{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:51:10Z","timestamp":1792180270640,"version":"4.4.0"},"reference-count":106,"publisher":"Oxford University Press (OUP)","issue":"13","license":[{"start":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T00:00:00Z","timestamp":1624492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-17-CE20-0002-01"],"award-info":[{"award-number":["ANR-17-CE20-0002-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"name":"PhenoVar","award":["ANR16-CE12-0019"],"award-info":[{"award-number":["ANR16-CE12-0019"]}]},{"name":"French State","award":["ANR-11-LABX-0011-01"],"award-info":[{"award-number":["ANR-11-LABX-0011-01"]}]},{"DOI":"10.13039\/501100000268","name":"BBSRC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In most eukaryotes, subtelomeres are dynamic genomic regions populated by multi-copy sequences of different origins, which can promote segmental duplications and chromosomal rearrangements. However, their repetitive nature has complicated the efforts to sequence them, analyse their structure and infer how they evolved. Here, we use recent genome assemblies of Chlamydomonas reinhardtii based on long-read sequencing to comprehensively describe the subtelomere architecture of the 17 chromosomes of this model unicellular green alga. We identify three main repeated elements present at subtelomeres, which we call Sultan, Subtile and Suber, alongside three chromosome extremities with ribosomal DNA as the only identified component of their subtelomeres. The most common architecture, present in 27 out of 34 subtelomeres, is a heterochromatic array of Sultan elements adjacent to the telomere, followed by a transcribed Spacer sequence, a G-rich microsatellite and transposable elements. Sequence similarity analyses suggest that Sultan elements underwent segmental duplications within each subtelomere and rearranged between subtelomeres at a much lower frequency. Analysis of other green algae reveals species-specific repeated elements that are shared across subtelomeres, with an overall organization similar to C. reinhardtii. This work uncovers the complexity and evolution of subtelomere architecture in green algae.<\/jats:p>","DOI":"10.1093\/nar\/gkab534","type":"journal-article","created":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T15:53:33Z","timestamp":1623167613000},"page":"7571-7587","source":"Crossref","is-referenced-by-count":25,"title":["Architecture and evolution of subtelomeres in the unicellular green alga\n                    <i>Chlamydomonas reinhardtii<\/i>"],"prefix":"10.1093","volume":"49","author":[{"given":"Fr\u00e9d\u00e9ric","family":"Chaux-Jukic","sequence":"first","affiliation":[{"name":"Sorbonne Universit\u00e9, CNRS, UMR7238, Institut de Biologie Paris-Seine, Laboratory of Computational and Quantitative Biology, 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2447-1993","authenticated-orcid":false,"given":"Samuel","family":"O\u2019Donnell","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, CNRS, UMR7238, Institut de Biologie Paris-Seine, Laboratory of Computational and Quantitative Biology, 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rory J","family":"Craig","sequence":"additional","affiliation":[{"name":"Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, EH9 3FL, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Eberhard","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, CNRS, UMR7141, Institut de Biologie Physico-Chimique, Laboratory of Chloroplast Biology and Light-Sensing in Microalgae, 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Vallon","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, CNRS, UMR7141, Institut de Biologie Physico-Chimique, Laboratory of Chloroplast Biology and Light-Sensing in Microalgae, 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9468-1406","authenticated-orcid":false,"given":"Zhou","family":"Xu","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, CNRS, UMR7238, Institut de Biologie Paris-Seine, Laboratory of Computational and Quantitative Biology, 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,6,24]]},"reference":[{"key":"2021071913030596200_B1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1146\/annurev-genet-102108-134841","article-title":"Telomeric strategies: means to an end","volume":"44","author":"Jain","year":"2010","journal-title":"Annu. 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