{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:02:11Z","timestamp":1791298931000,"version":"4.1.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1093\/mutage\/geu070","type":"journal-article","created":{"date-parts":[[2014,11,19]],"date-time":"2014-11-19T02:05:21Z","timestamp":1416362721000},"page":"277-286","source":"Crossref","is-referenced-by-count":13,"title":["Senescent bronchial fibroblasts induced to senescence by Cr(VI) promote epithelial\u2013mesenchymal transition when co-cultured with bronchial epithelial cells in the presence of Cr(VI)"],"prefix":"10.1093","volume":"30","author":[{"given":"Mariana Monteiro","family":"Val","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds Andr\u00e9","family":"Mendes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Alarc\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Carreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Fernando D.","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Carmen","family":"Alpoim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,11,17]]},"reference":[{"key":"key\n\t\t\t\t20170517095152_CIT0001","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1158\/1055-9965.EPI-10-0437","article-title":"Global patterns of cancer incidence and mortality rates and trends","volume":"19","author":"Jemal","year":"(2010)","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"key\n\t\t\t\t20170517095152_CIT0002","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3322\/caac.20107","article-title":"Global cancer statistics","volume":"61","author":"Jemal","year":"(2011)","journal-title":"CA. Cancer J. Clin."},{"key":"key\n\t\t\t\t20170517095152_CIT0003","doi-asserted-by":"crossref","first-page":"740","DOI":"10.6004\/jnccn.2010.0056","article-title":"Non-small cell lung cancer","volume":"8","author":"Ettinger","year":"(2010)","journal-title":"J. Natl. Compr. Canc. Netw."},{"key":"key\n\t\t\t\t20170517095152_CIT0004","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1039\/c2mt20074k","article-title":"Gene expression changes in human lung cells exposed to arsenic, chromium, nickel or vanadium indicate the first steps in cancer","volume":"4","author":"Clancy","year":"(2012)","journal-title":"Metallomics"},{"key":"key\n\t\t\t\t20170517095152_CIT0005","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1093\/toxsci\/kfg070","article-title":"Genotoxicity of samples of nickel refinery dust","volume":"73","author":"Clemens","year":"(2003)","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170517095152_CIT0006","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1165\/rcmb.2005-0213OC","article-title":"Molecular mechanisms of hexavalent chromium-induced apoptosis in human bronchoalveolar cells","volume":"33","author":"Russo","year":"(2005)","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"key\n\t\t\t\t20170517095152_CIT0007","first-page":"487","article-title":"Mechanism of apoptosis and determination of cellular fate in chromium(VI)-exposed populations of telomerase-immortalized human fibroblasts","volume":"12","author":"Pritchard","year":"(2001)","journal-title":"Cell Growth Differ."},{"key":"key\n\t\t\t\t20170517095152_CIT0008","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1021\/tx700198a","article-title":"Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium","volume":"21","author":"Salnikow","year":"(2008)","journal-title":"Chem. Res. Toxicol."},{"key":"key\n\t\t\t\t20170517095152_CIT0009","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s10555-010-9220-9","article-title":"Senescent cells as a source of inflammatory factors for tumor progression","volume":"29","author":"Davalos","year":"(2010)","journal-title":"Cancer Metastasis Rev."},{"key":"key\n\t\t\t\t20170517095152_CIT0010","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev-pathol-121808-102144","article-title":"The senescence-associated secretory phenotype: the dark side of tumor suppression","volume":"5","author":"Copp\u00e9","year":"(2010)","journal-title":"Annu. Rev. Pathol."},{"key":"key\n\t\t\t\t20170517095152_CIT0011","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s12307-011-0069-4","article-title":"Epithelial-mesenchymal transition induced by senescent fibroblasts","volume":"5","author":"Laberge","year":"(2012)","journal-title":"Cancer Microenviron."},{"key":"key\n\t\t\t\t20170517095152_CIT0012","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0092-8674(03)00401-X","article-title":"Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence","volume":"113","author":"Narita","year":"(2003)","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170517095152_CIT0013","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1242\/jcs.01635","article-title":"Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation","volume":"118","author":"Parrinello","year":"(2005)","journal-title":"J. Cell Sci."},{"key":"key\n\t\t\t\t20170517095152_CIT0014","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1158\/0008-5472.CAN-05-1716","article-title":"The gene expression program of prostate fibroblast senescence modulates neoplastic epithelial cell proliferation through paracrine mechanisms","volume":"66","author":"Bavik","year":"(2006)","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t20170517095152_CIT0015","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.mrfmmm.2009.07.004","article-title":"Human bronchial epithelial cells malignantly transformed by hexavalent chromium exhibit an aneuploid phenotype but no microsatellite instability","volume":"670","author":"Rodrigues","year":"(2009)","journal-title":"Mutat. Res."},{"key":"key\n\t\t\t\t20170517095152_CIT0016","doi-asserted-by":"crossref","first-page":"9363","DOI":"10.1073\/pnas.92.20.9363","article-title":"A biomarker that identifies senescent human cells in culture and in aging skin in vivo","volume":"92","author":"Dimri","year":"(1995)","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"key\n\t\t\t\t20170517095152_CIT0017","doi-asserted-by":"crossref","first-page":"3424","DOI":"10.1038\/sj.onc.1209399","article-title":"Effects of hTERT on metal ion-induced genomic instability","volume":"25","author":"Glaviano","year":"(2006)","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20170517095152_CIT0018","first-page":"353","article-title":"Carcinogenicity of hexavalent chromium","volume":"128","author":"Holmes","year":"(2008)","journal-title":"Indian J. Med. Res."},{"key":"key\n\t\t\t\t20170517095152_CIT0019","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/mc.20624","article-title":"Induction of morphological changes in BEAS-2B human bronchial epithelial cells following chronic sub-cytotoxic and mildly cytotoxic hexavalent chromium exposures","volume":"49","author":"Costa","year":"(2010)","journal-title":"Mol. Carcinog."},{"key":"key\n\t\t\t\t20170517095152_CIT0020","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1165\/rcmb.2005-0161OC","article-title":"Long-term cultures of polarized airway epithelial cells from patients with cystic fibrosis","volume":"34","author":"Wiszniewski","year":"(2006)","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"key\n\t\t\t\t20170517095152_CIT0021","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1600-0560.1996.tb01472.x","article-title":"Intermediate- and low-molecular-weight keratin detection with the monoclonal antibody MNF116. An immunohistochemical study on 232 paraffin-embedded cutaneous lesions","volume":"23","author":"Prieto","year":"(1996)","journal-title":"J. Cutan. Pathol."},{"key":"key\n\t\t\t\t20170517095152_CIT0022","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/modpathol.3880175","article-title":"Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: a survey of 435 cases","volume":"13","author":"Chu","year":"(2000)","journal-title":"Mod. Pathol."},{"key":"key\n\t\t\t\t20170517095152_CIT0023","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00428-011-1062-5","article-title":"EGFR\/erB-1, HER2\/erB-2, CK7, LP34, Ki67 and P53 expression in preneoplastic lesions of bronchial epithelium: an immunohistochemical and genetic study","volume":"458","author":"Sousa","year":"(2011)","journal-title":"Virchows Arch."},{"key":"key\n\t\t\t\t20170517095152_CIT0024","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1186\/1755-1536-5-S1-S5","article-title":"The myofibroblast, multiple origins for major roles in normal and pathological tissue repair","volume":"5","author":"Micallef","year":"(2012)","journal-title":"Fibrogenesis Tissue Repair"},{"key":"key\n\t\t\t\t20170517095152_CIT0025","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1016\/S0959-8049(12)71146-2","article-title":"exavalent Chromium, Cancer Stem Cells and Dedifferentiation: a view to a kill!. [abstract]","volume":"48","author":"Rodrigues","year":"(2012)","journal-title":"European Journal of Cancer"},{"key":"key\n\t\t\t\t20170517095152_CIT0026","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/sj.bjc.6604087","article-title":"Profiling influences of senescent and aged fibroblasts on prostate carcinogenesis","volume":"98","author":"Dean","year":"(2008)","journal-title":"Br. J. Cancer"},{"key":"key\n\t\t\t\t20170517095152_CIT0027","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1242\/jcs.089466","article-title":"Tiam1-regulated osteopontin in senescent fibroblasts contributes to the migration and invasion of associated epithelial cells","volume":"125","author":"Liu","year":"(2012)","journal-title":"J. Cell Sci."},{"key":"key\n\t\t\t\t20170517095152_CIT0028","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.exger.2006.02.006","article-title":"Senescent fibroblasts induce moderate stress in lung epithelial cells in vitro","volume":"41","author":"Bartling","year":"(2006)","journal-title":"Exp. Gerontol."},{"key":"key\n\t\t\t\t20170517095152_CIT0029","first-page":"1","article-title":"The role of senescent fibroblasts on epithelial cells malignant transformation","author":"Mendes","year":"(2011)","journal-title":"Diss. Univ. Coimbra"},{"key":"key\n\t\t\t\t20170517095152_CIT0030","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1183\/09031936.01.00069901","article-title":"Human lung fibroblasts secrete nerve growth factor: effect of inflammatory cytokines and glucocorticoids","volume":"18","author":"Olgart","year":"(2001)","journal-title":"Eur. Respir. J."},{"key":"key\n\t\t\t\t20170517095152_CIT0031","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/sj.jid.5700613","article-title":"Formation and function of the myofibroblast during tissue repair","volume":"127","author":"Hinz","year":"(2007)","journal-title":"J. Invest. Dermatol."},{"key":"key\n\t\t\t\t20170517095152_CIT0032","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.3748\/wjg.v20.i9.2237","article-title":"Pancreatic cancer stroma: understanding biology leads to new therapeutic strategies","volume":"20","author":"Rucki","year":"(2014)","journal-title":"World J. Gastroenterol."},{"key":"key\n\t\t\t\t20170517095152_CIT0033","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1471-2121-12-33","article-title":"Quantitative nucleolar proteomics reveals nuclear re-organization during stress- induced senescence in mouse fibroblast","volume":"12","author":"Kar","year":"(2011)","journal-title":"BMC Cell Biol."},{"key":"key\n\t\t\t\t20170517095152_CIT0034","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1165\/rcmb.2006-0169OC","article-title":"Cigarette smoke induces cellular senescence","volume":"35","author":"Nyunoya","year":"(2006)","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"key\n\t\t\t\t20170517095152_CIT0035","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.4161\/cc.20718","article-title":"Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production","volume":"11","author":"Capparelli","year":"(2012)","journal-title":"Cell Cycle"},{"key":"key\n\t\t\t\t20170517095152_CIT0036","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.taap.2013.03.006","article-title":"Epithelial-mesenchymal transition during oncogenic transformation induced by hexavalent chromium involves reactive oxygen species-dependent mechanism in lung epithelial cells","volume":"269","author":"Ding","year":"(2013)","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"key\n\t\t\t\t20170517095152_CIT0037","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.biocel.2006.11.005","article-title":"Fibroblasts and myofibroblasts: their source, function and role in disease","volume":"39","author":"McAnulty","year":"(2007)","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"key\n\t\t\t\t20170517095152_CIT0038","doi-asserted-by":"crossref","first-page":"9621","DOI":"10.1158\/0008-5472.CAN-10-1722","article-title":"Cancer exosomes trigger fibroblast to myofibroblast differentiation","volume":"70","author":"Webber","year":"(2010)","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t20170517095152_CIT0039","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.canlet.2008.02.068","article-title":"Differential impact of TGF-beta and EGF on fibroblast differentiation and invasion reciprocally promotes colon cancer cell invasion","volume":"266","author":"Denys","year":"(2008)","journal-title":"Cancer Lett."},{"key":"key\n\t\t\t\t20170517095152_CIT0040","article-title":"Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes","author":"Webber","year":"(2014)","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20170517095152_CIT0041","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1002\/ijc.23925","article-title":"Stromal myofibroblasts are drivers of invasive cancer growth","volume":"123","author":"De Wever","year":"(2008)","journal-title":"Int. J. Cancer"},{"key":"key\n\t\t\t\t20170517095152_CIT0042","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/nrc2620","article-title":"Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits","volume":"9","author":"Polyak","year":"(2009)","journal-title":"Nat. Rev. Cancer"},{"key":"key\n\t\t\t\t20170517095152_CIT0043","doi-asserted-by":"crossref","first-page":"745","DOI":"10.2174\/138945010791170860","article-title":"The role of Notch signaling pathway in epithelial-mesenchymal transition (EMT) during development and tumor aggressiveness","volume":"11","author":"Wang","year":"(2010)","journal-title":"Curr. Drug Targets"},{"key":"key\n\t\t\t\t20170517095152_CIT0044","volume-title":"Precancer : the beginning and the end of cancer","author":"Berman","year":"(2010)"},{"key":"key\n\t\t\t\t20170517095152_CIT0045","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1440-1827.2009.02487.x","article-title":"Significant high expression of cytokeratins 7, 8, 18, 19 in pulmonary large cell neuroendocrine carcinomas, compared to small cell lung carcinomas","volume":"60","author":"Nagashio","year":"(2010)","journal-title":"Pathol. Int."},{"key":"key\n\t\t\t\t20170517095152_CIT0046","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00428-013-1501-6","article-title":"Large cell carcinoma of the lung: clinically oriented classification integrating immunohistochemistry and molecular biology","volume":"464","author":"Rossi","year":"(2014)","journal-title":"Virchows Arch."},{"key":"key\n\t\t\t\t20170517095152_CIT0047","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.lungcan.2011.10.017","article-title":"The challenge of NSCLC diagnosis and predictive analysis on small samples. Practical approach of a working group","volume":"76","author":"Thunnissen","year":"(2012)","journal-title":"Lung Cancer"},{"key":"key\n\t\t\t\t20170517095152_CIT0048","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/S0873-2159(15)30195-1","article-title":"Reclassifying bronchial-pulmonary carcinoma: differentiating histological type in biopsies by immunohistochemistry","volume":"15","author":"Carvalho","year":"(2009)","journal-title":"Rev. Port. Pneumol."},{"key":"key\n\t\t\t\t20170517095152_CIT0049","doi-asserted-by":"crossref","first-page":"174306","DOI":"10.1155\/2011\/174306","article-title":"Ion transport by pulmonary epithelia","volume":"2011","author":"Hollenhorst","year":"(2011)","journal-title":"J. Biomed. Biotechnol."},{"key":"key\n\t\t\t\t20170517095152_CIT0050","first-page":"2342","article-title":"\u201cHot spots\u201d of chromium accumulation at bifurcations of chromate workers\u2019 bronchi","volume":"54","author":"Ishikawa","year":"(1994)","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t20170517095152_CIT0051","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1289\/ehp.0900715","article-title":"Lung inflammation, injury, and proliferative response after repetitive particulate hexavalent chromium exposure","volume":"117","author":"Beaver","year":"(2009)","journal-title":"Environ. Health Perspect."}],"container-title":["Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/mutage\/article-pdf\/30\/2\/277\/12734535\/geu070.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T04:42:11Z","timestamp":1717562531000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mutage\/article-lookup\/doi\/10.1093\/mutage\/geu070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,17]]},"references-count":51,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,11,17]]},"published-print":{"date-parts":[[2015,3]]}},"URL":"https:\/\/doi.org\/10.1093\/mutage\/geu070","relation":{},"ISSN":["1464-3804","0267-8357"],"issn-type":[{"value":"1464-3804","type":"electronic"},{"value":"0267-8357","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11,17]]}}}