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Their ability to form stable hairpin\/cruciform secondary structures is causative in triggering chromosome instability leading to several human diseases. Distance and sequence divergence between IRs are inversely correlated with their ability to induce gross chromosomal rearrangements (GCRs) because of a lesser probability of secondary structure formation and chromosomal breakage. In this study, we demonstrate that structural parameters that normally constrain the instability of IRs are overcome when the repeats interact in single-stranded DNA (ssDNA). We established a system in budding yeast whereby\u00a0&amp;gt;73 kb of ssDNA can be formed in cdc13-707fs mutants. We found that in ssDNA, 12 bp or 30 kb spaced Alu-IRs show similarly high levels of GCRs, while heterology only beyond 25% suppresses IR-induced instability. Mechanistically, rearrangements arise after cis-interaction of IRs leading to a DNA fold-back and the formation of a dicentric chromosome, which requires Rad52\/Rad59 for IR annealing as well as Rad1-Rad10, Slx4, Msh2\/Msh3 and Saw1 proteins for nonhomologous tail removal. Importantly, using structural characteristics rendering IRs permissive to DNA fold-back in yeast, we found that ssDNA regions mapped in cancer genomes contain a substantial number of potentially interacting and unstable IRs.<\/jats:p>","DOI":"10.1093\/nar\/gkad153","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T12:54:13Z","timestamp":1678884853000},"page":"3722-3734","source":"Crossref","is-referenced-by-count":20,"title":["Widely spaced and divergent inverted repeats become a potent source of chromosomal rearrangements in long single-stranded DNA regions"],"prefix":"10.1093","volume":"51","author":[{"given":"Anissia","family":"Ait\u00a0Saada","sequence":"first","affiliation":[{"name":"School of Biological Sciences and Institute for Bioengineering and Bioscience, Georgia Institute of Technology , Atlanta , GA \u00a030332, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenying","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Biological Sciences and Institute for Bioengineering and Bioscience, Georgia Institute of Technology , Atlanta , GA \u00a030332, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex B","family":"Costa","sequence":"additional","affiliation":[{"name":"School of Biological Sciences and Institute for Bioengineering and Bioscience, Georgia Institute of Technology , Atlanta , GA \u00a030332, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Computational Mathematics, Science and Engineering, Michigan State University , East Lansing , MI \u00a048824, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9290-4888","authenticated-orcid":false,"given":"Jianrong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Computational Mathematics, Science and Engineering, Michigan State University , East Lansing , MI \u00a048824, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5775-1679","authenticated-orcid":false,"given":"Kirill\u00a0S","family":"Lobachev","sequence":"additional","affiliation":[{"name":"School of Biological Sciences and Institute for Bioengineering and Bioscience, Georgia Institute of Technology , Atlanta , GA \u00a030332, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,3,15]]},"reference":[{"key":"2023050800304024800_B1","doi-asserted-by":"crossref","first-page":"e00110-20","DOI":"10.1128\/MMBR.00110-20","article-title":"Alternative DNA structures in vivo: molecular evidence and remaining questions","volume":"85","author":"Poggi","year":"2021","journal-title":"Microbiol. 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