{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:58:13Z","timestamp":1792180693952,"version":"4.4.0"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"16","license":[{"start":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T00:00:00Z","timestamp":1690502400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000854","name":"Human Frontier Science Program","doi-asserted-by":"publisher","award":["RGP0024\/2018"],"award-info":[{"award-number":["RGP0024\/2018"]}],"id":[{"id":"10.13039\/501100000854","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Villum Experiment Grant","award":["17595"],"award-info":[{"award-number":["17595"]}]},{"DOI":"10.13039\/501100001381","name":"National Research Foundation of Singapore","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001381","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Singapore-MIT Alliance for Research and Technology Antimicrobial Resistance Interdisciplinary Research Group"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Deazaguanine DNA modifications are widespread in phages, particularly in those with pathogenic hosts. Pseudomonas phage iggy substitutes \u223c16.5% of its genomic 2\u2032-deoxyguanosine (G) with dPreQ0, and the iggy deazaguanine transglycosylase (DpdA) is unique in having a strict GA target motif, not observed previously. The iggy PreQ0 modification is shown to provide protection against both restriction endonucleases and Cas9 (when present in PAM), thus expanding our understanding of the deazaguanine modification system, its potential, and diversity. Phage iggy represents a new genus of Pseudomonas phages within the Queuovirinae subfamily; which have very little in common with other published phage genomes in terms of nucleotide similarity (&amp;lt;10%) and common proteins (&amp;lt;2%). Interestingly, shared similarity is concentrated in dpdA and preQ0 biosynthesis genes. TEM imaging confirmed a siphovirus morphology with a prolate icosahedral head and a non-contractile flexible tail with one long central tail spike. The observed protective effect of the deazaguanine modification on the iggy DNA may contribute to its broad within-species host range. Phage iggy was isolated on Pseudomonas aeruginosa PAO1, but also infects PDO300, PAK, PA14, as well as 10 of 27 tested environmental isolates and 13 of 20 tested clinical isolates of P. aeruginosa from patients with cystic fibrosis.<\/jats:p>","DOI":"10.1093\/nar\/gkad622","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T11:04:11Z","timestamp":1690542251000},"page":"8663-8676","source":"Crossref","is-referenced-by-count":15,"title":["A novel <i>Queuovirinae<\/i> lineage of <i>Pseudomonas aeruginosa<\/i> phages encode dPreQ0 DNA modifications with a single GA motif that provide restriction and CRISPR Cas9 protection <i>in vitro<\/i>"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8400-2617","authenticated-orcid":false,"given":"Nikoline S","family":"Olsen","sequence":"first","affiliation":[{"name":"Department of Plant and Environmental Sciences, University of Copenhagen , Frederiksberg C, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6610-8450","authenticated-orcid":false,"given":"Tue K","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Plant and Environmental Sciences, University of Copenhagen , Frederiksberg C, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Cui","sequence":"additional","affiliation":[{"name":"Antimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology , Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0011-3067","authenticated-orcid":false,"given":"Peter","family":"Dedon","sequence":"additional","affiliation":[{"name":"Antimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology , Singapore"},{"name":"Department of Biological Engineering, Massachusetts Institute of Technology , Cambridge , MA , US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horst","family":"Neve","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Biotechnology, Max Rubner-Institut , Kiel , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0027-1524","authenticated-orcid":false,"given":"Lars\u00a0H","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Plant and Environmental Sciences, University of Copenhagen , Frederiksberg C, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0188-4587","authenticated-orcid":false,"given":"Witold","family":"Kot","sequence":"additional","affiliation":[{"name":"Department of Plant and Environmental Sciences, University of Copenhagen , Frederiksberg C, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,7,28]]},"reference":[{"key":"2023090800141186700_B1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/978-1-0716-0876-0_5","article-title":"Detection of modified bases in bacteriophage genomic DNA","volume":"2198","author":"Lee","year":"2021","journal-title":"Methods Mol. Biol."},{"key":"2023090800141186700_B2","doi-asserted-by":"crossref","first-page":"5442","DOI":"10.1038\/s41467-019-13384-y","article-title":"7-Deazaguanine modifications protect phage DNA from host restriction systems","volume":"10","author":"Hutinet","year":"2019","journal-title":"Nat. Commun."},{"key":"2023090800141186700_B3","doi-asserted-by":"crossref","first-page":"e01111-19","DOI":"10.1128\/JVI.01111-19","article-title":"Deoxyinosine and 7-deaza-2-deoxyguanosine as carriers of genetic information in the DNA of Campylobacter viruses","volume":"93","author":"Crippen","year":"2019","journal-title":"J. Virol."},{"key":"2023090800141186700_B4","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1128\/ecosalplus.ESP-0028-2019","article-title":"Hypermodified DNA in viruses of E.coli and Salmonella","volume":"9","author":"Hutinet","year":"2021","journal-title":"EcoSal Plus."},{"key":"2023090800141186700_B5","doi-asserted-by":"crossref","first-page":"7979","DOI":"10.1007\/s11033-020-05876-8","article-title":"A novel freshwater cyanophage vB_MelS-me-ZS1 infecting bloom-forming cyanobacterium microcystis elabens","volume":"47","author":"Lin","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"2023090800141186700_B6","doi-asserted-by":"crossref","first-page":"10383","DOI":"10.1093\/nar\/gkaa735","article-title":"Detection of preQ0deazaguanine modifications in bacteriophage CAjan DNA using Nanopore sequencing reveals same hypermodification at two distinct DNA motifs","volume":"48","author":"Kot","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"2023090800141186700_B7","first-page":"e1452","article-title":"Novel genomic island modifies DNA with 7-deazaguanine derivatives","volume":"113","author":"Thiaville","year":"2016","journal-title":"Proc Natl Acad SciUS A"},{"key":"2023090800141186700_B8","doi-asserted-by":"crossref","first-page":"506","DOI":"10.3390\/v13030506","article-title":"A roadmap for genome-based phage taxonomy","volume":"13","author":"Turner","year":"2021","journal-title":"Viruses"},{"key":"2023090800141186700_B9","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1128\/AEM.02256-13","article-title":"Narrow-host-range bacteriophages that infect rhizobium etli associate with distinct genomic types","volume":"80","author":"Santamar\u00eda","year":"2014","journal-title":"Appl Environ Microbiol."},{"key":"2023090800141186700_B10","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1089\/phage.2020.0016","article-title":"A new high-throughput screening (HiTS) method for phages \u2013 Enabling crude isolation and fast identification of diverse phages with therapeutic potential","volume":"1","author":"Olsen","year":"2020","journal-title":"PHAGE"},{"key":"2023090800141186700_B11","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1007\/s00705-022-05477-9","article-title":"Salmonella phage akira, infecting selected Salmonella enterica Enteritidis and Typhimurium strains, represents a new lineage of bacteriophages","volume":"167","author":"Olsen","year":"2022","journal-title":"Arch Virol"},{"key":"2023090800141186700_B12","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/0307-4412(83)90068-7","article-title":"Molecular cloning. A laboratory manual","volume":"11","author":"Wood","year":"1983","journal-title":"Biochem Educ."},{"key":"2023090800141186700_B13","volume-title":"Molecular Cloning: A Laboratory Manual","author":"Sambrook","year":"1989"},{"key":"2023090800141186700_B14","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1089\/cmb.2012.0021","article-title":"SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing","volume":"19","author":"Bankevich","year":"2012","journal-title":"J Comput Biol."},{"key":"2023090800141186700_B15","doi-asserted-by":"crossref","first-page":"8365","DOI":"10.1038\/srep08365","article-title":"RASTtk: a modular and extensible implementation of the RAST algorithm for building custom annotation pipelines and annotating batches of genomes","volume":"5","author":"Brettin","year":"2015","journal-title":"Sci Rep."},{"key":"2023090800141186700_B16","doi-asserted-by":"crossref","first-page":"W451","DOI":"10.1093\/nar\/gki487","article-title":"GeneMark: web software for gene finding in prokaryotes, eukaryotes and viruses","volume":"33","author":"Besemer","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"2023090800141186700_B17","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"Altschul","year":"1990","journal-title":"J Mol Biol."},{"key":"2023090800141186700_B18","doi-asserted-by":"crossref","first-page":"W244","DOI":"10.1093\/nar\/gki408","article-title":"The HHpred interactive server for protein homology detection and structure prediction","volume":"33","author":"Soding","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"2023090800141186700_B19","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1093\/jac\/dks261","article-title":"Identification of acquired antimicrobial resistance genes","volume":"67","author":"Zankari","year":"2012","journal-title":"J Antimicrob. Chemother."},{"key":"2023090800141186700_B20","doi-asserted-by":"crossref","first-page":"D298","DOI":"10.1093\/nar\/gku1046","article-title":"REBASE-a database for DNA restriction and modification: enzymes, genes and genomes","volume":"43","author":"Roberts","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"2023090800141186700_B21","doi-asserted-by":"crossref","first-page":"342","DOI":"10.3390\/v14020342","article-title":"PhageLeads: rapid assessment of phage therapeutic suitability using an ensemble machine learning approach","volume":"14","author":"Yukgehnaish","year":"2022","journal-title":"Viruses"},{"key":"2023090800141186700_B22","doi-asserted-by":"crossref","first-page":"e11396","DOI":"10.7717\/peerj.11396","article-title":"BACPHLIP: predicting bacteriophage lifestyle from conserved protein domains","volume":"9","author":"Hockenberry","year":"2021","journal-title":"PeerJ"},{"key":"2023090800141186700_B23","doi-asserted-by":"crossref","first-page":"D37","DOI":"10.1093\/nar\/gkw1070","article-title":"GenBank","volume":"45","author":"Benson","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"2023090800141186700_B24","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/nar\/gkn180","article-title":"Phylogeny.Fr: robust phylogenetic analysis for the non-specialist","volume":"36","author":"Dereeper","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"2023090800141186700_B25","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1089\/phage.2021.0007","article-title":"INfrastructure for a PHAge reference database: identification of large-scale biases in the current collection of cultured phage genomes","volume":"2","author":"Cook","year":"2021","journal-title":"PHAGE"},{"key":"2023090800141186700_B26","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s13059-016-0997-x","article-title":"Mash: fast genome and metagenome distance estimation using MinHash","volume":"17","author":"Ondov","year":"2016","journal-title":"Genome Biol."},{"key":"2023090800141186700_B27","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1093\/bioinformatics\/btx157","article-title":"ViPTree: the viral proteomic tree server","volume":"33","author":"Nishimura","year":"2017","journal-title":"Bioinformatics"},{"key":"2023090800141186700_B28","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.3390\/v12111268","article-title":"VIRIDIC\u2014A novel tool to calculate the intergenomic similarities of prokaryote-infecting viruses","volume":"12","author":"Moraru","year":"2020","journal-title":"Viruses"},{"key":"2023090800141186700_B29","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1093\/bioinformatics\/btab007","article-title":"clinker & clustermap.Js: automatic generation of gene cluster comparison figures","volume":"37","author":"Gilchrist","year":"2021","journal-title":"Bioinformatics"},{"key":"2023090800141186700_B30","article-title":"De novo identification of DNA modifications enabled by genome-guided nanopore signal processing","author":"Stoiber","year":"2017"},{"key":"2023090800141186700_B31","first-page":"28","article-title":"Fitting a mixture model by expectation maximization to discover motifs in biopolymers","volume":"2","author":"Bailey","year":"1994","journal-title":"Proc. Int. Conf. Intell. Syst. Mol. Biol."},{"key":"2023090800141186700_B32","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/978-1-4939-7395-8_7","article-title":"Determination of the bacteriophage host range: culture-based approach","volume":"1693","author":"Letarov","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"2023090800141186700_B33","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1128\/JB.01515-09","article-title":"Genome diversity of Pseudomonas aeruginosa PAO1 laboratory strains","volume":"192","author":"Klockgether","year":"2010","journal-title":"J Bacteriol."},{"key":"2023090800141186700_B34","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.1099\/mic.0.29175-0","article-title":"Sequence diversity of the mucABD locus in Pseudomonas aeruginosa isolates from patients with cystic fibrosis","volume":"152","author":"Bragonzi","year":"2006","journal-title":"Microbiology"},{"key":"2023090800141186700_B35","doi-asserted-by":"crossref","first-page":"e00865-19","DOI":"10.1128\/MRA.00865-19","article-title":"Complete genome sequence of Pseudomonas aeruginosa reference strain PAK","volume":"8","author":"Cain","year":"2019","journal-title":"Microbiol. Resour. Announc."},{"key":"2023090800141186700_B36","doi-asserted-by":"crossref","first-page":"e29113","DOI":"10.1371\/journal.pone.0029113","article-title":"The Pseudomonas aeruginosa reference strain PA14 displays increased virulence due to a mutation in ladS","volume":"6","author":"Mikkelsen","year":"2011","journal-title":"PLoS One"},{"key":"2023090800141186700_B37","doi-asserted-by":"crossref","first-page":"ftz011","DOI":"10.1093\/femspd\/ftz011","article-title":"P. Aeruginosa flow-cell biofilms are enhanced by repeated phage treatments but can be eradicated by phage\u2013ciprofloxacin combination \u2014monitoring the phage \u2013 P. aeruginosa biofilms interactions","volume":"77","author":"Henriksen","year":"2019","journal-title":"Pathog Dis."},{"key":"2023090800141186700_B38","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1093\/infdis\/130.Supplement.S33","article-title":"Phage typing of Pseudomonas aeruginosa : clinical and epidemiologic considerations","volume":"130","author":"Lindberg","year":"1974","journal-title":"J Infect Dis."},{"key":"2023090800141186700_B39","doi-asserted-by":"crossref","first-page":"7848","DOI":"10.1128\/jb.175.24.7848-7855.1993","article-title":"The Cox protein is a modulator of directionality in bacteriophage P2 site- specific recombination","volume":"175","author":"Yu","year":"1993","journal-title":"J Bacteriol."},{"key":"2023090800141186700_B40","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/mbo3.339","article-title":"Identification and functional analysis of a bacteriocin, pyocin S6, with ribonuclease activity from a Pseudomonas aeruginosa cystic fibrosis clinical isolate","volume":"5","author":"Dingemans","year":"2016","journal-title":"Microbiology open"},{"key":"2023090800141186700_B41","doi-asserted-by":"crossref","first-page":"6058","DOI":"10.1128\/JB.187.17.6058-6068.2005","article-title":"PtrB of Pseudomonas aeruginosa suppresses the type III secretion system under the stress of DNA damage","volume":"187","author":"Wu","year":"2005","journal-title":"J. Bacteriol."},{"key":"2023090800141186700_B42","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1128\/JB.01889-14","article-title":"Biological cost of pyocin production during the SOS response in Pseudomonas aeruginosa","volume":"196","author":"Penterman","year":"2014","journal-title":"J. Bacteriol."},{"key":"2023090800141186700_B43","doi-asserted-by":"crossref","first-page":"e799","DOI":"10.1371\/journal.pone.0000799","article-title":"Phage-antibiotic synergy (PAS): \u03b2-lactam and quinolone antibiotics stimulate virulent phage growth","volume":"2","author":"Comeau","year":"2007","journal-title":"PLoS One"},{"key":"2023090800141186700_B44","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1128\/AEM.02850-14","article-title":"Burkholderia cepacia complex phage-antibiotic synergy (PAS): antibiotics stimulate lytic phage activity","volume":"81","author":"Kamal","year":"2015","journal-title":"Appl Environ Microbiol."},{"key":"2023090800141186700_B45","volume-title":"Create one new subfamily (psQueuovirinae) including one new genus (Amoyvirus) and three existing genera (Caudovirales: Siphoviridae). International Committee on Taxonomy of Viruses (ICTV)","author":"International Committee on Taxonomy of Viruses","year":"2020"},{"key":"2023090800141186700_B46","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1080\/15476286.2016.1265200","article-title":"Deazaguanine derivatives, examples of crosstalk between RNA and DNA modification pathways","volume":"14","author":"Hutinet","year":"2017","journal-title":"RNA Biol."},{"key":"2023090800141186700_B47","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1111\/mec.16679","article-title":"Detection of nucleotide modifications in bacteria and bacteriophages: strengths and limitations of current technologies and software","volume":"32","author":"Nielsen","year":"2023","journal-title":"Mol Ecol."},{"key":"2023090800141186700_B48","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s13059-018-1462-9","article-title":"From squiggle to basepair: computational approaches for improving nanopore sequencing read accuracy","volume":"19","author":"Rang","year":"2018","journal-title":"Genome Biol."},{"key":"2023090800141186700_B49","doi-asserted-by":"crossref","first-page":"e02312-16","DOI":"10.1128\/mBio.02312-16","article-title":"Identification of a Pseudomonas aeruginosa PAO1 DNA methyltransferase, its targets, and physiological roles","volume":"8","author":"Doberenz","year":"2017","journal-title":"MBio"},{"key":"2023090800141186700_B50","doi-asserted-by":"crossref","first-page":"8348","DOI":"10.1038\/s41598-017-08864-4","article-title":"Restriction and modification of deoxyarchaeosine (dG+)-containing phage 9 g DNA","volume":"7","author":"Tsai","year":"2017","journal-title":"Sci Rep."},{"key":"2023090800141186700_B51","doi-asserted-by":"crossref","first-page":"583","DOI":"10.3390\/v10110583","article-title":"Pantoea bacteriophage vB_PagS_Vid5: a low-temperature siphovirus that harbors a cluster of genes involved in the biosynthesis of archaeosine","volume":"10","author":"\u0160imoli\u016bnas","year":"2018","journal-title":"Viruses"},{"key":"2023090800141186700_B52","doi-asserted-by":"crossref","first-page":"15206","DOI":"10.1016\/S0021-9258(17)43794-X","article-title":"Effect of nucleotide analogs on the cleavage of DNA by the restriction enzymes AluI, DdeI, HinfI, RsaI, and TaqI","volume":"258","author":"Bodnar","year":"1983","journal-title":"J Biol Chem."},{"key":"2023090800141186700_B53","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/nature13011","article-title":"DNA interrogation by the CRISPR RNA-guided endonuclease Cas9","volume":"507","author":"Sternberg","year":"2014","journal-title":"Nature"},{"key":"2023090800141186700_B54","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1093\/nar\/gkv094","article-title":"Mechanism of foreign DNA recognition by a CRISPR RNA-guided surveillance complex from Pseudomonas aeruginosa","volume":"43","author":"Rollins","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"2023090800141186700_B55","doi-asserted-by":"crossref","first-page":"3526","DOI":"10.1021\/acs.jpca.3c01358","article-title":"Calculated pKa values for a series of aza- and Deaza-modified nucleobases","volume":"27","author":"Mlotkowski","year":"2023","journal-title":"J. Phys. Chem. A."},{"key":"2023090800141186700_B56","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1080\/15476286.2018.1504546","article-title":"PAM identification by CRISPR-cas effector complexes: diversified mechanisms and structures","volume":"16","author":"Gleditzsch","year":"2019","journal-title":"RNA Biol."},{"key":"2023090800141186700_B57","doi-asserted-by":"crossref","first-page":"e01796-15","DOI":"10.1128\/mBio.01796-15","article-title":"Phylogenetic distribution of CRISPR-Cas systems in antibiotic-resistant Pseudomonas aeruginosa","volume":"6","author":"Belkum","year":"2015","journal-title":"MBio"},{"key":"2023090800141186700_B58","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1186\/s13059-021-02495-9","article-title":"PAM-repeat associations and spacer selection preferences in single and co-occurring CRISPR-Cas systems","volume":"22","author":"Vink","year":"2021","journal-title":"Genome Biol."},{"key":"2023090800141186700_B59","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41564-017-0061-y","article-title":"Pseudomonas aeruginosa defends against phages through type IV pilus glycosylation","volume":"3","author":"Harvey","year":"2018","journal-title":"Nat Microbiol."},{"key":"2023090800141186700_B60","doi-asserted-by":"crossref","first-page":"7022","DOI":"10.1128\/JB.00938-08","article-title":"Novel proteins that modulate type IV pilus retraction dynamics in Pseudomonas aeruginosa","volume":"190","author":"Asikyan","year":"2008","journal-title":"J Bacteriol."},{"key":"2023090800141186700_B61","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1099\/13500872-145-6-1349","article-title":"Mucoid conversion of Pseudomonas aeruginosa by hydrogen peroxide: a mechanism for virulence activation in the cystic fibrosis lung","volume":"145","author":"Mathee","year":"1999","journal-title":"Microbiology"},{"key":"2023090800141186700_B62","doi-asserted-by":"crossref","first-page":"46","DOI":"10.4161\/bact.1.1.13980","article-title":"Lysis from without","volume":"1","author":"Abedon","year":"2011","journal-title":"Bacteriophage"},{"key":"2023090800141186700_B63","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/s41586-019-1894-8","article-title":"The arms race between bacteria and their phage foes","volume":"577","author":"Hampton","year":"2020","journal-title":"Nature"},{"key":"2023090800141186700_B64","doi-asserted-by":"crossref","first-page":"eaar4120","DOI":"10.1126\/science.aar4120","article-title":"Systematic discovery of antiphage defense systems in the microbial pangenome","volume":"359","author":"Doron","year":"2018","journal-title":"Science"}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/51\/16\/8663\/51300276\/gkad622.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/51\/16\/8663\/51300276\/gkad622.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T00:14:56Z","timestamp":1694132096000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/51\/16\/8663\/7232840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,28]]},"references-count":64,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2023,7,28]]},"published-print":{"date-parts":[[2023,9,8]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkad622","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,9,8]]},"published":{"date-parts":[[2023,7,28]]}}}