{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:10:19Z","timestamp":1790741419482,"version":"4.1.0"},"reference-count":75,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T00:00:00Z","timestamp":1738972800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015257","name":"Northeastern University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015257","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI162996"],"award-info":[{"award-number":["R01AI162996"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The nosocomial pathogen Acinetobacter baumannii is a major threat to human health. The sensor kinase-response regulator system, BfmS-BfmR, is essential to multidrug resistance and virulence in the bacterium and represents a potential antimicrobial target. Important questions remain about how the system controls resistance and pathogenesis. Although BfmR knockout alters expression of\u00a0&amp;gt;1000 genes, its direct regulon is undefined. Moreover, how phosphorylation controls the regulator is unclear. Here, we address these problems by combining mutagenesis, ChIP-seq, and in vitro phosphorylation to study the functions of phospho-BfmR. We show that phosphorylation is required for BfmR-mediated gene regulation, antibiotic resistance, and sepsis development in vivo. Consistent with activating the protein, phosphorylation induces dimerization and target DNA affinity. Integrated analysis of genome-wide binding and transcriptional profiles of BfmR led to additional key findings: (1) Phosphorylation dramatically expands the number of genomic sites BfmR binds; (2) DNA recognition involves a direct repeat motif widespread across promoters; (3) BfmR directly regulates 303 genes as activator (e.g., capsule, peptidoglycan, and outer membrane biogenesis) or repressor (pilus biogenesis); (4) BfmR controls several non-coding sRNAs. These studies reveal the centrality of a phosphorylation signal in driving A. baumannii disease and disentangle the extensive pathogenic gene-regulatory network under its control.<\/jats:p>","DOI":"10.1093\/nar\/gkaf063","type":"journal-article","created":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T05:44:41Z","timestamp":1738993481000},"source":"Crossref","is-referenced-by-count":20,"title":["A phosphorylation signal activates genome-wide transcriptional control by BfmR, the global regulator of\n                    <i>Acinetobacter<\/i>\n                    resistance and virulence"],"prefix":"10.1093","volume":"53","author":[{"given":"Nicole","family":"Raustad","sequence":"first","affiliation":[{"name":"Department of Biology, Northeastern University , Boston , MA 02115 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfei","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Biology, Northeastern University , Boston , MA 02115 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Iinishi","sequence":"additional","affiliation":[{"name":"Antimicrobial Discovery Center, Department of Biology, Northeastern University , Boston , MA 02115 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arpita","family":"Mohapatra","sequence":"additional","affiliation":[{"name":"Department of Biology, Northeastern University , Boston , MA 02115 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark\u00a0W","family":"Soo","sequence":"additional","affiliation":[{"name":"Department of Biology, Northeastern University , Boston , MA 02115 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Everett","family":"Hay","sequence":"additional","affiliation":[{"name":"Department of Biology, Northeastern University , Boston , MA 02115 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle\u00a0M","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Department of Biology, Northeastern University , Boston , MA 02115 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9661-8072","authenticated-orcid":false,"given":"Edward","family":"Geisinger","sequence":"additional","affiliation":[{"name":"Department of Biology, Northeastern University , Boston , MA 02115 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,2,8]]},"reference":[{"key":"2025022511100081600_B1","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1038\/nrmicro1789","article-title":"An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii","volume":"5","author":"Dijkshoorn","year":"2007","journal-title":"Nat Rev Micro"},{"key":"2025022511100081600_B2","first-page":"44","article-title":"COVID-19: U.S. Impact on Antimicrobial Resistance, Special Report 2022","author":"CDC","year":"2022"},{"key":"2025022511100081600_B3","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.3390\/pathogens10081006","article-title":"Acinetobacter baumannii infections in times of COVID-19 Pandemic","volume":"10","author":"Rangel","year":"2021","journal-title":"Pathogens"},{"key":"2025022511100081600_B4","first-page":"64","article-title":"Antimicrobial Resistance Coordination and Strategy Unit. 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