"key\n\t\t\t\t20170517094956_CIT0023","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1159\/000346962","article-title":"Dietary folate intake and blood biomarkers reveal high-risk groups in a Mediterranean population of healthy women of childbearing potential","volume":"63","author":"Agodi","year":"(2013)","journal-title":"Ann. Nutr. Metab."},{"key":"key\n\t\t\t\t20170517094956_CIT0024","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1093\/nar\/gnf067","article-title":"Detection and quantification of mitochondrial DNA deletions in individual cells by real-time PCR","volume":"30","author":"He","year":"(2002)","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170517094956_CIT0025","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"(2008)","journal-title":"Nat. Protoc."},{"key":"key\n\t\t\t\t20170517094956_CIT0026","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.exger.2003.10.011","article-title":"Detection of the 4977bp deletion of mitochondrial DNA in different human blood cells","volume":"39","author":"Mohamed","year":"(2004)","journal-title":"Exp. Gerontol."},{"key":"key\n\t\t\t\t20170517094956_CIT0027","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s10549-007-9613-9","article-title":"Quantitative analysis of mitochondrial DNA 4977-bp deletion in sporadic breast cancer and benign breast diseases","volume":"108","author":"Ye","year":"(2008)","journal-title":"Breast Cancer Res. Treat."},{"key":"key\n\t\t\t\t20170517094956_CIT0028","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.mrfmmm.2009.07.009","article-title":"Correlation analysis between mtDNA 4977-bp deletion and ageing","volume":"670","author":"Pavicic","year":"(2009)","journal-title":"Mutat. Res."},{"key":"key\n\t\t\t\t20170517094956_CIT0029","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s00394-012-0372-y","article-title":"Overweight and obesity prevalence and determinants in Italy: an update to 2010","volume":"52","author":"Gallus","year":"(2013)","journal-title":"Eur. J. Nutr."},{"key":"key\n\t\t\t\t20170517094956_CIT0030","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.cmet.2012.10.016","article-title":"Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance","volume":"16","author":"Vernochet","year":"(2012)","journal-title":"Cell Metab."},{"key":"key\n\t\t\t\t20170517094956_CIT0031","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1165\/ajrcmb.19.6.3130","article-title":"Smoking-associated mitochondrial DNA mutations and lipid peroxidation in human lung tissues","volume":"19","author":"Fahn","year":"(1998)","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"key\n\t\t\t\t20170517094956_CIT0032","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1093\/carcin\/bgi042","article-title":"Low intake of calcium, folate, nicotinic acid, vitamin E, retinol, beta-carotene and high intake of pantothenic acid, biotin and riboflavin are significantly associated with increased genome instability\u2014results from a dietary intake and micronucleus index survey in South Australia","volume":"26","author":"Fenech","year":"(2005)","journal-title":"Carcinogenesis"},{"key":"key\n\t\t\t\t20170517094956_CIT0033","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.mrfmmm.2011.11.003","article-title":"Folate (vitamin B9) and vitamin B12 and their function in the maintenance of nuclear and mitochondrial genome integrity","volume":"733","author":"Fenech","year":"(2012)","journal-title":"Mutat. Res."},{"key":"key\n\t\t\t\t20170517094956_CIT0034","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0027-5107(01)00168-3","article-title":"Recommended dietary allowances (RDAs) for genomic stability","volume":"480\u2013481","author":"Fenech","year":"(2001)","journal-title":"Mutat. Res."},{"key":"key\n\t\t\t\t20170517094956_CIT0035","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1017\/S0007114511005733","article-title":"Comparison of standardised dietary folate intake across ten countries participating in the European Prospective Investigation into Cancer and Nutrition","volume":"108","author":"Park","year":"(2005)","journal-title":"Br. J. Nutr."}],"container-title":["Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/mutage\/article-pdf\/29\/2\/101\/12703424\/get065.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T13:07:18Z","timestamp":1565096838000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mutage\/article-lookup\/doi\/10.1093\/mutage\/get065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,13]]},"references-count":35,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,1,13]]},"published-print":{"date-parts":[[2014,3]]}},"URL":"https:\/\/doi.org\/10.1093\/mutage\/get065","relation":{},"ISSN":["1464-3804","0267-8357"],"issn-type":[{"value":"1464-3804","type":"electronic"},{"value":"0267-8357","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1,13]]}}}