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In addition to its canonical functions in DSB signaling, RNF168 may facilitate DNA replication fork progression. However, the precise role of RNF168 in DNA replication remains unclear. Here, we demonstrate that RNF168 is recruited to DNA replication factories in a manner that is independent of the canonical DSB response pathway regulated by Ataxia-Telangiectasia Mutated (ATM) and RNF8. We identify a degenerate Proliferating Cell Nuclear Antigen (PCNA)-interacting peptide (DPIP) motif in the C-terminus of RNF168, which together with its Motif Interacting with Ubiquitin (MIU) domain mediates binding to mono-ubiquitylated\u00a0PCNA at replication factories. An RNF168 mutant harboring inactivating substitutions in its DPIP box and MIU1 domain (termed RNF168 \u0394DPIP\/\u0394MIU1) is not recruited to sites of DNA synthesis and fails to support ongoing DNA replication. Notably, the PCNA interaction-deficient RNF168 \u0394DPIP\/\u0394MIU1 mutant fully rescues the ability of RNF168\u2212\/\u2212 cells to form 53BP1 foci in response to DNA DSBs. Therefore, RNF168 functions in DNA replication and DSB signaling are fully separable. Our results define a new mechanism by which RNF168 promotes DNA replication independently of its canonical functions in DSB signaling.<\/jats:p>","DOI":"10.1093\/nar\/gkae918","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T12:59:39Z","timestamp":1729774779000},"page":"13019-13035","source":"Crossref","is-referenced-by-count":5,"title":["PCNA-binding activity separates RNF168 functions in DNA replication and DNA double-stranded break signaling"],"prefix":"10.1093","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5936-4090","authenticated-orcid":false,"given":"Yang","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill , 614 Brinkhous-Bullitt Building , 160 Medical Drive, Chapel Hill , NC\u00a0 27599 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepika","family":"Jayaprakash","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill , 614 Brinkhous-Bullitt Building , 160 Medical Drive, Chapel Hill , NC\u00a0 27599 ,","place":["USA"]},{"name":"Oral and Craniofacial Biomedicine Program, Adam\u2019s School of Dentistry, University of North Carolina at Chapel Hill, 385 S Columbia Street, Chapel Hill, NC\u00a0 27599 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satpal\u00a0S","family":"Jhujh","sequence":"additional","affiliation":[{"name":"Institute of Cancer and Genomic Sciences, University of Birmingham , Vincent Drive, Edgbaston, Birmingham\u00a0 B15 2TT ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John\u00a0J","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Institute of Cancer and Genomic Sciences, University of Birmingham , Vincent Drive, Edgbaston, Birmingham\u00a0 B15 2TT ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Chen","sequence":"additional","affiliation":[{"name":"Cytiva Life Sciences, Global Life Sciences Solutions USA LLC , 100 Results Way, Marlborough , MA\u00a0 01752 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanzhe","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill , 614 Brinkhous-Bullitt Building , 160 Medical Drive, Chapel Hill , NC\u00a0 27599 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2071-9891","authenticated-orcid":false,"given":"Jay\u00a0Ramanlal","family":"Anand","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill , 614 Brinkhous-Bullitt Building , 160 Medical Drive, Chapel Hill , NC\u00a0 27599 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Mutter-Rottmayer","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill , 614 Brinkhous-Bullitt Building , 160 Medical Drive, Chapel Hill , NC\u00a0 27599 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8494-0379","authenticated-orcid":false,"given":"Pablo","family":"Ariel","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill , 614 Brinkhous-Bullitt Building , 160 Medical Drive, Chapel Hill , NC\u00a0 27599 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"An","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill , 614 Brinkhous-Bullitt Building , 160 Medical Drive, Chapel Hill , NC\u00a0 27599 ,","place":["USA"]},{"name":"Institute of Cancer Prevention and Treatment, Harbin Medical University , 6 Bao Jian Street, Nan Gang District, Harbin 150081 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill , 614 Brinkhous-Bullitt Building , 160 Medical Drive, Chapel Hill , NC\u00a0 27599 ,","place":["USA"]},{"name":"Department of Neuro-Oncology, Chongqing University Cancer Hospital and Chongqing Cancer Institute and Chongqing Cancer Hospital ,181 Hanyu Road, Shapingba District, Chongqing 400044,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth\u00a0H","family":"Pearce","sequence":"additional","affiliation":[{"name":"Center For Integrated Chemical Biology and Drug Discovery , UNC Eshelman School of Pharmacy, Marsico Hall, 125 Mason Farm Road, CB# 7363 , Chapel Hill, NC\u00a027599 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie-Anne","family":"Blanchet","sequence":"additional","affiliation":[{"name":"CHU de Qu\u00e9bec-Universit\u00e9 Laval Research Center (Oncology division), Universit\u00e9 Laval Cancer Research Center and Department of Molecular Biology, Medical Biochemistry and Pathology, Faculty of Medecine, Universit\u00e9 Laval , 9 McMahon, Qu\u00e9bec,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nandana","family":"Nandakumar","sequence":"additional","affiliation":[{"name":"CHU de Qu\u00e9bec-Universit\u00e9 Laval Research Center (Oncology division), Universit\u00e9 Laval Cancer Research Center and Department of Molecular Biology, Medical Biochemistry and Pathology, Faculty of Medecine, Universit\u00e9 Laval , 9 McMahon, Qu\u00e9bec,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Duke University School of Medicine , 307 Research Drive, Durham , NC\u00a0 27710 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5431-8650","authenticated-orcid":false,"given":"Am\u00e9lie","family":"Fradet-Turcotte","sequence":"additional","affiliation":[{"name":"CHU de Qu\u00e9bec-Universit\u00e9 Laval Research Center (Oncology division), Universit\u00e9 Laval Cancer Research Center and Department of Molecular Biology, Medical Biochemistry and Pathology, Faculty of Medecine, Universit\u00e9 Laval , 9 McMahon, Qu\u00e9bec,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grant\u00a0S","family":"Stewart","sequence":"additional","affiliation":[{"name":"Institute of Cancer and Genomic Sciences, University of Birmingham , Vincent Drive, Edgbaston, Birmingham\u00a0 B15 2TT ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cyrus","family":"Vaziri","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill , 614 Brinkhous-Bullitt Building , 160 Medical Drive, Chapel Hill , NC\u00a0 27599 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,10,24]]},"reference":[{"key":"2024112721431282800_B1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3389\/fgene.2016.00122","article-title":"Writers, readers, and erasers of histone ubiquitylation in DNA double-strand break 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