{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T04:22:03Z","timestamp":1778127723394,"version":"3.51.4"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"16","license":[{"start":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T00:00:00Z","timestamp":1594857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SO 251\/5-1"],"award-info":[{"award-number":["SO 251\/5-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GRK2162"],"award-info":[{"award-number":["GRK2162"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["270949263"],"award-info":[{"award-number":["270949263"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,18]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Schwann cells are the nerve ensheathing cells of the peripheral nervous system. Absence, loss and malfunction of Schwann cells or their myelin sheaths lead to peripheral neuropathies such as Charcot-Marie-Tooth disease in humans. During Schwann cell development and myelination chromatin is dramatically modified. However, impact and functional relevance of these modifications are poorly understood. Here, we analyzed histone H2B monoubiquitination as one such chromatin modification by conditionally deleting the Rnf40 subunit of the responsible E3 ligase in mice. Rnf40-deficient Schwann cells were arrested immediately before myelination or generated abnormally thin, unstable myelin, resulting in a peripheral neuropathy characterized by hypomyelination and progressive axonal degeneration. By combining sequencing techniques with functional studies we show that H2B monoubiquitination does not influence global gene expression patterns, but instead ensures selective high expression of myelin and lipid biosynthesis genes and proper repression of immaturity genes. This requires the specific recruitment of the Rnf40-containing E3 ligase by Egr2, the central transcriptional regulator of peripheral myelination, to its target genes. Our study identifies histone ubiquitination as essential for Schwann cell myelination and unravels new disease-relevant links between chromatin modifications and transcription factors in the underlying regulatory network.<\/jats:p>","DOI":"10.1093\/nar\/gkaa606","type":"journal-article","created":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T19:10:43Z","timestamp":1594149043000},"page":"8959-8976","source":"Crossref","is-referenced-by-count":31,"title":["Egr2-guided histone H2B monoubiquitination is required for peripheral nervous system myelination"],"prefix":"10.1093","volume":"48","author":[{"given":"Hannah M","family":"W\u00fcst","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Biochemie, Emil-Fischer-Zentrum, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Fahrstrasse 17, D-91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Am\u00e9lie","family":"Wegener","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Biochemie, Emil-Fischer-Zentrum, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Fahrstrasse 17, D-91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franziska","family":"Fr\u00f6b","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Biochemie, Emil-Fischer-Zentrum, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Fahrstrasse 17, D-91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna C","family":"Hartwig","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Biochemie, Emil-Fischer-Zentrum, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Fahrstrasse 17, D-91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Wegwitz","sequence":"additional","affiliation":[{"name":"Department of General, Visceral, and Pediatric Surgery, University Medical Center G\u00f6ttingen, D-37075 G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijayalakshmi","family":"Kari","sequence":"additional","affiliation":[{"name":"Department of General, Visceral, and Pediatric Surgery, University Medical Center G\u00f6ttingen, D-37075 G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margit","family":"Schimmel","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Humananatomie und Embryologie, Universit\u00e4t Regensburg, Universit\u00e4tsstrasse 31, D-93053 Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernst R","family":"Tamm","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Humananatomie und Embryologie, Universit\u00e4t Regensburg, Universit\u00e4tsstrasse 31, D-93053 Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1198-5805","authenticated-orcid":false,"given":"Steven A","family":"Johnsen","sequence":"additional","affiliation":[{"name":"Department of General, Visceral, and Pediatric Surgery, University Medical Center G\u00f6ttingen, D-37075 G\u00f6ttingen, Germany"},{"name":"Gene Regulatory Mechanisms and Molecular Epigenetics Lab, Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First St SW, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4586-3294","authenticated-orcid":false,"given":"Michael","family":"Wegner","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Biochemie, Emil-Fischer-Zentrum, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Fahrstrasse 17, D-91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Sock","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Biochemie, Emil-Fischer-Zentrum, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Fahrstrasse 17, D-91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,7,16]]},"reference":[{"key":"2020091720044018400_B1","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.molcel.2005.09.025","article-title":"Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation","volume":"20","author":"Zhu","year":"2005","journal-title":"Mol. Cell"},{"key":"2020091720044018400_B2","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.cell.2009.02.027","article-title":"RAD6-mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells","volume":"137","author":"Kim","year":"2009","journal-title":"Cell"},{"key":"2020091720044018400_B3","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.molcel.2014.04.013","article-title":"H2B ubiquitylation promotes RNA Pol II processivity via PAF1 and pTEFb","volume":"54","author":"Wu","year":"2014","journal-title":"Mol. Cell"},{"key":"2020091720044018400_B4","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13059-017-1159-5","article-title":"RNF40 regulates gene expression in an epigenetic context-dependent manner","volume":"18","author":"Xie","year":"2017","journal-title":"Genome Biol."},{"key":"2020091720044018400_B5","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.molcel.2016.08.034","article-title":"Monoubiquitination of histone H2B blocks eviction of histone variant H2A.Z from inducible enhancers","volume":"64","author":"Segala","year":"2016","journal-title":"Mol. Cell"},{"key":"2020091720044018400_B6","doi-asserted-by":"crossref","first-page":"3495","DOI":"10.4161\/cc.10.20.17769","article-title":"The H2B ubiquitin ligase RNF40 cooperates with SUPT16H to induce dynamic changes in chromatin structure during DNA double-strand break repair","volume":"10","author":"Kari","year":"2011","journal-title":"Cell Cycle"},{"key":"2020091720044018400_B7","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.molcel.2011.02.015","article-title":"Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks","volume":"41","author":"Moyal","year":"2011","journal-title":"Mol. Cell"},{"key":"2020091720044018400_B8","doi-asserted-by":"crossref","first-page":"00488","DOI":"10.1128\/MCB.00488-18","article-title":"E3 ubiquitin ligases RNF20 and RNF40 are required for Double-Stranded Break (DSB) repair: evidence for monoubiquitination of histone H2B lysine 120 as a novel axis of DSB signaling and repair","volume":"39","author":"So","year":"2019","journal-title":"Mol. Cell. Biol."},{"key":"2020091720044018400_B9","doi-asserted-by":"crossref","first-page":"5739","DOI":"10.1158\/0008-5472.CAN-11-1896","article-title":"Estrogen-dependent gene transcription in human breast cancer cells relies upon proteasome-dependent monoubiquitination of histone H2B","volume":"71","author":"Prenzel","year":"2011","journal-title":"Cancer Res."},{"key":"2020091720044018400_B10","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.mce.2011.11.025","article-title":"Histone H2B ubiquitin ligases RNF20 and RNF40 in androgen signaling and prostate cancer cell growth","volume":"350","author":"J\u00e4\u00e4skel\u00e4inen","year":"2012","journal-title":"Mol. Cell. Endocrinol."},{"key":"2020091720044018400_B11","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/jmcb\/mjz045","article-title":"The RNF20\/40 complex regulates p53-dependent gene transcription and mRNA splicing","volume":"12","author":"Wu","year":"2019","journal-title":"J. Mol. Cell Biol"},{"key":"2020091720044018400_B12","doi-asserted-by":"crossref","first-page":"11728","DOI":"10.1074\/jbc.RA118.006985","article-title":"LIM-domain transcription complexes interact with ring-finger ubiquitin ligases and thereby impact islet beta-cell function","volume":"294","author":"Wade","year":"2019","journal-title":"J. Biol. Chem"},{"key":"2020091720044018400_B13","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.molcel.2005.11.012","article-title":"The human homolog of yeast BRE1 functions as a transcriptional coactivator through direct activator interactions","volume":"20","author":"Kim","year":"2005","journal-title":"Mol. Cell"},{"key":"2020091720044018400_B14","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.molcel.2012.05.022","article-title":"The histone H2B monoubiquitination regulatory pathway is required for differentiation of multipotent stem cells","volume":"46","author":"Karpiuk","year":"2012","journal-title":"Mol. Cell"},{"key":"2020091720044018400_B15","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.15252\/embj.201591279","article-title":"The Mediator subunit MED23 couples H2B mono-ubiquitination to transcriptional control and cell fate determination","volume":"34","author":"Yao","year":"2015","journal-title":"EMBO J."},{"key":"2020091720044018400_B16","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.molcel.2012.05.023","article-title":"RNF20 and USP44 regulate stem cell differentiation by modulating H2B monoubiquitylation","volume":"46","author":"Fuchs","year":"2012","journal-title":"Mol. Cell"},{"key":"2020091720044018400_B17","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/s41419-020-2482-4","article-title":"The H2B ubiquitin-protein ligase RNF40 is required for somatic cell reprogramming","volume":"11","author":"Xie","year":"2020","journal-title":"Cell Death. Dis."},{"key":"2020091720044018400_B18","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3390\/genes10010067","article-title":"Writing histone monoubiquitination in human malignancy-the role of RING finger E3 ubiquitin ligases","volume":"10","author":"Marsh","year":"2019","journal-title":"Genes (Basel)"},{"key":"2020091720044018400_B19","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nrn1746","article-title":"The origin and development of glial cells in peripheral nerves","volume":"6","author":"Jessen","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"2020091720044018400_B20","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/371796a0","article-title":"Krox-20 controls myelination in the peripheral nervous system","volume":"371","author":"Topilko","year":"1994","journal-title":"Nature"},{"key":"2020091720044018400_B21","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1093\/ecco-jcc\/jjy165","article-title":"Loss of RNF40 decreases NF-kappaB activity in colorectal cancer cells and reduces colitis burden in mice","volume":"13","author":"Kosinsky","year":"2019","journal-title":"J Crohns Colitis"},{"key":"2020091720044018400_B22","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1101\/gad.258203","article-title":"The POU proteins Brn-2 and Oct-6 share important functions in Schwann cell development","volume":"17","author":"Jaegle","year":"2003","journal-title":"Genes Dev."},{"key":"2020091720044018400_B23","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1242\/dev.037341","article-title":"Stage-dependent modes of Pax6-Sox2 epistasis regulate lens development and eye morphogenesis","volume":"136","author":"Smith","year":"2009","journal-title":"Development"},{"key":"2020091720044018400_B24","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1242\/dev.098418","article-title":"Stem cell factor Sox2 and its close relative Sox3 have differentiation functions in oligodendrocytes","volume":"141","author":"Hoffmann","year":"2014","journal-title":"Development"},{"key":"2020091720044018400_B25","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1038\/s41467-019-10287-w","article-title":"Ep400 deficiency in Schwann cells causes persistent expression of early developmental regulators and peripheral neuropathy","volume":"10","author":"Fr\u00f6b","year":"2019","journal-title":"Nat. Commun."},{"key":"2020091720044018400_B26","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.devcel.2012.05.017","article-title":"Chromatin-remodeling factor Brg1 is required for Schwann cell differentiation and myelination","volume":"23","author":"Weider","year":"2012","journal-title":"Dev. Cell"},{"key":"2020091720044018400_B27","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ydbio.2004.09.014","article-title":"Identification of Sox8 as a modifier gene in a mouse model of Hirschsprung disease reveals underlying molecular defect","volume":"277","author":"Maka","year":"2005","journal-title":"Dev. Biol."},{"key":"2020091720044018400_B28","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1002\/glia.22310","article-title":"Establishment of myelinating Schwann cells and barrier integrity between central and peripheral nervous systems depend on Sox10","volume":"60","author":"Fr\u00f6b","year":"2012","journal-title":"Glia"},{"key":"2020091720044018400_B29","doi-asserted-by":"crossref","first-page":"E1142","DOI":"10.3390\/cancers11081142","article-title":"Epigenome mapping identifies Tumor-Specific gene expression in primary rectal cancer","volume":"11","author":"Flebbe","year":"2019","journal-title":"Cancers (Basel)"},{"key":"2020091720044018400_B30","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/nn1490","article-title":"Nab proteins are essential for peripheral nervous system myelination","volume":"8","author":"Le","year":"2005","journal-title":"Nat. Neurosci."},{"key":"2020091720044018400_B31","doi-asserted-by":"crossref","first-page":"6449","DOI":"10.1093\/nar\/gks313","article-title":"Genome-wide analysis of EGR2\/SOX10 binding in myelinating peripheral nerve","volume":"40","author":"Srinivasan","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"2020091720044018400_B32","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/s41467-018-03336-3","article-title":"Nfat\/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning","volume":"9","author":"Weider","year":"2018","journal-title":"Nat. Commun."},{"key":"2020091720044018400_B33","doi-asserted-by":"crossref","first-page":"6208","DOI":"10.1093\/nar\/gkz376","article-title":"Chromatin remodeler Ep400 ensures oligodendrocyte survival and is required for myelination in the vertebrate central nervous system","volume":"47","author":"Elsesser","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2020091720044018400_B34","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1093\/nar\/gkq951","article-title":"Olig2 regulates Sox10 expression in oligodendrocyte precursors through an evolutionary conserved distal enhancer","volume":"39","author":"K\u00fcspert","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"2020091720044018400_B35","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1523\/JNEUROSCI.18-01-00237.1998","article-title":"Sox10, a novel transcriptional modulator in glial cells","volume":"18","author":"Kuhlbrodt","year":"1998","journal-title":"J. Neurosci."},{"key":"2020091720044018400_B36","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1073\/pnas.0407836102","article-title":"Analysis of congenital hypomyelinating Egr2Lo\/Lo nerves identifies Sox2 as an inhibitor of Schwann cell differentiation and myelination","volume":"102","author":"Le","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2020091720044018400_B37","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1126\/science.273.5274.507","article-title":"The POU factor Oct-6 and Schwann cell differentiation","volume":"273","author":"Jaegle","year":"1996","journal-title":"Science"},{"key":"2020091720044018400_B38","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nature03837","article-title":"Neural crest origins of the neck and shoulder","volume":"436","author":"Matsuoka","year":"2005","journal-title":"Nature"},{"key":"2020091720044018400_B39","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1101\/gad.10.14.1751","article-title":"Tst-1\/Oct-6\/SCIP regulates a unique step in peripheral myelination and is required for normal respiration","volume":"10","author":"Bermingham","year":"1996","journal-title":"Genes Dev."},{"key":"2020091720044018400_B40","doi-asserted-by":"crossref","first-page":"3114","DOI":"10.1242\/dev.150656","article-title":"Sox2 expression in Schwann cells inhibits myelination in vivo and induces influx of macrophages to the nerve","volume":"144","author":"Roberts","year":"2017","journal-title":"Development"},{"key":"2020091720044018400_B41","doi-asserted-by":"crossref","first-page":"9771","DOI":"10.1523\/JNEUROSCI.0716-06.2006","article-title":"Peripheral myelin maintenance is a dynamic process requiring constant Krox20 expression","volume":"26","author":"Decker","year":"2006","journal-title":"J. Neurosci."},{"key":"2020091720044018400_B42","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1242\/dev.126.7.1397","article-title":"Krox-20 controls SCIP expression, cell cycle exit and susceptibility to apoptosis in developing myelinating Schwann cells","volume":"126","author":"Zorick","year":"1999","journal-title":"Development"},{"key":"2020091720044018400_B43","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1002\/glia.22855","article-title":"Differential Sox10 genomic occupancy in myelinating glia","volume":"63","author":"Lopez-Anido","year":"2015","journal-title":"Glia"},{"key":"2020091720044018400_B44","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.molcel.2011.01.024","article-title":"WAC, a functional partner of RNF20\/40, regulates histone H2B ubiquitination and gene transcription","volume":"41","author":"Zhang","year":"2011","journal-title":"Mol. Cell"},{"key":"2020091720044018400_B45","doi-asserted-by":"crossref","first-page":"14049","DOI":"10.1073\/pnas.1808341116","article-title":"Histone H2B monoubiquitination regulates heart development via epigenetic control of cilia motility","volume":"116","author":"Robson","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2020091720044018400_B46","doi-asserted-by":"crossref","first-page":"14272","DOI":"10.1038\/ncomms14272","article-title":"Delaying histone deacetylase response to injury accelerates conversion into repair Schwann cells and nerve regeneration","volume":"8","author":"Br\u00fcgger","year":"2017","journal-title":"Nat. Commun."},{"key":"2020091720044018400_B47","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nn.2762","article-title":"HDAC1 and HDAC2 control the transcriptional program of myelination and the survival of Schwann cells","volume":"14","author":"Jacob","year":"2011","journal-title":"Nat. Neurosci."},{"key":"2020091720044018400_B48","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.cell.2006.04.029","article-title":"Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II","volume":"125","author":"Pavri","year":"2006","journal-title":"Cell"},{"key":"2020091720044018400_B49","doi-asserted-by":"crossref","first-page":"11552","DOI":"10.1523\/JNEUROSCI.5497-06.2007","article-title":"Misexpression of Pou3f1 results in peripheral nerve hypomyelination and axonal loss","volume":"27","author":"Ryu","year":"2007","journal-title":"J. Neurosci."},{"key":"2020091720044018400_B50","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1111\/j.1471-4159.2006.04069.x","article-title":"In vivo detection of Egr2 binding to target genes during peripheral nerve myelination","volume":"98","author":"Jang","year":"2006","journal-title":"J. Neurochem."},{"key":"2020091720044018400_B51","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1111\/j.1471-4159.2010.07045.x","article-title":"Locus-wide identification of Egr2\/Krox20 regulatory targets in myelin genes","volume":"115","author":"Jang","year":"2010","journal-title":"J. Neurochem."},{"key":"2020091720044018400_B52","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1017\/S1740925X08000173","article-title":"Interactions of Sox10 and Egr2 in myelin gene regulation","volume":"3","author":"Jones","year":"2007","journal-title":"Neuron Glia Biol"},{"key":"2020091720044018400_B53","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/glia.23532","article-title":"Repair Schwann cell update: adaptive reprogramming, EMT, and stemness in regenerating nerves","volume":"67","author":"Jessen","year":"2019","journal-title":"Glia"}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/48\/16\/8959\/33746679\/gkaa606.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/48\/16\/8959\/33746679\/gkaa606.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T17:00:51Z","timestamp":1667322051000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/48\/16\/8959\/5872470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,16]]},"references-count":53,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2020,7,16]]},"published-print":{"date-parts":[[2020,9,18]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkaa606","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,9,18]]},"published":{"date-parts":[[2020,7,16]]}}}