{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:23:02Z","timestamp":1790893382404,"version":"4.1.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"16","license":[{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002923","name":"National Scientific and Technical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Agencia Nacional de Promoci\u00f3n de la Investigaci\u00f3n, el DesarrolloTecnol\u00f3gico y la Innovaci\u00f3n","award":["PICT-2018-00561\/PICT-2021-00067"],"award-info":[{"award-number":["PICT-2018-00561\/PICT-2021-00067"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Chikungunya virus (CHIKV) is a rapidly spreading re-emergent virus transmitted from mosquitoes to humans. The emergence of epidemic variants has been associated with changes in the viral genome, such as the duplication of repeated sequences in the 3\u2032 untranslated region (UTR). Indeed, blocks of repeated sequences seemingly favor RNA recombination, providing the virus with a unique ability to continuously change the 3\u2032UTR architecture during host switching. In this work, we provide experimental data on the molecular mechanism of RNA recombination and describe specific sequence and structural elements in the viral 3\u2032UTR that favor template switching of the viral RNA-dependent RNA polymerase on the 3\u2032UTR. Furthermore, we found that a 3\u2032UTR deletion mutant that exhibits markedly delayed replication in mosquito cells and impaired transmission in vivo, recombines in reference laboratory strains of mosquitoes. Altogether, our data provide novel experimental evidence indicating that RNA recombination can act as a nucleic acid repair mechanism to add repeated sequences that are associated to high viral fitness in mosquito during chikungunya virus replication.<\/jats:p>","DOI":"10.1093\/nar\/gkae650","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T11:09:53Z","timestamp":1721905793000},"page":"9727-9744","source":"Crossref","is-referenced-by-count":5,"title":["Molecular basis of RNA recombination in the 3\u2032UTR of chikungunya virus genome"],"prefix":"10.1093","volume":"52","author":[{"given":"Eugenia S","family":"Bardossy","sequence":"first","affiliation":[{"name":"Escuela de Bio y Nanotecnolog\u00eda, Universidad de San Mart\u00edn - CONICET , Buenos Aires, Argentina"},{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9 , CNRS UMR3569, Viruses and RNA Interference Unit, 75015\u00a0 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiano","family":"Volpe","sequence":"additional","affiliation":[{"name":"Escuela de Bio y Nanotecnolog\u00eda, Universidad de San Mart\u00edn - CONICET , Buenos Aires, Argentina"},{"name":"Instituto de Qu\u00edmica y Fisicoqu\u00edmica Biol\u00f3gicas \u201cProf. Alejandro C. Paladini\u201d (IQUIFIB), Universidad de Buenos Aires - CONICET , Buenos Aires , Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasutsugu","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9 , CNRS UMR3569, Viruses and RNA Interference Unit, 75015\u00a0 Paris , France"},{"name":"Center for Marine Environmental Studies (CMES), Ehime University , Matsuyama , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Merwaiss","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9 , CNRS UMR3569, Viruses and RNA Interference Unit, 75015\u00a0 Paris , France"},{"name":"Instituto de Biolog\u00eda Molecular y Celular de Plantas (CSIC-Universitat Polit\u00e8cnica de Val\u00e8ncia) , 46022\u00a0 Valencia , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6608-4700","authenticated-orcid":false,"given":"Santiago","family":"Faraj","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica y Fisicoqu\u00edmica Biol\u00f3gicas \u201cProf. Alejandro C. Paladini\u201d (IQUIFIB), Universidad de Buenos Aires - CONICET , Buenos Aires , Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Montes","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica y Fisicoqu\u00edmica Biol\u00f3gicas \u201cProf. Alejandro C. Paladini\u201d (IQUIFIB), Universidad de Buenos Aires - CONICET , Buenos Aires , Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Carla","family":"Saleh","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9 , CNRS UMR3569, Viruses and RNA Interference Unit, 75015\u00a0 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego\u00a0E","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Escuela de Bio y Nanotecnolog\u00eda, Universidad de San Mart\u00edn - CONICET , Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0728-5227","authenticated-orcid":false,"given":"Claudia\u00a0V","family":"Filomatori","sequence":"additional","affiliation":[{"name":"Escuela de Bio y Nanotecnolog\u00eda, Universidad de San Mart\u00edn - CONICET , Buenos Aires, Argentina"},{"name":"Instituto de Qu\u00edmica y Fisicoqu\u00edmica Biol\u00f3gicas \u201cProf. Alejandro C. 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