{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:35:28Z","timestamp":1791549328836,"version":"4.3.4"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"15","license":[{"start":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:00:00Z","timestamp":1687910400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014364","name":"Samsung Science and Technology Foundation","doi-asserted-by":"publisher","award":["SSTF-BA1901-13"],"award-info":[{"award-number":["SSTF-BA1901-13"]}],"id":[{"id":"10.13039\/501100014364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["NRF-2020R1I1A1A01074294"],"award-info":[{"award-number":["NRF-2020R1I1A1A01074294"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["2016M3A9D5A01952411"],"award-info":[{"award-number":["2016M3A9D5A01952411"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["2022R1A4A1021318"],"award-info":[{"award-number":["2022R1A4A1021318"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010446","name":"Institute for Basic Science","doi-asserted-by":"publisher","award":["IBS-R022-D1"],"award-info":[{"award-number":["IBS-R022-D1"]}],"id":[{"id":"10.13039\/501100010446","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Replication protein A (RPA), a eukaryotic single-stranded DNA (ssDNA) binding protein, dynamically interacts with ssDNA in different binding modes and plays essential roles in DNA metabolism such as replication, repair, and recombination. RPA accumulation on ssDNA due to replication stress triggers the DNA damage response (DDR) by activating the ataxia telangiectasia and RAD3-related (ATR) kinase, which phosphorylates itself and downstream DDR factors, including RPA. We recently reported that the N-methyl-D-aspartate receptor synaptonuclear signaling and neuronal migration factor (NSMF), a neuronal protein associated with Kallmann syndrome, promotes RPA32 phosphorylation via ATR upon replication stress. However, how NSMF enhances ATR-mediated RPA32 phosphorylation remains elusive. Here, we demonstrate that NSMF colocalizes and physically interacts with RPA at DNA damage sites in vivo and in vitro. Using purified RPA and NSMF in biochemical and single-molecule assays, we find that NSMF selectively displaces RPA in the more weakly bound 8- and 20-nucleotide binding modes from ssDNA, allowing the retention of more stable RPA molecules in the 30-nt binding mode. The 30-nt binding mode of RPA enhances RPA32 phosphorylation by ATR, and phosphorylated RPA becomes stabilized on ssDNA. Our findings provide new mechanistic insight into how NSMF facilitates the role of RPA in the ATR pathway.<\/jats:p>","DOI":"10.1093\/nar\/gkad543","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T13:13:13Z","timestamp":1687957993000},"page":"7936-7950","source":"Crossref","is-referenced-by-count":14,"title":["Alteration of replication protein A binding mode on single-stranded DNA by NSMF potentiates RPA phosphorylation by ATR kinase"],"prefix":"10.1093","volume":"51","author":[{"given":"Yujin","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Ulsan National Institute of Science and Technology , Ulsan \u00a044919, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye Gi","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Ulsan National Institute of Science and Technology , Ulsan \u00a044919, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keon Woo","family":"Khim","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Ulsan National Institute of Science and Technology , Ulsan \u00a044919, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo Gyun","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Ulsan National Institute of Science and Technology , Ulsan \u00a044919, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Kyung","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Ulsan National Institute of Science and Technology , Ulsan \u00a044919, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kibeom","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Ulsan National Institute of Science and Technology , Ulsan \u00a044919, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyeong Jin","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Ulsan National Institute of Science and Technology , Ulsan \u00a044919, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5869-5250","authenticated-orcid":false,"given":"Young Chan","family":"Chae","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Ulsan National Institute of Science and Technology , Ulsan \u00a044919, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jang Hyun","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Ulsan National Institute of Science and Technology , Ulsan \u00a044919, Republic of Korea"},{"name":"Institute of Basic Science Center for Genomic Integrity , Ulsan \u00a044919, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongtae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Ulsan National Institute of Science and Technology , Ulsan \u00a044919, Republic of Korea"},{"name":"Institute of Basic Science Center for Genomic Integrity , Ulsan \u00a044919, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5726-9022","authenticated-orcid":false,"given":"Ja Yil","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Ulsan National Institute of Science and Technology , Ulsan \u00a044919, Republic of Korea"},{"name":"Institute of Basic Science Center for Genomic Integrity , Ulsan \u00a044919, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,6,28]]},"reference":[{"key":"2023082505114751800_B1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1146\/annurev.biochem.66.1.61","article-title":"Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism","volume":"66","author":"Wold","year":"1997","journal-title":"Annu. Rev. Biochem."},{"key":"2023082505114751800_B2","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1080\/10409239991209255","article-title":"Replication protein A (RPA): the eukaryotic SSB","volume":"34","author":"Iftode","year":"1999","journal-title":"Crit. Rev. Biochem. Mol."},{"key":"2023082505114751800_B3","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.molcel.2010.09.019","article-title":"The DNA damage response: making it safe to play with knives","volume":"40","author":"Ciccia","year":"2010","journal-title":"Molecular Cell"},{"key":"2023082505114751800_B4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/cr.2014.147","article-title":"RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response","volume":"25","author":"Marechal","year":"2015","journal-title":"Cell Res."},{"key":"2023082505114751800_B5","first-page":"5","article-title":"DNA damage sensing by the ATM and ATR kinases","author":"Marechal","year":"2013","journal-title":"Cold Spring Harb. Perspect. 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