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This is a landmark event of meiosis that ensures genetic diversity in sexually reproducing organisms. However, the regulatory mechanism of DMC1\/RAD51-ssDNA nucleoprotein filaments during homologous recombination in mammals has remained largely elusive. Here, we show that SPIDR (scaffold protein involved in DNA repair) regulates the assembly or stability of RAD51\/DMC1 on ssDNA. Knockout of Spidr in male mice causes complete meiotic arrest, accompanied by defects in synapsis and crossover formation, which leads to male infertility. In females, loss of Spidr leads to subfertility; some Spidr\u2212\/\u2212 oocytes are able to complete meiosis. Notably, fertility is rescued partially by ablation of the DNA damage checkpoint kinase CHK2 in Spidr\u2212\/\u2212 females but not in males. Thus, our study identifies SPIDR as an essential meiotic recombination factor in homologous recombination in mammals.<\/jats:p>","DOI":"10.1093\/nar\/gkad154","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T13:27:10Z","timestamp":1679318830000},"page":"3855-3868","source":"Crossref","is-referenced-by-count":24,"title":["SPIDR is required for homologous recombination during mammalian meiosis"],"prefix":"10.1093","volume":"51","author":[{"given":"Tao","family":"Huang","sequence":"first","affiliation":[{"name":"Center for Reproductive Medicine, Shandong University , Jinan , Shandong 250012 , China"},{"name":"Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University , Jinan , Shandong 250012 , China"},{"name":"Shandong Provincial Clinical Medicine Research Center for Reproductive Health , Jinan , Shandong 250012 , China"},{"name":"Shandong Technology Innovation Center for Reproductive Health , Jinan , Shandong 250012 , China"},{"name":"CUHK-SDU Joint Laboratory on Reproductive Genetics, School of Biomedical Sciences, the Chinese University of Hong Kong , Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Wu","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Shandong University , Jinan , Shandong 250012 , China"},{"name":"Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University , Jinan , Shandong 250012 , China"},{"name":"Shandong Provincial Clinical Medicine Research Center for Reproductive Health , Jinan , Shandong 250012 , China"},{"name":"Shandong Technology Innovation Center for Reproductive Health , Jinan , Shandong 250012 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Shandong University , Jinan , Shandong 250012 , China"},{"name":"Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University , Jinan , Shandong 250012 , China"},{"name":"Shandong Provincial Clinical Medicine Research Center for Reproductive Health , Jinan , Shandong 250012 , China"},{"name":"Shandong Technology Innovation Center for Reproductive Health , Jinan , Shandong 250012 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyou","family":"Bao","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Shandong University , Jinan , Shandong 250012 , China"},{"name":"Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University , Jinan , Shandong 250012 , China"},{"name":"Shandong Provincial Clinical Medicine Research Center for Reproductive Health , Jinan , Shandong 250012 , China"},{"name":"Shandong Technology Innovation Center for Reproductive Health , Jinan , Shandong 250012 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Wan","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Shandong University , Jinan , Shandong 250012 , China"},{"name":"Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University , Jinan , Shandong 250012 , China"},{"name":"Shandong Provincial Clinical Medicine Research Center for Reproductive Health , Jinan , Shandong 250012 , China"},{"name":"Shandong Technology Innovation Center for Reproductive Health , Jinan , Shandong 250012 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Shandong University , Jinan , Shandong 250012 , China"},{"name":"Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University , Jinan , Shandong 250012 , China"},{"name":"Shandong Provincial Clinical Medicine Research Center for Reproductive Health , Jinan , Shandong 250012 , China"},{"name":"Shandong Technology Innovation Center for Reproductive Health , Jinan , Shandong 250012 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjing","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Shandong University , Jinan , Shandong 250012 , China"},{"name":"Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University , Jinan , Shandong 250012 , China"},{"name":"Shandong Provincial Clinical Medicine Research Center for Reproductive Health , Jinan , Shandong 250012 , China"},{"name":"Shandong Technology Innovation Center for Reproductive Health , Jinan , Shandong 250012 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochen","family":"Yu","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Shandong University , Jinan , Shandong 250012 , 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, China"},{"name":"CUHK-SDU Joint Laboratory on Reproductive Genetics, School of Biomedical Sciences, the Chinese University of Hong Kong , Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,3,20]]},"reference":[{"key":"2023050800332196200_B1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/nrg2723","article-title":"Genetics of mammalian meiosis: regulation, dynamics and impact on fertility","volume":"11","author":"Handel","year":"2010","journal-title":"Nat. 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