{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:29:14Z","timestamp":1787009354038,"version":"build-2736575974"},"reference-count":141,"publisher":"Oxford University Press (OUP)","issue":"22","license":[{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35 GM138120"],"award-info":[{"award-number":["R35 GM138120"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 GM132066"],"award-info":[{"award-number":["T32 GM132066"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The p53 family of transcription factors (p53, p63 and p73) regulate diverse organismal processes including tumor suppression, maintenance of genome integrity and the development of skin and limbs. Crosstalk between transcription factors with highly similar DNA binding profiles, like those in the p53 family, can dramatically alter gene regulation. While p53 is primarily associated with transcriptional activation, p63 mediates both activation and repression. The specific mechanisms controlling p63-dependent gene regulatory activity are not well understood. Here, we use massively parallel reporter assays (MPRA) to investigate how local DNA sequence context influences p63-dependent transcriptional activity. Most regulatory elements with a p63 response element motif (p63RE) activate transcription, although binding of the p63 paralog, p53, drives a substantial proportion of that activity. p63RE sequence content and co-enrichment with other known activating and repressing transcription factors, including lineage-specific factors, correlates with differential p63RE-mediated activities. p63 isoforms dramatically alter transcriptional behavior, primarily shifting inactive regulatory elements towards high p63-dependent activity. Our analysis provides novel insight into how local sequence and cellular context influences p63-dependent behaviors and highlights the key, yet still understudied, role of transcription factor paralogs and isoforms in controlling gene regulatory element activity.<\/jats:p>","DOI":"10.1093\/nar\/gkae1143","type":"journal-article","created":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T08:17:14Z","timestamp":1730449034000},"page":"13812-13831","source":"Crossref","is-referenced-by-count":6,"title":["Crosstalk between paralogs and isoforms influences p63-dependent regulatory element activity"],"prefix":"10.1093","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0235-7938","authenticated-orcid":false,"given":"Gabriele","family":"Baniulyte","sequence":"first","affiliation":[{"name":"Department of Biological Sciences and The RNA Institute, University at Albany, State University of New York , 1400 Washington Ave , Albany , NY 12222,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abby A","family":"McCann","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences and The RNA Institute, University at Albany, State University of New York , 1400 Washington Ave , Albany , NY 12222,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana L","family":"Woodstock","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences and The RNA Institute, University at Albany, State University of New York , 1400 Washington Ave , Albany , NY 12222,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5329-1169","authenticated-orcid":false,"given":"Morgan A","family":"Sammons","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences and The RNA Institute, University at Albany, State University of New York , 1400 Washington Ave , Albany , NY 12222,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,11,20]]},"reference":[{"key":"2024122115582138600_B1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.tibs.2014.07.002","article-title":"Absence of a simple code: how transcription factors read the genome","volume":"39","author":"Slattery","year":"2014","journal-title":"Trends Biochem. Sci."},{"key":"2024122115582138600_B2","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.molcel.2009.09.005","article-title":"Transcription dynamics","volume":"35","author":"Hager","year":"2009","journal-title":"Mol. Cell"},{"key":"2024122115582138600_B3","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1126\/science.aba7582","article-title":"Decoupling transcription factor expression and activity enables dimmer switch gene regulation","volume":"372","author":"Ricci-Tam","year":"2021","journal-title":"Science"},{"key":"2024122115582138600_B4","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/nrg3207","article-title":"Transcription factors: from enhancer binding to developmental control","volume":"13","author":"Spitz","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"2024122115582138600_B5","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.cell.2016.09.018","article-title":"Ever-changing landscapes: transcriptional enhancers in development and evolution","volume":"167","author":"Long","year":"2016","journal-title":"Cell"},{"key":"2024122115582138600_B6","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.tig.2023.10.007","article-title":"Pioneer factors: roles and their regulation in development","volume":"40","author":"Barral","year":"2024","journal-title":"Trends Genet."},{"key":"2024122115582138600_B7","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.cell.2007.02.045","article-title":"p63 Is essential for the proliferative potential of stem cells in stratified epithelia","volume":"129","author":"Senoo","year":"2007","journal-title":"Cell"},{"key":"2024122115582138600_B8","doi-asserted-by":"crossref","first-page":"re9","DOI":"10.1126\/scisignal.aaa1033","article-title":"Maintaining epithelial stemness with p63","volume":"8","author":"Melino","year":"2015","journal-title":"Sci. Signal."},{"key":"2024122115582138600_B9","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1038\/s41388-023-02859-4","article-title":"p63: a crucial player in epithelial stemness regulation","volume":"42","author":"Li","year":"2023","journal-title":"Oncogene"},{"key":"2024122115582138600_B10","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S1097-2765(00)80275-0","article-title":"p63, a p53 homolog at 3q27\u201329, encodes multiple products with transactivating, death-inducing, and dominant-negative activities","volume":"2","author":"Yang","year":"1998","journal-title":"Mol. Cell"},{"key":"2024122115582138600_B11","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/19531","article-title":"p63 is a p53 homologue required for limb and epidermal morphogenesis","volume":"398","author":"Mills","year":"1999","journal-title":"Nature"},{"key":"2024122115582138600_B12","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0092-8674(00)81646-3","article-title":"Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome","volume":"99","author":"Celli","year":"1999","journal-title":"Cell"},{"key":"2024122115582138600_B13","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/sj.ejhg.5200676","article-title":"TP63 gene mutation in ADULT syndrome","volume":"9","author":"Amiel","year":"2001","journal-title":"Eur. J. Hum. Genet."},{"key":"2024122115582138600_B14","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/hmg\/10.3.221","article-title":"Hay\u2013Wells syndrome is caused by heterozygous missense mutations in the SAM domain of p63","volume":"10","author":"McGrath","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"2024122115582138600_B15","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1086\/323123","article-title":"p63 Gene mutations in EEC syndrome, limb-mammary syndrome, and isolated split hand\u2013Split foot malformation suggest a genotype-phenotype correlation","volume":"69","author":"van\u00a0Bokhoven","year":"2001","journal-title":"Am. Hum. Genet."},{"key":"2024122115582138600_B16","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/sj.ejhg.5201004","article-title":"The Rapp\u2013Hodgkin syndrome results from mutations of the TP63 gene","volume":"11","author":"Bougeard","year":"2003","journal-title":"Eur. J. Hum. Genet."},{"key":"2024122115582138600_B17","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.neuron.2011.09.009","article-title":"p63 Regulates olfactory stem cell self-renewal and differentiation","volume":"72","author":"Fletcher","year":"2011","journal-title":"Neuron"},{"key":"2024122115582138600_B18","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/cdd.2013.199","article-title":"p63 is a prosurvival factor in the adult mammary gland during post-lactational involution, affecting PI-MECs and ErbB2 tumorigenesis","volume":"21","author":"Yallowitz","year":"2014","journal-title":"Cell Death Differ."},{"key":"2024122115582138600_B19","doi-asserted-by":"crossref","first-page":"e1006828","DOI":"10.1371\/journal.pgen.1006828","article-title":"p63 exerts spatio-temporal control of palatal epithelial cell fate to prevent cleft palate","volume":"13","author":"Richardson","year":"2017","journal-title":"PLoS Genet."},{"key":"2024122115582138600_B20","doi-asserted-by":"crossref","first-page":"14043","DOI":"10.1038\/s41598-018-32343-z","article-title":"Genetic and scRNA-seq analysis reveals distinct cell populations that contribute to salivary gland development and maintenance","volume":"8","author":"Song","year":"2018","journal-title":"Sci. Rep."},{"key":"2024122115582138600_B21","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1038\/ng.242","article-title":"Disruption of an AP-2alpha binding site in an IRF6 enhancer is associated with cleft lip","volume":"40","author":"Rahimov","year":"2008","journal-title":"Nat. Genet."},{"key":"2024122115582138600_B22","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1172\/JCI40266","article-title":"Cooperation between the transcription factors p63 and IRF6 is essential to prevent cleft palate in mice","volume":"120","author":"Thomason","year":"2010","journal-title":"J. Clin. Invest."},{"key":"2024122115582138600_B23","doi-asserted-by":"crossref","first-page":"eaaw0946","DOI":"10.1126\/sciadv.aaw0946","article-title":"p63 establishes epithelial enhancers at critical craniofacial development genes","volume":"5","author":"Lin-Shiao","year":"2019","journal-title":"Sci. Adv."},{"key":"2024122115582138600_B24","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.1172\/JCI68899","article-title":"FGFR2 signaling underlies p63 oncogenic function in squamous cell carcinoma","volume":"123","author":"Ramsey","year":"2013","journal-title":"J. Clin. Invest."},{"key":"2024122115582138600_B25","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ccell.2016.12.001","article-title":"ACTL6A Is Co-amplified with p63 in squamous cell carcinoma to drive YAP activation, regenerative proliferation, and poor prognosis","volume":"31","author":"Saladi","year":"2017","journal-title":"Cancer Cell"},{"key":"2024122115582138600_B26","doi-asserted-by":"crossref","first-page":"3224","DOI":"10.1016\/j.celrep.2018.08.058","article-title":"\u0394Np63\u03b1 Suppresses TGFB2 expression and RHOA activity to drive cell proliferation in squamous cell carcinomas","volume":"24","author":"Abraham","year":"2018","journal-title":"Cell Rep."},{"key":"2024122115582138600_B27","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1038\/s41467-018-04356-9","article-title":"Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models","volume":"9","author":"Ng","year":"2018","journal-title":"Nat. Commun."},{"key":"2024122115582138600_B28","doi-asserted-by":"crossref","first-page":"3590","DOI":"10.3390\/ijms20143590","article-title":"Molecular mechanisms of p63-mediated squamous cancer pathogenesis","volume":"20","author":"Moses","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"2024122115582138600_B29","doi-asserted-by":"crossref","first-page":"eadi7244","DOI":"10.1126\/scitranslmed.adi7244","article-title":"TP63 fusions drive multicomplex enhancer rewiring, lymphomagenesis, and EZH2 dependence","volume":"15","author":"Wu","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"2024122115582138600_B30","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.molcel.2006.10.018","article-title":"Relationships between p63 binding, DNA sequence, transcription activity, and biological function in Human cells","volume":"24","author":"Yang","year":"2006","journal-title":"Mol. Cell"},{"key":"2024122115582138600_B31","doi-asserted-by":"crossref","first-page":"7363","DOI":"10.1038\/sj.onc.1210561","article-title":"p63 consensus DNA-binding site: identification, analysis and application into a p63MH algorithm","volume":"26","author":"Perez","year":"2007","journal-title":"Oncogene"},{"key":"2024122115582138600_B32","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.cell.2018.01.029","article-title":"The Human transcription factors","volume":"172","author":"Lambert","year":"2018","journal-title":"Cell"},{"key":"2024122115582138600_B33","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1038\/sj.cdd.4401926","article-title":"Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice","volume":"13","author":"Candi","year":"2006","journal-title":"Cell Death Differ."},{"key":"2024122115582138600_B34","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/sj.cdd.4401914","article-title":"p53\/p63\/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress","volume":"13","author":"Murray-Zmijewski","year":"2006","journal-title":"Cell Death Differ."},{"key":"2024122115582138600_B35","first-page":"584","article-title":"A global analysis of the complex landscape of isoforms and regulatory networks of p63 in human cells and tissues","volume":"16","author":"Sethi","year":"2015","journal-title":"Bmc Genomics [Electronic Resource]"},{"key":"2024122115582138600_B36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-021-04017-8","article-title":"Tissue-specific expression of p73 and p63 isoforms in human tissues","volume":"12","author":"Marshall","year":"2021","journal-title":"Cell Death. Dis."},{"key":"2024122115582138600_B37","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/s41418-022-00975-4","article-title":"Structural diversity of p63 and p73 isoforms","volume":"29","author":"Osterburg","year":"2022","journal-title":"Cell Death Differ."},{"key":"2024122115582138600_B38","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.stem.2009.04.003","article-title":"TAp63 prevents premature aging by promoting adult stem cell maintenance","volume":"5","author":"Su","year":"2009","journal-title":"Cell Stem Cell"},{"key":"2024122115582138600_B39","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1242\/jcs.204859","article-title":"Control mechanisms in germ cells mediated by p53 family proteins","volume":"130","author":"Gebel","year":"2017","journal-title":"J. Cell Sci."},{"key":"2024122115582138600_B40","doi-asserted-by":"crossref","first-page":"jcs228015","DOI":"10.1242\/jcs.228015","article-title":"p63-related signaling at a glance","volume":"133","author":"Fisher","year":"2020","journal-title":"J. Cell Sci."},{"key":"2024122115582138600_B41","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1038\/s41588-018-0263-0","article-title":"Retinoic acid and BMP4 cooperate with p63 to alter chromatin dynamics during surface epithelial commitment","volume":"50","author":"Pattison","year":"2018","journal-title":"Nat. Genet."},{"key":"2024122115582138600_B42","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.stem.2018.12.012","article-title":"TFAP2C- and p63-dependent networks sequentially rearrange chromatin landscapes to drive Human epidermal lineage commitment","volume":"24","author":"Li","year":"2019","journal-title":"Cell Stem Cell"},{"key":"2024122115582138600_B43","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13072-021-00394-8","article-title":"\u0394Np63 is a pioneer factor that binds inaccessible chromatin and elicits chromatin remodeling","volume":"14","author":"Yu","year":"2021","journal-title":"Epigenetics Chromatin"},{"key":"2024122115582138600_B44","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1186\/s13059-015-0840-9","article-title":"A novel ATAC-seq approach reveals lineage-specific reinforcement of the open chromatin landscape via cooperation between BAF and p63","volume":"16","author":"Bao","year":"2015","journal-title":"Genome Biol."},{"key":"2024122115582138600_B45","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.str.2018.05.013","article-title":"Regulation of the activity in the p53 Family depends on the organization of the transactivation domain","volume":"26","author":"Krauskopf","year":"2018","journal-title":"Structure"},{"key":"2024122115582138600_B46","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.neo.2019.03.010","article-title":"C-terminal \u03b1 domain of p63 binds to p300 to coactivate \u03b2-catenin","volume":"21","author":"Katoh","year":"2019","journal-title":"Neoplasia"},{"key":"2024122115582138600_B47","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.4049\/jimmunol.1901178","article-title":"A TGF-\u03b2\u2013 and p63-responsive enhancer regulates IFN-\u03ba expression in Human keratinocytes","volume":"204","author":"Klein","year":"2020","journal-title":"J. Immunol."},{"key":"2024122115582138600_B48","doi-asserted-by":"crossref","first-page":"4436","DOI":"10.1038\/s41388-020-1299-z","article-title":"TGF\u03b2 and EGF signaling orchestrates the AP-1- and p63 transcriptional regulation of breast cancer invasiveness","volume":"39","author":"Sundqvist","year":"2020","journal-title":"Oncogene"},{"key":"2024122115582138600_B49","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.devcel.2010.10.015","article-title":"Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells","volume":"19","author":"LeBoeuf","year":"2010","journal-title":"Dev. Cell"},{"key":"2024122115582138600_B50","doi-asserted-by":"crossref","first-page":"4373","DOI":"10.1158\/0008-5472.CAN-11-0046","article-title":"Physical association of HDAC1 and HDAC2 with p63 mediates transcriptional repression and tumor maintenance in squamous cell carcinoma","volume":"71","author":"Ramsey","year":"2011","journal-title":"Cancer Res."},{"key":"2024122115582138600_B51","first-page":"1042","article-title":"Role of chromatin and transcriptional co-regulators in mediating p63-genome interactions in keratinocytes","volume":"15","author":"Sethi","year":"2014","journal-title":"Bmc Genomics [Electronic Resource]"},{"key":"2024122115582138600_B52","doi-asserted-by":"crossref","first-page":"6569","DOI":"10.1242\/dev.00890","article-title":"Information display by transcriptional enhancers","volume":"130","author":"Kulkarni","year":"2003","journal-title":"Development"},{"key":"2024122115582138600_B53","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.gde.2015.12.003","article-title":"Pioneer transcription factors, chromatin dynamics, and cell fate control","volume":"37","author":"Zaret","year":"2016","journal-title":"Curr. Opin. Genet. Dev."},{"key":"2024122115582138600_B54","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.tig.2019.12.005","article-title":"Silencers, enhancers, and the multifunctional regulatory genome","volume":"36","author":"Halfon","year":"2020","journal-title":"Trends Genet."},{"key":"2024122115582138600_B55","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1126\/science.1232542","article-title":"Genome-wide quantitative enhancer activity maps identified by STARR-seq","volume":"339","author":"Arnold","year":"2013","journal-title":"Science"},{"key":"2024122115582138600_B56","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S1097-2765(00)80002-7","article-title":"14-3-3\u03c3 Is a p53-regulated inhibitor of G2\/M progression","volume":"1","author":"Hermeking","year":"1997","journal-title":"Mol. Cell"},{"key":"2024122115582138600_B57","doi-asserted-by":"crossref","first-page":"e63266","DOI":"10.7554\/eLife.63266","article-title":"Dissecting the DNA binding landscape and gene regulatory network of p63 and p53","volume":"9","author":"Riege","year":"2020","journal-title":"eLife"},{"key":"2024122115582138600_B58","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/s41586-022-04779-x","article-title":"Differential cofactor dependencies define distinct types of human enhancers","volume":"606","author":"Neumayr","year":"2022","journal-title":"Nature"},{"key":"2024122115582138600_B59","first-page":"1","article-title":"Shared gene targets of the ATF4 and p53 transcriptional networks","volume":"0","author":"Baniulyte","year":"2023","journal-title":"Mol. Cell. Biol."},{"key":"2024122115582138600_B60","doi-asserted-by":"crossref","first-page":"10720","DOI":"10.1074\/jbc.RA119.007965","article-title":"Control of p53-dependent transcription and enhancer activity by the p53 family member p63","volume":"294","author":"Karsli\u00a0Uzunbas","year":"2019","journal-title":"J. Biol. Chem."},{"key":"2024122115582138600_B61","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The sequence alignment\/map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"2024122115582138600_B62","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","article-title":"Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype","volume":"37","author":"Kim","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"2024122115582138600_B63","doi-asserted-by":"crossref","first-page":"W160","DOI":"10.1093\/nar\/gkw257","article-title":"deepTools2: a next generation web server for deep-sequencing data analysis","volume":"44","author":"Ram\u00edrez","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2024122115582138600_B64","doi-asserted-by":"crossref","first-page":"D316","DOI":"10.1093\/nar\/gkab996","article-title":"ReMap 2022: a database of Human, Mouse, Drosophila and Arabidopsis regulatory regions from an integrative analysis of DNA-binding sequencing experiments","volume":"50","author":"Hammal","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"2024122115582138600_B65","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1093\/bioinformatics\/btq351","article-title":"BigWig and BigBed: enabling browsing of large distributed datasets","volume":"26","author":"Kent","year":"2010","journal-title":"Bioinformatics"},{"key":"2024122115582138600_B66","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","article-title":"BEDTools: a flexible suite of utilities for comparing genomic features","volume":"26","author":"Quinlan","year":"2010","journal-title":"Bioinformatics"},{"key":"2024122115582138600_B67","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","article-title":"Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities","volume":"38","author":"Heinz","year":"2010","journal-title":"Mol. Cell"},{"key":"2024122115582138600_B68","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1101\/gr.253492.119","article-title":"Identification and dynamic quantification of regulatory elements using total RNA","volume":"29","author":"Duttke","year":"2019","journal-title":"Genome Res."},{"key":"2024122115582138600_B69","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nmeth.4556","article-title":"GIGGLE: a search engine for large-scale integrated genome analysis","volume":"15","author":"Layer","year":"2018","journal-title":"Nat. Methods"},{"key":"2024122115582138600_B70","doi-asserted-by":"crossref","first-page":"zcad038","DOI":"10.1093\/narcan\/zcad038","article-title":"An integrated genomic approach identifies follistatin as a target of the p63-epidermal growth factor receptor oncogenic network in head and neck squamous cell carcinoma","volume":"5","author":"Oyelakin","year":"2023","journal-title":"NAR Cancer"},{"key":"2024122115582138600_B71","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nbt.3519","article-title":"Near-optimal probabilistic RNA-seq quantification","volume":"34","author":"Bray","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"2024122115582138600_B72","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"2024122115582138600_B73","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nmeth.4534","article-title":"Resolving systematic errors in widely used enhancer activity assays in human cells","volume":"15","author":"Muerdter","year":"2018","journal-title":"Nat. Methods"},{"key":"2024122115582138600_B74","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/s41586-020-2493-4","article-title":"Expanded encyclopaedias of DNA elements in the human and mouse genomes","volume":"583","author":"Moore","year":"2020","journal-title":"Nature"},{"key":"2024122115582138600_B75","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nature11232","article-title":"The accessible chromatin landscape of the human genome","volume":"489","author":"Thurman","year":"2012","journal-title":"Nature"},{"key":"2024122115582138600_B76","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1101\/gr.152140.112","article-title":"Patterns of regulatory activity across diverse human cell types predict tissue identity, transcription factor binding, and long-range interactions","volume":"23","author":"Sheffield","year":"2013","journal-title":"Genome Res."},{"key":"2024122115582138600_B77","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/nbt.3157","article-title":"Large-scale imputation of epigenomic datasets for systematic annotation of diverse human tissues","volume":"33","author":"Ernst","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"2024122115582138600_B78","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13059-021-02572-z","article-title":"Universal annotation of the human genome through integration of over a thousand epigenomic datasets","volume":"23","author":"Vu","year":"2022","journal-title":"Genome Biol."},{"key":"2024122115582138600_B79","doi-asserted-by":"crossref","first-page":"e1003731","DOI":"10.1371\/journal.pcbi.1003731","article-title":"iRegulon: from a gene list to a gene regulatory network using large motif and track collections","volume":"10","author":"Janky","year":"2014","journal-title":"PLoS Comput. Biol."},{"key":"2024122115582138600_B80","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1101\/gr.204149.116","article-title":"Multiplex enhancer-reporter assays uncover unsophisticated TP53 enhancer logic","volume":"26","author":"Verfaillie","year":"2016","journal-title":"Genome Res."},{"key":"2024122115582138600_B81","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/s41588-021-01009-4","article-title":"Sequence determinants of human gene regulatory elements","volume":"54","author":"Sahu","year":"2022","journal-title":"Nat. Genet."},{"key":"2024122115582138600_B82","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.4161\/15384101.2014.949083","article-title":"The transcription factor p53: not a repressor, solely an activator","volume":"13","author":"Fischer","year":"2014","journal-title":"Cell Cycle"},{"key":"2024122115582138600_B83","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1128\/MCB.21.10.3375-3386.2001","article-title":"Kinetics of p53 binding to promoter sites In Vivo","volume":"21","author":"Szak","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"2024122115582138600_B84","doi-asserted-by":"crossref","first-page":"e2305713120","DOI":"10.1073\/pnas.2305713120","article-title":"A molecular mechanism for the \u201cdigital\u201d response of p53 to stress","volume":"120","author":"Safieh","year":"2023","journal-title":"Proc. Natl. Acad. Sci."},{"key":"2024122115582138600_B85","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/ng0492-45","article-title":"Definition of a consensus binding site for p53","volume":"1","author":"el-Deiry","year":"1992","journal-title":"Nat. Genet."},{"key":"2024122115582138600_B86","doi-asserted-by":"crossref","first-page":"D165","DOI":"10.1093\/nar\/gkab1113","article-title":"JASPAR 2022: the 9th release of the open-access database of transcription factor binding profiles","volume":"50","author":"Castro-Mondragon","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"2024122115582138600_B87","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1101\/gr.132811.111","article-title":"Uncovering cis-regulatory sequence requirements for context-specific transcription factor binding","volume":"22","author":"Yanez-Cuna","year":"2012","journal-title":"Genome Res."},{"key":"2024122115582138600_B88","doi-asserted-by":"crossref","first-page":"11952","DOI":"10.1073\/pnas.1307449110","article-title":"Massively parallel in vivo enhancer assay reveals that highly local features determine the cis-regulatory function of ChIP-seq peaks","volume":"110","author":"White","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"key":"2024122115582138600_B89","first-page":"536","article-title":"Short DNA sequence patterns accurately identify broadly active human enhancers","volume":"18","author":"Colbran","year":"2017","journal-title":"Bmc Genomics [Electronic Resource]"},{"key":"2024122115582138600_B90","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1534\/genetics.118.301116","article-title":"Human enhancers harboring specific sequence composition, activity, and genome organization are linked to the immune response","volume":"209","author":"Lecellier","year":"2018","journal-title":"Genetics"},{"key":"2024122115582138600_B91","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.devcel.2021.02.016","article-title":"Enhancer grammar in development, evolution, and disease: dependencies and interplay","volume":"56","author":"Jindal","year":"2021","journal-title":"Dev. Cell"},{"key":"2024122115582138600_B92","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.molcel.2011.06.016","article-title":"Transcription factor AP1 potentiates chromatin accessibility and glucocorticoid receptor binding","volume":"43","author":"Biddie","year":"2011","journal-title":"Mol. Cell"},{"key":"2024122115582138600_B93","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1101\/gr.267898.120","article-title":"AP-1 subunits converge promiscuously at enhancers to potentiate transcription","volume":"31","author":"Seo","year":"2021","journal-title":"Genome Res."},{"key":"2024122115582138600_B94","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nrc2131","article-title":"Snail, zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?","volume":"7","author":"Peinado","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"2024122115582138600_B95","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1172\/JCI39104","article-title":"The basics of epithelial-mesenchymal transition","volume":"119","author":"Kalluri","year":"2009","journal-title":"J. Clin. Invest."},{"key":"2024122115582138600_B96","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.tcb.2018.12.001","article-title":"EMT transition states during tumor progression and metastasis","volume":"29","author":"Pastushenko","year":"2019","journal-title":"Trends Cell Biol."},{"key":"2024122115582138600_B97","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1093\/nar\/gkaa1283","article-title":"The complex architecture of p53 binding sites","volume":"49","author":"Senitzki","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"2024122115582138600_B98","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1101\/gad.1406006","article-title":"Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation","volume":"20","author":"Nguyen","year":"2006","journal-title":"Genes Dev."},{"key":"2024122115582138600_B99","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1038\/cdd.2010.37","article-title":"Antagonistic roles of Notch and p63 in controlling mammary epithelial cell fates","volume":"17","author":"Yalcin-Ozuysal","year":"2010","journal-title":"Cell Death Differ."},{"key":"2024122115582138600_B100","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1111\/exd.12764","article-title":"Transcriptional control of late differentiation in human keratinocytes by TAp63 and Notch","volume":"24","author":"Koh","year":"2015","journal-title":"Exp. Dermatol."},{"key":"2024122115582138600_B101","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.stem.2016.10.018","article-title":"Cell-type-specific chromatin states differentially prime squamous Cell carcinoma tumor-initiating cells for epithelial to mesenchymal transition","volume":"20","author":"Latil","year":"2017","journal-title":"Cell Stem Cell"},{"key":"2024122115582138600_B102","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/7651_2013_42","article-title":"Growth and differentiation of HaCaT keratinocytes","volume-title":"Epidermal Cells","author":"Wilson","year":"2013"},{"key":"2024122115582138600_B103","first-page":"1065","article-title":"Endogenous p63 acts as a survival factor for tumour cells of SCCHN origin","volume":"16","author":"Thurfjell","year":"2005","journal-title":"Int. J. Mol. Med."},{"key":"2024122115582138600_B104","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s11658-022-00323-x","article-title":"Identifying pathways regulating the oncogenic p53 family member \u0394Np63 provides therapeutic avenues for squamous cell carcinoma","volume":"27","author":"Pokorna","year":"2022","journal-title":"Cell. Mol. Biol. Lett."},{"key":"2024122115582138600_B105","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/sj.bjc.6601894","article-title":"The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website","volume":"91","author":"Bamford","year":"2004","journal-title":"Br. J. Cancer"},{"key":"2024122115582138600_B106","doi-asserted-by":"crossref","first-page":"dev196675","DOI":"10.1242\/dev.196675","article-title":"TEAD family transcription factors in development and disease","volume":"148","author":"Currey","year":"2021","journal-title":"Development"},{"key":"2024122115582138600_B107","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1101\/gad.1165104","article-title":"p63 is the molecular switch for initiation of an epithelial stratification program","volume":"18","author":"Koster","year":"2004","journal-title":"Genes Dev."},{"key":"2024122115582138600_B108","doi-asserted-by":"crossref","first-page":"3185","DOI":"10.1101\/gad.1463206","article-title":"p63 regulates proliferation and differentiation of developmentally mature keratinocytes","volume":"20","author":"Truong","year":"2006","journal-title":"Genes Dev."},{"key":"2024122115582138600_B109","doi-asserted-by":"crossref","first-page":"3624","DOI":"10.1073\/pnas.1016201108","article-title":"Endogenous retrovirus drives hitherto unknown proapoptotic p63 isoforms in the male germ line of humans and great apes","volume":"108","author":"Beyer","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024122115582138600_B110","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.cell.2011.01.013","article-title":"DNA damage in oocytes induces a switch of the quality control factor TAp63\u03b1 from Dimer to tetramer","volume":"144","author":"Deutsch","year":"2011","journal-title":"Cell"},{"key":"2024122115582138600_B111","doi-asserted-by":"crossref","first-page":"e13909","DOI":"10.7554\/eLife.13909","article-title":"Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular and cellular level","volume":"5","author":"Coutandin","year":"2016","journal-title":"eLife"},{"key":"2024122115582138600_B112","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/s41467-020-20669-0","article-title":"The p63 C-terminus is essential for murine oocyte integrity","volume":"12","author":"Lena","year":"2021","journal-title":"Nat. Commun."},{"key":"2024122115582138600_B113","doi-asserted-by":"crossref","first-page":"701986","DOI":"10.3389\/fcell.2021.701986","article-title":"p63 and p53: collaborative partners or dueling rivals?","volume":"9","author":"Woodstock","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"2024122115582138600_B114","doi-asserted-by":"crossref","first-page":"E6107","DOI":"10.1073\/pnas.1613417113","article-title":"Repression of p63 and induction of EMT by mutant Ras in mammary epithelial cells","volume":"113","author":"Yoh","year":"2016","journal-title":"Proc. Natl. Acad. Sci."},{"key":"2024122115582138600_B115","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1038\/s41467-019-11121-z","article-title":"Pioneer and repressive functions of p63 during zebrafish embryonic ectoderm specification","volume":"10","author":"Santos-Pereira","year":"2019","journal-title":"Nat. Commun."},{"key":"2024122115582138600_B116","doi-asserted-by":"crossref","first-page":"9690","DOI":"10.1093\/nar\/gkad718","article-title":"Optimisation of TP53 reporters by systematic dissection of synthetic TP53 response elements","volume":"51","author":"Trauernicht","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"2024122115582138600_B117","doi-asserted-by":"crossref","first-page":"863","DOI":"10.15252\/embr.201439941","article-title":"Transcription factor p63 bookmarks and regulates dynamic enhancers during epidermal differentiation","volume":"16","author":"Kouwenhoven","year":"2015","journal-title":"EMBO Rep."},{"key":"2024122115582138600_B118","doi-asserted-by":"crossref","first-page":"3490","DOI":"10.1016\/j.celrep.2018.11.039","article-title":"Mutant p63 affects epidermal cell identity through rewiring the enhancer landscape","volume":"25","author":"Qu","year":"2018","journal-title":"Cell Rep."},{"key":"2024122115582138600_B119","doi-asserted-by":"crossref","first-page":"7190","DOI":"10.1093\/nar\/gks389","article-title":"Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation","volume":"40","author":"McDade","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"2024122115582138600_B120","doi-asserted-by":"crossref","first-page":"8208","DOI":"10.1093\/nar\/gkx416","article-title":"Evolutionary re-wiring of p63 and the epigenomic regulatory landscape in keratinocytes and its potential implications on species-specific gene expression and phenotypes","volume":"45","author":"Sethi","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"2024122115582138600_B121","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/dvdy.22786","article-title":"MCS9.7 enhancer activity is highly, but not completely, associated with expression of Irf6 and p63","volume":"241","author":"Fakhouri","year":"2012","journal-title":"Dev. Dyn."},{"key":"2024122115582138600_B122","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1093\/hmg\/ddt664","article-title":"An etiologic regulatory mutation in IRF6 with loss- and gain-of-function effects","volume":"23","author":"Fakhouri","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"2024122115582138600_B123","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.cell.2014.11.041","article-title":"Low affinity binding site clusters confer hox specificity and regulatory robustness","volume":"160","author":"Crocker","year":"2015","journal-title":"Cell"},{"key":"2024122115582138600_B124","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1126\/science.aac6948","article-title":"Suboptimization of developmental enhancers","volume":"350","author":"Farley","year":"2015","journal-title":"Science"},{"key":"2024122115582138600_B125","doi-asserted-by":"crossref","first-page":"6508","DOI":"10.1073\/pnas.1605085113","article-title":"Syntax compensates for poor binding sites to encode tissue specificity of developmental enhancers","volume":"113","author":"Farley","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024122115582138600_B126","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41586-023-06922-8","article-title":"Affinity-optimizing enhancer variants disrupt development","volume":"626","author":"Lim","year":"2024","journal-title":"Nature"},{"key":"2024122115582138600_B127","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ygeno.2015.06.005","article-title":"Decoding enhancers using massively parallel reporter assays","volume":"106","author":"Inoue","year":"2015","journal-title":"Genomics"},{"key":"2024122115582138600_B128","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.tibs.2019.10.006","article-title":"Deciphering gene regulation using massively parallel reporter assays","volume":"45","author":"Trauernicht","year":"2020","journal-title":"Trends Biochem. Sci"},{"key":"2024122115582138600_B129","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13072-019-0280-y","article-title":"p63 cooperates with CTCF to modulate chromatin architecture in skin keratinocytes","volume":"12","author":"Qu","year":"2019","journal-title":"Epigenetics Chromatin"},{"key":"2024122115582138600_B130","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/nrm3949","article-title":"The selection and function of cell type-specific enhancers","volume":"16","author":"Heinz","year":"2015","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2024122115582138600_B131","first-page":"7113","article-title":"Significance of p63 amplification and overexpression in lung cancer development and prognosis","volume":"63","author":"Massion","year":"2003","journal-title":"Cancer Res."},{"key":"2024122115582138600_B132","first-page":"57","article-title":"Role of p63 in cancer development","volume":"1816","author":"Graziano","year":"2011","journal-title":"Biochim. Biophys. Acta. (BBA)"},{"key":"2024122115582138600_B133","doi-asserted-by":"crossref","first-page":"15312","DOI":"10.1073\/pnas.1110977109","article-title":"Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer","volume":"109","author":"Tucci","year":"2012","journal-title":"Proc. Natl. Acad. Sci."},{"key":"2024122115582138600_B134","doi-asserted-by":"crossref","first-page":"6582","DOI":"10.1158\/1078-0432.CCR-14-1768","article-title":"Mutational landscape of aggressive cutaneous squamous cell carcinoma","volume":"20","author":"Pickering","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"2024122115582138600_B135","doi-asserted-by":"crossref","first-page":"100191","DOI":"10.1016\/j.xgen.2022.100191","article-title":"A cis-regulatory lexicon of DNA motif combinations mediating cell-type-specific gene regulation","volume":"2","author":"Donohue","year":"2022","journal-title":"Cell Genom"},{"key":"2024122115582138600_B136","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/s41586-023-06936-2","article-title":"Cell-type-directed design of synthetic enhancers","volume":"626","author":"Taskiran","year":"2024","journal-title":"Nature"},{"key":"2024122115582138600_B137","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nature07509","article-title":"Alternative isoform regulation in human tissue transcriptomes","volume":"456","author":"Wang","year":"2008","journal-title":"Nature"},{"key":"2024122115582138600_B138","doi-asserted-by":"crossref","DOI":"10.1101\/2024.03.12.584681","article-title":"Widespread variation in molecular interactions and regulatory properties among transcription factor isoforms","author":"Lambourne","year":"2024"},{"key":"2024122115582138600_B139","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1186\/s13059-020-02156-3","article-title":"STARR-seq identifies active, chromatin-masked, and dormant enhancers in pluripotent mouse embryonic stem cells","volume":"21","author":"Peng","year":"2020","journal-title":"Genome Biol."},{"key":"2024122115582138600_B140","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.tig.2021.03.008","article-title":"Studying transcription factor function in the genome at molecular resolution","volume":"37","author":"Krebs","year":"2021","journal-title":"Trends Genet."},{"key":"2024122115582138600_B141","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-023-06213-0","article-title":"DARPins detect the formation of hetero-tetramers of p63 and p73 in epithelial tissues and in squamous cell carcinoma","volume":"14","author":"Strubel","year":"2023","journal-title":"Cell Death. Dis."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/52\/22\/13812\/60766320\/gkae1143.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/52\/22\/13812\/60766320\/gkae1143.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,21]],"date-time":"2024-12-21T10:59:23Z","timestamp":1734778763000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/52\/22\/13812\/7905314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,20]]},"references-count":141,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2024,11,20]]},"published-print":{"date-parts":[[2024,12,11]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkae1143","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,12,11]]},"published":{"date-parts":[[2024,11,20]]}}}