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It acts as a chromatin regulator and binds with exquisite specificity to gene promoters. The set of epigenetic marks recognized by MeCP2 has been already established (mainly, cytosine modifications in CpG and CpA), as well as many of the constituents of its interactome. We unveil a new set of interactions for MeCP2 with the four canonical nucleosomal histones. MeCP2 interacts with high affinity with H2A, H2B, H3\u00a0and H4. In addition, Rett syndrome associated mutations in MeCP2 and histone epigenetic marks modulate these interactions. Given the abundance and the structural\/functional relevance of histones and their involvement in epigenetic regulation, this new set of interactions and its modulating elements provide a new addition to the \u2018alphabet\u2019 for this epigenetic reader.<\/jats:p>","DOI":"10.1093\/nar\/gkae051","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T09:33:05Z","timestamp":1707298385000},"page":"3636-3653","source":"Crossref","is-referenced-by-count":24,"title":["Extending MeCP2 interactome: canonical nucleosomal histones interact with MeCP2"],"prefix":"10.1093","volume":"52","author":[{"given":"David","family":"Ortega-Alarcon","sequence":"first","affiliation":[{"name":"Institute of Biocomputation and Physics of Complex Systems (BIFI), Joint Unit GBsC-CSIC-BIFI, Universidad de Zaragoza , 50018 Zaragoza, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n (IIS Arag\u00f3n) , 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Claveria-Gimeno","sequence":"additional","affiliation":[{"name":"Certest Biotec S.L. , 50840 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Vega","sequence":"additional","affiliation":[{"name":"Institute of Biocomputation and Physics of Complex Systems (BIFI), Joint Unit GBsC-CSIC-BIFI, Universidad de Zaragoza , 50018 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0892-3745","authenticated-orcid":false,"given":"Ladan","family":"Kalani","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Microbiology, University of Victoria , Victoria, BCV8W 2Y2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga\u00a0C","family":"Jorge-Torres","sequence":"additional","affiliation":[{"name":"Josep Carreras Leukaemia Research Institute (IJC) , 08916 Badalona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4490-6093","authenticated-orcid":false,"given":"Manel","family":"Esteller","sequence":"additional","affiliation":[{"name":"Josep Carreras Leukaemia Research Institute (IJC) , 08916 Badalona, Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red C\u00e1ncer (CIBERONC) , 28029 Madrid, Spain"},{"name":"Institucio Catalana de Recerca i Estudis Avan\u00e7ats (ICREA) , 08010 Barcelona, Spain"},{"name":"Physiological Sciences Department, School of Medicine and Health Sciences, University of Barcelona (UB) , 08907 l\u2019Hospitalet de Llobregat, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Ausio","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Microbiology, University of Victoria , Victoria, BCV8W 2Y2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Abian","sequence":"additional","affiliation":[{"name":"Institute of Biocomputation and Physics of Complex Systems (BIFI), Joint Unit GBsC-CSIC-BIFI, Universidad de Zaragoza , 50018 Zaragoza, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n (IIS Arag\u00f3n) , 50009 Zaragoza, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en el \u00c1rea Tem\u00e1tica de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) , 28029\u00a0 Madrid , Spain"},{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular y Celular, Universidad de Zaragoza , 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5702-4538","authenticated-orcid":false,"given":"Adrian","family":"Velazquez-Campoy","sequence":"additional","affiliation":[{"name":"Institute of Biocomputation and Physics of Complex Systems (BIFI), Joint Unit GBsC-CSIC-BIFI, Universidad de Zaragoza , 50018 Zaragoza, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n (IIS Arag\u00f3n) , 50009 Zaragoza, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en el \u00c1rea Tem\u00e1tica de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) , 28029\u00a0 Madrid , Spain"},{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular y Celular, Universidad de Zaragoza , 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,2,7]]},"reference":[{"key":"2024042404520820500_B1","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.molmed.2014.03.004","article-title":"MeCP2: the long trip from a chromatin protein to neurological disorders","volume":"20","author":"Ausio","year":"2014","journal-title":"Trends Mol. 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