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It plays several roles in human physiology and has been linked to several disorders. Large-scale deep transcriptome sequencing has fostered the characterization of A-to-I editing at the single nucleotide level and the development of dedicated computational resources. REDIportal is a unique and specialized database collecting \u223c16 million\u00a0of putative A-to-I editing sites designed to face the current challenges of epitranscriptomics. Its running version has been enriched with sites from the TCGA project (using data from 31 studies). REDIportal provides an accurate, sustainable and accessible tool enriched with interconnections with widespread ELIXIR core resources such as Ensembl, RNAcentral, UniProt\u00a0and PRIDE. Additionally, REDIportal now includes information regarding RNA editing in putative double-stranded RNAs, relevant for the immune-related roles of editing, as well as an extended catalog of recoding events. Finally, we report a reliability score per site calculated using a deep learning model trained using a huge collection of positive and negative instances. REDIportal is available at http:\/\/srv00.recas.ba.infn.it\/atlas\/.<\/jats:p>","DOI":"10.1093\/nar\/gkae1083","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T15:24:41Z","timestamp":1729697081000},"page":"D233-D242","source":"Crossref","is-referenced-by-count":33,"title":["REDIportal: toward\u00a0an integrated view of the A-to-I editing"],"prefix":"10.1093","volume":"53","author":[{"given":"Pietro","family":"D\u2019Addabbo","sequence":"first","affiliation":[{"name":"Department of Biosciences, Biotechnologies and Environment, University of Bari Aldo Moro , via Orabona 4, 70125, Bari ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roni","family":"Cohen-Fultheim","sequence":"additional","affiliation":[{"name":"Institute of Nanotechnology and Advanced Materials, Bar-Ilan University , Ramat Gan, 52900 ,","place":["Israel"]},{"name":"Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University , Ramat Gan, 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