{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T23:44:02Z","timestamp":1773445442174,"version":"3.50.1"},"reference-count":85,"publisher":"Oxford University Press (OUP)","issue":"22","license":[{"start":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T00:00:00Z","timestamp":1698883200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01-ES025987"],"award-info":[{"award-number":["R01-ES025987"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01-ES024050"],"award-info":[{"award-number":["R01-ES024050"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01-CA168469"],"award-info":[{"award-number":["R01-CA168469"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Ultraviolet light generates cyclobutane pyrimidine dimer (CPD) and pyrimidine 6\u22124 pyrimidone (6\u22124PP) photoproducts that cause skin malignancies if not repaired by nucleotide excision repair (NER). While the faster repair of the more distorting 6\u20134PPs is attributed mainly to more efficient recognition by XPC, the XPD lesion verification helicase may play a role, as it directly scans the damaged DNA strand. With extensive molecular dynamics simulations of XPD-bound single-strand DNA containing each lesion outside the entry pore of XPD, we elucidate strikingly different verification processes for these two lesions that have very different topologies. The open book-like CPD thymines are sterically blocked from pore entry and preferably entrapped by sensors that are outside the pore; however, the near-perpendicular 6\u22124PP thymines can enter, accompanied by a displacement of the Arch domain toward the lesion, which is thereby tightly accommodated within the pore. This trapped 6\u22124PP may inhibit XPD helicase activity to foster lesion verification by locking the Arch to other domains. Furthermore, the movement of the Arch domain, only in the case of 6\u22124PP, may trigger signaling to the XPG nuclease for subsequent lesion incision by fostering direct contact between the Arch domain and XPG, and thereby facilitating repair of 6\u22124PP.<\/jats:p>","DOI":"10.1093\/nar\/gkad974","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:05:11Z","timestamp":1699362311000},"page":"12261-12274","source":"Crossref","is-referenced-by-count":11,"title":["Differing structures and dynamics of two photolesions portray verification differences by the human XPD helicase"],"prefix":"10.1093","volume":"51","author":[{"given":"Iwen","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Biology, New York University , 24 Waverly Place, 6th Floor, New\u00a0York , NY\u00a0 10003 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas E","family":"Geacintov","sequence":"additional","affiliation":[{"name":"Department of Chemistry, New York University , 100 Washington Square East, New\u00a0York , NY\u00a0 10003 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3802-7511","authenticated-orcid":false,"given":"Suse","family":"Broyde","sequence":"additional","affiliation":[{"name":"Department of Biology, New York University , 24 Waverly Place, 6th Floor, New\u00a0York , NY\u00a0 10003 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,11,2]]},"reference":[{"key":"2023121117223101600_B1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/php.12542","article-title":"Photobiological origins of the field of genomic maintenance","volume":"92","author":"Ganesan","year":"2016","journal-title":"Photochem. Photobiol."},{"key":"2023121117223101600_B2","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/php.12646","article-title":"UV-induced DNA damage and mutagenesis in chromatin","volume":"93","author":"Mao","year":"2017","journal-title":"Photochem. Photobiol."},{"key":"2023121117223101600_B3","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1039\/c7pp00395a","article-title":"Formation of UV-induced DNA damage contributing to skin cancer development","volume":"17","author":"Cadet","year":"2018","journal-title":"Photochem. Photobiol. Sci."},{"key":"2023121117223101600_B4","doi-asserted-by":"crossref","first-page":"8502","DOI":"10.1002\/anie.201601524","article-title":"Mechanisms of DNA repair by photolyase and excision nuclease (Nobel Lecture)","volume":"55","author":"Sancar","year":"2016","journal-title":"Angew. Chem. Int. Ed Engl."},{"key":"2023121117223101600_B5","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1056\/NEJMra0804615","article-title":"DNA damage, aging, and cancer","volume":"361","author":"Hoeijmakers","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"2023121117223101600_B6","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1021\/cr040483f","article-title":"Molecular mechanisms of mammalian global genome nucleotide excision repair","volume":"106","author":"Gillet","year":"2006","journal-title":"Chem. Rev."},{"key":"2023121117223101600_B7","doi-asserted-by":"crossref","first-page":"a012609","DOI":"10.1101\/cshperspect.a012609","article-title":"Nucleotide excision repair in eukaryotes","volume":"5","author":"Sch\u00e4rer","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"2023121117223101600_B8","doi-asserted-by":"crossref","first-page":"2946","DOI":"10.1002\/anie.200200523","article-title":"Chemistry and biology of DNA repair","volume":"42","author":"Sch\u00e4rer","year":"2003","journal-title":"Angew. Chem. Int. Ed Engl."},{"key":"2023121117223101600_B9","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/nature08467","article-title":"The DNA-damage response in human biology and disease","volume":"461","author":"Jackson","year":"2009","journal-title":"Nature"},{"key":"2023121117223101600_B10","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/jid.2011.426","article-title":"Shining a light on xeroderma pigmentosum","volume":"132","author":"DiGiovanna","year":"2012","journal-title":"J. Invest. Dermatol."},{"key":"2023121117223101600_B11","doi-asserted-by":"crossref","first-page":"12222","DOI":"10.3390\/ijms140612222","article-title":"UV radiation and the skin","volume":"14","author":"D\u2019Orazio","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"2023121117223101600_B12","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nrm3822","article-title":"Understanding nucleotide excision repair and its roles in cancer and ageing","volume":"15","author":"Marteijn","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2023121117223101600_B13","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/em.22087","article-title":"Mechanisms of DNA damage, repair, and mutagenesis","volume":"58","author":"Chatterjee","year":"2017","journal-title":"Environ. Mol. Mutagen."},{"key":"2023121117223101600_B14","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3389\/fgene.2016.00068","article-title":"Global-genome nucleotide excision repair controlled by ubiquitin\/sumo modifiers","volume":"7","author":"R\u00fcthemann","year":"2016","journal-title":"Front. Genet."},{"key":"2023121117223101600_B15","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature01408","article-title":"DNA damage and repair","volume":"421","author":"Friedberg","year":"2003","journal-title":"Nature"},{"key":"2023121117223101600_B16","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/218652a0","article-title":"Defective repair replication of DNA in xeroderma pigmentosum","volume":"218","author":"Cleaver","year":"1968","journal-title":"Nature"},{"key":"2023121117223101600_B17","first-page":"254","article-title":"Photosensitivity, corneal scarring and developmental delay: xeroderma Pigmentosum in a tropical country","volume":"1","author":"Halpern","year":"2008","journal-title":"Yinanbing Zazhi"},{"key":"2023121117223101600_B18","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.cell.2008.10.045","article-title":"Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex","volume":"135","author":"Scrima","year":"2008","journal-title":"Cell"},{"key":"2023121117223101600_B19","first-page":"16","article-title":"Multiple DNA damage recognition factors involved in mammalian nucleotide excision repair","volume":"76","author":"Sugasawa","year":"2011","journal-title":"Biochemistry"},{"key":"2023121117223101600_B20","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.cell.2005.02.035","article-title":"UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex","volume":"121","author":"Sugasawa","year":"2005","journal-title":"Cell"},{"key":"2023121117223101600_B21","doi-asserted-by":"crossref","first-page":"46906","DOI":"10.1074\/jbc.M307254200","article-title":"In vivo recruitment of XPC to UV-induced cyclobutane pyrimidine dimers by the DDB2 gene product","volume":"278","author":"Fitch","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2023121117223101600_B22","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S1097-2765(00)80252-X","article-title":"Xeroderma pigmentosum p48 gene enhances global genomic repair and suppresses UV-induced mutagenesis","volume":"5","author":"Tang","year":"2000","journal-title":"Mol. Cell"},{"key":"2023121117223101600_B23","first-page":"E3408","article-title":"Single-nucleotide resolution dynamic repair maps of UV damage in Saccharomyces cerevisiae genome","volume":"115","author":"Li","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023121117223101600_B24","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1101\/gad.261271.115","article-title":"Genome-wide analysis of human global and transcription-coupled excision repair of UV damage at single-nucleotide resolution","volume":"29","author":"Hu","year":"2015","journal-title":"Genes Dev."},{"key":"2023121117223101600_B25","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0165-7992(85)80018-X","article-title":"(6-4)Photoproducts are removed from the DNA of UV-irradiated mammalian cells more efficiently than cyclobutane pyrimidine dimers","volume":"143","author":"Mitchell","year":"1985","journal-title":"Mutat. Res."},{"key":"2023121117223101600_B26","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1111\/1523-1747.ep12349031","article-title":"The In situ repair kinetics of epidermal thymine dimers and 6-4 photoproducts in Human skin types I and II","volume":"106","author":"Young","year":"1996","journal-title":"J. Invest. Dermatol."},{"key":"2023121117223101600_B27","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1158\/0008-5472.CAN-03-2070","article-title":"Differential repair of the two major UV-induced photolesions in trichothiodystrophy fibroblasts","volume":"64","author":"Riou","year":"2004","journal-title":"Cancer Res."},{"key":"2023121117223101600_B28","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1101\/gad.866301","article-title":"A multistep damage recognition mechanism for global genomic nucleotide excision repair","volume":"15","author":"Sugasawa","year":"2001","journal-title":"Genes Dev."},{"key":"2023121117223101600_B29","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1006\/jmbi.2000.3857","article-title":"Stable binding of human XPC complex to irradiated DNA confers strong discrimination for damaged sites","volume":"300","author":"Batty","year":"2000","journal-title":"J. Mol. Biol."},{"key":"2023121117223101600_B30","doi-asserted-by":"crossref","first-page":"13765","DOI":"10.1073\/pnas.0604213103","article-title":"Cyclobutane pyrimidine dimers are predominant DNA lesions in whole human skin exposed to UVA radiation","volume":"103","author":"Mouret","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2023121117223101600_B31","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0921-8777(00)00082-3","article-title":"Diversity of the damage recognition step in the global genomic nucleotide excision repair in vitro","volume":"485","author":"Kusumoto","year":"2001","journal-title":"Mutat. Res."},{"key":"2023121117223101600_B32","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1101\/gad.1131003","article-title":"Recognition and repair of the cyclobutane thymine dimer, a major cause of skin cancers, by the human excision nuclease","volume":"17","author":"Reardon","year":"2003","journal-title":"Genes Dev."},{"key":"2023121117223101600_B33","doi-asserted-by":"crossref","first-page":"44688","DOI":"10.1074\/jbc.M107696200","article-title":"Cyclobutane pyrimidine dimers are responsible for the vast majority of mutations induced by UVB irradiation in mammalian cells","volume":"276","author":"You","year":"2001","journal-title":"J. Biol. Chem."},{"key":"2023121117223101600_B34","doi-asserted-by":"crossref","first-page":"E2124","DOI":"10.1073\/pnas.1603388113","article-title":"Genome-wide kinetics of DNA excision repair in relation to chromatin state and mutagenesis","volume":"113","author":"Adar","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2023121117223101600_B35","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1269\/jrr.10175","article-title":"The mechanisms of UV mutagenesis","volume":"52","author":"Ikehata","year":"2011","journal-title":"J. Radiat. Res."},{"key":"2023121117223101600_B36","doi-asserted-by":"crossref","first-page":"102972","DOI":"10.1016\/j.dnarep.2020.102972","article-title":"Envisioning how the prototypic molecular machine TFIIH functions in transcription initiation and DNA repair","volume":"96","author":"Tsutakawa","year":"2020","journal-title":"DNA Repair (Amst.)"},{"key":"2023121117223101600_B37","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1042\/BST20210246","article-title":"Mechanism of action of nucleotide excision repair machinery","volume":"50","author":"D'Souza","year":"2022","journal-title":"Biochem. Soc. Trans."},{"key":"2023121117223101600_B38","doi-asserted-by":"crossref","first-page":"102605","DOI":"10.1016\/j.sbi.2023.102605","article-title":"At the core of nucleotide excision repair","volume":"80","author":"Kuper","year":"2023","journal-title":"Curr. Opin. Struct. Biol."},{"key":"2023121117223101600_B39","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/nrm2549","article-title":"Transcription-coupled DNA repair: two decades of progress and surprises","volume":"9","author":"Hanawalt","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2023121117223101600_B40","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s00018-015-2075-z","article-title":"Xeroderma pigmentosum group C sensor: unprecedented recognition strategy and tight spatiotemporal regulation","volume":"73","author":"Puumalainen","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"2023121117223101600_B41","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s41021-019-0119-6","article-title":"Mechanism and regulation of DNA damage recognition in nucleotide excision repair","volume":"41","author":"Kusakabe","year":"2019","journal-title":"Genes Environ"},{"key":"2023121117223101600_B42","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/s41586-019-1259-3","article-title":"DNA damage detection in nucleosomes involves DNA register shifting","volume":"571","author":"Matsumoto","year":"2019","journal-title":"Nature"},{"key":"2023121117223101600_B43","doi-asserted-by":"crossref","first-page":"e2207408119","DOI":"10.1073\/pnas.2207408119","article-title":"Two interaction surfaces between XPA and RPA organize the preincision complex in nucleotide excision repair","volume":"119","author":"Kim","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2023121117223101600_B44","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1038\/s41467-019-10745-5","article-title":"Structural basis of TFIIH activation for nucleotide excision repair","volume":"10","author":"Kokic","year":"2019","journal-title":"Nat. Commun."},{"key":"2023121117223101600_B45","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1093\/nar\/gkac1095","article-title":"A scanning-to-incision switch in TFIIH-XPG induced by DNA damage licenses nucleotide excision repair","volume":"51","author":"Bralic","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"2023121117223101600_B46","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/s41586-023-05959-z","article-title":"Lesion recognition by XPC, TFIIH and XPA in DNA excision repair","volume":"617","author":"Kim","year":"2023","journal-title":"Nature"},{"key":"2023121117223101600_B47","doi-asserted-by":"crossref","first-page":"5293","DOI":"10.1093\/emboj\/cdg489","article-title":"The comings and goings of nucleotide excision repair factors on damaged DNA","volume":"22","author":"Riedl","year":"2003","journal-title":"EMBO J."},{"key":"2023121117223101600_B48","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1038\/emboj.2009.49","article-title":"Coordination of dual incision and repair synthesis in human nucleotide excision repair","volume":"28","author":"Staresincic","year":"2009","journal-title":"EMBO J."},{"key":"2023121117223101600_B49","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1021\/acs.chemrestox.7b00128","article-title":"Repair-resistant DNA lesions","volume":"30","author":"Geacintov","year":"2017","journal-title":"Chem. Res. Toxicol."},{"key":"2023121117223101600_B50","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1751-1097.1995.tb05236.x","article-title":"Contrasting structural impacts induced by cis-syn cyclobutane dimer and (6-4) adduct in DNA duplex decamers: implication in mutagenesis and repair activity","volume":"62","author":"Kim","year":"1995","journal-title":"Photochem. Photobiol."},{"key":"2023121117223101600_B51","doi-asserted-by":"crossref","first-page":"20321","DOI":"10.3390\/ijms151120321","article-title":"Structural biology of DNA (6-4) photoproducts formed by ultraviolet radiation and interactions with their binding proteins","volume":"15","author":"Yokoyama","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"2023121117223101600_B52","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1111\/j.1432-1033.1995.tb20331.x","article-title":"The solution structure of DNA duplex-decamer containing the (6-4) photoproduct of thymidylyl(3'\u21925')thymidine by NMR and relaxation matrix refinement","volume":"228","author":"Kim","year":"1995","journal-title":"Eur. J. Biochem."},{"key":"2023121117223101600_B53","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0300-9084(99)80036-4","article-title":"DNA damage recognition during nucleotide excision repair in mammalian cells","volume":"81","author":"Wood","year":"1999","journal-title":"Biochimie"},{"key":"2023121117223101600_B54","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S1097-2765(00)80132-X","article-title":"Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repair","volume":"2","author":"Sugasawa","year":"1998","journal-title":"Mol. Cell"},{"key":"2023121117223101600_B55","doi-asserted-by":"crossref","first-page":"5664","DOI":"10.1128\/MCB.25.13.5664-5674.2005","article-title":"Centrin 2 stimulates nucleotide excision repair by interacting with xeroderma pigmentosum group C protein","volume":"25","author":"Nishi","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"2023121117223101600_B56","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1242\/jcs.031708","article-title":"Versatile DNA damage detection by the global genome nucleotide excision repair protein XPC","volume":"121","author":"Hoogstraten","year":"2008","journal-title":"J. Cell Sci."},{"key":"2023121117223101600_B57","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.dnarep.2018.08.005","article-title":"Molecular basis for damage recognition and verification by XPC-RAD23B and TFIIH in nucleotide excision repair","volume":"71","author":"Mu","year":"2018","journal-title":"DNA Repair (Amst.)"},{"key":"2023121117223101600_B58","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1021\/acs.chemrestox.8b00231","article-title":"Lesion sensing during initial binding by Yeast XPC\/Rad4: toward predicting resistance to nucleotide excision repair","volume":"31","author":"Mu","year":"2018","journal-title":"Chem. Res. Toxicol."},{"key":"2023121117223101600_B59","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/emboj.2011.374","article-title":"Functional and structural studies of the nucleotide excision repair helicase XPD suggest a polarity for DNA translocation","volume":"31","author":"Kuper","year":"2012","journal-title":"EMBO J."},{"key":"2023121117223101600_B60","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.1074\/jbc.M113.523001","article-title":"Strand-specific recognition of DNA damages by XPD provides insights into nucleotide excision repair substrate versatility","volume":"289","author":"Buechner","year":"2014","journal-title":"J. Biol. Chem."},{"key":"2023121117223101600_B61","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.molcel.2015.08.012","article-title":"Tripartite DNA lesion recognition and verification by XPC, TFIIH, and XPA in nucleotide excision repair","volume":"59","author":"Li","year":"2015","journal-title":"Mol. Cell"},{"key":"2023121117223101600_B62","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S0021-9258(18)48507-9","article-title":"The DNA helicase and adenosine triphosphatase activities of yeast Rad3 protein are inhibited by DNA damage. A potential mechanism for damage-specific recognition","volume":"267","author":"Naegeli","year":"1992","journal-title":"J. Biol. Chem."},{"key":"2023121117223101600_B63","doi-asserted-by":"crossref","first-page":"17545","DOI":"10.1073\/pnas.1004339107","article-title":"Strand- and site-specific DNA lesion demarcation by the xeroderma pigmentosum group D helicase","volume":"107","author":"Mathieu","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2023121117223101600_B64","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.cub.2012.12.032","article-title":"DNA quality control by a lesion sensor pocket of the xeroderma pigmentosum group D helicase subunit of TFIIH","volume":"23","author":"Mathieu","year":"2013","journal-title":"Curr. Biol."},{"key":"2023121117223101600_B65","first-page":"4325","article-title":"Different removal of ultraviolet photoproducts in genetically related xeroderma pigmentosum and trichothiodystrophy diseases","volume":"55","author":"Eveno","year":"1995","journal-title":"Cancer Res."},{"key":"2023121117223101600_B66","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1002\/humu.20768","article-title":"Persistence of repair proteins at unrepaired DNA damage distinguishes diseases with ERCC2 (XPD) mutations: cancer-prone xeroderma pigmentosum vs. non-cancer-prone trichothiodystrophy","volume":"29","author":"Boyle","year":"2008","journal-title":"Hum. Mutat."},{"key":"2023121117223101600_B67","doi-asserted-by":"crossref","first-page":"6837","DOI":"10.1093\/nar\/gkac496","article-title":"Mechanism of lesion verification by the human XPD helicase in nucleotide excision repair","volume":"50","author":"Fu","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"2023121117223101600_B68","doi-asserted-by":"crossref","first-page":"6015","DOI":"10.1093\/nar\/gkz359","article-title":"Structure and mechanism of pyrimidine-pyrimidone (6-4) photoproduct recognition by the Rad4\/XPC nucleotide excision repair complex","volume":"47","author":"Paul","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2023121117223101600_B69","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.bbrc.2016.01.170","article-title":"Crystal structure of the nucleosome containing ultraviolet light-induced cyclobutane pyrimidine dimer","volume":"471","author":"Horikoshi","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2023121117223101600_B70","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0263-7855(96)00018-5","article-title":"VMD - Visual Molecular Dynamics","volume":"14","author":"Humphrey","year":"1996","journal-title":"J. Mol. Graphics"},{"key":"2023121117223101600_B71","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1126\/science.164.3876.183","article-title":"Crystal and molecular structure of a thymine-thymine adduct","volume":"164","author":"Karle","year":"1969","journal-title":"Science"},{"key":"2023121117223101600_B72","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1107\/S0907444912000327","article-title":"Structure of the DNA (6-4) photoproduct dTT(6-4)TT in complex with the 64M-2 antibody Fab fragment implies increased antibody-binding affinity by the flanking nucleotides","volume":"68","author":"Yokoyama","year":"2012","journal-title":"Acta. Crystallogr. D Biol. Crystallogr."},{"key":"2023121117223101600_B73","doi-asserted-by":"crossref","first-page":"e1001954","DOI":"10.1371\/journal.pbio.1001954","article-title":"In TFIIH, XPD helicase is exclusively devoted to DNA repair","volume":"12","author":"Kuper","year":"2014","journal-title":"PLoS Biol."},{"key":"2023121117223101600_B74","doi-asserted-by":"crossref","first-page":"5920","DOI":"10.1021\/nl502890g","article-title":"Direct correlation of DNA binding and single protein domain motion via dual illumination fluorescence microscopy","volume":"14","author":"Ghoneim","year":"2014","journal-title":"Nano Lett."},{"key":"2023121117223101600_B75","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.molcel.2006.07.019","article-title":"The DNA repair helicases XPD and FancJ have essential iron-sulfur domains","volume":"23","author":"Rudolf","year":"2006","journal-title":"Mol. Cell"},{"key":"2023121117223101600_B76","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.cell.2008.04.030","article-title":"XPD helicase structures and activities: insights into the cancer and aging phenotypes from XPD mutations","volume":"133","author":"Fan","year":"2008","journal-title":"Cell"},{"key":"2023121117223101600_B77","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1016\/S1097-2765(03)00182-5","article-title":"Basal transcription defect discriminates between xeroderma pigmentosum and trichothiodystrophy in XPD patients","volume":"11","author":"Dubaele","year":"2003","journal-title":"Mol. Cell"},{"key":"2023121117223101600_B78","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.cell.2008.04.029","article-title":"Structure of the DNA repair helicase XPD","volume":"133","author":"Liu","year":"2008","journal-title":"Cell"},{"key":"2023121117223101600_B79","doi-asserted-by":"crossref","first-page":"e149","DOI":"10.1371\/journal.pbio.0060149","article-title":"Crystal structure of the FeS cluster\u2013Containing nucleotide excision repair helicase XPD","volume":"6","author":"Wolski","year":"2008","journal-title":"PLoS Biol."},{"key":"2023121117223101600_B80","doi-asserted-by":"crossref","first-page":"2806","DOI":"10.1093\/nar\/gkw102","article-title":"Mechanism of DNA loading by the DNA repair helicase XPD","volume":"44","author":"Constantinescu-Aruxandei","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2023121117223101600_B81","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1038\/s41467-023-38416-6","article-title":"Dynamic conformational switching underlies TFIIH function in transcription and DNA repair and impacts genetic diseases","volume":"14","author":"Yu","year":"2023","journal-title":"Nat. Commun."},{"key":"2023121117223101600_B82","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev.biochem.76.052305.115300","article-title":"Structure and mechanism of helicases and nucleic acid translocases","volume":"76","author":"Singleton","year":"2007","journal-title":"Annu. Rev. Biochem."},{"key":"2023121117223101600_B83","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/emboj.2011.412","article-title":"Regulation of translocation polarity by helicase domain 1 in SF2B helicases","volume":"31","author":"Pugh","year":"2012","journal-title":"EMBO J."},{"key":"2023121117223101600_B84","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/nchembio.238","article-title":"NMR spectroscopy brings invisible protein states into focus","volume":"5","author":"Baldwin","year":"2009","journal-title":"Nat. Chem. Biol."},{"key":"2023121117223101600_B85","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.cell.2011.03.004","article-title":"Human flap endonuclease structures, DNA double-base flipping, and a unified understanding of the FEN1 superfamily","volume":"145","author":"Tsutakawa","year":"2011","journal-title":"Cell"}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/51\/22\/12261\/54238825\/gkad974.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/51\/22\/12261\/54238825\/gkad974.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T01:38:09Z","timestamp":1702345089000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/51\/22\/12261\/7337618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,2]]},"references-count":85,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2023,11,2]]},"published-print":{"date-parts":[[2023,12,11]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkad974","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,12,11]]},"published":{"date-parts":[[2023,11,2]]}}}