{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:57:18Z","timestamp":1792497438953,"version":"4.5.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Natural Sciences Research Council"},{"DOI":"10.13039\/501100000038","name":"NSERC","doi-asserted-by":"publisher","award":["RGPIN-2024-04314"],"award-info":[{"award-number":["RGPIN-2024-04314"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"CIHR","doi-asserted-by":"publisher","award":["519474"],"award-info":[{"award-number":["519474"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008176","name":"CFI","doi-asserted-by":"publisher","award":["225404"],"award-info":[{"award-number":["225404"]}],"id":[{"id":"10.13039\/100008176","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008176","name":"CFI","doi-asserted-by":"publisher","award":["30865"],"award-info":[{"award-number":["30865"]}],"id":[{"id":"10.13039\/100008176","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ontario Research Fund","award":["34876"],"award-info":[{"award-number":["34876"]}]},{"name":"Ontario Research Fund","award":["RE010-020"],"award-info":[{"award-number":["RE010-020"]}]},{"DOI":"10.13039\/501100003579","name":"University of Toronto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003579","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009663","name":"University Health Network","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019210","name":"UHN Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019210","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Biomedical research benefits from the rapid growth and diversity of experimentally detected protein\u2013protein interactions (PPIs) by gaining important biological insights. However, increasingly dense PPI networks can be challenging to interpret and apply. The 2025 update of the Integrated Interactions Database (IID) enhances accessibility and utility through several new features. We identify and incorporate network structural components from co-purified protein sets, as well as curated and predicted complexes, enabling users to explore network organization beyond binary interactions. Functional, pathway, and disease associations of these components can be analyzed, enabling interactions to be grouped into higher-order structures with known or provisional biological roles. Users can now filter interactions by five detection types: pairwise, co-purification, colocalization, proximity, and other evidence. To extend the value and information of predicted interactions, we include interaction interface predictions for 53 647 PPIs, generated using the MEGADOCK docking algorithm, adding molecular detail for structural biology and variant impact studies. Finally, we map PPIs to 15 immune cell types and 12 additional normal tissues, offering tissue-specific views of interaction networks increasingly relevant in disease and immunology research. IID 2025 now includes over 1 million experimentally detected human PPIs, representing an 83% increase from the previous release, alongside expanded non-human networks. The portal remains publicly available at\u00a0https:\/\/ophid.utoronto.ca\/iid.<\/jats:p>","DOI":"10.1093\/nar\/gkaf1259","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T12:45:09Z","timestamp":1761655509000},"page":"D593-D600","source":"Crossref","is-referenced-by-count":7,"title":["IID 2025: Physical protein interaction data with detection types, co-purified protein sets, molecular docking, and immune cell networks"],"prefix":"10.1093","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1111-8667","authenticated-orcid":false,"given":"Max","family":"Kotlyar","sequence":"first","affiliation":[{"name":"Osteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute and Data Science Discovery Centre for Chronic Diseases, Krembil Research Institute, University Health Network , Toronto, ON M5T 0S8 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1934-7472","authenticated-orcid":false,"given":"Chiara","family":"Pastrello","sequence":"additional","affiliation":[{"name":"Osteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute and Data Science Discovery Centre for Chronic Diseases, Krembil Research Institute, University Health Network , Toronto, ON M5T 0S8 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Abovsky","sequence":"additional","affiliation":[{"name":"Osteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute and Data Science Discovery Centre for Chronic Diseases, Krembil Research Institute, University Health Network , Toronto, ON M5T 0S8 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandru","family":"Mizeranschi","sequence":"additional","affiliation":[{"name":"Research and Development Station for Bovine Arad , Arad 310059 ,","place":["Romania"]},{"name":"Institute for Advanced Environmental Research, West University of Timisoara , Timisoara 300086 ,","place":["Romania"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armand","family":"Keating","sequence":"additional","affiliation":[{"name":"Osteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute and Data Science Discovery Centre for Chronic Diseases, Krembil Research Institute, University Health Network , Toronto, ON M5T 0S8 ,","place":["Canada"]},{"name":"Princess Margaret Cancer Centre , Toronto, ON M5G 2M9 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz-Claudio","family":"Cameron","sequence":"additional","affiliation":[{"name":"Osteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute and Data Science Discovery Centre for Chronic Diseases, Krembil Research Institute, University Health Network , Toronto, ON M5T 0S8 ,","place":["Canada"]},{"name":"Gladman Krembil Psoriatic Arthritis Program, Schroeder Arthritis Institute, University Health Network , Toronto, ON M5T 0S8 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Chandran","sequence":"additional","affiliation":[{"name":"Gladman Krembil Psoriatic Arthritis Program, Schroeder Arthritis Institute, University Health Network , Toronto, ON M5T 0S8 ,","place":["Canada"]},{"name":"Department of Laboratory Medicine and Pathobiology, University of Toronto , Toronto, ON ,","place":["Canada"]},{"name":"Division of Rheumatology, Department of Medicine, University of Toronto , Toronto ,","place":["Canada"]},{"name":"Institute of Medical Science, University of Toronto , Toronto, ON ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Jurisica","sequence":"additional","affiliation":[{"name":"Osteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute and Data Science Discovery Centre for Chronic Diseases, Krembil Research Institute, University Health Network , Toronto, ON M5T 0S8 ,","place":["Canada"]},{"name":"Departments of Medical Biophysics and Computer Science, and Faculty of Dentistry, University of Toronto , Toronto, ON ,","place":["Canada"]},{"name":"Institute of Neuroimmunology, Slovak Academy of Sciences , D\u00fabravsk\u00e1 cesta 9, Bratislava 845 10 ,","place":["Slovakia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"2026011523472031300_B1","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1093\/bioinformatics\/btq076","article-title":"The power of protein interaction networks for associating genes with diseases","volume":"26","author":"Navlakha","year":"2010","journal-title":"Bioinformatics"},{"key":"2026011523472031300_B2","doi-asserted-by":"publisher","first-page":"17417","DOI":"10.1038\/srep17417","article-title":"Drug target prioritization by perturbed gene expression and network information","volume":"5","author":"Isik","year":"2015","journal-title":"Sci Rep"},{"key":"2026011523472031300_B3","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1002\/pmic.201100607","article-title":"Combining many interaction networks to predict gene function and analyze gene lists","volume":"12","author":"Mostafavi","year":"2012","journal-title":"Proteomics"},{"key":"2026011523472031300_B4","doi-asserted-by":"publisher","first-page":"3215","DOI":"10.1093\/bioinformatics\/btu508","article-title":"Walking the interactome for candidate prioritization in exome sequencing studies of Mendelian diseases","volume":"30","author":"Smedley","year":"2014","journal-title":"Bioinformatics"},{"key":"2026011523472031300_B5","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1186\/s12859-016-1215-2","article-title":"Effective comparative analysis of protein\u2013protein interaction networks by measuring the steady-state network flow using a Markov model","volume":"17","author":"Jeong","year":"2016","journal-title":"BMC Bioinformatics"},{"key":"2026011523472031300_B6","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s13040-025-00457-6","article-title":"Recent advances in deep learning for protein\u2013protein interaction: a review","volume":"18","author":"Cui","year":"2025","journal-title":"BioData Mining"},{"key":"2026011523472031300_B7","doi-asserted-by":"publisher","first-page":"6959","DOI":"10.1073\/pnas.0708078105","article-title":"Estimating the size of the human interactome","volume":"105","author":"Stumpf","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026011523472031300_B8","doi-asserted-by":"publisher","first-page":"237","DOI":"10.3389\/fgene.2015.00237","article-title":"Quantitative affinity purification mass spectrometry: a versatile technology to study protein-protein interactions","volume":"6","author":"Meyer","year":"2015","journal-title":"Front Genet"},{"key":"2026011523472031300_B9","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s12859-018-2073-x","article-title":"MEGADOCK-Web: an integrated database of high-throughput structure-based protein\u2013protein interaction predictions","volume":"19","author":"Hayashi","year":"2018","journal-title":"BMC Bioinformatics"},{"key":"2026011523472031300_B10","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1002\/pro.3978","article-title":"The BioGRID database: a comprehensive biomedical resource of curated protein, genetic, and chemical interactions","volume":"30","author":"Oughtred","year":"2021","journal-title":"Protein Sci"},{"key":"2026011523472031300_B11","doi-asserted-by":"publisher","first-page":"D449","DOI":"10.1093\/nar\/gkh086","article-title":"The Database of Interacting Proteins: 2004 update","volume":"32","author":"Salwinski","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"2026011523472031300_B12","doi-asserted-by":"publisher","first-page":"D767","DOI":"10.1093\/nar\/gkn892","article-title":"Human Protein Reference Database\u20142009 update","volume":"37","author":"Keshava\u00a0Prasad","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"2026011523472031300_B13","doi-asserted-by":"publisher","first-page":"D1228","DOI":"10.1093\/nar\/gks1147","article-title":"InnateDB: systems biology of innate immunity and beyond\u2014recent updates and continuing curation","volume":"41","author":"Breuer","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"2026011523472031300_B14","doi-asserted-by":"publisher","first-page":"D358","DOI":"10.1093\/nar\/gkt1115","article-title":"The MIntAct project\u2014IntAct as a common curation platform for 11 molecular interaction databases","volume":"42","author":"Orchard","year":"2014","journal-title":"Nucl Acids Res"},{"key":"2026011523472031300_B15","doi-asserted-by":"publisher","first-page":"D1677","DOI":"10.1093\/nar\/gkae1088","article-title":"MatrixDB 2024: an increased coverage of extracellular matrix interactions, a new Network Explorer and a new web interface","volume":"53","author":"Samarasinghe","year":"2025","journal-title":"Nucleic Acids Res"},{"key":"2026011523472031300_B16","doi-asserted-by":"publisher","first-page":"D857","DOI":"10.1093\/nar\/gkr930","article-title":"MINT, the molecular interaction database: 2012 Update","volume":"40","author":"Licata","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"2026011523472031300_B17","doi-asserted-by":"publisher","first-page":"D581","DOI":"10.1093\/nar\/gky1037","article-title":"IID 2018 update: context-specific physical protein\u2013protein interactions in human, model organisms and domesticated species","volume":"47","author":"Kotlyar","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2026011523472031300_B18","doi-asserted-by":"publisher","first-page":"D948","DOI":"10.1093\/nar\/gkae1071","article-title":"Ensembl 2025","volume":"53","author":"Dyer","year":"2025","journal-title":"Nucleic Acids Res"},{"key":"2026011523472031300_B19","doi-asserted-by":"publisher","first-page":"D609","DOI":"10.1093\/nar\/gkae1010","article-title":"UniProt: the Universal Protein Knowledgebase in 2025","volume":"53","author":"Consortium","year":"2025","journal-title":"Nucleic Acids Res"},{"key":"2026011523472031300_B20","doi-asserted-by":"publisher","first-page":"71","DOI":"10.3233\/CBM-181758","article-title":"Gene expression profiling identifies potential molecular markers of papillary thyroid carcinoma","volume":"24","author":"Reyes","year":"2019","journal-title":"CBM"},{"key":"2026011523472031300_B21","doi-asserted-by":"publisher","first-page":"e5645","DOI":"10.1371\/journal.pone.0005645","article-title":"Evaluation of microarray preprocessing algorithms based on concordance with RT-PCR in clinical samples","volume":"4","author":"Gyorffy","year":"2009","journal-title":"PLoS One"},{"key":"2026011523472031300_B22","doi-asserted-by":"publisher","first-page":"2359","DOI":"10.1007\/s00018-005-5250-9","article-title":"Gene signatures of testicular seminoma with emphasis on expression of ets variant gene 4","volume":"62","author":"Gashaw","year":"2005","journal-title":"Cell Mol Life Sci"},{"key":"2026011523472031300_B23","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1158\/1541-7786.MCR-07-0267","article-title":"Transcriptome profile of human colorectal adenomas","volume":"5","author":"Sabates-Bellver","year":"2007","journal-title":"Mol Cancer Res"},{"key":"2026011523472031300_B24","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/modpathol.2008.174","article-title":"Novel markers for enterochromaffin cells and gastrointestinal neuroendocrine carcinomas","volume":"22","author":"Leja","year":"2009","journal-title":"Mod Pathol"},{"key":"2026011523472031300_B25","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1186\/1471-2164-10-199","article-title":"Gene expression profile of bladder tissue of patients with ulcerative interstitial cystitis","volume":"10","author":"Gamper","year":"2009","journal-title":"Bmc Genomics"},{"key":"2026011523472031300_B26","doi-asserted-by":"publisher","first-page":"e2737","DOI":"10.1371\/journal.pone.0002737","article-title":"Type I interferon: potential therapeutic target for psoriasis?","volume":"3","author":"Yao","year":"2008","journal-title":"PLoS One"},{"key":"2026011523472031300_B27","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/1755-8794-3-58","article-title":"Comparative gene expression profiling analysis of urothelial carcinoma of the renal pelvis and bladder","volume":"3","author":"Zhang","year":"2010","journal-title":"BMC Med Genomics"},{"key":"2026011523472031300_B28","doi-asserted-by":"publisher","first-page":"4796","DOI":"10.1158\/0008-5472.CAN-14-0210","article-title":"Neuronal pentraxin 2 supports clear cell renal cell carcinoma by activating the AMPA-selective glutamate receptor-4","volume":"74","author":"von\u00a0Roemeling","year":"2014","journal-title":"Cancer Res"},{"key":"2026011523472031300_B29","doi-asserted-by":"publisher","first-page":"e0142229","DOI":"10.1371\/journal.pone.0142229","article-title":"Profiling of discrete gynecological cancers reveals novel transcriptional modules and common features shared by other cancer types and embryonic stem cells","volume":"10","author":"Pappa","year":"2015","journal-title":"PLoS One"},{"key":"2026011523472031300_B30","doi-asserted-by":"publisher","first-page":"E697","DOI":"10.1210\/jc.2014-2764","article-title":"Aberrant lipid metabolism in anaplastic thyroid carcinoma reveals stearoyl CoA desaturase 1 as a novel therapeutic target","volume":"100","author":"von\u00a0Roemeling","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"2026011523472031300_B31","doi-asserted-by":"publisher","first-page":"714274","DOI":"10.3389\/fimmu.2021.714274","article-title":"ULK1 inhibition as a targeted therapeutic strategy for psoriasis by regulating keratinocytes and their crosstalk with neutrophils","volume":"12","author":"Qiu","year":"2021","journal-title":"Front Immunol"},{"key":"2026011523472031300_B32","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1038\/msb.2009.17","article-title":"Tissue specificity and the human protein interaction network","volume":"5","author":"Bossi","year":"2009","journal-title":"Mol Syst Biol"},{"key":"2026011523472031300_B33","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1016\/j.cell.2018.10.022","article-title":"Impact of genetic polymorphisms on human immune cell gene expression","volume-title":"Cell","author":"Schmiedel","year":"2018"},{"key":"2026011523472031300_B34","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/s41588-020-00745-3","article-title":"Promoter-interacting expression quantitative trait loci are enriched for functional genetic variants","volume":"53","author":"Chandra","year":"2021","journal-title":"Nat Genet"},{"key":"2026011523472031300_B35","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"2026011523472031300_B36","doi-asserted-by":"publisher","first-page":"D368","DOI":"10.1093\/nar\/gkad1011","article-title":"AlphaFold Protein Structure Database in 2024: providing structure coverage for over 214 million protein sequences","volume":"52","author":"Varadi","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"2026011523472031300_B37","doi-asserted-by":"publisher","first-page":"e4792","DOI":"10.1002\/pro.4792","article-title":"UCSF ChimeraX: tools for structure building and analysis","volume":"32","author":"Meng","year":"2023","journal-title":"Protein Sci"},{"key":"2026011523472031300_B38","doi-asserted-by":"publisher","first-page":"e70621","DOI":"10.1096\/fj.202500793R","article-title":"Annexin A2 contributes to release of extracellular vimentin in response to inflammation","volume":"39","author":"Yuan","year":"2025","journal-title":"FASEB J"},{"key":"2026011523472031300_B39","doi-asserted-by":"publisher","first-page":"D644","DOI":"10.1093\/nar\/gkae1085","article-title":"Complex portal 2025: predicted human complexes and enhanced visualisation tools for the comparison of orthologous and paralogous complexes","volume":"53","author":"Balu","year":"2025","journal-title":"Nucleic Acids Res"},{"key":"2026011523472031300_B40","doi-asserted-by":"publisher","first-page":"D651","DOI":"10.1093\/nar\/gkae1033","article-title":"CORUM in 2024: protein complexes as drug targets","volume":"53","author":"Steinkamp","year":"2025","journal-title":"Nucleic Acids Res"},{"key":"2026011523472031300_B41","doi-asserted-by":"publisher","first-page":"D672","DOI":"10.1093\/nar\/gkad1025","article-title":"The Reactome Pathway Knowledgebase 2024","volume":"52","author":"Milacic","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"2026011523472031300_B42","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/s44320-025-00121-5","article-title":"hu.MAP3.0: atlas of human protein complexes by integration of &gt;25,000 proteomic experiments","volume":"21","author":"Fischer","year":"2025","journal-title":"Mol Syst Biol"},{"key":"2026011523472031300_B43","doi-asserted-by":"publisher","first-page":"baac019","DOI":"10.1093\/database\/baac019","article-title":"Diseases 2.0: a weekly updated database of disease\u2013gene associations from text mining and data integration","volume":"2022","author":"Grissa","year":"2022","journal-title":"Database (Oxford)"},{"key":"2026011523472031300_B44","doi-asserted-by":"publisher","first-page":"iyad031","DOI":"10.1093\/genetics\/iyad031","article-title":"The Gene Ontology knowledgebase in 2023","volume":"224","author":"Ontology\u00a0Consortium","year":"2023","journal-title":"Genetics"},{"key":"2026011523472031300_B45","doi-asserted-by":"publisher","first-page":"D663","DOI":"10.1093\/nar\/gkad1027","article-title":"PathDIP 5: improving coverage and making enrichment analysis more biologically meaningful","volume":"52","author":"Pastrello","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"2026011523472031300_B46","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.3390\/biomedicines13081804","article-title":"Functional disruption of IQGAP1 by truncated PALB2 in two cases of breast cancer: implications for proliferation and invasion","volume":"13","author":"P\u00e9rez-Rodr\u00edguez","year":"2025","journal-title":"Biomedicines"},{"key":"2026011523472031300_B47","doi-asserted-by":"publisher","first-page":"2493","DOI":"10.18632\/oncotarget.27623","article-title":"IQGAP1 control of centrosome function defines distinct variants of triple negative breast cancer","volume":"11","author":"Osman","year":"2020","journal-title":"Oncotarget"},{"key":"2026011523472031300_B48","doi-asserted-by":"publisher","first-page":"892","DOI":"10.3389\/fimmu.2017.00892","article-title":"CD56 in the immune system: more than a marker for cytotoxicity?","volume":"8","author":"Van\u00a0Acker","year":"2017","journal-title":"Front Immunol"},{"key":"2026011523472031300_B49","doi-asserted-by":"publisher","first-page":"ar64","DOI":"10.1091\/mbc.E23-12-0463","article-title":"CD56\/NCAM mediates cell migration of human NK cells by promoting integrin-mediated adhesion turnover","volume":"35","author":"Martinez","year":"2024","journal-title":"MBoC"},{"key":"2026011523472031300_B50","doi-asserted-by":"publisher","first-page":"775447","DOI":"10.3389\/fimmu.2021.775447","article-title":"\u03b22 integrin CD11d\/CD18: from expression to an emerging role in staged leukocyte migration","volume":"12","author":"Blythe","year":"2021","journal-title":"Front Immunol"},{"key":"2026011523472031300_B51","doi-asserted-by":"publisher","first-page":"1436_4363","DOI":"10.4049\/jimmunol.212.supp.1436.4363","article-title":"CD11d, an NK cell ally in their fight against tumours","volume":"212","author":"Bourel","year":"2024","journal-title":"J Immunol"},{"key":"2026011523472031300_B52","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1002\/eji.202249868","article-title":"Human NK cells responses are enhanced by CD56 engagement","volume":"52","author":"Picard","year":"2022","journal-title":"Eur J Immunol"},{"key":"2026011523472031300_B53","doi-asserted-by":"publisher","first-page":"D408","DOI":"10.1093\/nar\/gkw985","article-title":"HIPPIE v2.0: enhancing meaningfulness and reliability of protein\u2013protein interaction networks","volume":"45","author":"Alanis-Lobato","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"2026011523472031300_B54","doi-asserted-by":"publisher","first-page":"W258","DOI":"10.1093\/nar\/gkv515","article-title":"MyProteinNet: build up-to-date protein interaction networks for organisms, tissues and user-defined contexts","volume":"43","author":"Basha","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"2026011523472031300_B55","doi-asserted-by":"publisher","first-page":"167532","DOI":"10.1016\/j.jmb.2022.167532","article-title":"The TissueNet v.3 database: protein\u2013protein interactions in adult and embryonic human tissue contexts","volume":"434","author":"Ziv","year":"2022","journal-title":"J Mol Biol"},{"key":"2026011523472031300_B56","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/1752-0509-6-92","article-title":"HINT: high-quality protein interactomes and their applications in understanding human disease","volume":"6","author":"Das","year":"2012","journal-title":"BMC Syst Biol"},{"key":"2026011523472031300_B57","doi-asserted-by":"crossref","first-page":"baz005","DOI":"10.1093\/database\/baz005","article-title":"APID database: redefining protein\u2013protein interaction experimental evidences and binary interactomes","volume":"2019","author":"Alonso-L\u00f3pez","year":"2019","journal-title":"Database"},{"key":"2026011523472031300_B58","doi-asserted-by":"publisher","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein\u2013protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res"}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/54\/D1\/D593\/65551609\/gkaf1259.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/54\/D1\/D593\/65551609\/gkaf1259.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T04:47:29Z","timestamp":1768538849000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/54\/D1\/D593\/8343505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,26]]},"references-count":58,"journal-issue":{"issue":"D1","published-print":{"date-parts":[[2026,1,6]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkaf1259","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,1,6]]},"published":{"date-parts":[[2025,11,26]]}}}