{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T10:35:00Z","timestamp":1787308500591,"version":"build-2736575974"},"reference-count":70,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:00:00Z","timestamp":1714003200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"CIHR","doi-asserted-by":"publisher","award":["FRN_106608"],"award-info":[{"award-number":["FRN_106608"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Manitoba Rady Innovation Funds"},{"DOI":"10.13039\/501100000038","name":"NSERC","doi-asserted-by":"publisher","award":["RGPIN-2016-06004"],"award-info":[{"award-number":["RGPIN-2016-06004"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"NSERC","doi-asserted-by":"publisher","award":["RGPIN-2022-05023"],"award-info":[{"award-number":["RGPIN-2022-05023"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Manitoba Research Chair","award":["2016-06035"],"award-info":[{"award-number":["2016-06035"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Interval-training activities induce adaptive cellular changes without altering their fundamental identity, but the precise underlying molecular mechanisms are not fully understood. In this study, we demonstrate that interval-training depolarization (ITD) of pituitary cells triggers distinct adaptive or homeostatic splicing responses of alternative exons. This occurs while preserving the steady-state expression of the Prolactin and other hormone genes. The nature of these splicing responses depends on the exon's DNA methylation status, the methyl-C-binding protein MeCP2 and its associated CA-rich motif-binding hnRNP L. Interestingly, the steady expression of the Prolactin gene is also reliant on MeCP2, whose disruption leads to exacerbated multi-exon aberrant splicing and overexpression of the hormone gene transcripts upon ITD, similar to the observed hyperprolactinemia or activity-dependent aberrant splicing in Rett Syndrome. Therefore, epigenetic control is crucial for both adaptive and homeostatic splicing and particularly the steady expression of the Prolactin hormone gene during ITD. Disruption in this regulation may have significant implications for the development of progressive diseases.<\/jats:p>","DOI":"10.1093\/nar\/gkae311","type":"journal-article","created":{"date-parts":[[2024,4,14]],"date-time":"2024-04-14T20:01:22Z","timestamp":1713124882000},"page":"7211-7224","source":"Crossref","is-referenced-by-count":5,"title":["Epigenetic control of adaptive or homeostatic splicing during interval-training activities"],"prefix":"10.1093","volume":"52","author":[{"given":"Ling","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Physiology & Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Physiology & Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urmi","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Physiology & Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Ogunsola","sequence":"additional","affiliation":[{"name":"Department of Physiology & Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiankun","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Physiology & Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Physiology & Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Kung","sequence":"additional","affiliation":[{"name":"Department of Physiology & Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shervin","family":"Pejhan","sequence":"additional","affiliation":[{"name":"Biochemistry & Medical Genetics, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba , Winnipeg , MB , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojgan","family":"Rastegar","sequence":"additional","affiliation":[{"name":"Biochemistry & Medical Genetics, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba , Winnipeg , MB , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2909-1033","authenticated-orcid":false,"given":"Jiuyong","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Physiology & Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,4,25]]},"reference":[{"key":"2024070813480799800_B1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.biopsych.2019.06.027","article-title":"Epigenetic mechanisms of opioid addiction","volume":"87","author":"Browne","year":"2020","journal-title":"Biol. Psychiatry"},{"key":"2024070813480799800_B2","doi-asserted-by":"crossref","first-page":"987","DOI":"10.2165\/00007256-200232150-00003","article-title":"Growth hormone release during acute and chronic aerobic and resistance exercise: recent findings","volume":"32","author":"Wideman","year":"2002","journal-title":"Sports Med."},{"key":"2024070813480799800_B3","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1113\/JP273196","article-title":"Physiological adaptations to interval training and the role of exercise intensity","volume":"595","author":"MacInnis","year":"2017","journal-title":"J. Physiol."},{"key":"2024070813480799800_B4","doi-asserted-by":"crossref","first-page":"112499","DOI":"10.1016\/j.celrep.2023.112499","article-title":"Conserved multi-tissue transcriptomic adaptations to exercise training in humans and mice","volume":"42","author":"Moore","year":"2023","journal-title":"Cell Rep."},{"key":"2024070813480799800_B5","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.cmet.2012.12.012","article-title":"Exercise metabolism and the molecular regulation of skeletal muscle adaptation","volume":"17","author":"Egan","year":"2013","journal-title":"Cell Metab."},{"key":"2024070813480799800_B6","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.drudis.2014.03.006","article-title":"Epigenetic adaptation to regular exercise in humans","volume":"19","author":"Ling","year":"2014","journal-title":"Drug. Discov. Today"},{"key":"2024070813480799800_B7","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1146\/annurev-biochem-060614-034316","article-title":"Mechanisms and regulation of alternative pre-mRNA splicing","volume":"84","author":"Lee","year":"2015","journal-title":"Annu. Rev. Biochem."},{"key":"2024070813480799800_B8","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/418236a","article-title":"Alternative pre-mRNA splicing and proteome expansion in metazoans","volume":"418","author":"Maniatis","year":"2002","journal-title":"Nature"},{"key":"2024070813480799800_B9","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cell.2006.06.023","article-title":"Alternative splicing: new insights from global analyses","volume":"126","author":"Blencowe","year":"2006","journal-title":"Cell"},{"key":"2024070813480799800_B10","doi-asserted-by":"crossref","first-page":"22709","DOI":"10.1074\/jbc.M112.357343","article-title":"A conserved serine of heterogeneous nuclear ribonucleoprotein L (hnRNP L) mediates depolarization-regulated alternative splicing of potassium channels","volume":"287","author":"Liu","year":"2012","journal-title":"J. Biol. Chem."},{"key":"2024070813480799800_B11","doi-asserted-by":"crossref","first-page":"4527","DOI":"10.1007\/s00018-013-1390-5","article-title":"Emerging mechanisms and consequences of calcium regulation of alternative splicing in neurons and endocrine cells","volume":"70","author":"Razanau","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"2024070813480799800_B12","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1038\/35073593","article-title":"A CaMK IV responsive RNA element mediates depolarization-induced alternative splicing of ion channels","volume":"410","author":"Xie","year":"2001","journal-title":"Nature"},{"key":"2024070813480799800_B13","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1261\/rna.2171205","article-title":"A consensus CaMK IV-responsive RNA sequence mediates regulation of alternative exons in neurons","volume":"11","author":"Xie","year":"2005","journal-title":"RNA"},{"key":"2024070813480799800_B14","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/j.cell.2020.05.013","article-title":"Neuronal inactivity co-opts LTP machinery to drive potassium channel splicing and homeostatic spike widening","volume":"181","author":"Li","year":"2020","journal-title":"Cell"},{"key":"2024070813480799800_B15","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1016\/j.cell.2011.11.028","article-title":"SAM68 regulates neuronal activity-dependent alternative splicing of neurexin-1","volume":"147","author":"Iijima","year":"2011","journal-title":"Cell"},{"key":"2024070813480799800_B16","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.neuron.2012.08.010","article-title":"Activity-mediated AMPA receptor remodeling, driven by alternative splicing in the ligand-binding domain","volume":"76","author":"Penn","year":"2012","journal-title":"Neuron"},{"key":"2024070813480799800_B17","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1074\/jbc.M805113200","article-title":"The heterogeneous nuclear ribonucleoprotein L is an essential component in the Ca2+\/calmodulin-dependent protein kinase IV-regulated alternative splicing through cytidine-adenosine repeats","volume":"284","author":"Yu","year":"2009","journal-title":"J. Biol. Chem."},{"key":"2024070813480799800_B18","doi-asserted-by":"crossref","first-page":"4325","DOI":"10.1073\/pnas.0810666106","article-title":"Neuronal cell depolarization induces intragenic chromatin modifications affecting NCAM alternative splicing","volume":"106","author":"Schor","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2024070813480799800_B19","doi-asserted-by":"crossref","first-page":"E5363","DOI":"10.1073\/pnas.1722546115","article-title":"Activity-dependent aberrations in gene expression and alternative splicing in a mouse model of Rett syndrome","volume":"115","author":"Osenberg","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2024070813480799800_B20","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3389\/fnins.2011.00141","article-title":"Depolarization-mediated regulation of alternative splicing","volume":"5","author":"Sharma","year":"2011","journal-title":"Front. Neurosci."},{"key":"2024070813480799800_B21","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nn.4194","article-title":"DNA methylation changes in plasticity genes accompany the formation and maintenance of memory","volume":"19","author":"Halder","year":"2016","journal-title":"Nat. Neurosci."},{"key":"2024070813480799800_B22","doi-asserted-by":"crossref","first-page":"12780","DOI":"10.1093\/nar\/gkx900","article-title":"Independence between pre-mRNA splicing and DNA methylation in an isogenic minigene resource","volume":"45","author":"Nanan","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"2024070813480799800_B23","doi-asserted-by":"crossref","first-page":"e54879","DOI":"10.7554\/eLife.54879","article-title":"Cell-specific exon methylation and CTCF binding in neurons regulate calcium ion channel splicing and function","volume":"9","author":"Lopez\u00a0Soto","year":"2020","journal-title":"eLife"},{"key":"2024070813480799800_B24","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1038\/cr.2013.110","article-title":"Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition","volume":"23","author":"Maunakea","year":"2013","journal-title":"Cell Res."},{"key":"2024070813480799800_B25","doi-asserted-by":"crossref","first-page":"17551","DOI":"10.1073\/pnas.0507856102","article-title":"Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2","volume":"102","author":"Young","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2024070813480799800_B26","doi-asserted-by":"crossref","first-page":"e1006793","DOI":"10.1371\/journal.pgen.1006793","article-title":"MeCP2 recognizes cytosine methylated tri-nucleotide and di-nucleotide sequences to tune transcription in the mammalian brain","volume":"13","author":"Lagger","year":"2017","journal-title":"PLoS Genet."},{"key":"2024070813480799800_B27","doi-asserted-by":"crossref","first-page":"15114","DOI":"10.1073\/pnas.1618737114","article-title":"DNA methylation in the gene body influences MeCP2-mediated gene repression","volume":"113","author":"Kinde","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2024070813480799800_B28","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1177\/0883073807308715","article-title":"Rett syndrome: North American database","volume":"22","author":"Percy","year":"2007","journal-title":"J. Child Neurol."},{"key":"2024070813480799800_B29","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/13810","article-title":"Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2","volume":"23","author":"Amir","year":"1999","journal-title":"Nat. Genet."},{"key":"2024070813480799800_B30","first-page":"131","article-title":"Rett syndrome: Novel correlations linking&gt;96% genotype, disease severity, and seizures","volume":"5","author":"Rodriguez","year":"2020","journal-title":"Transl. Sci. Rare Dis."},{"key":"2024070813480799800_B31","doi-asserted-by":"crossref","first-page":"e01250","DOI":"10.1002\/brb3.1250","article-title":"Epilepsy and genetic in Rett syndrome: a review","volume":"9","author":"Operto","year":"2019","journal-title":"Brain Behav."},{"key":"2024070813480799800_B32","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nature14319","article-title":"Disruption of DNA-methylation-dependent long gene repression in Rett syndrome","volume":"522","author":"Gabel","year":"2015","journal-title":"Nature"},{"key":"2024070813480799800_B33","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1172\/JCI22854","article-title":"Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV","volume":"115","author":"Juang","year":"2005","journal-title":"J. Clin. Invest."},{"key":"2024070813480799800_B34","doi-asserted-by":"crossref","first-page":"16606","DOI":"10.1073\/pnas.1210129109","article-title":"cAMP response element modulator alpha controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus","volume":"109","author":"Hedrich","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2024070813480799800_B35","doi-asserted-by":"crossref","first-page":"30967","DOI":"10.1074\/jbc.M112.382507","article-title":"Nuclear calcium signaling controls methyl-CpG-binding protein 2 (MeCP2) phosphorylation on serine 421 following synaptic activity","volume":"287","author":"Buchthal","year":"2012","journal-title":"J. Biol. Chem."},{"key":"2024070813480799800_B36","doi-asserted-by":"crossref","first-page":"42790","DOI":"10.1038\/srep42790","article-title":"Regulation of mRNA splicing by MeCP2 via epigenetic modifications in the brain","volume":"7","author":"Cheng","year":"2017","journal-title":"Sci. Rep."},{"key":"2024070813480799800_B37","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1038\/nm.2828","article-title":"Epigenetic mechanisms in neurological disease","volume":"18","author":"Jakovcevski","year":"2012","journal-title":"Nat. Med."},{"key":"2024070813480799800_B38","doi-asserted-by":"crossref","first-page":"e1009087","DOI":"10.1371\/journal.pgen.1009087","article-title":"Quantitative analysis questions the role of MeCP2 as a global regulator of alternative splicing","volume":"16","author":"Chhatbar","year":"2020","journal-title":"PLoS Genet."},{"key":"2024070813480799800_B39","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1083\/jcb.47.1.61","article-title":"Production of both prolactin and growth hormone by clonal strains of rat pituitary tumor cells. Differential effects of hydrocortisone and tissue extracts","volume":"47","author":"Tashjian","year":"1970","journal-title":"J. Cell Biol."},{"key":"2024070813480799800_B40","doi-asserted-by":"crossref","first-page":"e00651-17","DOI":"10.1128\/MCB.00651-17","article-title":"Multilevel differential control of hormone gene expression programs by hnRNP L and LL in pituitary cells","volume":"38","author":"Lei","year":"2018","journal-title":"Mol. Cell. Biol."},{"key":"2024070813480799800_B41","doi-asserted-by":"crossref","first-page":"e40","DOI":"10.1371\/journal.pbio.0050040","article-title":"Depolarization and CaM kinase IV modulate NMDA receptor splicing through two essential RNA elements","volume":"5","author":"Lee","year":"2007","journal-title":"PLoS Biol."},{"key":"2024070813480799800_B42","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1101\/gr.133744.111","article-title":"Detecting differential usage of exons from RNA-seq data","volume":"22","author":"Anders","year":"2012","journal-title":"Genome Res."},{"key":"2024070813480799800_B43","doi-asserted-by":"crossref","first-page":"e61","DOI":"10.1093\/nar\/gkr1291","article-title":"MATS: A Bayesian framework for flexible detection of differential alternative splicing from RNA-Seq data","volume":"40","author":"Shen","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"2024070813480799800_B44","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"2024070813480799800_B45","volume-title":"Babraham Bioinformatics","author":"Andrews","year":"2010"},{"key":"2024070813480799800_B46","doi-asserted-by":"crossref","first-page":"615821","DOI":"10.3389\/fonc.2021.615821","article-title":"Characterization of cell free plasma methyl-dna from xenografted tumors to guide the selection of diagnostic markers for early-stage cancers","volume":"11","author":"Liu","year":"2021","journal-title":"Front. Oncol."},{"key":"2024070813480799800_B47","doi-asserted-by":"crossref","first-page":"W216","DOI":"10.1093\/nar\/gkac194","article-title":"DAVID: A web server for functional enrichment analysis and functional annotation of gene lists (2021 update)","volume":"50","author":"Sherman","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"2024070813480799800_B48","doi-asserted-by":"crossref","first-page":"W39","DOI":"10.1093\/nar\/gkv416","article-title":"The MEME suite","volume":"43","author":"Bailey","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"2024070813480799800_B49","first-page":"28","article-title":"Fitting a mixture model by expectation maximization to discover motifs in bipolymers","volume":"2","author":"Bailey","year":"1994","journal-title":"Proc. Int. Conf. Intell. Syst. Mol. Biol."},{"key":"2024070813480799800_B50","doi-asserted-by":"crossref","first-page":"e85","DOI":"10.1136\/jmg.2003.014480","article-title":"Screening of MECP2 coding sequence in patients with phenotypes of decreasing likelihood for Rett syndrome: A cohort of 171 cases","volume":"41","author":"Kammoun","year":"2004","journal-title":"J. Med. Genet."},{"key":"2024070813480799800_B51","doi-asserted-by":"crossref","first-page":"21542","DOI":"10.1074\/jbc.271.35.21542","article-title":"A unique phosphorylation-dependent mechanism for the activation of Ca2+\/calmodulin-dependent protein kinase type IV\/GR","volume":"271","author":"Chatila","year":"1996","journal-title":"J. Biol. Chem."},{"key":"2024070813480799800_B52","doi-asserted-by":"crossref","first-page":"3672","DOI":"10.1128\/MCB.15.7.3672","article-title":"Calcium activates serum response factor-dependent transcription by a Ras- and Elk-1-independent mechanism that involves a Ca2+\/calmodulin-dependent kinase","volume":"15","author":"Miranti","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"2024070813480799800_B53","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nn.3607","article-title":"Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain","volume":"17","author":"Guo","year":"2014","journal-title":"Nat. Neurosci."},{"key":"2024070813480799800_B54","doi-asserted-by":"crossref","first-page":"635","DOI":"10.3389\/fgene.2018.00635","article-title":"MECP2 mutation interrupts nucleolin-mTOR-P70S6K signaling in Rett syndrome patients","volume":"9","author":"Olson","year":"2018","journal-title":"Front. Genet."},{"key":"2024070813480799800_B55","doi-asserted-by":"crossref","first-page":"763","DOI":"10.3389\/fcell.2020.00763","article-title":"The MeCP2E1\/E2-BDNF-miR132 homeostasis regulatory network is region-dependent in the human brain and is impaired in Rett syndrome patients","volume":"8","author":"Pejhan","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"2024070813480799800_B56","first-page":"35","article-title":"The rat prolactin gene is expressed in brain tissue: detection of normal and alternatively spliced prolactin messenger RNA","volume":"6","author":"Emanuele","year":"1992","journal-title":"Mol. Endocrinol."},{"key":"2024070813480799800_B57","doi-asserted-by":"crossref","first-page":"5483","DOI":"10.1038\/sj.onc.1205699","article-title":"5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy","volume":"21","author":"Christman","year":"2002","journal-title":"Oncogene"},{"key":"2024070813480799800_B58","first-page":"763","article-title":"Effect of 5-azacytidine on differentiation and DNA methylation in human promyelocytic leukemia cells (HL-60)","volume":"43","author":"Christman","year":"1983","journal-title":"Cancer Res."},{"key":"2024070813480799800_B59","doi-asserted-by":"crossref","first-page":"10157","DOI":"10.3390\/ijms231710157","article-title":"Transcriptome-Wide Detection of Intron\/Exon Definition in the Endogenous Pre-mRNA Transcripts of Mammalian Cells and Its Regulation by Depolarization","volume":"23","author":"Liu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"2024070813480799800_B60","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jpsychires.2010.09.001","article-title":"Association study of six candidate genes asymmetrically expressed in the two cerebral hemispheres suggests the involvement of BAIAP2 in autism","volume":"45","author":"Toma","year":"2011","journal-title":"J. Psychiatr. Res."},{"key":"2024070813480799800_B61","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1093\/nar\/18.5.1145","article-title":"Cloning, characterization, and expression in Escherichia coli of the gene coding for the CpG DNA methylase from Spiroplasma sp. strain MQ1(M.SssI)","volume":"18","author":"Renbaum","year":"1990","journal-title":"Nucleic Acids Res."},{"key":"2024070813480799800_B62","doi-asserted-by":"crossref","first-page":"D200","DOI":"10.1093\/nar\/gkw1129","article-title":"CDD\/SPARCLE: functional classification of proteins via subfamily domain architectures","volume":"45","author":"Marchler-Bauer","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"2024070813480799800_B63","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1001\/archpedi.1986.02140220043029","article-title":"Rett syndrome: a commonly overlooked progressive encephalopathy in girls","volume":"140","author":"Al-Mateen","year":"1986","journal-title":"Am. J. Dis. Child."},{"key":"2024070813480799800_B64","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1021\/acschemneuro.7b00346","article-title":"Rett syndrome: a genetic update and clinical review focusing on comorbidities","volume":"9","author":"Gold","year":"2018","journal-title":"ACS Chem. Neurosci."},{"key":"2024070813480799800_B65","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1111\/j.1528-1167.2012.03656.x","article-title":"Epilepsy in Rett syndrome, and CDKL5- and FOXG1-gene-related encephalopathies","volume":"53","author":"Guerrini","year":"2012","journal-title":"Epilepsia"},{"key":"2024070813480799800_B66","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1523\/JNEUROSCI.2623-05.2006","article-title":"Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome","volume":"26","author":"Moretti","year":"2006","journal-title":"J. Neurosci."},{"key":"2024070813480799800_B67","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/ajmg.1320250533","article-title":"Plasma endorphins in Rett syndrome: preliminary data","volume":"1","author":"Facchinetti","year":"1986","journal-title":"Am. J. Med. Genet. Suppl."},{"key":"2024070813480799800_B68","first-page":"352","volume-title":"Hormone Research in Paeditrics. Karger Allschwilerstrasse 10, CH-4009 Basel, Switzerlannd","author":"Pepe","year":"2023"},{"key":"2024070813480799800_B69","doi-asserted-by":"crossref","first-page":"20523","DOI":"10.1074\/jbc.M803021200","article-title":"Rett syndrome-causing mutations in human MeCP2 result in diverse structural changes that impact folding and DNA interactions","volume":"283","author":"Ghosh","year":"2008","journal-title":"J. Biol. Chem."},{"key":"2024070813480799800_B70","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/nrg3778","article-title":"Context-dependent control of alternative splicing by RNA-binding proteins","volume":"15","author":"Fu","year":"2014","journal-title":"Nat. Rev. Genet."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/52\/12\/7211\/58470043\/gkae311.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/52\/12\/7211\/58470043\/gkae311.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T09:50:16Z","timestamp":1720432216000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/52\/12\/7211\/7658046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,25]]},"references-count":70,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,4,25]]},"published-print":{"date-parts":[[2024,7,8]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkae311","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.02.23.581772","asserted-by":"object"}]},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,7,8]]},"published":{"date-parts":[[2024,4,25]]}}}