{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:30:34Z","timestamp":1792215034926,"version":"4.4.0"},"reference-count":127,"publisher":"Oxford University Press (OUP)","issue":"20","license":[{"start":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T00:00:00Z","timestamp":1601683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01ES019566"],"award-info":[{"award-number":["R01ES019566"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R35ES031638"],"award-info":[{"award-number":["R35ES031638"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The six major mammalian DNA repair pathways were discovered as independent processes, each dedicated to remove specific types of lesions, but the past two decades have brought into focus the significant interplay between these pathways. In particular, several studies have demonstrated that certain proteins of the nucleotide excision repair (NER) and base excision repair (BER) pathways work in a cooperative manner in the removal of oxidative lesions. This review focuses on recent data showing how the NER proteins, XPA, XPC, XPG, CSA, CSB and UV-DDB, work to stimulate known glycosylases involved in the removal of certain forms of base damage resulting from oxidative processes, and also discusses how some oxidative lesions are probably directly repaired through NER. Finally, since many glycosylases are inhibited from working on damage in the context of chromatin, we detail how we believe UV-DDB may be the first responder in altering the structure of damage containing-nucleosomes, allowing access to BER enzymes.<\/jats:p>","DOI":"10.1093\/nar\/gkaa777","type":"journal-article","created":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T15:14:44Z","timestamp":1599491684000},"page":"11227-11243","source":"Crossref","is-referenced-by-count":123,"title":["The involvement of nucleotide excision repair proteins in the removal of oxidative DNA damage"],"prefix":"10.1093","volume":"48","author":[{"given":"Namrata","family":"Kumar","sequence":"first","affiliation":[{"name":"Molecular Genetics and Developmental Biology Graduate Program, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213 USA"},{"name":"UPMC Hillman Cancer Center, University of Pittsburgh, PA 15213, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sripriya","family":"Raja","sequence":"additional","affiliation":[{"name":"UPMC Hillman Cancer Center, University of Pittsburgh, PA 15213, USA"},{"name":"Molecular Pharmacology Graduate Program, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4009-2478","authenticated-orcid":false,"given":"Bennett","family":"Van\u00a0Houten","sequence":"additional","affiliation":[{"name":"Molecular Genetics and Developmental Biology Graduate Program, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213 USA"},{"name":"UPMC Hillman Cancer Center, University of Pittsburgh, PA 15213, USA"},{"name":"Molecular Pharmacology Graduate Program, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213 USA"},{"name":"Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,10,3]]},"reference":[{"key":"2020111803364061800_B1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.dnarep.2017.09.007","article-title":"Not breathing is not an option: how to deal with oxidative DNA damage","volume":"59","author":"Markkanen","year":"2017","journal-title":"DNA Repair (Amst.)"},{"key":"2020111803364061800_B2","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/j.freeradbiomed.2010.09.006","article-title":"Oxidative stress, inflammation, and cancer: how are they linked","volume":"49","author":"Reuter","year":"2010","journal-title":"Free Radic. 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