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However, whether and how SIRT2 promotes base excision repair (BER) remain to be determined. Here, we found that independent of its catalytic activity SIRT2 interacted with the critical glycosylase OGG1 to promote OGG1 recruitment to its own promoter upon oxidative stress, thereby enhancing OGG1 promoter activity and increasing BER efficiency. Further studies revealed that SIRT2 was phosphorylated on S46 and S53 by ATM\/ATR upon oxidative stress, and SIRT2 phosphorylation enhanced the SIRT2-OGG1 interaction and mediated the stimulatory effect of SIRT2 on OGG1 promoter activity. We also characterized 37 cancer-derived SIRT2 mutants and found that 5 exhibited the loss of the stimulatory effects on OGG1 transcription. Together, our data reveal that SIRT2 acts as a tumor suppressor by promoting OGG1 transcription and increasing BER efficiency in an ATM\/ATR-dependent manner.<\/jats:p>","DOI":"10.1093\/nar\/gkae190","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T12:00:33Z","timestamp":1710158433000},"page":"5107-5120","source":"Crossref","is-referenced-by-count":23,"title":["SIRT2 promotes base excision repair by transcriptionally activating OGG1 in an ATM\/ATR-dependent manner"],"prefix":"10.1093","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9459-0480","authenticated-orcid":false,"given":"Anke","family":"Geng","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University , Shanghai\u00a0200092 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Sun","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University , Shanghai\u00a0200092 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanyin","family":"Tang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University , Shanghai\u00a0200092 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yu","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University , Shanghai\u00a0200092 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyue","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Medicine, Tongji University , Shanghai \u00a0200092, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University , Shanghai\u00a0200092 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaona","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University , Shanghai\u00a0200092 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiang","family":"Sun","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University , Shanghai\u00a0200092 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Oncology, Xiangya Cancer Center, Xiangya Hospital, Central South University , Changsha\u00a0 410008 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neng","family":"Gao","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University , Shanghai\u00a0200092 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3629-8668","authenticated-orcid":false,"given":"Rong","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Oncology, Xiangya Cancer Center, Xiangya Hospital, Central South University , Changsha\u00a0 410008 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu","family":"Xu","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University , Shanghai\u00a0200092 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Jiang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University , Shanghai\u00a0200092 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5298-1918","authenticated-orcid":false,"given":"Zhiyong","family":"Mao","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University , Shanghai\u00a0200092 , China"},{"name":"School of Medicine, Tongji University , Shanghai \u00a0200092, China"},{"name":"Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University , Shanghai\u00a0 200092 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,30]]},"reference":[{"key":"2024052209484722300_B1","doi-asserted-by":"crossref","first-page":"a003236","DOI":"10.1101\/cshperspect.a003236","article-title":"Oncogenes and tumor suppressor genes","volume":"2","author":"Lee","year":"2010","journal-title":"Cold Spring Harb. 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