{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:41:58Z","timestamp":1772138518997,"version":"3.50.1"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM141381"],"award-info":[{"award-number":["GM141381"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>L1 elements are retrotransposons currently active in mammals. Although L1s are typically silenced in most normal tissues, elevated L1 expression is associated with a variety of conditions, including cancer, aging, infertility and neurological disease. These associations have raised interest in the mapping of human endogenous de novo L1 insertions, and a variety of methods have been developed for this purpose. Adapting these methods to mouse genomes would allow us to monitor endogenous in vivo L1 activity in controlled, experimental conditions using mouse disease models. Here, we use a modified version of transposon insertion profiling, called nanoTIPseq, to selectively enrich young mouse L1s. By linking this amplification step with nanopore sequencing, we identified\u00a0&amp;gt;95% annotated L1s from C57BL\/6 genomic DNA using only 200\u00a0000 sequencing reads. In the process, we discovered 82 unannotated L1 insertions from a single C57BL\/6 genome. Most of these unannotated L1s were near repetitive sequence and were not found with short-read TIPseq. We used nanoTIPseq on individual mouse breast cancer cells and were able to identify the annotated and unannotated L1s, as well as new insertions specific to individual cells, providing proof of principle for using nanoTIPseq to interrogate retrotransposition activity at the single-cell level in vivo.<\/jats:p>","DOI":"10.1093\/nar\/gkae273","type":"journal-article","created":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T04:20:03Z","timestamp":1712377203000},"page":"5166-5178","source":"Crossref","is-referenced-by-count":3,"title":["Comprehensive profiling of L1 retrotransposons in mouse"],"prefix":"10.1093","volume":"52","author":[{"given":"Xuanming","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Tulane University School of Medicine , New Orleans, LA 70112, USA"},{"name":"Tulane Cancer Center, Tulane University School of Medicine , New Orleans, LA 70112, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana","family":"Celic","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Tulane University School of Medicine , New Orleans, LA 70112, USA"},{"name":"Tulane Cancer Center, Tulane University School of Medicine , New Orleans, LA 70112, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Tulane University School of Medicine , New Orleans, LA 70112, USA"},{"name":"Tulane Cancer Center, Tulane University School of Medicine , New Orleans, LA 70112, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam","family":"Stuckert","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Tulane University School of Medicine , New Orleans, LA 70112, USA"},{"name":"Tulane Cancer Center, Tulane University School of Medicine , New Orleans, LA 70112, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lalitha","family":"Vedula","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Tulane University School of Medicine , New Orleans, LA 70112, USA"},{"name":"Tulane Cancer Center, Tulane University School of Medicine , New Orleans, LA 70112, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5189-0547","authenticated-orcid":false,"given":"Jeffrey\u00a0S","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Tulane University School of Medicine , New Orleans, LA 70112, USA"},{"name":"Tulane Cancer Center, Tulane University School of Medicine , New Orleans, LA 70112, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,4,22]]},"reference":[{"key":"2024052209520897800_B1","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/35057062","article-title":"Initial sequencing and analysis of the human genome","volume":"409","author":"International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, Center for Genome Research","year":"2001","journal-title":"Nature"},{"key":"2024052209520897800_B2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1759-8753-4-3","article-title":"Revisiting the evolution of mouse LINE-1 in the genomic era","volume":"4","author":"Sookdeo","year":"2013","journal-title":"Mobile DNA"},{"key":"2024052209520897800_B3","doi-asserted-by":"crossref","first-page":"5280","DOI":"10.1073\/pnas.0831042100","article-title":"Hot L1s account for the bulk of retrotransposition in the human population","volume":"100","author":"Brouha","year":"2003","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"2024052209520897800_B4","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.cell.2010.05.026","article-title":"Mobile interspersed repeats are major structural variants in the human genome","volume":"141","author":"Huang","year":"2010","journal-title":"Cell"},{"key":"2024052209520897800_B5","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/ng0597-37","article-title":"Many human L1 elements are capable of retrotransposition","volume":"16","author":"Sassaman","year":"1997","journal-title":"Nat. Genet."},{"key":"2024052209520897800_B6","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1126\/science.1222077","article-title":"Landscape of somatic retrotransposition in human cancers","volume":"337","author":"Lee","year":"2012","journal-title":"Science"},{"key":"2024052209520897800_B7","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.cell.2010.05.020","article-title":"Natural mutagenesis of human genomes by endogenous retrotransposons","volume":"141","author":"Iskow","year":"2010","journal-title":"Cell"},{"key":"2024052209520897800_B8","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/S0092-8674(00)81997-2","article-title":"Human L1 retrotransposon encodes a conserved endonuclease required for retrotransposition","volume":"87","author":"Feng","year":"1996","journal-title":"Cell"},{"key":"2024052209520897800_B9","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/S0092-8674(00)81998-4","article-title":"High frequency retrotransposition in cultured mammalian cells","volume":"87","author":"Moran","year":"1996","journal-title":"Cell"},{"key":"2024052209520897800_B10","doi-asserted-by":"crossref","first-page":"10155","DOI":"10.1073\/pnas.94.19.10155","article-title":"In vitro properties of the first ORF protein from mouse LINE-1 support its role in ribonucleoprotein particle formation during\u2009retrotransposition","volume":"94","author":"Kolosha","year":"1997","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"2024052209520897800_B11","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1128\/MCB.21.4.1429-1439.2001","article-title":"Human L1 retrotransposition: cis preference versus transcomplementation","volume":"21","author":"Wei","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"2024052209520897800_B12","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/j.1460-2075.1996.tb00395.x","article-title":"Cytoplasmic ribonucleoprotein complexes containing human LINE-1 protein and RNA","volume":"15","author":"Hohjoh","year":"1996","journal-title":"EMBO J."},{"key":"2024052209520897800_B13","doi-asserted-by":"crossref","first-page":"8112","DOI":"10.1074\/jbc.M210487200","article-title":"High-affinity, non-sequence-specific RNA binding by the open reading frame 1 (ORF1) protein from long interspersed nuclear element 1 (LINE-1)","volume":"278","author":"Kolosha","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2024052209520897800_B14","doi-asserted-by":"crossref","first-page":"3237","DOI":"10.1093\/hmg\/ddi354","article-title":"Ribonucleoprotein particle formation is necessary but not sufficient for LINE-1 retrotransposition","volume":"14","author":"Kulpa","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"2024052209520897800_B15","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1128\/MCB.21.2.467-475.2001","article-title":"Nucleic acid chaperone activity of the ORF1 protein from the mouse LINE-1 retrotransposon","volume":"21","author":"Martin","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"2024052209520897800_B16","doi-asserted-by":"crossref","first-page":"e1006837","DOI":"10.1371\/journal.pgen.1006837","article-title":"A conserved role for the ESCRT membrane budding complex in LINE retrotransposition","volume":"13","author":"Horn","year":"2017","journal-title":"PLoS Genet."},{"key":"2024052209520897800_B17","doi-asserted-by":"crossref","first-page":"e30058","DOI":"10.7554\/eLife.30058","article-title":"LINE-1 protein localization and functional dynamics during the cell cycle","volume":"7","author":"Mita","year":"2018","journal-title":"eLife"},{"key":"2024052209520897800_B18","doi-asserted-by":"crossref","first-page":"18081","DOI":"10.1021\/bi981858s","article-title":"Targeting of human retrotransposon integration is directed by the specificity of the L1 endonuclease for regions of unusual DNA structure","volume":"37","author":"Cost","year":"1998","journal-title":"Biochemistry"},{"key":"2024052209520897800_B19","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1126\/science.1722352","article-title":"Reverse transcriptase encoded by a human transposable element","volume":"254","author":"Mathias","year":"1991","journal-title":"Science"},{"key":"2024052209520897800_B20","doi-asserted-by":"crossref","first-page":"5899","DOI":"10.1093\/emboj\/cdf592","article-title":"Human L1 element target-primed reverse transcription in vitro","volume":"21","author":"Cost","year":"2002","journal-title":"EMBO J."},{"key":"2024052209520897800_B21","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/0092-8674(93)90078-5","article-title":"Reverse transcription of R2Bm RNA is primed by a nick at the chromosomal target site: a mechanism for non-LTR retrotransposition","volume":"72","author":"Luan","year":"1993","journal-title":"Cell"},{"key":"2024052209520897800_B22","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41586-018-0784-9","article-title":"L1 drives IFN in senescent cells and promotes age-associated inflammation","volume":"566","author":"De\u00a0Cecco","year":"2019","journal-title":"Nature"},{"key":"2024052209520897800_B23","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/s41586-021-03542-y","article-title":"The role of retrotransposable elements in aging and age-associated diseases","volume":"596","author":"Gorbunova","year":"2021","journal-title":"Nature"},{"key":"2024052209520897800_B24","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13100-016-0065-9","article-title":"Roles for retrotransposon insertions in human disease","volume":"7","author":"Hancks","year":"2016","journal-title":"Mobile DNA"},{"key":"2024052209520897800_B25","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/332164a0","article-title":"Haemophilia A resulting from de novo insertion of L1 sequences represents a novel mechanism for mutation in man","volume":"332","author":"Kazazian","year":"1988","journal-title":"Nature"},{"key":"2024052209520897800_B26","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/333087a0","article-title":"Insertional mutagenesis of the myc locus by a LINE-1 sequence in a human breast carcinoma","volume":"333","author":"Morse","year":"1988","journal-title":"Nature"},{"key":"2024052209520897800_B27","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1016\/j.ajpath.2014.01.007","article-title":"Long interspersed element-1 protein expression is a hallmark of many human cancers","volume":"184","author":"Rodi\u0107","year":"2014","journal-title":"Am. J. Pathol."},{"key":"2024052209520897800_B28","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1002\/dneu.22567","article-title":"LINE-1 retrotransposons in healthy and diseased human brain","volume":"78","author":"Suarez","year":"2018","journal-title":"Dev. Neurobiol."},{"key":"2024052209520897800_B29","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.devcel.2007.03.001","article-title":"MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline","volume":"12","author":"Carmell","year":"2007","journal-title":"Dev. Cell"},{"key":"2024052209520897800_B30","doi-asserted-by":"crossref","first-page":"E5635","DOI":"10.1073\/pnas.1701069114","article-title":"Intact piRNA pathway prevents L1 mobilization in male meiosis","volume":"114","author":"Newkirk","year":"2017","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"2024052209520897800_B31","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.devcel.2008.05.015","article-title":"Mouse maelstrom, a component of nuage, is essential for spermatogenesis and transposon repression in meiosis","volume":"15","author":"Soper","year":"2008","journal-title":"Dev. Cell"},{"key":"2024052209520897800_B32","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1038\/s41467-022-31322-3","article-title":"Frequency and mechanisms of LINE-1 retrotransposon insertions at CRISPR\/Cas9 sites","volume":"13","author":"Tao","year":"2022","journal-title":"Nat. Commun."},{"key":"2024052209520897800_B33","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/nature10531","article-title":"Somatic retrotransposition alters the genetic landscape of the human brain","volume":"479","author":"Baillie","year":"2011","journal-title":"Nature"},{"key":"2024052209520897800_B34","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1186\/s13059-022-02778-9","article-title":"INSERT-seq enables high-resolution mapping of genomically integrated DNA using Nanopore sequencing","volume":"23","author":"Ivan\u010di\u0107","year":"2022","journal-title":"Genome Biol."},{"key":"2024052209520897800_B35","doi-asserted-by":"crossref","first-page":"E733","DOI":"10.1073\/pnas.1619797114","article-title":"Human transposon insertion profiling: analysis, visualization and identification of somatic LINE-1 insertions in ovarian cancer","volume":"114","author":"Tang","year":"2017","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"2024052209520897800_B36","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1093\/nar\/gkz1173","article-title":"Identification and characterization of occult human-specific LINE-1 insertions using long-read sequencing technology","volume":"48","author":"Zhou","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"2024052209520897800_B37","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.molcel.2020.10.024","article-title":"Nanopore sequencing enables comprehensive transposable element epigenomic profiling","volume":"80","author":"Ewing","year":"2020","journal-title":"Mol. Cell"},{"key":"2024052209520897800_B38","doi-asserted-by":"crossref","first-page":"7470","DOI":"10.1038\/s41467-022-35180-x","article-title":"Retrotransposon instability dominates the acquired mutation landscape of mouse induced pluripotent stem cells","volume":"13","author":"Gerdes","year":"2022","journal-title":"Nat. Commun."},{"key":"2024052209520897800_B39","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13100-019-0148-5","article-title":"Transposon insertion profiling by sequencing (TIPseq) for mapping LINE-1 insertions in the human genome","volume":"10","author":"Steranka","year":"2019","journal-title":"Mobile DNA"},{"key":"2024052209520897800_B40","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/nature01262","article-title":"Initial sequencing and comparative analysis of the mouse genome","volume":"420","author":"Mouse Genome Sequencing Consortium","year":"2002","journal-title":"Nature"},{"key":"2024052209520897800_B41","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1101\/gr.198301","article-title":"A novel active L1 retrotransposon subfamily in the mouse","volume":"11","author":"Goodier","year":"2001","journal-title":"Genome Res."},{"key":"2024052209520897800_B42","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13100-019-0157-4","article-title":"Mouse germ line mutations due to retrotransposon insertions","volume":"10","author":"Gagnier","year":"2019","journal-title":"Mobile DNA"},{"key":"2024052209520897800_B43","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1101\/gr.1.1.39","article-title":"Vectorette PCR: a novel approach to genomic walking","volume":"1","author":"Arnold","year":"1991","journal-title":"PCR Methods Appl."},{"key":"2024052209520897800_B44","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13100-020-00230-y","article-title":"The Dfam community resource of transposable element families, sequence models, and genome annotations","volume":"12","author":"Storer","year":"2021","journal-title":"Mobile DNA"},{"key":"2024052209520897800_B45","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","article-title":"BEDTools: a flexible suite of utilities for comparing genomic features","volume":"26","author":"Quinlan","year":"2010","journal-title":"Bioinformatics"},{"key":"2024052209520897800_B46","doi-asserted-by":"crossref","first-page":"3827","DOI":"10.1083\/jcb.201904051","article-title":"Chemotherapy-induced senescent cancer cells engulf other cells to enhance their survival","volume":"218","author":"Tonnessen-Murray","year":"2019","journal-title":"J. Cell Biol."},{"key":"2024052209520897800_B47","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/3104","article-title":"Rapid amplification of a retrotransposon subfamily is evolving the mouse genome","volume":"20","author":"DeBerardinis","year":"1998","journal-title":"Nat. Genet."},{"key":"2024052209520897800_B48","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/nnano.2009.12","article-title":"Continuous base identification for single-molecule nanopore DNA sequencing","volume":"4","author":"Clarke","year":"2009","journal-title":"Nat. Nanotechnol."},{"key":"2024052209520897800_B49","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1038\/s41587-021-01108-x","article-title":"Nanopore sequencing technology, bioinformatics and applications","volume":"39","author":"Wang","year":"2021","journal-title":"Nat. Biotechnol."},{"key":"2024052209520897800_B50","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/nbt.3103","article-title":"MinION nanopore sequencing identifies the position and structure of a bacterial antibiotic resistance island","volume":"33","author":"Ashton","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"2024052209520897800_B51","doi-asserted-by":"crossref","first-page":"e0257521","DOI":"10.1371\/journal.pone.0257521","article-title":"Sequencing DNA with nanopores: troubles and biases","volume":"16","author":"Delahaye","year":"2021","journal-title":"PLoS One"},{"key":"2024052209520897800_B52","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2105-15-7","article-title":"Skylign: a tool for creating informative, interactive logos representing sequence alignments and profile hidden Markov models","volume":"15","author":"Wheeler","year":"2014","journal-title":"BMC Bioinformatics"},{"key":"2024052209520897800_B53","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nature05610","article-title":"Patterns of somatic mutation in human cancer genomes","volume":"446","author":"Greenman","year":"2007","journal-title":"Nature"},{"key":"2024052209520897800_B54","doi-asserted-by":"crossref","first-page":"1237758","DOI":"10.1126\/science.1237758","article-title":"Somatic mutation, genomic variation, and neurological disease","volume":"341","author":"Poduri","year":"2013","journal-title":"Science"},{"key":"2024052209520897800_B55","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3390\/v9060131","article-title":"The role of somatic L1 retrotransposition in human cancers","volume":"9","author":"Scott","year":"2017","journal-title":"Viruses"},{"key":"2024052209520897800_B56","doi-asserted-by":"crossref","first-page":"20190335","DOI":"10.1098\/rstb.2019.0335","article-title":"Human transposon insertion profiling by sequencing (TIPseq) to map LINE-1 insertions in single cells","volume":"375","author":"McKerrow","year":"2020","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"2024052209520897800_B57","doi-asserted-by":"crossref","first-page":"e2024176118","DOI":"10.1073\/pnas.2024176118","article-title":"Accurate genomic variant detection in single cells with primary template-directed amplification","volume":"118","author":"Gonzalez-Pena","year":"2021","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"2024052209520897800_B58","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1146\/annurev-genom-090413-025352","article-title":"Single-cell whole-genome amplification and sequencing: methodology and applications","volume":"16","author":"Huang","year":"2015","journal-title":"Annu. Rev. Genom. Hum. Genet."},{"key":"2024052209520897800_B59","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.cmet.2019.02.014","article-title":"LINE1 derepression in aged wild-type and SIRT6-deficient mice drives inflammation","volume":"29","author":"Simon","year":"2019","journal-title":"Cell Metab."},{"key":"2024052209520897800_B60","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.18632\/oncotarget.1188","article-title":"Increased expression and copy number amplification of LINE-1 and SINE B1 retrotransposable elements in murine mammary carcinoma progression","volume":"4","author":"Gualtieri","year":"2013","journal-title":"Oncotarget"},{"key":"2024052209520897800_B61","doi-asserted-by":"crossref","first-page":"eaav2606","DOI":"10.1126\/science.aav2606","article-title":"Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity","volume":"363","author":"Zhang","year":"2019","journal-title":"Science"},{"key":"2024052209520897800_B62","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/s41598-018-37444-3","article-title":"Heterochromatic genome instability and neurodegeneration sharing similarities with Alzheimer\u2019s disease in old Bmi1+\/\u2212 mice","volume":"9","author":"El\u00a0Hajjar","year":"2019","journal-title":"Sci. Rep."},{"key":"2024052209520897800_B63","doi-asserted-by":"crossref","first-page":"e97374","DOI":"10.15252\/embj.201797374","article-title":"Engrailed homeoprotein blocks degeneration in adult dopaminergic neurons through LINE-1 repression","volume":"37","author":"Blaudin\u00a0de\u00a0Th\u00e9","year":"2018","journal-title":"EMBO J."},{"key":"2024052209520897800_B64","doi-asserted-by":"crossref","first-page":"3644","DOI":"10.12659\/MSM.907328","article-title":"A possible role for long interspersed nuclear elements-1 (LINE-1) in Huntington\u2019s disease progression","volume":"24","author":"Tan","year":"2018","journal-title":"Med. Sci. Monit."},{"key":"2024052209520897800_B65","doi-asserted-by":"crossref","first-page":"20382","DOI":"10.1073\/pnas.1100273108","article-title":"Ataxia telangiectasia mutated (ATM) modulates long interspersed element-1 (L1) retrotransposition in human neural stem cells","volume":"108","author":"Coufal","year":"2011","journal-title":"Proc. Natl Acad. Sci. U.S.A."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/52\/9\/5166\/57810290\/gkae273.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/52\/9\/5166\/57810290\/gkae273.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T05:53:40Z","timestamp":1716357220000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/52\/9\/5166\/7655787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,22]]},"references-count":65,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,4,22]]},"published-print":{"date-parts":[[2024,5,22]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkae273","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.11.13.566638","asserted-by":"object"}]},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,5,22]]},"published":{"date-parts":[[2024,4,22]]}}}