{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:56:06Z","timestamp":1787496966180,"version":"build-2736575974"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:00:00Z","timestamp":1712102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB-TRR 267 TP A05"],"award-info":[{"award-number":["SFB-TRR 267 TP A05"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["RTG2355"],"award-info":[{"award-number":["RTG2355"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031240","name":"Max Planck Institute for Heart and Lung Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031240","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Enzyme activity is determined by various different mechanisms, including posttranslational modifications and allosteric regulation. Allosteric activators are often metabolites but other molecules serve similar functions. So far, examples of long non-coding RNAs (lncRNAs) acting as allosteric activators of enzyme activity are missing. Here, we describe the function of mitolnc in cardiomyocytes, a nuclear encoded long non-coding RNA, located in mitochondria and directly interacting with the branched-chain ketoacid dehydrogenase (BCKDH) complex to increase its activity. The BCKDH complex is critical for branched-chain amino acid catabolism (BCAAs). Inactivation of mitolnc in mice reduces BCKDH complex activity, resulting in accumulation of BCAAs in the heart and cardiac hypertrophy via enhanced mTOR signaling. We found that mitolnc allosterically activates the BCKDH complex, independent of phosphorylation. Mitolnc-mediated regulation of the BCKDH complex constitutes an important additional layer to regulate the BCKDH complex in a tissue-specific manner, evading direct coupling of BCAA metabolism to ACLY-dependent lipogenesis.<\/jats:p>","DOI":"10.1093\/nar\/gkae226","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T13:51:33Z","timestamp":1710856293000},"page":"6629-6646","source":"Crossref","is-referenced-by-count":14,"title":["Mitolnc controls cardiac BCAA metabolism and heart hypertrophy by allosteric activation of BCKDH"],"prefix":"10.1093","volume":"52","author":[{"given":"Maria","family":"Weiss","sequence":"first","affiliation":[{"name":"Max Planck Institute for Heart- and Lung Research, Department of Cardiac Development and Remodelling , Ludwigstr. 43, D-61231\u00a0 Bad Nauheim , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Hettrich","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Heart- and Lung Research, Department of Cardiac Development and Remodelling , Ludwigstr. 43, D-61231\u00a0 Bad Nauheim , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Hofmann","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Heart- and Lung Research, Department of Cardiac Development and Remodelling , Ludwigstr. 43, D-61231\u00a0 Bad Nauheim , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salma","family":"Hachim","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Heart- and Lung Research, Department of Cardiac Development and Remodelling , Ludwigstr. 43, D-61231\u00a0 Bad Nauheim , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5594-4549","authenticated-orcid":false,"given":"Stefan","family":"G\u00fcnther","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Heart- and Lung Research, Department of Cardiac Development and Remodelling , Ludwigstr. 43, D-61231\u00a0 Bad Nauheim , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6165-4804","authenticated-orcid":false,"given":"Thomas","family":"Braun","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Heart- and Lung Research, Department of Cardiac Development and Remodelling , Ludwigstr. 43, D-61231\u00a0 Bad Nauheim , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4280-8449","authenticated-orcid":false,"given":"Thomas","family":"Boettger","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Heart- and Lung Research, Department of Cardiac Development and Remodelling , Ludwigstr. 43, D-61231\u00a0 Bad Nauheim , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,4,3]]},"reference":[{"key":"2024062323592124500_B1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1146\/annurev-physiol-020518-114455","article-title":"Branched chain amino acids","volume":"81","author":"Neinast","year":"2019","journal-title":"Annu. 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