{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T18:28:25Z","timestamp":1775413705810,"version":"3.50.1"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U24CA248138"],"award-info":[{"award-number":["U24CA248138"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["75N93019C00001"],"award-info":[{"award-number":["75N93019C00001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We established The Cancer Epitope Database and Analysis Resource (CEDAR) to catalog all epitope data in the context of cancer. The specific molecular targets of adaptive T cell and B cell immune responses are referred to as epitopes. Epitopes derived from cancer antigens are of high relevance as they are recognized by anti-cancer immune cells. Detailed knowledge of the molecular characteristic of cancer epitopes and associated metadata is relevant to understanding and planning prophylactic and therapeutic applications and accurately characterizing naturally occurring immune responses and cancer immunopathology. CEDAR provides a freely accessible, comprehensive collection of cancer epitope and receptor data curated from the literature and serves as a companion site to the Immune Epitope Database (IEDB), which is focused on infectious, autoimmune, and allergic diseases. CEDAR is freely accessible at https:\/\/cedar.iedb.org\/.<\/jats:p>","DOI":"10.1093\/nar\/gkac902","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T12:14:34Z","timestamp":1666008874000},"page":"D845-D852","source":"Crossref","is-referenced-by-count":60,"title":["The Cancer Epitope Database and Analysis Resource (CEDAR)"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0961-5055","authenticated-orcid":false,"given":"Zeynep","family":"Ko\u015falo\u011flu-Yal\u00e7\u0131n","sequence":"first","affiliation":[{"name":"Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology ,\u00a0 La Jolla ,\u00a0 CA , USA"}]},{"given":"Nina","family":"Blazeska","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology ,\u00a0 La Jolla ,\u00a0 CA , USA"}]},{"given":"Randi","family":"Vita","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology ,\u00a0 La Jolla ,\u00a0 CA , USA"}]},{"given":"Hannah","family":"Carter","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Diego , La Jolla ,\u00a0 CA ,\u00a0 USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7885-4311","authenticated-orcid":false,"given":"Morten","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Bio and Health Informatics, Technical University of Denmark ,\u00a0 Lyngby ,\u00a0 Denmark"},{"name":"Instituto de Investigaciones Biotecnol\u00f3gicas, Universidad Nacional de San Mart\u00edn , San Mart\u00edn , Argentina"}]},{"given":"Stephen","family":"Schoenberger","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Immunology, La Jolla Institute for Immunology , La Jolla ,\u00a0 CA ,\u00a0 USA"}]},{"given":"Alessandro","family":"Sette","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology ,\u00a0 La Jolla ,\u00a0 CA , USA"},{"name":"Department of Medicine, University of California San Diego , La Jolla ,\u00a0 CA ,\u00a0 USA"}]},{"given":"Bjoern","family":"Peters","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology ,\u00a0 La Jolla ,\u00a0 CA , USA"},{"name":"Department of Medicine, University of California San Diego , La Jolla ,\u00a0 CA ,\u00a0 USA"}]}],"member":"286","published-online":{"date-parts":[[2022,10,17]]},"reference":[{"key":"2023010804292178000_B1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nrclinonc.2014.111","article-title":"Therapeutic vaccines for cancer: an overview of clinical trials","volume":"11","author":"Melero","year":"2014","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"2023010804292178000_B2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41541-019-0103-y","article-title":"Turning the corner on therapeutic cancer vaccines","volume":"4","author":"Hollingsworth","year":"2019","journal-title":"NPJ Vaccines"},{"key":"2023010804292178000_B3","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1159\/000333258","article-title":"Prevention of hepatocellular carcinoma in patients with chronic hepatitis b virus infection","volume":"81","author":"Kim","year":"2011","journal-title":"Oncology"},{"key":"2023010804292178000_B4","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/nrc.2018.13","article-title":"Opportunities and challenges for human papillomavirus vaccination in cancer","volume":"18","author":"Roden","year":"2018","journal-title":"Nat. Rev. Cancer"},{"key":"2023010804292178000_B5","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41572-020-0160-6","article-title":"Immune-related adverse events of checkpoint inhibitors","volume":"6","author":"Ramos-Casals","year":"2020","journal-title":"Nat. Rev. Dis. Primers"},{"key":"2023010804292178000_B6","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s40425-016-0145-x","article-title":"B cell regulation of the anti-tumor response and role in carcinogenesis","volume":"4","author":"Schwartz","year":"2016","journal-title":"J. Immunother. Cancer"},{"key":"2023010804292178000_B7","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.ccell.2021.09.007","article-title":"B cells and cancer","volume":"39","author":"Engelhard","year":"2021","journal-title":"Cancer Cell"},{"key":"2023010804292178000_B8","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/s41568-022-00466-1","article-title":"Tumour-infiltrating b cells: immunological mechanisms, clinical impact and therapeutic opportunities","volume":"22","author":"Laumont","year":"2022","journal-title":"Nat. Rev. Cancer"},{"key":"2023010804292178000_B9","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/s41568-019-0210-0","article-title":"Context-dependent roles of complement in cancer","volume":"19","author":"Roumenina","year":"2019","journal-title":"Nat. Rev. Cancer"},{"key":"2023010804292178000_B10","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1158\/1078-0432.CCR-15-2762","article-title":"Tumor-Infiltrating plasma cells are associated with tertiary lymphoid structures, cytolytic T-Cell responses, and superior prognosis in ovarian cancer","volume":"22","author":"Kroeger","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"2023010804292178000_B11","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1182\/blood-2008-02-078071","article-title":"B lymphocytes: how they develop and function","volume":"112","author":"LeBien","year":"2008","journal-title":"Blood"},{"key":"2023010804292178000_B12","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.immuni.2018.01.007","article-title":"Human t cell development, localization, and function throughout life","volume":"48","author":"Kumar","year":"2018","journal-title":"Immunity"},{"key":"2023010804292178000_B13","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/s41577-018-0044-0","article-title":"CD4(+) t cell help in cancer immunology and immunotherapy","volume":"18","author":"Borst","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"2023010804292178000_B14","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1016\/j.immuni.2021.11.015","article-title":"Cytotoxic CD4(+) t cells in cancer: expanding the immune effector toolbox","volume":"54","author":"Oh","year":"2021","journal-title":"Immunity"},{"key":"2023010804292178000_B15","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/s41568-021-00339-z","article-title":"Antigen presentation in cancer: insights into tumour immunogenicity and immune evasion","volume":"21","author":"Jhunjhunwala","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"2023010804292178000_B16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.immuni.2013.07.012","article-title":"Oncology meets immunology: the cancer-immunity cycle","volume":"39","author":"Chen","year":"2013","journal-title":"Immunity"},{"key":"2023010804292178000_B17","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s12859-021-03962-7","article-title":"TANTIGEN 2.0: a knowledge base of tumor t cell antigens and epitopes","volume":"22","author":"Zhang","year":"2021","journal-title":"BMC Bioinf."},{"key":"2023010804292178000_B18","doi-asserted-by":"crossref","first-page":"644637","DOI":"10.3389\/fimmu.2021.644637","article-title":"NEPdb: a database of T-cell experimentally-validated neoantigens and pan-cancer predicted neoepitopes for cancer immunotherapy","volume":"12","author":"Xia","year":"2021","journal-title":"Front. Immunol."},{"key":"2023010804292178000_B19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/database\/baaa004","article-title":"dbPepNeo: a manually curated database for human tumor neoantigen peptides","volume":"2020","author":"Tan","year":"2020","journal-title":"Database (Oxford)"},{"key":"2023010804292178000_B20","doi-asserted-by":"crossref","first-page":"D339","DOI":"10.1093\/nar\/gky1006","article-title":"The immune epitope database (IEDB): 2018 update","volume":"47","author":"Vita","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2023010804292178000_B21","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/imm.13234","article-title":"A behind-the-scenes tour of the IEDB curation process: an optimized process empirically integrating automation and human curation efforts","volume":"161","author":"Salimi","year":"2020","journal-title":"Immunology"},{"key":"2023010804292178000_B22","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1186\/1471-2105-12-482","article-title":"Cost sensitive hierarchical document classification to triage pubmed abstracts for manual curation","volume":"12","author":"Seymour","year":"2011","journal-title":"BMC Bioinf."},{"key":"2023010804292178000_B23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/database\/bax014","article-title":"Better living through ontologies at the immune epitope database","volume":"2017","author":"Vita","year":"2017","journal-title":"Database (Oxford)"},{"key":"2023010804292178000_B24","volume-title":"Holland-Frei Cancer Medicine","author":"Kufe","year":"2003"},{"key":"2023010804292178000_B25","doi-asserted-by":"crossref","first-page":"D20","DOI":"10.1093\/nar\/gkab1112","article-title":"Database resources of the national center for biotechnology information","volume":"50","author":"Sayers","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"2023010804292178000_B26","doi-asserted-by":"crossref","first-page":"D506","DOI":"10.1093\/nar\/gky1049","article-title":"UniProt: a worldwide hub of protein knowledge","volume":"47","author":"UniProt","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2023010804292178000_B27","doi-asserted-by":"crossref","first-page":"D456","DOI":"10.1093\/nar\/gks1146","article-title":"The ChEBI reference database and ontology for biologically relevant chemistry: enhancements for","volume":"41","author":"Hastings","year":"2013","journal-title":"Nucleic Acids Res."},{"issue":"Suppl. 1","key":"2023010804292178000_B28","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1186\/2041-1480-1-S1-S7","article-title":"Modeling biomedical experimental processes with OBI","volume":"1","author":"Brinkman","year":"2010","journal-title":"J. Biomed. Semantics"},{"key":"2023010804292178000_B29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13326-016-0045-5","article-title":"An ontology for major histocompatibility restriction","volume":"7","author":"Vita","year":"2016","journal-title":"J. Biomed. Semantics"},{"key":"2023010804292178000_B30","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13326-016-0088-7","article-title":"The cell ontology 2016: enhanced content, modularization, and ontology interoperability","volume":"7","author":"Diehl","year":"2016","journal-title":"J. Biomed. Semantics"},{"key":"2023010804292178000_B31","doi-asserted-by":"crossref","first-page":"R5","DOI":"10.1186\/gb-2012-13-1-r5","article-title":"Uberon, an integrative multi-species anatomy ontology","volume":"13","author":"Mungall","year":"2012","journal-title":"Genome Biol."},{"key":"2023010804292178000_B32","doi-asserted-by":"crossref","first-page":"D1255","DOI":"10.1093\/nar\/gkab1063","article-title":"The human disease ontology 2022 update","volume":"50","author":"Schriml","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"2023010804292178000_B33","doi-asserted-by":"crossref","first-page":"e53244","DOI":"10.7554\/eLife.53244","article-title":"Landscape mapping of shared antigenic epitopes and their cognate TCRs of tumor-infiltrating T lymphocytes in melanoma","volume":"9","author":"Murata","year":"2020","journal-title":"Elife"}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/51\/D1\/D845\/48441093\/gkac902.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/51\/D1\/D845\/48441093\/gkac902.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,8]],"date-time":"2023-01-08T04:30:42Z","timestamp":1673152242000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/51\/D1\/D845\/6761984"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,17]]},"references-count":33,"journal-issue":{"issue":"D1","published-online":{"date-parts":[[2022,10,17]]},"published-print":{"date-parts":[[2023,1,6]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkac902","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,1,6]]},"published":{"date-parts":[[2022,10,17]]}}}